CTNNB1 (catenin beta 1) - Rat Genome Database
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Gene: CTNNB1 (catenin beta 1) Pan paniscus
Analyze
Symbol: CTNNB1
Name: catenin beta 1
RGD ID: 11824331
Description: ENCODES a protein that exhibits alpha-catenin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN adherens junction assembly (ortholog); adherens junction organization (ortholog); animal organ development (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; E-cadherin signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); adenocarcinoma (ortholog); adenoma (ortholog); FOUND IN adherens junction (ortholog); apical junction complex (ortholog); apical part of cell (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: catenin beta-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1341,372,368 - 41,414,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl341,373,726 - 41,414,030 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0341,104,940 - 41,145,934 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
adenocarcinoma  (ISO)
adenoma  (ISO)
adrenal carcinoma  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
adult hepatocellular carcinoma  (ISO)
Alzheimer's disease  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
autosomal dominant non-syndromic intellectual disability 19  (ISO)
bladder urothelial carcinoma  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cecal Neoplasms  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Craniofacial Abnormalities  (ISO)
craniopharyngioma  (ISO)
Diabetic Cardiomyopathies  (ISO)
dilated cardiomyopathy  (ISO)
disease  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
endodermal sinus tumor  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
exudative vitreoretinopathy 1  (ISO)
exudative vitreoretinopathy 7  (ISO)
fibrolamellar carcinoma  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
granulosa cell tumor  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatoblastoma  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary desmoid disease  (ISO)
hypertrophic cardiomyopathy  (ISO)
imperforate anus  (ISO)
in situ carcinoma  (ISO)
intellectual disability  (ISO)
Intestinal Neoplasms  (ISO)
invasive lobular carcinoma  (ISO)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cancer  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Mandibular Neoplasms  (ISO)
mantle cell lymphoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
Multiple Abnormalities  (ISO)
muscular atrophy  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
Nerve Degeneration  (ISO)
Neurodevelopmental Disorders  (ISO)
No-Reflow Phenomenon  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
papillary renal cell carcinoma  (ISO)
Parathyroid Neoplasms  (ISO)
Peritoneal Neoplasms  (ISO)
Phyllodes Tumor  (ISO)
pilomatrixoma  (ISO)
progressive osseous heteroplasia  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
teratoma  (ISO)
thyroid gland papillary carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)
Vascular Calcification  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction assembly  (ISO)
adherens junction organization  (ISO)
animal organ development  (ISO)
anterior/posterior axis specification  (ISO)
astrocyte-dopaminergic neuron signaling  (ISO)
bicellular tight junction assembly  (ISO)
bone remodeling  (ISO)
bone resorption  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  (ISO)
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation  (ISO)
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition  (ISO)
cell adhesion  (ISO)
cell differentiation  (ISO)
cell fate determination  (ISO)
cell fate specification  (ISO)
cell maturation  (ISO)
cell morphogenesis involved in differentiation  (ISO)
cell population proliferation  (ISO)
cell-cell adhesion  (ISO)
cell-matrix adhesion  (ISO)
cellular process  (ISO)
cellular protein localization  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to indole-3-methanol  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
central nervous system vasculogenesis  (ISO)
chemical synaptic transmission  (ISO)
cranial ganglion development  (ISO)
cranial skeletal system development  (ISO)
dorsal root ganglion development  (ISO)
dorsal/ventral axis specification  (ISO)
dorsal/ventral pattern formation  (ISO)
ectoderm development  (ISO)
embryonic axis specification  (ISO)
embryonic brain development  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic heart tube development  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic organ development  (ISO)
embryonic skeletal limb joint morphogenesis  (ISO)
endoderm formation  (ISO)
endodermal cell fate commitment  (ISO)
endothelial tube morphogenesis  (ISO)
epithelial cell differentiation involved in prostate gland development  (ISO)
