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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:48607
Term: lithium chloride
Definition: A metal chloride salt with a Li(+) counterion.
Chemical ID: MESH:D018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1increases activityEXP 6480464CTDLithium Chloride results in increased activity of CTNNB1 proteinPMID:19582394 PMID:20118494
Ctnnb1increases expressionEXP 6480464CTDLithium Chloride results in increased expression of CTNNB1 mRNA; Lithium Chloride results in increased expression of CTNNB1 proteinPMID:22935447 PMID:27018151 PMID:27226553
Ctnnb1increases localizationEXP 6480464CTDLithium Chloride results in increased localization of CTNNB1 proteinPMID:19442631
Ctnnb1increases stabilityEXP 6480464CTDLithium Chloride results in increased stability of CTNNB1 proteinPMID:23326414
Ctnnb1multiple interactionsEXP 6480464CTD[[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein] which results in increased expression of GIP mRNA; [Lithium Chloride results in increased activity of CTNNB1 protein] which results in increased expression of GSTM3 mRNA; [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein; Lithium Chloride inhibits the reaction [Paraquat results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CTNNB1 protein]; Lithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GCG promoter]; Lithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GIP promoter]; Lithium Chloride promotes the reaction [CTNNB1 protein binds to GCG promoter]; Lithium Chloride promotes the reaction [CTNNB1 protein binds to GIP promoter]; Lithium Chloride results in increased expression of and affects the localization of CTNNB1 proteinPMID:15364539 PMID:19582394 PMID:20118494 PMID:27018151 PMID:30171970
Ctnnb1affects localizationISOCTNNB1 (Homo sapiens)6480464CTDLithium Chloride affects the localization of CTNNB1 protein; Lithium Chloride affects the localization of CTNNB1 protein modified formPMID:22493441 PMID:24244343 PMID:24534281
Ctnnb1decreases phosphorylationISOCTNNB1 (Homo sapiens)6480464CTDLithium Chloride results in decreased phosphorylation of CTNNB1 proteinPMID:16076840
Ctnnb1increases activityISOCtnnb1 (Rattus norvegicus)6480464CTDLithium Chloride results in increased activity of CTNNB1 proteinPMID:20694829
Ctnnb1increases expressionISOCtnnb1 (Rattus norvegicus)6480464CTDLithium Chloride results in increased expression of CTNNB1 mRNAPMID:27045591
Ctnnb1increases expressionISOCTNNB1 (Homo sapiens)6480464CTDLithium Chloride results in increased expression of CTNNB1 mRNA; Lithium Chloride results in increased expression of CTNNB1 proteinPMID:16053526 PMID:16735606 PMID:20069066 PMID:28886972 PMID:28901456
Ctnnb1multiple interactionsISOCtnnb1 (Rattus norvegicus)6480464CTD[[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein] which affects the expression of GJA1 protein; [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein; CTNNB1 protein affects the reaction [Lithium Chloride results in increased expression of NR4A2 mRNA]; Lithium Chloride inhibits the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [Heparin promotes the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]]; Lithium Chloride inhibits the reaction [manganese chloride results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [Rotenone results in decreased expression of and results in decreased phosphorylation of CTNNB1 protein]; Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]; Lithium Chloride promotes the reaction [CTNNB1 protein binds to NR4A2 promoter]; Lithium Chloride promotes the reaction [CTNNB1 protein binds to NR4A2 protein]PMID:18972237 PMID:23872260 PMID:24464479 PMID:27045591 PMID:30377735
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTD[Lithium Chloride co-treated with ESR1 protein] results in increased expression of CTNNB1 protein; [Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein] which results in increased expression of and results in increased phosphorylation of CTNNB1 protein; Arsenic Trioxide inhibits the reaction [Lithium Chloride results in increased expression of CTNNB1 protein]; CTNNB1 protein affects the reaction [[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein]; CTNNB1 protein promotes the reaction [Lithium Chloride results in increased expression of POU5F1 mRNA]; CTNNB1 protein promotes the reaction [Lithium Chloride results in increased expression of POU5F1 protein]; Hexachlorophene inhibits the reaction [Lithium Chloride results in increased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [Aspirin results in increased phosphorylation of CTNNB1 protein]; Lithium Chloride inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [hydroquinone results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [Indomethacin results in increased phosphorylation of CTNNB1 protein]; Lithium Chloride inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]; Lithium Chloride inhibits the reaction [Proanthocyanidins results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [quinocetone results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]; Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]; Lithium Chloride results in increased activity of [TCF4 protein co-treated with CTNNB1 protein]; Lithium Chloride results in increased expression of and results in decreased phosphorylation of CTNNB1 protein; Lithium Chloride results in increased expression of and results in increased localization of CTNNB1 protein; Lithium Chloride results in increased expression of and results in increased phosphorylation of CTNNB1 protein; Lithium Chloride results in increased localization of and results in increased activity of CTNNB1 protein; MALAT1 protein affects the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; MALAT1 protein affects the reaction [Resveratrol inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein modified form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Resveratrol inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Resveratrol inhibits the reaction [Lithium Chloride results in increased activity of [TCF4 protein co-treated with CTNNB1 protein]]; SFRP2 protein affects the reaction [Lithium Chloride results in increased expression of CTNNB1 mRNA]; XAV939 inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]PMID:12813129 PMID:16735606 PMID:19228266 PMID:19274078 PMID:19679347 PMID:20069066 PMID:20074550 PMID:20696143 PMID:22134133 PMID:22493441 PMID:22935447 PMID:23872260 PMID:24244343 PMID:24534281 PMID:26990689 PMID:28343033 PMID:28886972 PMID:28901456 PMID:31715269 PMID:32112862 PMID:35985571 PMID:37551626
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