Sars1 (seryl-tRNA synthetase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Sars1 (seryl-tRNA synthetase 1) Mus musculus
Analyze
Symbol: Sars1
Name: seryl-tRNA synthetase 1
RGD ID: 1552505
MGI Page MGI
Description: Predicted to enable several functions, including aminoacyl-tRNA ligase activity; protein homodimerization activity; and tRNA binding activity. Predicted to be involved in several processes, including negative regulation of angiogenesis; negative regulation of macromolecule biosynthetic process; and translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; exocrine system; and genitourinary system. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C78314; S; Sars; serine--tRNA ligase; serine--tRNA ligase, cytoplasmic; serRS; seryl-aminoacyl-tRNA synthetase 1; seryl-tRNA synthetase, cytoplasmic; seryl-tRNA(Ser/Sec) synthetase; Strs
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393108,332,180 - 108,352,575 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3108,332,181 - 108,352,525 (-)EnsemblGRCm39 Ensembl
GRCm383108,424,864 - 108,445,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3108,424,865 - 108,445,209 (-)EnsemblGRCm38mm10GRCm38
MGSCv373108,229,530 - 108,248,087 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,554,668 - 108,573,225 (-)NCBIMGSCv36mm8
Celera3110,760,829 - 110,779,384 (-)NCBICelera
Cytogenetic Map3F3NCBI
cM Map347.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sars1Mouseintellectual disability  ISORGD:134858341410435protein:missense mutation:CDS:p.D172N (human)RGD 
Sars1Mouseprostate carcinoma  ISORGD:134858341410436mRNA:decreased expression:prostate gland (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sars1Mousearteriovenous malformations of the brain  ISORGD:13485838554872ClinVar Annotator: match by term: Cerebral arteriovenous malformationClinVarPMID:25741868
Sars1Mouseautistic disorder  ISORGD:13485838554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
Sars1Mousehereditary spastic paraplegia 63  ISORGD:13485838554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 63ClinVarPMID:23911318|PMID:28492532
Sars1MouseHUPRA Syndrome  ISORGD:13485838554872ClinVar Annotator: match by term: HYPERURICEMIA, PULMONARY HYPERTENSION, RENAL FAILURE, AND ALKALOSIS SYNDROMEClinVarPMID:25741868|PMID:28492532
Sars1MouseNEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ATAXIA, AND SEIZURES  ISORGD:13485838554872ClinVar Annotator: match by term: Neurodevelopmental disorder with microcephaly, ataxia, and seizures | ClinVar Annotator: more ...ClinVarPMID:25741868|PMID:28236339|PMID:28492532|PMID:34570399|PMID:35790048|PMID:36004946|PMID:36041817
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sars1Mousecoronary artery disease  ISORGD:134858311554173CTD Direct Evidence: marker/mechanismCTDPMID:34961328
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sars1MouseNEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ATAXIA, AND SEIZURES  ISORGD:13485837240710 OMIM 

