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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7337056480464CTDwortmannin results in decreased expression of CTNNB1 protein

PMID:11739494
increases phosphorylationISORGD:7337056480464CTDwortmannin results in increased phosphorylation of CTNNB1 protein

PMID:28163245
multiple interactionsISORGD:7337056480464CTDwortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTNNB1 protein], wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CTNNB1 protein], wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CTNNB1 protein]

PMID:28163245, PMID:28321046
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.