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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:704876480464CTDClozapine results in increased expression of CTNNB1 protein

PMID:16144542
multiple interactionsISORGD:704876480464CTDDRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]

PMID:16144542
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.