Grm2 (glutamate receptor, metabotropic 2) - Rat Genome Database
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Gene: Grm2 (glutamate receptor, metabotropic 2) Mus musculus
Analyze
Symbol: Grm2
Name: glutamate receptor, metabotropic 2
RGD ID: 1557983
MGI Page MGI
Description: Exhibits calcium channel regulator activity and group II metabotropic glutamate receptor activity. Involved in cellular response to stress; chemical synaptic transmission; and glutamate homeostasis. Localizes to neuron projection. Is expressed in brain. Orthologous to human GRM2 (glutamate metabotropic receptor 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; Gprc; Gprc1b; metabotropic glutamate receptor 2; mGlu; mGluR2; mGluR7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,521,733 - 106,533,308 (-)NCBIGRCm39mm39
GRCm389106,644,534 - 106,656,109 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,643,095 - 106,656,082 (-)EnsemblGRCm38mm10GRCm38
MGSCv379106,546,865 - 106,558,440 (-)NCBIGRCm37mm9NCBIm37
MGSCv369106,546,755 - 106,558,434 (-)NCBImm8
Celera9106,265,562 - 106,277,130 (-)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7965099   PMID:8189254   PMID:8662555   PMID:8838577   PMID:8889548   PMID:9920659   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11584003   PMID:11805343   PMID:12074840  
PMID:12091320   PMID:12213275   PMID:12477932   PMID:12679517   PMID:15081787   PMID:15619115   PMID:15753323   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16606834   PMID:16733060  
PMID:16764720   PMID:16957075   PMID:17510730   PMID:17670976   PMID:18297054   PMID:18720515   PMID:19477188   PMID:19554387   PMID:19633665   PMID:19638469   PMID:20875805   PMID:20970439  
PMID:21057775   PMID:21267068   PMID:21276828   PMID:21289196   PMID:21360593   PMID:21628565   PMID:21677750   PMID:21832989   PMID:21873635   PMID:22089319   PMID:22118459   PMID:22243746  
PMID:22723691   PMID:23129762   PMID:23261870   PMID:23382250   PMID:23392308   PMID:23508685   PMID:23558090   PMID:23616537   PMID:23624743   PMID:24053122   PMID:24082084   PMID:24243579  
PMID:24381270   PMID:24821401   PMID:24952961   PMID:25158312   PMID:25434487   PMID:25583490   PMID:25741727   PMID:25781000   PMID:25950516   PMID:25979088   PMID:26758213   PMID:27056679  
PMID:27432639   PMID:27818290   PMID:27911756   PMID:28159646   PMID:28285415   PMID:28671696   PMID:28706196   PMID:28781167   PMID:28821279   PMID:29024663   PMID:29079293   PMID:29446202  
PMID:30939596   PMID:31665922   PMID:31735403  


Genomics

Comparative Map Data
Grm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,521,733 - 106,533,308 (-)NCBIGRCm39mm39
GRCm389106,644,534 - 106,656,109 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,643,095 - 106,656,082 (-)EnsemblGRCm38mm10GRCm38
MGSCv379106,546,865 - 106,558,440 (-)NCBIGRCm37mm9NCBIm37
MGSCv369106,546,755 - 106,558,434 (-)NCBImm8
Celera9106,265,562 - 106,277,130 (-)NCBICelera
Cytogenetic Map9F1NCBI
GRM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl351,707,068 - 51,718,613 (+)EnsemblGRCh38hg38GRCh38
GRCh38351,707,068 - 51,718,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37351,741,081 - 51,752,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36351,718,004 - 51,727,669 (+)NCBINCBI36hg18NCBI36
Build 34351,718,037 - 51,727,168NCBI
Celera351,718,848 - 51,731,506 (+)NCBI
Cytogenetic Map3p21.2NCBI
HuRef351,802,839 - 51,816,142 (+)NCBIHuRef
CHM1_1351,693,893 - 51,705,447 (+)NCBICHM1_1
Grm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08115,344,999 - 115,358,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,344,999 - 115,358,046 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,705,123 - 114,718,193 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48111,837,086 - 111,850,133 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18111,857,819 - 111,869,581 (-)NCBI
Celera8106,592,051 - 106,605,096 (-)NCBICelera
Cytogenetic Map8q32NCBI
Grm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555323,309,028 - 3,320,966 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555323,309,034 - 3,320,954 (+)NCBIChiLan1.0ChiLan1.0
GRM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1352,873,144 - 52,884,401 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl352,873,144 - 52,884,395 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0351,639,792 - 51,652,779 (+)NCBIMhudiblu_PPA_v0panPan3
GRM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2037,915,665 - 37,924,296 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12037,915,178 - 37,926,276 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Grm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365293,042,220 - 3,053,670 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,893,931 - 33,938,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11333,924,303 - 33,938,279 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,130,553 - 37,141,351 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRM2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2213,046,641 - 13,056,453 (+)Ensembl
ChlSab1.12213,044,974 - 13,056,469 (+)NCBI
Grm2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247305,419,892 - 5,431,268 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:184
Interacting mature miRNAs:209
Transcripts:ENSMUST00000023959
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023959   ⟹   ENSMUSP00000023959
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,643,117 - 106,656,080 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200826   ⟹   ENSMUSP00000144076
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,643,095 - 106,648,103 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201681   ⟹   ENSMUSP00000144631
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,644,885 - 106,656,082 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201955
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,644,984 - 106,646,613 (-)Ensembl
RefSeq Acc Id: NM_001160353   ⟹   NP_001153825
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399106,521,733 - 106,533,308 (-)NCBI
GRCm389106,644,534 - 106,656,109 (-)ENTREZGENE
MGSCv379106,546,865 - 106,558,440 (-)RGD
Celera9106,265,562 - 106,277,130 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001153825 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI15867 (Get FASTA)   NCBI Sequence Viewer  
  AAO85115 (Get FASTA)   NCBI Sequence Viewer  
  EDL21160 (Get FASTA)   NCBI Sequence Viewer  
  Q14BI2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001153825   ⟸   NM_001160353
- Peptide Label: precursor
- UniProtKB: Q14BI2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000144631   ⟸   ENSMUST00000201681
RefSeq Acc Id: ENSMUSP00000023959   ⟸   ENSMUST00000023959
RefSeq Acc Id: ENSMUSP00000144076   ⟸   ENSMUST00000200826
Protein Domains
ANF_receptor   G_PROTEIN_RECEP_F3_4

Promoters
RGD ID:6844638
Promoter ID:MM_KWN:58685
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC009RKI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369106,549,376 - 106,549,876 (-)MPROMDB
RGD ID:8670754
Promoter ID:EPDNEW_M13408
Type:single initiation site
Name:Grm2_1
Description:Mus musculus glutamate receptor, metabotropic 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389106,656,089 - 106,656,149EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351339 AgrOrtholog
Ensembl Genes ENSMUSG00000023192 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUSG00000063284
Ensembl Protein ENSMUSP00000023959 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000144076 UniProtKB/TrEMBL
  ENSMUSP00000144631 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023959 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000200826 UniProtKB/TrEMBL
  ENSMUST00000201681 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:108068 UniProtKB/Swiss-Prot
MGD MGI:1351339 ENTREZGENE
NCBI Gene 108068 ENTREZGENE
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grm2 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPC2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.410822 ENTREZGENE
  Mm.424639 ENTREZGENE
UniProt A0A0J9YU95_MOUSE UniProtKB/TrEMBL
  A0A0J9YVF0_MOUSE UniProtKB/TrEMBL
  GRM2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q80T43_MOUSE UniProtKB/TrEMBL