epithelial tube branching involved in lung morphogenesis  (ISO)
forebrain development  (ISO)
fungiform papilla formation  (ISO)
gastrulation with mouth forming second  (ISO)
genitalia morphogenesis  (ISO)
glial cell fate determination  (ISO)
hair cycle process  (ISO)
hair follicle morphogenesis  (ISO)
hair follicle placode formation  (ISO)
heart development  (ISO)
hemopoiesis  (ISO)
hindbrain development  (ISO)
in utero embryonic development  (ISO)
kidney development  (ISO)
layer formation in cerebral cortex  (ISO)
lens morphogenesis in camera-type eye  (ISO)
limb development  (ISO)
liver development  (ISO)
lung cell differentiation  (ISO)
lung development  (ISO)
lung induction  (ISO)
lung-associated mesenchyme development  (ISO)
male genitalia development  (ISO)
mesenchymal cell proliferation involved in lung development  (ISO)
metanephros morphogenesis  (ISO)
midbrain development  (ISO)
midbrain dopaminergic neuron differentiation  (ISO)
midgut development  (ISO)
morphogenesis of embryonic epithelium  (ISO)
myoblast differentiation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
negative regulation of mitotic cell cycle, embryonic  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of oxidative stress-induced neuron death  (ISO)
negative regulation of protein sumoylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
nephron tubule formation  (ISO)
neural plate development  (ISO)
neuron differentiation  (ISO)
neuron migration  (ISO)
neuron projection extension  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
oocyte development  (ISO)
osteoclast differentiation  (ISO)
oviduct development  (ISO)
pancreas development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of branching involved in lung morphogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of core promoter binding  (ISO)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of epithelial cell differentiation  (ISO)
positive regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heparan sulfate proteoglycan biosynthetic process  (ISO)
positive regulation of histone H3-K4 methylation  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of molecular function  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of skeletal muscle tissue development  (ISO)
positive regulation of telomerase activity  (ISO)
positive regulation of telomere maintenance via telomerase  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription elongation from RNA polymerase II promoter  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein localization to cell surface  (ISO)
protein polyubiquitination  (ISO)
proximal/distal pattern formation  (ISO)
regulation of apoptotic process  (ISO)
regulation of calcium ion import  (ISO)
regulation of cell differentiation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of centriole-centriole cohesion  (ISO)
regulation of centromeric sister chromatid cohesion  (ISO)
regulation of core promoter binding  (ISO)
regulation of epithelial cell differentiation  (ISO)
regulation of gene expression  (ISO)
regulation of myelination  (ISO)
regulation of nephron tubule epithelial cell differentiation  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of osteoclast differentiation  (ISO)
regulation of protein localization to cell surface  (ISO)
regulation of secondary heart field cardioblast proliferation  (ISO)
regulation of smooth muscle cell proliferation  (ISO)
regulation of T cell proliferation  (ISO)
regulation of timing of anagen  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
renal inner medulla development  (ISO)
renal outer medulla development  (ISO)
renal vesicle formation  (ISO)
response to activity  (ISO)
response to cadmium ion  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to hormone  (ISO)
response to organic cyclic compound  (ISO)
Schwann cell proliferation  (ISO)
skeletal system development  (ISO)
skin development  (ISO)
smooth muscle cell differentiation  (ISO)
sympathetic ganglion development  (ISO)
synapse organization  (ISO)
synaptic vesicle clustering  (ISO)
synaptic vesicle transport  (ISO)
T cell differentiation  (ISO)
T cell differentiation in thymus  (ISO)
thymus development  (ISO)
tissue homeostasis  (ISO)
trachea formation  (ISO)
trachea morphogenesis  (ISO)
vasculature development  (ISO)
vasculogenesis  (ISO)

References

Genomics

Comparative Map Data
CTNNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1341,372,368 - 41,414,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl341,373,726 - 41,414,030 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0341,104,940 - 41,145,934 (+)NCBIMhudiblu_PPA_v0panPan3
CTNNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl341,194,741 - 41,260,096 (+)EnsemblGRCh38hg38GRCh38
