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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1decreases expressionISOCTNNB1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CTNNB1 mRNA; Arsenic Trioxide results in decreased expression of CTNNB1 proteinPMID:17512576 PMID:18485479 PMID:26966376 PMID:28565807 PMID:28901456 PMID:29059232 PMID:30093655 PMID:32305283
Ctnnb1increases cleavageISOCTNNB1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased cleavage of CTNNB1 proteinPMID:12181429
Ctnnb1increases expressionISOCTNNB1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CTNNB1 mRNAPMID:20458559
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTD[Arsenic Trioxide binds to PIN1 protein] affects the reaction [Arsenic Trioxide results in decreased expression of CTNNB1 protein]; Arsenic Trioxide inhibits the reaction [CTNNB1 protein results in decreased susceptibility to Bortezomib]; Arsenic Trioxide inhibits the reaction [Lithium Chloride results in increased expression of CTNNB1 protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of CTNNB1 protein]; CAB39L protein alternative form inhibits the reaction [Arsenic Trioxide results in decreased expression of CTNNB1 mRNA]; CAB39L protein alternative form inhibits the reaction [Arsenic Trioxide results in decreased expression of CTNNB1 protein]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Arsenic Trioxide results in decreased expression of CTNNB1 protein]; PIN1 protein affects the reaction [Arsenic Trioxide results in decreased expression of CTNNB1 protein]; Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of CTNNB1 protein]PMID:18485479 PMID:28901456 PMID:29059232 PMID:30093655 PMID:32305283
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