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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDEstradiol results in increased expression of CTNNB1 mRNA

PMID:14648872
multiple interactionsEXP 6480464CTD[Bromocriptine co-treated with Estradiol] results in decreased expression of CTNNB1 protein, Estradiol results in increased expression of and affects the localization of CTNNB1 protein

PMID:11786374, PMID:23684557
affects localizationISORGD:704876480464CTDEstradiol affects the localization of CTNNB1 protein

PMID:17170212
multiple interactionsISORGD:704876480464CTD[Estradiol co-treated with bisphenol A] results in decreased expression of CTNNB1 mRNA, Estradiol inhibits the reaction [Estrogens deficiency results in increased expression of CTNNB1 protein alternative form], Estradiol promotes the reaction [CTNNB1 protein binds to LEF1 protein]

PMID:17170212, PMID:27174447, PMID:30565903
multiple interactionsISORGD:7337056480464CTDEstradiol inhibits the reaction [ESR1 protein promotes the reaction [BTRC protein binds to CTNNB1 protein]], Estradiol promotes the reaction [CTNNB1 protein binds to ESR1 protein], Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter], Estradiol results in increased expression of and affects the localization of CTNNB1 protein, Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]

PMID:16053526, PMID:26990689, PMID:27156127
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.