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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDToluene 2, 4-Diisocyanate affects the localization of CTNNB1 protein

PMID:30261222
increases phosphorylationEXP 6480464CTDToluene 2, 4-Diisocyanate results in increased phosphorylation of CTNNB1 protein

PMID:26089345
multiple interactionsEXP 6480464CTD2-(1, 3-dimethyl-2, 6-dioxo-1, 2, 3, 6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2, 4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased phosphorylation of CTNNB1 protein], AG 1879 inhibits the reaction [Toluene 2, 4-Diisocyanate affects the localization of CTNNB1 protein], FPS-ZM1 inhibits the reaction [Toluene 2, 4-Diisocyanate affects the localization of CTNNB1 protein], GSK2193874 inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein], Toluene 2, 4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein, Toluene 2, 4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein

PMID:26089345, PMID:30261222, PMID:30517707
affects localizationISORGD:7337056480464CTDToluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein

PMID:30261222
multiple interactionsISORGD:7337056480464CTDAG 1879 inhibits the reaction [Toluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein], AGER protein affects the reaction [Toluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein], CAV1 protein mutant form inhibits the reaction [Toluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein], FPS-ZM1 inhibits the reaction [Toluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein]

PMID:30261222
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.