1 to 20 of 123 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sars1Mouse(+)-schisandrin B multiple interactionsISORGD:6288136480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SARS1 mRNA]CTDPMID:31150632
Sars1Mouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SARS1 mRNACTDPMID:36331819
Sars1Mouse1,2-dimethylhydrazine multiple interactionsEXP 6480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SARS1 mRNACTDPMID:22206623
Sars1Mouse17alpha-ethynylestradiol affects expressionISORGD:13485836480464Ethinyl Estradiol affects the expression of SARS1 mRNACTDPMID:20170705|PMID:26865667
Sars1Mouse17alpha-ethynylestradiol affects expressionISORGD:6288136480464Ethinyl Estradiol affects the expression of SARS1 mRNACTDPMID:20170705|PMID:26865667
Sars1Mouse17beta-estradiol multiple interactionsISORGD:6288136480464[bisphenol A co-treated with Estradiol] results in decreased expression of SARS1 mRNACTDPMID:26496021
Sars1Mouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of SARS1 mRNACTDPMID:39298647
Sars1Mouse2,2',4,4'-Tetrabromodiphenyl ether increases expressionISORGD:134858364804642,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of SARS1 mRNACTDPMID:19095052
Sars1Mouse2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsEXP 6480464[Flame Retardants results in increased abundance of 2,2',4,4'-tetrabromodiphenyl ether] which results in increased expression of more ...CTDPMID:38995820
Sars1Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:6288136480464Tetrachlorodibenzodioxin results in increased expression of SARS1 mRNACTDPMID:33387578
Sars1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of SARS1 mRNACTDPMID:21570461
Sars1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:6288136480464Tetrachlorodibenzodioxin affects the expression of SARS1 mRNACTDPMID:22298810
Sars1Mouse2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionISORGD:134858364804642,2',4,4',5-brominated diphenyl ether results in increased expression of SARS1 mRNACTDPMID:26705709
Sars1Mouse3-chloropropane-1,2-diol increases expressionISORGD:6288136480464alpha-Chlorohydrin results in increased expression of SARS1 proteinCTDPMID:34915118
Sars1Mouse4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of SARS1 mRNACTDPMID:39298647
Sars1Mouse4,4'-sulfonyldiphenol increases expressionISORGD:13485836480464bisphenol S results in increased expression of SARS1 proteinCTDPMID:34186270
Sars1Mouseaconitine decreases expressionISORGD:6288136480464Aconitine results in decreased expression of SARS1 proteinCTDPMID:33236894
Sars1Mouseactinomycin D multiple interactionsISORGD:13485836480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of SARS1 proteinCTDPMID:38460933
Sars1Mouseaflatoxin B1 decreases methylationISORGD:13485836480464Aflatoxin B1 results in decreased methylation of SARS1 geneCTDPMID:27153756
Sars1Mouseall-trans-retinoic acid decreases expressionISORGD:13485836480464Tretinoin results in decreased expression of SARS1 mRNACTDPMID:33167477

1 to 20 of 123 rows

Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sars1Mousecytoplasmic translation involved_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mousecytoplasmic translation involved_inISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mousenegative regulation of angiogenesis involved_inISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mousenegative regulation of angiogenesis involved_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mousenegative regulation of transcription by RNA polymerase II involved_inISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mousenegative regulation of transcription by RNA polymerase II involved_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mousenegative regulation of vascular endothelial growth factor production involved_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mousenegative regulation of vascular