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Gene: JUP (junction plakoglobin) Homo sapiens
Symbol: JUP
Name: junction plakoglobin
Description: Exhibits several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in several processes, including cellular response to indole-3-methanol; desmosome assembly; and regulation of heart contraction. Localizes to several cellular components, including catenin complex; gamma-catenin-TCF7L2 complex; and intercalated disc. Implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Biomarker of several diseases, including invasive ductal carcinoma; prostate cancer; seminoma; urinary system cancer (multiple); and uterine disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARVD12; catenin (cadherin-associated protein), gamma (80kD); catenin (cadherin-associated protein), gamma 80kDa; catenin gamma; CTNNG; desmoplakin III; desmoplakin-3; DP3; DPIII; gamma-catenin; PDGB; PKGB
Mus musculus (house mouse) : Jup (junction plakoglobin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Jup (junction plakoglobin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jup (junction plakoglobin)
Pan paniscus (bonobo/pygmy chimpanzee) : JUP (junction plakoglobin)
Canis lupus familiaris (dog) : JUP (junction plakoglobin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jup (junction plakoglobin)
Sus scrofa (pig) : JUP (junction plakoglobin)
Chlorocebus sabaeus (African green monkey) : JUP (junction plakoglobin)
Heterocephalus glaber (naked mole-rat) : Jup (junction plakoglobin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1741,754,604 - 41,786,931 (-)EnsemblGRCh38hg38GRCh38
GRCh381741,754,607 - 41,786,768 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371739,910,859 - 39,942,964 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,164,390 - 37,196,475 (-)NCBINCBI36hg18NCBI36
Build 341737,164,389 - 37,196,475NCBI
Celera1736,562,207 - 36,594,276 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1735,672,969 - 35,704,921 (-)NCBIHuRef
CHM1_11740,146,477 - 40,178,584 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on JUP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732396
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.