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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:78030
Term: LGK974
Definition: A carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor).
Chemical ID: MESH:C586458
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7337056480464CTDLGK974 inhibits the reaction [Paraquat affects the localization of CTNNB1 protein], LGK974 inhibits the reaction [Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]

PMID:30205152
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.