endothelial growth factor production involved_inISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mouseselenocysteine incorporation involved_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mouseselenocysteine incorporation involved_inISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mouseseryl-tRNA aminoacylation involved_inISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mouseseryl-tRNA aminoacylation involved_inIBAPANTHER:PTN002623036|UniProtKB:P49591|ZFIN:ZDB-GENE-040831-1|SGD:S000002430|UniProtKB:Q9N0F3|FB:FBgn0021750|SGD:S000001053|FB:FBgn0051133|UniProtKB:Q9HGT62290270 GO_CentralGO_REF:0000033
Sars1Mouseseryl-tRNA aminoacylation involved_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1MousetRNA modification involved_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sars1Mousecytoplasm located_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mousecytosol located_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mousecytosol located_inISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mousecytosol is_active_inIBAPANTHER:PTN000207087|UniProtKB:P495912290270 GO_CentralGO_REF:0000033
Sars1Mousemitochondrion located_inHDA 2290270 PMID:18614015MGIPMID:18614015
Sars1Mousenucleus located_inISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mousenucleus located_inISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sars1MouseATP binding enablesIEAUniProtKB-KW:KW-00672290270 UniProtGO_REF:0000043
Sars1Mouseenzyme binding enablesISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mousemolecular adaptor activity enablesISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mouseprotein binding enablesISOUniProtKB:A6NJ78-4|UniProtKB:O14544|UniProtKB:O15534|UniProtKB:O43504|UniProtKB:O77932|UniProtKB:P09525|UniProtKB:P38936|UniProtKB:P79522|UniProtKB:Q14181|UniProtKB:Q496A3|UniProtKB:Q6DHV7-2|UniProtKB:Q7Z6I5|UniProtKB:Q7Z7C8-2|UniProtKB:Q8N0U2|UniProtKB:Q8N2H9-4|UniProtKB:Q92615|UniProtKB:Q96FT7-4|UniProtKB:Q9BRR0|UniProtKB:Q9BYN7-2|UniProtKB:Q9NS23-4|UniProtKB:Q9NUC0|UniProtKB:Q9NX94|UniProtKB:Q9UH65|UniProtKB:Q9Y4F5-39068941 PMID:32814053IntActPMID:32814053
Sars1Mouseprotein binding enablesISOUniProtKB:Q8TCB79068941 PMID:34268557UniProtPMID:34268557
Sars1Mouseprotein binding enablesISOUniProtKB:P495919068941 PMID:26433229UniProtPMID:26433229
Sars1Mouseprotein homodimerization activity enablesISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1MouseRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1MouseRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mouseselenocysteine-tRNA ligase activity enablesISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mouseselenocysteine-tRNA ligase activity enablesISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mouseserine-tRNA ligase activity enablesISSUniProtKB:P495912290270 UniProtGO_REF:0000024
Sars1Mouseserine-tRNA ligase activity enablesISOUniProtKB:P495912290270 GO_CentralGO_REF:0000119
Sars1Mouseserine-tRNA ligase activity enablesIBAPANTHER:PTN002623036|SGD:S000002430|UniProtKB:Q9N0F3|ZFIN:ZDB-GENE-040831-1|UniProtKB:P49591|SGD:S000001053|UniProtKB:Q9HGT62290270 GO_CentralGO_REF:0000033
Sars1MousetRNA binding enablesIBAPANTHER:PTN002623036|FB:FBgn00511332290270 GO_CentralGO_REF:0000033
1 to 15 of 15 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sars1Mousedihydropyrimidine dehydrogenase deficiency pathway  ISORGD:134858310402751 SMPDBSMP:00179
Sars1Mousedimethylglycine dehydrogenase deficiency pathway  ISORGD:134858310402751 SMPDBSMP:00484
Sars1Mousedimethylglycine dehydrogenase deficiency pathway  ISORGD:134858310402751 SMPDBSMP:00242
Sars1Mousenonketotic hyperglycinemia pathway  ISORGD:134858310402751 SMPDBSMP:00485
Sars1Mousenonketotic hyperglycinemia pathway  ISORGD:134858310402751 SMPDBSMP:00223
Sars1Mousesarcosinemia pathway  ISORGD:134858310402751 SMPDBSMP:00244
1 to 9 of 9 rows
1 to 9 of 9 rows

