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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1decreases expressionEXP 6480464CTDParaquat results in decreased expression of CTNNB1 mRNA; Paraquat results in decreased expression of CTNNB1 proteinPMID:27788593 PMID:30171970
Ctnnb1decreases response to substanceEXP 6480464CTDCTNNB1 protein results in decreased susceptibility to ParaquatPMID:23620592
Ctnnb1increases expressionEXP 6480464CTDParaquat results in increased expression of CTNNB1 mRNA; Paraquat results in increased expression of CTNNB1 proteinPMID:32462952
Ctnnb1multiple interactionsEXP 6480464CTDCTNNB1 protein inhibits the reaction [Paraquat results in increased abundance of Reactive Oxygen Species]; Lithium Chloride inhibits the reaction [Paraquat results in decreased expression of CTNNB1 protein]; MIR140 mRNA inhibits the reaction [Paraquat results in increased expression of CTNNB1 protein]; Paraquat inhibits the reaction [CTNNB1 protein binds to MPZ promoter]; Paraquat inhibits the reaction [CTNNB1 protein binds to PMP22 promoter]; Xuebijing inhibits the reaction [Paraquat results in increased expression of CTNNB1 mRNA]; Xuebijing inhibits the reaction [Paraquat results in increased expression of CTNNB1 protein]PMID:23620592 PMID:27788593 PMID:30171970 PMID:32462952
Ctnnb1affects localizationISOCTNNB1 (Homo sapiens)6480464CTDParaquat affects the localization of CTNNB1 proteinPMID:30205152
Ctnnb1decreases expressionISOCtnnb1 (Rattus norvegicus)6480464CTDParaquat results in decreased expression of CTNNB1 mRNAPMID:26887261 PMID:34655599
Ctnnb1increases expressionISOCtnnb1 (Rattus norvegicus)6480464CTDParaquat results in increased expression of CTNNB1 proteinPMID:30726711
Ctnnb1multiple interactionsISOCtnnb1 (Rattus norvegicus)6480464CTDFebuxostat inhibits the reaction [Paraquat results in increased expression of CTNNB1 protein]; naringenin inhibits the reaction [Paraquat results in decreased expression of CTNNB1 mRNA]PMID:30726711 PMID:34655599
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTDLGK974 inhibits the reaction [Paraquat affects the localization of CTNNB1 protein]; LGK974 inhibits the reaction [Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein; WNT1 protein inhibits the reaction [Paraquat results in decreased expression of CTNNB1 mRNA]; WNT1 protein inhibits the reaction [Paraquat results in decreased expression of CTNNB1 protein]PMID:30171970 PMID:30205152
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