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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:74023
Term: dioscin
Definition: A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Chemical ID: MESH:C019357
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDdioscin results in increased expression of CTNNB1 mRNA, dioscin results in increased expression of CTNNB1 protein

PMID:24742230
multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA]

PMID:24742230
increases expressionISORGD:7337056480464CTDdioscin results in increased expression of CTNNB1 protein

PMID:24742230
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.