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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:39112
Term: bosutinib
Definition: An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.
Chemical ID: MESH:C471992
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationISORGD:7337056480464CTDbosutinib affects the localization of CTNNB1 protein

PMID:16489032
decreases phosphorylationISORGD:7337056480464CTDbosutinib results in decreased phosphorylation of CTNNB1 protein

PMID:16489032
multiple interactionsISORGD:7337056480464CTDbosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein], bosutinib inhibits the reaction [SRC protein results in increased phosphorylation of CTNNB1 protein], bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein], CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein]

PMID:16489032
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.