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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7337056480464CTDOkadaic Acid results in increased expression of CTNNB1 mRNA

PMID:31115591
increases phosphorylationISORGD:7337056480464CTDOkadaic Acid results in increased phosphorylation of CTNNB1 protein

PMID:16878161
multiple interactionsISORGD:7337056480464CTDOkadaic Acid promotes the reaction [CTNNB1 protein binds to CDH1 protein], Okadaic Acid promotes the reaction [CTNNB1 protein binds to CTNNBIP1 protein], Okadaic Acid promotes the reaction [CTNNB1 protein binds to TCF4 protein], Okadaic Acid results in increased activity of and results in decreased phosphorylation of CTNNB1 protein, Okadaic Acid results in increased expression of and affects the localization of CTNNB1 protein

PMID:31115591
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.