Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of LRRN4 mRNA | CTD | PMID:28960355 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LRRN4 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LRRN4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LRRN4 mRNA | CTD | PMID:21570461 and PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LRRN4 mRNA | CTD | PMID:20106945 and PMID:21632981 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of LRRN4 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | LRRN4 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of LRRN4 gene | CTD | PMID:31601247 | 4-hydroxyphenyl retinamide | decreases expression | EXP | | 6480464 | Fenretinide results in decreased expression of LRRN4 mRNA | CTD | PMID:28973697 | aconitine | increases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | Aconitine results in increased expression of LRRN4 protein | CTD | PMID:33236894 | all-trans-retinoic acid | increases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of LRRN4 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | affects expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Tretinoin affects the expression of LRRN4 mRNA | CTD | PMID:31600526 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to LRRN4 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of LRRN4 intron | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | LRRN4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of LRRN4 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | LRRN4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of LRRN4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of LRRN4 mRNA | CTD | PMID:20106945 more ... | Benzo[ghi]perylene | increases expression | EXP | | 6480464 | 1 and 12-benzoperylene results in increased expression of LRRN4 mRNA | CTD | PMID:26377693 | bis(2-ethylhexyl) phthalate | increases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of LRRN4 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of LRRN4 mRNA | CTD | PMID:26063408 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LRRN4 mRNA | CTD | PMID:32156529 | bisphenol A | decreases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of LRRN4 mRNA | CTD | PMID:25181051 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chloroprene | decreases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | Chloroprene results in decreased expression of LRRN4 mRNA | CTD | PMID:23125180 | chrysene | increases expression | EXP | | 6480464 | chrysene results in increased expression of LRRN4 mRNA | CTD | PMID:26377693 | copper(II) sulfate | decreases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of LRRN4 mRNA | CTD | PMID:19549813 | Cuprizon | increases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of LRRN4 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of LRRN4 mRNA | CTD | PMID:19159671 | cytarabine | decreases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of LRRN4 mRNA | CTD | PMID:21198554 | diethyl maleate | increases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | diethyl maleate results in increased expression of LRRN4 mRNA | CTD | PMID:21161181 | dimethylarsinic acid | decreases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | Cacodylic Acid results in decreased expression of LRRN4 mRNA | CTD | PMID:37567419 | dorsomorphin | multiple interactions | ISO | LRRN4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of LRRN4 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of LRRN4 mRNA | CTD | PMID:29391264 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of LRRN4 mRNA | CTD | PMID:32186404 | gentamycin | decreases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of LRRN4 mRNA | CTD | PMID:33387578 | hexamethylene diisocyanate | increases methylation | ISO | LRRN4 (Homo sapiens) | 6480464 | 1 and 6-hexamethylene diisocyanate results in increased methylation of LRRN4 gene | CTD | PMID:25445006 | Indeno[1,2,3-cd]pyrene | decreases expression | EXP | | 6480464 | indeno(1 more ... | CTD | PMID:26377693 | indole-3-methanol | multiple interactions | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of LRRN4 mRNA | CTD | PMID:22129741 | Licochalcone B | increases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of LRRN4 mRNA | CTD | PMID:33647349 | mercury dibromide | increases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of LRRN4 mRNA | CTD | PMID:26272509 | N-nitrosodiethylamine | multiple interactions | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of LRRN4 mRNA | CTD | PMID:22129741 | orphenadrine | affects expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | Orphenadrine affects the expression of LRRN4 mRNA | CTD | PMID:23665939 | panobinostat | multiple interactions | ISO | LRRN4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRN4 mRNA | CTD | PMID:27188386 | paracetamol | decreases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of LRRN4 mRNA | CTD | PMID:33387578 | pirinixic acid | multiple interactions | ISO | LRRN4 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LRRN4 mRNA | CTD | PMID:19710929 | SB 431542 | multiple interactions | ISO | LRRN4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silver atom | decreases expression | EXP | | 6480464 | Silver results in decreased expression of LRRN4 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | EXP | | 6480464 | Silver results in decreased expression of LRRN4 mRNA | CTD | PMID:27131904 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of LRRN4 mRNA | CTD | PMID:37682722 | sunitinib | decreases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of LRRN4 mRNA | CTD | PMID:31533062 | tetraphene | decreases expression | EXP | | 6480464 | benz(a)anthracene results in decreased expression of LRRN4 mRNA | CTD | PMID:26377693 | titanium dioxide | affects expression | EXP | | 6480464 | titanium dioxide affects the expression of LRRN4 mRNA | CTD | PMID:23557971 | trichostatin A | increases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of LRRN4 mRNA | CTD | PMID:24935251 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of LRRN4 mRNA | CTD | PMID:33045310 | urethane | decreases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Urethane results in decreased expression of LRRN4 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | LRRN4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of LRRN4 gene | CTD | PMID:29154799 | valproic acid | multiple interactions | ISO | LRRN4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRN4 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of LRRN4 mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | LRRN4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of LRRN4 mRNA | CTD | PMID:25979313 | vinclozolin | decreases expression | ISO | Lrrn4 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of LRRN4 mRNA | CTD | PMID:22615374 | |