Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - TERM ANNOTATION REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: DOID:1909
Term: melanoma
Definition: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Definition Source(s): MESH:D008545, http://en.wikipedia.org/wiki/Melanoma, https://www.ncbi.nlm.nih.gov/pubmed/22123420
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Malignant melanoma

PMID:25157968
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Malignant melanoma, somatic

PMID:10027390, PMID:10192393, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:25157968, PMID:26619011, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Malignant melanoma, somatic

PMID:10027390, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:25157968, PMID:26619011, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Malignant melanoma, somatic

PMID:10192393, PMID:25157968, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Malignant melanoma, somatic

PMID:19234609, PMID:25157968, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Malignant melanoma, somatic

PMID:23265383, PMID:25157968, PMID:26619011, PMID:9927029
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:10027390, PMID:10435629, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:24788118, PMID:25157968, PMID:26619011, PMID:26822237, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:10027390, PMID:10435629, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:24788118, PMID:25157968, PMID:26619011, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:10192393, PMID:10666372, PMID:26619011, PMID:26822237
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:10192393, PMID:25157968, PMID:26619011, PMID:26822237
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:10192393, PMID:25157968, PMID:26619011, PMID:26822237, PMID:9927029
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:10192393, PMID:25157968, PMID:26619011, PMID:9065402, PMID:9294210
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:10192393, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:10398436, PMID:10435629, PMID:10655994, PMID:26619011, PMID:26822237, PMID:9500465, PMID:9927029
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:25157968, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:25157968, PMID:26619011, PMID:26822237
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC

PMID:26619011
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.