Gene: Grm2 (glutamate receptor, metabotropic 2) Mus musculus
Analyze
Symbol:
Grm2
Name:
glutamate receptor, metabotropic 2
Description:
ENCODES a protein that exhibits calcium channel regulator activity; group II metabotropic glutamate receptor activity; INVOLVED IN chemical synaptic transmission; glutamate homeostasis; glutamate secretion (ortholog); PARTICIPATES IN glutamate signaling pathway; ASSOCIATED WITH abnormal anxiety-related response; abnormal excitatory postsynaptic potential; abnormal GABAergic neuron physiology; ASSOCIATED WITH amphetamine abuse (ortholog); schizophrenia (ortholog); substance-induced psychosis (ortholog); FOUND IN neuron projection; axon (ortholog); integral component of postsynaptic membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; curcumin; ethanol
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; Gprc1b; metabotropic glutamate receptor 2; mGluR2; mGluR7
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
GRM2 (glutamate metabotropic receptor 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Grm2 (glutamate metabotropic receptor 2) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Grm2 (glutamate metabotropic receptor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
GRM2 (glutamate metabotropic receptor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
GRM2 (glutamate metabotropic receptor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Grm2 (glutamate metabotropic receptor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
GRM2 (glutamate metabotropic receptor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Grm2 (glutamate metabotropic receptor 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
GRM2 (glutamate metabotropic receptor 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
grm2b (glutamate receptor, metabotropic 2b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam, ZFIN)
Danio rerio (zebrafish):
grm2a (glutamate receptor, metabotropic 2a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
mGluR
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
mgl-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 106,644,534 - 106,656,109 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 106,546,865 - 106,558,440 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 106,546,755 - 106,558,434 (-) NCBI mm8 Celera 9 106,265,562 - 106,277,130 (-) NCBI Celera Cytogenetic Map 9 F1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-pilocarpine decreases expression ISO RGD:2743 6480464 Pilocarpine results in decreased expression of GRM2 mRNA, Pilocarpine results in decreased expression of GRM2 protein CTD PMID:16793029 more ... 17beta-estradiol increases activity ISO RGD:2743 6480464 Estradiol results in increased activity of GRM2 protein CTD PMID:15901789 2,3,7,8-tetrachlorodibenzodioxine increases methylation EXP 6480464 Tetrachlorodibenzodioxin results in increased methylation of GRM2 gene CTD PMID:21212295 4-amino-2,6-dinitrotoluene affects expression ISO RGD:2743 6480464 4-amino-2, 6-dinitrotoluene affects the expression of GRM2 mRNA CTD PMID:21346803 6-propyl-2-thiouracil decreases expression ISO RGD:2743 6480464 Propylthiouracil results in decreased expression of GRM2 mRNA CTD PMID:24780913 aflatoxin B1 decreases expression ISO RGD:732930 6480464 Aflatoxin B1 results in decreased expression of GRM2 mRNA CTD PMID:22100608 amiodarone increases expression ISO RGD:732930 6480464 Amiodarone results in increased expression of GRM2 mRNA CTD PMID:19774075 ammonium chloride affects expression ISO RGD:2743 6480464 Ammonium Chloride affects the expression of GRM2 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:732930 6480464 Arsenic affects the methylation of GRM2 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:732930 6480464 Arsenic affects the methylation of GRM2 gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:732930 6480464 Arsenic affects the methylation of GRM2 gene CTD PMID:25304211 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:2743 6480464 Diethylhexyl Phthalate results in decreased expression of GRM2 mRNA CTD PMID:15620428 bisphenol A decreases expression ISO RGD:2743 6480464 bisphenol A results in decreased expression of GRM2 mRNA CTD PMID:25181051 , PMID:25812946 carbamazepine affects expression ISO RGD:732930 6480464 Carbamazepine affects the expression of GRM2 mRNA CTD PMID:25979313 chlorpyrifos increases expression ISO RGD:2743 6480464 Chlorpyrifos results in increased expression of GRM2 mRNA CTD PMID:17452286 cocaine increases activity ISO RGD:2743 6480464 Cocaine results in increased activity of GRM2 protein CTD PMID:20416862 cocaine affects expression ISO RGD:2743 6480464 Cocaine affects the expression of GRM2 protein CTD PMID:19105975 cocaine decreases activity ISO RGD:2743 6480464 Cocaine results in decreased activity of GRM2 protein CTD PMID:18673447 curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of GRM2 protein CTD PMID:25406541 diazinon increases expression ISO RGD:2743 6480464 Diazinon results in increased expression of GRM2 mRNA CTD PMID:17452286 entinostat decreases expression ISO RGD:732930 6480464 entinostat results in decreased expression of GRM2 mRNA CTD PMID:27188386 ethanol affects expression EXP 6480464 Ethanol affects the expression of GRM2 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of GRM2 mRNA CTD PMID:30319688 fonofos increases methylation ISO RGD:732930 6480464 Fonofos results in increased methylation of GRM2 promoter CTD PMID:22847954 haloperidol increases expression ISO RGD:2743 6480464 Haloperidol results in increased expression of GRM2 mRNA CTD PMID:18923069 mescaline multiple interactions EXP 6480464 [Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to Mescaline CTD PMID:21366332 methamphetamine increases response to substance ISO RGD:732930 6480464 GRM2 gene SNP results in increased susceptibility to Methamphetamine CTD PMID:20211215 methamphetamine multiple interactions EXP 6480464 [Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to Methamphetamine CTD PMID:21366332 N-acetyl-L-cysteine increases activity ISO RGD:732930 6480464 Acetylcysteine results in increased activity of GRM2 protein CTD PMID:19136971 Nonylphenol decreases expression ISO RGD:2743 6480464 nonylphenol results in decreased expression of GRM2 mRNA CTD PMID:15620428 paraquat affects expression ISO RGD:2743 6480464 Paraquat affects the expression of GRM2 mRNA CTD PMID:15206577 parathion increases methylation ISO RGD:732930 6480464 Parathion results in increased methylation of GRM2 promoter CTD PMID:22847954 piperidines multiple interactions EXP 6480464 [Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to Mescaline, [Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to Methamphetamine CTD PMID:21366332 rotenone decreases expression ISO RGD:732930 6480464 Rotenone results in decreased expression of GRM2 mRNA CTD PMID:29955902 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of GRM2 protein CTD PMID:29748927 Soman decreases expression ISO RGD:2743 6480464 Soman results in decreased expression of GRM2 mRNA CTD PMID:19281266 terbufos increases methylation ISO RGD:732930 6480464 terbufos results in increased methylation of GRM2 promoter CTD PMID:22847954 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of GRM2 mRNA, titanium dioxide results in decreased expression of GRM2 protein CTD PMID:25411160 triclosan increases expression ISO RGD:732930 6480464 Triclosan results in increased expression of GRM2 mRNA CTD PMID:30510588 tunicamycin increases expression EXP 6480464 Tunicamycin results in increased expression of GRM2 mRNA CTD PMID:17127020 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of GRM2 mRNA CTD PMID:17963808 
Gene-Chemical Interaction Annotations
