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RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): GOC:bf, GOC:dph, PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IDA 2290270CAFA (MGI:MGI:2386811, PMID:12235125), (MGI:MGI:2446944, PMID:12464179), (MGI:MGI:2662628, PMID:12717450), (MGI:MGI:3054506, PMID:15314168), (MGI:MGI:3577701, PMID:15781477), (MGI:MGI:5571208, PMID:24681597)

MGI:MGI:2386811, MGI:MGI:2446944, MGI:MGI:2662628, MGI:MGI:3054506, MGI:MGI:3577701, MGI:MGI:5571208, PMID:12235125, PMID:12464179, PMID:12717450, PMID:15314168, PMID:15781477, PMID:24681597
 IGIMGI:MGI:1093302290270MGI (MGI:MGI:3690195, PMID:16678101)

MGI:MGI:3690195, PMID:16678101
 IGIMGI:MGI:1261834, MGI:MGI:989542290270MGI (MGI:MGI:4360856, PMID:19686689)

MGI:MGI:4360856, PMID:19686689
 IGIMGI:MGI:24460842290270MGI (MGI:MGI:3701031, PMID:16818445)

MGI:MGI:3701031, PMID:16818445
 IGIMGI:MGI:989572290270MGI (MGI:MGI:4454604, PMID:20454446)

MGI:MGI:4454604, PMID:20454446
 IMP 2290270MGI (MGI:MGI:3821953, PMID:19060336), (MGI:MGI:4355652, PMID:19619491)

MGI:MGI:3821953, MGI:MGI:4355652, PMID:19060336, PMID:19619491
 IMPMGI:MGI:2148567, MGI:MGI:35771062290270MGI (MGI:MGI:4359548, PMID:19690384)

MGI:MGI:4359548, PMID:19690384
 ISOUniProtKB:P352222290270MGI GO_REF:0000096, MGI:MGI:4834177
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.