Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | increases expression | EXP | | 6480464 | ethylene dichloride results in increased expression of SHROOM3 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SHROOM3 mRNA | CTD | PMID:22206623 | 17beta-estradiol | affects expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Estradiol affects the expression of SHROOM3 mRNA | CTD | PMID:22574217 | 17beta-estradiol | decreases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of SHROOM3 mRNA | CTD | PMID:32145629 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of SHROOM3 mRNA | CTD | PMID:29581250 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SHROOM3 mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SHROOM3 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SHROOM3 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SHROOM3 promoter] | CTD | PMID:19654925 and PMID:25975270 | 4,4'-sulfonyldiphenol | increases methylation | EXP | | 6480464 | bisphenol S results in increased methylation of SHROOM3 exon and bisphenol S results in increased methylation of SHROOM3 promoter | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of SHROOM3 gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of SHROOM3 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of SHROOM3 mRNA | CTD | PMID:24780913 | 6-propyl-2-thiouracil | decreases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of SHROOM3 mRNA | CTD | PMID:36843608 | aflatoxin B1 | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of SHROOM3 mRNA | CTD | PMID:21641981 | aflatoxin B1 | increases methylation | ISO | SHROOM3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SHROOM3 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SHROOM3 mRNA | CTD | PMID:21934132 | arsane | affects methylation | ISO | SHROOM3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SHROOM3 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | SHROOM3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SHROOM3 gene | CTD | PMID:25304211 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of SHROOM3 mRNA | CTD | PMID:22228805 and PMID:27195522 | benzo[a]pyrene | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SHROOM3 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | decreases methylation | ISO | SHROOM3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SHROOM3 3' UTR and Benzo(a)pyrene results in decreased methylation of SHROOM3 exon | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | SHROOM3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SHROOM3 intron and Benzo(a)pyrene affects the methylation of SHROOM3 promoter | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SHROOM3 protein | CTD | PMID:32717239 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | affects expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of SHROOM3 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SHROOM3 mRNA | CTD | PMID:32156529 | bisphenol A | decreases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SHROOM3 mRNA | CTD | PMID:32145629 | bisphenol A | increases methylation | ISO | Shroom3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of SHROOM3 gene | CTD | PMID:28505145 | bisphenol A | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SHROOM3 mRNA | CTD | PMID:27685785 | bisphenol F | multiple interactions | ISO | SHROOM3 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in increased methylation of SHROOM3 gene | CTD | PMID:31601247 | butanal | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of SHROOM3 mRNA | CTD | PMID:26079696 | C60 fullerene | increases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | fullerene C60 results in increased expression of SHROOM3 mRNA | CTD | PMID:19167457 | calcitriol | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of SHROOM3 mRNA | CTD | PMID:26485663 | carbamazepine | affects expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SHROOM3 mRNA | CTD | PMID:25979313 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of SHROOM3 mRNA | CTD | PMID:37019170 | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of SHROOM3 mRNA | CTD | PMID:28472532 | cisplatin | increases phosphorylation | EXP | | 6480464 | Cisplatin results in increased phosphorylation of SHROOM3 protein | CTD | PMID:22006019 | cisplatin | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of SHROOM3 mRNA | CTD | PMID:27392435 | coumarin | affects phosphorylation | ISO | SHROOM3 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of SHROOM3 protein | CTD | PMID:35688186 | coumestrol | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of SHROOM3 mRNA | CTD | PMID:19167446 | Cuprizon | increases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of SHROOM3 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SHROOM3 mRNA | CTD | PMID:20106945 and PMID:27989131 | Di-n-octyl phthalate | decreases expression | EXP | | 6480464 | di-n-octyl phthalate results in decreased expression of SHROOM3 mRNA | CTD | PMID:37810885 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of SHROOM3 mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | ISO | SHROOM3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHROOM3 mRNA | CTD | PMID:27188386 | doxorubicin | affects expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Doxorubicin affects the expression of SHROOM3 mRNA | CTD | PMID:29803840 | endosulfan | affects expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Endosulfan affects the expression of SHROOM3 mRNA | CTD | PMID:29391264 | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of SHROOM3 mRNA | CTD | PMID:35436446 | fenvalerate | increases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of SHROOM3 mRNA | CTD | PMID:30307764 | FR900359 | decreases phosphorylation | ISO | SHROOM3 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of SHROOM3 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | SHROOM3 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in increased methylation of SHROOM3 gene | CTD | PMID:31601247 | hexadecanoic acid | affects phosphorylation | ISO | SHROOM3 (Homo sapiens) | 6480464 | Palmitic Acid affects the phosphorylation of SHROOM3 protein | CTD | PMID:28073184 | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of SHROOM3 mRNA | CTD | PMID:22609695 | lipopolysaccharide | multiple interactions | ISO | SHROOM3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of SHROOM3 mRNA] | CTD | PMID:35811015 | lipopolysaccharide | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of SHROOM3 mRNA | CTD | PMID:35811015 | melphalan | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Melphalan results in decreased expression of SHROOM3 mRNA | CTD | PMID:22363485 | methoxychlor | affects methylation | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of SHROOM3 gene | CTD | PMID:35440735 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Shroom3 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of SHROOM3 gene | CTD | PMID:33148267 | nickel atom | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Nickel results in decreased expression of SHROOM3 mRNA | CTD | PMID:24768652 and PMID:25583101 | orphenadrine | affects expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Orphenadrine affects the expression of SHROOM3 mRNA | CTD | PMID:23665939 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of SHROOM3 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of SHROOM3 mRNA | CTD | PMID:32479839 and PMID:33387578 | paracetamol | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SHROOM3 mRNA | CTD | PMID:21420995 | permethrin | multiple interactions | ISO | Shroom3 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of SHROOM3 gene | CTD | PMID:33148267 | potassium chromate | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SHROOM3 mRNA | CTD | PMID:22714537 | potassium dichromate | increases expression | EXP | | 6480464 | Potassium Dichromate results in increased expression of SHROOM3 mRNA | CTD | PMID:23608068 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of SHROOM3 mRNA | CTD | PMID:33725128 and PMID:35811015 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | SHROOM3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of SHROOM3 mRNA] | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | SHROOM3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHROOM3 mRNA | CTD | PMID:27188386 | silver atom | increases expression | EXP | | 6480464 | Silver results in increased expression of SHROOM3 mRNA | CTD | PMID:27131904 | silver(0) | increases expression | EXP | | 6480464 | Silver results in increased expression of SHROOM3 mRNA | CTD | PMID:27131904 | sodium arsenate | decreases expression | EXP | | 6480464 | sodium arsenate results in decreased expression of SHROOM3 mRNA | CTD | PMID:30953684 | sodium dodecyl sulfate | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Sodium Dodecyl Sulfate results in increased expression of SHROOM3 mRNA | CTD | PMID:31734321 | temozolomide | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of SHROOM3 mRNA | CTD | PMID:31758290 | tetrachloromethane | decreases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of SHROOM3 mRNA | CTD | PMID:31150632 | thapsigargin | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Thapsigargin results in decreased expression of SHROOM3 mRNA | CTD | PMID:22378314 | thioacetamide | decreases expression | ISO | Shroom3 (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of SHROOM3 mRNA | CTD | PMID:34492290 | trichostatin A | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of SHROOM3 mRNA | CTD | PMID:22723015 more ... | trichostatin A | multiple interactions | ISO | SHROOM3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHROOM3 mRNA | CTD | PMID:27188386 | tunicamycin | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of SHROOM3 mRNA | CTD | PMID:22378314 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of SHROOM3 mRNA | CTD | PMID:21427059 | valproic acid | decreases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SHROOM3 mRNA | CTD | PMID:24935251 | valproic acid | affects expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SHROOM3 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | SHROOM3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SHROOM3 mRNA | CTD | PMID:23179753 | | 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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
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Disease Annotations
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 2. | Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. | Klezovitch O, etal., Genes Dev 2004 Mar 1;18(5):559-71. |
| 3. | Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. | Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 4. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 5. | MGD IEA | MGD IEA |
| 6. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 7. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 8. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 10. | Database resources of the National Center for Biotechnology Information. | Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6. |
Additional References at PubMed
| PMID:7671812 | PMID:8889548 | PMID:10349636 | PMID:10512203 | PMID:10585775 | PMID:10589677 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:12477932 | PMID:12520002 | PMID:14610273 |
| PMID:14613977 | PMID:14621295 | PMID:15271968 | PMID:15306695 | PMID:15840001 | PMID:16141072 | PMID:16141073 | PMID:16249236 | PMID:17110338 | PMID:17623803 | PMID:17666436 | PMID:17967808 |
| PMID:18339671 | PMID:18799693 | PMID:18829867 | PMID:20081189 | PMID:20926658 | PMID:21267068 | PMID:21677750 | PMID:21693562 | PMID:21726547 | PMID:21873635 | PMID:21880782 | PMID:22493320 |
| PMID:22689267 | PMID:23175632 | PMID:24282618 | PMID:24457600 | PMID:25038041 | PMID:25171888 | PMID:25596276 | PMID:26238476 | PMID:26772200 | PMID:26902112 | PMID:28671696 | PMID:29237740 |
| PMID:29555813 | PMID:29636380 | PMID:30228103 | PMID:32511952 | PMID:32741376 | PMID:33273487 | PMID:33951476 | PMID:35368578 |
Genomics
Comparative Map Data
| Shroom3 (Mus musculus - house mouse) |
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| SHROOM3 (Homo sapiens - human) |
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| Shroom3 (Rattus norvegicus - Norway rat) |
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| Shroom3 (Chinchilla lanigera - long-tailed chinchilla) |
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| SHROOM3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| SHROOM3 (Canis lupus familiaris - dog) |
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| Shroom3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| SHROOM3 (Sus scrofa - pig) |
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| SHROOM3 (Chlorocebus sabaeus - green monkey) |
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| Shroom3 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Shroom3
10917 total Variants 
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