RGD Reference Report - Combined E-cadherin, alpha-catenin, and beta-catenin expression is a favorable prognostic factor in endometrial carcinoma. - Rat Genome Database

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Combined E-cadherin, alpha-catenin, and beta-catenin expression is a favorable prognostic factor in endometrial carcinoma.

Authors: Scholten, AN  Aliredjo, R  Creutzberg, CL  Smit, VT 
Citation: Scholten AN, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1379-85.
RGD ID: 2298485
Pubmed: PMID:16803534   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1525-1438.2006.00406.x   (Journal Full-text)

Cell adhesion molecules, such as epithelial cadherin (E-cadherin), might be involved in the processes of tumor invasion and differentiation. The aim of this study was to investigate the expression of E-cadherin, alpha-catenin, and beta-catenin in endometrial carcinoma and to determine the prognostic value of these factors. We have investigated the expression of E-cadherin, alpha-catenin, and beta-catenin by immunohistochemistry in 225 endometrial carcinomas. The correlation between the E-cadherin and the catenins and their correlation with several histologic and clinical parameters were analyzed. Negative E-cadherin, alpha-catenin, and beta-catenin expression was observed in 44%, 47%, and 33% of endometrial carcinomas, respectively, and was correlated with histologic FIGO grade 3 (P < 0.001). Negative E-cadherin expression was more often observed in nonendometrioid endometrial carcinomas (NEECs) than in endometrioid carcinomas (75% versus 43%; P= 0.04). Combined positive E-cadherin, alpha-catenin, and beta-catenin expression was an independent positive prognostic factor for survival in patients with grade 1-2 carcinomas (P= 0.02). Negative E-cadherin expression was found to be associated with histologic grade 3 and with NEEC. Combined positive E-cadherin, alpha-catenin, and beta-catenin expression was a significant prognostic factor.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CTNNA1HumanEndometrial Neoplasms disease_progressionIEP  RGD 
CTNNB1HumanEndometrial Neoplasms disease_progressionIEP  RGD 
Ctnna1RatEndometrial Neoplasms disease_progressionISOCTNNA1 (Homo sapiens) RGD 
Ctnna1MouseEndometrial Neoplasms disease_progressionISOCTNNA1 (Homo sapiens) RGD 
Ctnnb1RatEndometrial Neoplasms disease_progressionISOCTNNB1 (Homo sapiens) RGD 
Ctnnb1MouseEndometrial Neoplasms disease_progressionISOCTNNB1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ctnna1  (catenin alpha 1)
Ctnnb1  (catenin beta 1)

Genes (Mus musculus)
Ctnna1  (catenin alpha 1)
Ctnnb1  (catenin beta 1)

Genes (Homo sapiens)
CTNNA1  (catenin alpha 1)
CTNNB1  (catenin beta 1)


Additional Information