1 to 10 of 10 rows
#
Reference Title
Reference Citation
1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
2. Functional Epigenetic Analysis of Prostate Carcinoma: A Role for Seryl-tRNA Synthetase? Ikromov O, etal., J Biomark. 2014;2014:362164. doi: 10.1155/2014/362164. Epub 2014 Mar 27.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Mammalian seryl-tRNA synthetase associates with mRNA in vivo and has homology to elongation factor 1 alpha. Miseta A, etal., J Biol Chem 1991 Oct 15;266(29):19158-61.
7. Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. Musante L, etal., Hum Mutat. 2017 Jun;38(6):621-636. doi: 10.1002/humu.23205. Epub 2017 Mar 23.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 10 of 10 rows
PMID:8889548   PMID:10349636   PMID:10469639   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15747579   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16512683   PMID:16602821   PMID:18614015   PMID:21267068   PMID:21873635   PMID:24194600   PMID:25284223   PMID:26496610   PMID:27160897   PMID:30457570  
PMID:31138677   PMID:32325033   PMID:32554809   PMID:34400610   PMID:36293380   PMID:37142655   PMID:38355793  



Sars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393108,332,180 - 108,352,575 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3108,332,181 - 108,352,525 (-)EnsemblGRCm39 Ensembl
GRCm383108,424,864 - 108,445,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3108,424,865 - 108,445,209 (-)EnsemblGRCm38mm10GRCm38
MGSCv373108,229,530 - 108,248,087 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,554,668 - 108,573,225 (-)NCBIMGSCv36mm8
Celera3110,760,829 - 110,779,384 (-)NCBICelera
Cytogenetic Map3F3NCBI
cM Map347.08NCBI
SARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,213,893 - 109,238,182 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,213,918 - 109,238,182 (+)EnsemblGRCh38hg38GRCh38
GRCh371109,756,515 - 109,780,804 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361109,558,063 - 109,582,308 (+)NCBINCBI36Build 36hg18NCBI36
Build 341109,468,581 - 109,492,827NCBI
Celera1108,025,871 - 108,050,163 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1107,649,736 - 107,674,024 (+)NCBIHuRef
CHM1_11109,871,309 - 109,895,637 (+)NCBICHM1_1
T2T-CHM13v2.01109,246,703 - 109,270,991 (+)NCBIT2T-CHM13v2.0
Sars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,753,673 - 198,769,411 (-)NCBIGRCr8
mRatBN7.22196,065,543 - 196,081,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2196,065,430 - 196,081,277 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,708,691 - 203,726,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,590,809 - 201,608,303 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02196,407,774 - 196,425,268 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02211,219,743 - 211,235,475 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2211,219,750 - 211,235,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,689,709 - 230,705,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,995,537 - 204,011,262 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,960,370 - 203,964,749 (-)NCBI
Celera2188,711,760 - 188,728,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
Sars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543512,641,776 - 12,660,682 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543512,642,485 - 12,659,833 (+)NCBIChiLan1.0ChiLan1.0
SARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21118,065,900 - 118,091,212 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,225,766 - 117,251,171 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01111,590,850 - 111,615,068 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11110,755,241 - 110,779,616 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,755,054 - 110,779,704 (+)Ensemblpanpan1.1panPan2
SARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,584,792 - 42,605,201 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,584,798 - 42,605,136 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha645,359,499 - 45,379,900 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,916,110 - 42,936,514 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,915,405 - 42,936,515 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,647,449 - 42,667,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,605,509 - 42,625,891 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0643,040,831 - 43,061,242 (-)NCBIUU_Cfam_GSD_1.0
Sars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505819,347,165 - 19,367,040 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936704746,775 - 771,305 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936704747,109 - 766,981 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,857,089 - 110,874,815 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,857,067 - 110,874,712 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24121,350,908 - 121,368,532 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103225885
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12024,303,741 - 24,321,931 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236664117 - 23,332 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247724,963,173 - 4,978,294 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Sars1
1013 total Variants

Predicted Target Of
Summary Value
Count of predictions:1392
Count of miRNA genes:652
Interacting mature miRNAs:814
Transcripts:ENSMUST00000090553, ENSMUST00000102625, ENSMUST00000132467, ENSMUST00000153499
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 42 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
1357599msrvh1_mmodifier of susceptibility to renal vascular hypertrophy/hyperplasia 1 (mouse)Not determined3107376936115624197Mouse

1 to 10 of 42 rows
MDB0358  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383108,426,553 - 108,426,750UniSTSGRCm38
MGSCv373108,229,471 - 108,229,668UniSTSGRCm37
Celera3110,760,770 - 110,760,967UniSTS
Cytogenetic Map3F3UniSTS
cM Map355.7UniSTS
Whitehead_YAC3 UniSTS
RH126345  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383108,426,622 - 108,426,824UniSTSGRCm38
MGSCv373108,229,540 - 108,229,742UniSTSGRCm37
Celera3110,760,839 - 110,761,041UniSTS
Cytogenetic Map3F3UniSTS
cM Map355.7UniSTS
Sars1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383108,426,512 - 108,426,663UniSTSGRCm38
MGSCv373108,229,430 - 108,229,581UniSTSGRCm37
Celera3110,760,729 - 110,760,880UniSTS
Cytogenetic Map3F3UniSTS
cM Map355.7UniSTS






1 to 24 of 24 rows
RefSeq Transcripts NM_001204979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK028154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP765728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY034232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 24 of 24 rows

