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GENE - TERM ANNOTATION REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: DOID:684
Term: hepatocellular carcinoma
Definition: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Definition Source(s): MESH:D006528, http://cancergenome.nih.gov/cancersselected/LiverHepatocellularCarcinoma, http://en.wikipedia.org/wiki/Hepatocellular_carcinoma, http://www.omim.org/entry/114550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:733705734850RGDDNA:mutation:exon 3

 
 ISORGD:7337057240710OMIM  
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10027390, PMID:10192393, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:25157968, PMID:26619011, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10027390, PMID:10435629, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:24788118, PMID:25157968, PMID:26619011, PMID:26822237, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10027390, PMID:10435629, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:24788118, PMID:25157968, PMID:26619011, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10027390, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:25157968, PMID:26619011, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10192393, PMID:10391090, PMID:25157968, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10192393, PMID:10666372, PMID:26619011, PMID:26822237
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10192393, PMID:25157968, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10192393, PMID:25157968, PMID:26619011, PMID:26822237
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10192393, PMID:25157968, PMID:26619011, PMID:26822237, PMID:9927029
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10192393, PMID:25157968, PMID:26619011, PMID:9065402, PMID:9294210
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10192393, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:10398436, PMID:10435629, PMID:10655994, PMID:26619011, PMID:26822237, PMID:9500465, PMID:9927029
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:19234609, PMID:25157968, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:23265383, PMID:25157968, PMID:26619011, PMID:9927029
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:25157968, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:25157968, PMID:26619011, PMID:26822237
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:26619011
 ISORGD:73370511554173CTDCTD Direct Evidence: marker/mechanism

PMID:20118494, PMID:21147764, PMID:25822088, PMID:27738331, PMID:28284560
 ISORGD:73370514402052RGDprotein:increased expression:liver:

 
severityISORGD:73370514402052RGDDNA:Mutations:exon:

 
susceptibilityISORGD:73370514402039RGDassociated with Hepatitis B, Chronic, DNA:SNP, haplotype: :rs3864004 (human)

 
susceptibilityISORGD:73370514402040RGDassociated with hepatitis B, DNA:SNPs: :rs3864004, rs11564475(human)

 
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.