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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1increases expressionEXP 6480464CTDTestosterone results in increased expression of CTNNB1 proteinPMID:21468052
Ctnnb1decreases phosphorylationISOCTNNB1 (Homo sapiens)6480464CTDTestosterone results in decreased phosphorylation of CTNNB1 proteinPMID:28163245
Ctnnb1increases expressionISOCTNNB1 (Homo sapiens)6480464CTDTestosterone results in increased expression of CTNNB1 proteinPMID:21468052
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Testosterone results in decreased phosphorylation of CTNNB1 protein]; wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CTNNB1 protein]PMID:28163245
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