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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1affects response to substanceEXP 6480464CTDCTNNB1 protein affects the susceptibility to PhenobarbitalPMID:21705713
Ctnnb1increases expressionEXP 6480464CTDPhenobarbital results in increased expression of CTNNB1 protein alternative formPMID:31836555
Ctnnb1increases mutagenesisEXP 6480464CTDPhenobarbital results in increased mutagenesis of CTNNB1 exon; Phenobarbital results in increased mutagenesis of CTNNB1 gene; Phenobarbital results in increased mutagenesis of CTNNB1 proteinPMID:11753661 PMID:12384525 PMID:31836555
Ctnnb1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased mutagenesis of CTNNB1 gene; [Phenobarbital co-treated with CTNNB1 protein mutant form] results in increased expression of GSTM2 mRNA; [Phenobarbital co-treated with CTNNB1 protein mutant form] results in increased expression of GSTM3 mRNA; [Phenobarbital co-treated with CTNNB1 protein mutant form] results in increased expression of GSTM6 mRNA; [Phenobarbital co-treated with CTNNB1 protein mutant form] results in increased expression of NR1I3 mRNA; [Phenobarbital co-treated with Diethylnitrosamine] results in increased mutagenesis of CTNNB1 gene; [Phenobarbital results in increased mutagenesis of CTNNB1 gene] which results in increased expression of GLUL mRNA; [Phenobarbital results in increased mutagenesis of CTNNB1 gene] which results in increased expression of GLUL protein; CTNNB1 protein affects the reaction [Phenobarbital results in increased expression of MEG3 mRNA]; CTNNB1 protein affects the reaction [Phenobarbital results in increased expression of RIAN mRNA]; Phenobarbital affects the reaction [Cycloheximide results in decreased expression of CTNNB1 protein]; Phenobarbital inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CTNNB1 protein]PMID:12384525 PMID:20118494 PMID:21047994 PMID:23091169 PMID:24535843 PMID:27693619
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