Ensembl Acc Id: ENSMUST00000090553   ⟹   ENSMUSP00000088041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3108,332,181 - 108,352,514 (-)Ensembl
GRCm38.p6 Ensembl3108,424,865 - 108,445,198 (-)Ensembl
Ensembl Acc Id: ENSMUST00000102625   ⟹   ENSMUSP00000099685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3108,333,928 - 108,352,485 (-)Ensembl
GRCm38.p6 Ensembl3108,426,612 - 108,445,169 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132467   ⟹   ENSMUSP00000120879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3108,335,547 - 108,352,459 (-)Ensembl
GRCm38.p6 Ensembl3108,428,231 - 108,445,143 (-)Ensembl
Ensembl Acc Id: ENSMUST00000153499   ⟹   ENSMUSP00000118676
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3108,336,666 - 108,352,525 (-)Ensembl
GRCm38.p6 Ensembl3108,429,350 - 108,445,209 (-)Ensembl
Ensembl Acc Id: ENSMUST00000197647
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3108,341,713 - 108,352,472 (-)Ensembl
GRCm38.p6 Ensembl3108,434,397 - 108,445,156 (-)Ensembl
RefSeq Acc Id: NM_001204979   ⟹   NP_001191908
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393108,332,180 - 108,352,575 (-)NCBI
GRCm383108,424,864 - 108,445,259 (-)ENTREZGENE
Celera3110,759,081 - 110,779,474 (-)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011319   ⟹   NP_035449
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393108,332,180 - 108,352,575 (-)NCBI
GRCm383108,424,864 - 108,445,259 (-)ENTREZGENE
MGSCv373108,229,530 - 108,248,087 (-)RGD
Celera3110,759,081 - 110,779,474 (-)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035449   ⟸   NM_011319
- Peptide Label: isoform 1
- UniProtKB: Q8C483 (UniProtKB/TrEMBL),   Q3U6F6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001191908   ⟸   NM_001204979
- Peptide Label: isoform 2
- UniProtKB: A2AFR8 (UniProtKB/Swiss-Prot),   P26638 (UniProtKB/Swiss-Prot),   Q3U6F6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000088041   ⟸   ENSMUST00000090553
Ensembl Acc Id: ENSMUSP00000120879   ⟸   ENSMUST00000132467
Ensembl Acc Id: ENSMUSP00000118676   ⟸   ENSMUST00000153499
Name Modeler Protein Id AA Range Protein Structure
AF-P26638-F1-model_v2 AlphaFold P26638 1-512 view protein structure

RGD ID:6834409
Promoter ID:MM_KWN:35785
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000090552,   ENSMUST00000102625,   ENSMUST00000106632,   OTTMUST00000016763,   OTTMUST00000016765,   OTTMUST00000016766,   UC008QZC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363108,247,716 - 108,248,317 (-)MPROMDB
RGD ID:6882078
Promoter ID:EPDNEW_M4490
Type:initiation region
Name:Sars_1
Description:Mus musculus seryl-aminoacyl-tRNA synthetase , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383108,445,194 - 108,445,254EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000068739 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000090553 ENTREZGENE
  ENSMUST00000090553.12 UniProtKB/Swiss-Prot
  ENSMUST00000102625 ENTREZGENE
Gene3D-CATH 1.10.287.40 UniProtKB/Swiss-Prot
  Bira Bifunctional Protein, Domain 2 UniProtKB/Swiss-Prot
InterPro aa-tRNA-synt_IIb UniProtKB/Swiss-Prot
  aa-tRNA-synth_II UniProtKB/Swiss-Prot
  aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot
  Ser-tRNA-ligase_type_1 UniProtKB/Swiss-Prot
  Ser-tRNA-synth_1_N UniProtKB/Swiss-Prot
  SerRS_1_N_sf UniProtKB/Swiss-Prot
  SerRS_core UniProtKB/Swiss-Prot
  tRNA-bd_arm UniProtKB/Swiss-Prot
KEGG Report mmu:20226 UniProtKB/Swiss-Prot
MGD MGI:102809 ENTREZGENE
NCBI Gene 20226 ENTREZGENE
PANTHER PTHR11778 UniProtKB/Swiss-Prot
Pfam Seryl_tRNA_N UniProtKB/Swiss-Prot
  tRNA-synt_2b UniProtKB/Swiss-Prot
PhenoGen Sars1 PhenoGen
PIRSF Ser-tRNA-synth_IIa UniProtKB/Swiss-Prot
PRINTS TRNASYNTHSER UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_II UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46589 UniProtKB/Swiss-Prot
  SSF55681 UniProtKB/Swiss-Prot
UniProt A2AFR8 ENTREZGENE
  A2AFS0_MOUSE UniProtKB/TrEMBL
  A2AFS1_MOUSE UniProtKB/TrEMBL
  P26638 ENTREZGENE
  Q3U6F6 ENTREZGENE, UniProtKB/TrEMBL
  Q3U8N1_MOUSE UniProtKB/TrEMBL
  Q8C483 ENTREZGENE, UniProtKB/TrEMBL
  Q8CEH3_MOUSE UniProtKB/TrEMBL
  SYSC_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2AFR8 UniProtKB/Swiss-Prot
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-05 Sars1  seryl-tRNA synthetase 1  Sars  seryl-aminoacyl-tRNA synthetase  Symbol and/or name updated 27372883 PROVISIONAL