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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDresveratrol affects the localization of CTNNB1 protein

PMID:19665018
increases activityEXP 6480464CTDresveratrol results in increased activity of CTNNB1 protein

PMID:19665018
increases stabilityEXP 6480464CTDresveratrol results in increased stability of CTNNB1 protein

PMID:19665018, PMID:20542495
multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased stability of CTNNB1 protein], [resveratrol co-treated with Excitatory Amino Acid Agents] results in increased stability of CTNNB1 protein, CTNNB1 protein promotes the reaction [resveratrol results in decreased susceptibility to Excitatory Amino Acid Agents], CTNNB1 protein promotes the reaction [resveratrol results in increased expression of SOD2 protein], resveratrol inhibits the reaction [TCF4 protein binds to CTNNB1 protein], resveratrol inhibits the reaction [WNT3A protein promotes the reaction [TCF4 protein binds to CTNNB1 protein]], resveratrol results in decreased expression of and affects the localization of CTNNB1 protein

PMID:20542495, PMID:22935447, PMID:25280562
affects localizationISORGD:704876480464CTDresveratrol affects the localization of CTNNB1 protein

PMID:17188708
affects localizationISORGD:7337056480464CTDresveratrol affects the localization of CTNNB1 protein

PMID:22314268, PMID:24244343, PMID:25297617, PMID:25896424
decreases expressionISORGD:7337056480464CTDresveratrol results in decreased expression of CTNNB1 mRNA, resveratrol results in decreased expression of CTNNB1 protein

PMID:11895924, PMID:18347188, PMID:22245592, PMID:25061499
increases degradationISORGD:7337056480464CTDresveratrol results in increased degradation of CTNNB1 protein

PMID:26040106
increases expressionISORGD:704876480464CTDresveratrol results in increased expression of CTNNB1 mRNA

PMID:23848300
multiple interactionsISORGD:704876480464CTD[resveratrol co-treated with Pravastatin] affects the localization of CTNNB1 protein

PMID:17188708
multiple interactionsISORGD:7337056480464CTD[[resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]] which results in decreased acetylation of and results in decreased activity of CTNNB1 protein, [resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased phosphorylation of and results in decreased localization of CTNNB1 protein, [resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein, [resveratrol results in increased localization of and results in increased activity of CTNNB1 protein] which results in increased expression of VEGFA mRNA, [resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein] which results in decreased phosphorylation of and results in increased localization of CTNNB1 protein, CTNNB1 protein promotes the reaction [resveratrol results in increased expression of VEGFA protein], lactacystin inhibits the reaction [resveratrol results in increased degradation of CTNNB1 protein], MALAT1 protein affects the reaction [resveratrol inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]], MALAT1 protein inhibits the reaction [resveratrol affects the localization of CTNNB1 protein], resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin], resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide], resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA], resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein], resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA], resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein], resveratrol inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein], resveratrol inhibits the reaction [Lithium Chloride results in increased activity of [TCF4 protein co-treated with CTNNB1 protein]], resveratrol inhibits the reaction [Oxygen deficiency affects the localization of CTNNB1 protein], resveratrol inhibits the reaction [TCF4 protein binds to CTNNB1 protein], resveratrol promotes the reaction [CASP3 protein results in increased degradation of CTNNB1 protein], resveratrol results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein], resveratrol results in decreased expression of and affects the localization of CTNNB1 protein, resveratrol results in increased localization of and results in increased activity of CTNNB1 protein

PMID:19047049, PMID:20696143, PMID:22245592, PMID:22935447, PMID:24244343, PMID:25280562, PMID:25297617, PMID:26040106
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.