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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1affects expressionEXP 6480464CTDsodium arsenite affects the expression of CTNNB1 mRNAPMID:16507464 PMID:28206643
Ctnnb1decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of CTNNB1 mRNA; sodium arsenite results in decreased expression of CTNNB1 protein; sodium arsenite results in decreased expression of CTNNB1 protein modified formPMID:23143138 PMID:27158593 PMID:33957193
Ctnnb1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of CTNNB1 mRNAPMID:25825268
Ctnnb1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [sodium arsenite results in decreased expression of CTNNB1 protein]; [Folic Acid co-treated with sodium arsenite] results in increased methylation of CTNNB1 mRNAPMID:22959928 PMID:23143138
Ctnnb1affects localizationISOCTNNB1 (Homo sapiens)6480464CTDsodium arsenite affects the localization of CTNNB1 proteinPMID:22859221
Ctnnb1decreases expressionISOCtnnb1 (Rattus norvegicus)6480464CTDsodium arsenite results in decreased expression of CTNNB1 mRNAPMID:23137061
Ctnnb1decreases expressionISOCTNNB1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of CTNNB1 proteinPMID:23219847 PMID:25879800 PMID:34032870
Ctnnb1increases expressionISOCTNNB1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of CTNNB1 proteinPMID:16054901 PMID:22859221 PMID:24961358 PMID:29107899 PMID:31120745
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [sodium arsenite results in decreased expression of CTNNB1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein]PMID:22859221 PMID:23219847 PMID:24961358
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