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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7337056480464CTDdiallyl trisulfide results in decreased expression of CTNNB1 protein

PMID:29626521
decreases phosphorylationISORGD:7337056480464CTDdiallyl trisulfide results in decreased phosphorylation of CTNNB1 protein

PMID:23663050
increases cleavageISORGD:7337056480464CTDdiallyl trisulfide results in increased cleavage of CTNNB1 protein

PMID:22578287
multiple interactionsISORGD:7337056480464CTDdiallyl trisulfide inhibits the reaction [CTNNB1 protein results in decreased expression of CDKN1A protein], diallyl trisulfide inhibits the reaction [CTNNB1 protein results in increased expression of ALDH1A1 protein], diallyl trisulfide inhibits the reaction [CTNNB1 protein results in increased expression of NANOG protein], diallyl trisulfide inhibits the reaction [CTNNB1 protein results in increased expression of PCNA protein], diallyl trisulfide inhibits the reaction [CTNNB1 protein results in increased expression of PROM1 protein]

PMID:29626521
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.