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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCisplatin results in decreased expression of CTNNB1 mRNA, Cisplatin results in decreased expression of CTNNB1 protein

PMID:23628706, PMID:29148169
decreases localizationEXP 6480464CTDCisplatin results in decreased localization of CTNNB1 protein

PMID:21745194
decreases response to substanceEXP 6480464CTDCTNNB1 protein results in decreased susceptibility to Cisplatin

PMID:24560772
increases phosphorylationEXP 6480464CTDCisplatin results in increased phosphorylation of CTNNB1 protein

PMID:24560772
multiple interactionsEXP 6480464CTD8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate inhibits the reaction [Cisplatin results in decreased localization of CTNNB1 protein], CTNNB1 mutant form inhibits the reaction [SB 216763 inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA]], CTNNB1 mutant form inhibits the reaction [SB 216763 inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]], RAPGEF3 mutant form inhibits the reaction [8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate inhibits the reaction [Cisplatin results in decreased localization of CTNNB1 protein]], SB 216763 inhibits the reaction [Cisplatin results in increased phosphorylation of CTNNB1 protein]

PMID:21745194, PMID:24560772
decreases response to substanceISORGD:7337056480464CTDCTNNB1 results in decreased susceptibility to Cisplatin

PMID:22000491
increases expressionISORGD:704876480464CTDCisplatin results in increased expression of CTNNB1 protein

PMID:31103702
increases expressionISORGD:7337056480464CTDCisplatin results in increased expression of CTNNB1 protein

PMID:20074550
multiple interactionsISORGD:704876480464CTDwogonin inhibits the reaction [Cisplatin results in increased expression of CTNNB1 protein]

PMID:31103702
multiple interactionsISORGD:7337056480464CTD[NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of and affects the phosphorylation of CTNNB1 protein

PMID:30291867
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.