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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1affects expressionEXP 6480464CTDAcetaminophen affects the expression of CTNNB1 mRNAPMID:17562736 PMID:19679878
Ctnnb1affects localizationEXP 6480464CTDAcetaminophen affects the localization of CTNNB1 proteinPMID:19679878
Ctnnb1increases response to substanceEXP 6480464CTDCTNNB1 mutant form results in increased susceptibility to AcetaminophenPMID:19679878
Ctnnb1multiple interactionsEXP 6480464CTDAcetaminophen affects the phosphorylation of and affects the localization of CTNNB1 protein; Acetaminophen results in increased expression of and results in increased activity of CTNNB1 protein; coenzyme Q10 inhibits the reaction [Acetaminophen affects the phosphorylation of and affects the localization of CTNNB1 protein]; YAP1 gene mutant form promotes the reaction [Acetaminophen results in increased activity of CTNNB1 protein]PMID:19679878 PMID:34546377 PMID:34668565
Ctnnb1affects localizationISOCTNNB1 (Homo sapiens)6480464CTDAcetaminophen affects the localization of CTNNB1 proteinPMID:30567741
Ctnnb1decreases expressionISOCTNNB1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of CTNNB1 mRNAPMID:27761495
Ctnnb1increases expressionISOCTNNB1 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of CTNNB1 mRNAPMID:21420995
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of CTNNB1 mRNA; Acetaminophen promotes the reaction [CTNNB1 protein binds to PPP2R5A protein]; Acetaminophen results in increased expression of and results in decreased phosphorylation of CTNNB1 protein; PPP2CA protein affects the reaction [Acetaminophen affects the localization of CTNNB1 protein]; PPP2CA protein affects the reaction [Acetaminophen results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; PPP2R5A protein affects the reaction [Acetaminophen affects the localization of CTNNB1 protein]; PPP2R5A protein affects the reaction [Acetaminophen results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]PMID:30567741 PMID:33819548
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