GRCh38341,199,422 - 41,240,445 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37341,240,996 - 41,281,934 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36341,215,946 - 41,256,943 (+)NCBINCBI36hg18NCBI36
Build 34341,216,015 - 41,256,938NCBI
Celera341,179,363 - 41,220,269 (+)NCBI
Cytogenetic Map3p22.1NCBI
HuRef341,285,983 - 41,326,988 (+)NCBIHuRef
CHM1_1341,191,513 - 41,232,505 (+)NCBICHM1_1
Ctnnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399120,762,466 - 120,789,573 (+)NCBIGRCm39mm39
GRCm39 Ensembl9120,758,282 - 120,789,573 (+)Ensembl
GRCm389120,933,400 - 120,960,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,929,216 - 120,960,507 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,842,518 - 120,869,625 (+)NCBIGRCm37mm9NCBIm37
MGSCv369120,782,173 - 120,809,205 (+)NCBImm8
Celera9121,404,098 - 121,431,499 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map972.19NCBI
Ctnnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28120,640,008 - 120,667,110 (+)NCBI
Rnor_6.0 Ensembl8129,617,812 - 129,627,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08129,601,511 - 129,628,378 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08128,798,888 - 128,825,828 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,978,161 - 125,987,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18125,997,897 - 126,007,407 (+)NCBI
Celera8119,795,816 - 119,805,325 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ctnnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542029,030,716 - 29,047,449 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542029,030,716 - 29,047,447 (-)NCBIChiLan1.0ChiLan1.0
CTNNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2310,559,718 - 10,572,927 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12310,559,722 - 10,572,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ctnnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647329,999,542 - 30,034,610 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTNNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1325,137,173 - 25,208,311 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11325,163,550 - 25,208,314 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21327,623,189 - 27,667,260 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTNNB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1222,679,488 - 2,725,034 (+)NCBI
ChlSab1.1 Ensembl222,684,022 - 2,723,949 (+)Ensembl
Ctnnb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473077,876,361 - 77,887,228 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000047519   ⟹   ENSPPAP00000024694
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl341,373,726 - 41,414,030 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047524   ⟹   ENSPPAP00000024699
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl341,397,635 - 41,398,459 (+)Ensembl
RefSeq Acc Id: XM_034956181   ⟹   XP_034812072
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0341,104,975 - 41,145,934 (+)NCBI
RefSeq Acc Id: XM_034956182   ⟹   XP_034812073
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0341,104,975 - 41,145,934 (+)NCBI
RefSeq Acc Id: XM_034956183   ⟹   XP_034812074
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0341,104,975 - 41,145,934 (+)NCBI
RefSeq Acc Id: XM_034956184   ⟹   XP_034812075
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0341,104,940 - 41,145,934 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034812072 (Get FASTA)   NCBI Sequence Viewer  
  XP_034812073 (Get FASTA)   NCBI Sequence Viewer  
  XP_034812074 (Get FASTA)   NCBI Sequence Viewer  
  XP_034812075 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034812075   ⟸   XM_034956184
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034812072   ⟸   XM_034956181
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034812073   ⟸   XM_034956182
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034812074   ⟸   XM_034956183
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000024694   ⟸   ENSPPAT00000047519
RefSeq Acc Id: ENSPPAP00000024699   ⟸   ENSPPAT00000047524


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035475 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000024694 UniProtKB/TrEMBL
  ENSPPAP00000024699 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047519 UniProtKB/TrEMBL
  ENSPPAT00000047524 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Beta-catenin UniProtKB/TrEMBL
KEGG Report pps:100982035 UniProtKB/TrEMBL
NCBI Gene CTNNB1 ENTREZGENE
PANTHER PTHR45976 UniProtKB/TrEMBL
Pfam Arm UniProtKB/TrEMBL
PRINTS BCATNINFAMLY UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/TrEMBL
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A2R9BC13_PANPA UniProtKB/TrEMBL
  A0A2R9BC18_PANPA UniProtKB/TrEMBL