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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the phosphorylation of and affects the localization of CTNNB1 protein, benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of CTNNB1 protein, Phenobarbital inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CTNNB1 protein]

PMID:27693619
decreases degradationISORGD:7337056480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of CTNNB1 protein

PMID:26990689
multiple interactionsISORGD:7337056480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Aspirin results in increased ubiquitination of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [quinocetone results in decreased expression of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [RASSF5 protein results in decreased expression of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Vitamin A results in decreased expression of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Nitroglycerin results in increased degradation of CTNNB1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and affects the localization of CTNNB1 protein

PMID:14555707, PMID:16878161, PMID:17030184, PMID:17219422, PMID:21472727, PMID:25217643, PMID:28343033, PMID:28548306, PMID:31115591
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.