Ereg (epiregulin) - Rat Genome Database

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Gene: Ereg (epiregulin) Mus musculus
Analyze
Symbol: Ereg
Name: epiregulin
RGD ID: 730899
MGI Page MGI
Description: Enables epidermal growth factor receptor binding activity; receptor ligand activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of mitotic nuclear division. Located in extracellular space. Is expressed in several structures, including extraembryonic component; heart; lung; ovary; and skin. Human ortholog(s) of this gene implicated in extrapulmonary tuberculosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human EREG (epiregulin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E; EPR; MGC36144; proepiregulin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,222,476 - 91,241,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,222,481 - 91,241,505 (+)EnsemblGRCm39 Ensembl
GRCm38591,074,617 - 91,093,649 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl591,074,622 - 91,093,646 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,503,643 - 91,522,675 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36592,149,822 - 92,168,846 (+)NCBIMGSCv36mm8
Celera589,212,781 - 89,230,978 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-Dinitropyrene  (ISO)
1-nitropyrene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (ISO)
4-aminosalicylic acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
AL 8810  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpidem  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (ISO)
batimastat  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bifenthrin  (ISO)
biperiden  (ISO)
bisphenol A  (ISO)
bromfenac  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
Chorionic gonadotropin  (EXP,ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
citric acid  (ISO)
clavulanic acid  (ISO)
cobalt atom  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (EXP,ISO)
cumene  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
entacapone  (ISO)
esmolol  (ISO)
etodolac  (ISO)
etoposide  (ISO)
ferroheme b  (EXP)
Fexofenadine hydrochloride  (ISO)
flavonoids  (ISO)
fludrocortisone  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (ISO)
griseofulvin  (EXP)
heme b  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
Iproniazid  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
ketoconazole  (ISO)
ketorolac tromethamine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lumiracoxib  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mebendazole  (ISO)
meloxicam  (EXP)
metam  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
microcystin-LR  (EXP)
minoxidil  (ISO)
mirex  (ISO)
monobenzyl phthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalenes  (ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
Nonylphenol  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
penbutolol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
Phenoxybenzamine  (ISO)
phentolamine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (EXP)
pioglitazone  (ISO)
pirprofen  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
primaquine  (ISO)
procyclidine  (ISO)
propanal  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (EXP)
protein kinase inhibitor  (ISO)
protoporphyrins  (EXP)
protriptyline  (ISO)
quercetin  (ISO)
retinyl palmitate  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (EXP)
tienilic acid  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
trazodone  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
Trihexyphenidyl  (ISO)
triphenyl phosphate  (ISO)
triprolidine  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinyl carbamate  (EXP)
zafirlukast  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (TAS)
angiogenesis  (IEA)
animal organ morphogenesis  (TAS)
cell-cell signaling  (ISO,ISS)
cytokine-mediated signaling pathway  (ISO,ISS)
epidermal growth factor receptor signaling pathway  (IBA,IDA,IGI,ISO,ISS)
ERBB2-EGFR signaling pathway  (ISO)
ERBB2-ERBB4 signaling pathway  (ISO)
ERBB4-ERBB4 signaling pathway  (ISO)
female meiotic nuclear division  (ISO,ISS)
keratinocyte proliferation  (ISO,ISS)
luteinizing hormone signaling pathway  (ISO,ISS)
mRNA transcription  (ISO,ISS)
negative regulation of cell population proliferation  (IDA)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of smooth muscle cell differentiation  (ISO,ISS)
oocyte maturation  (ISO,ISS)
ovarian cumulus expansion  (ISO,ISS)
ovulation  (ISO,ISS)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (IBA,IDA,ISO,ISS)
positive regulation of cytokine production  (IMP,ISO,ISS)
positive regulation of DNA replication  (IDA,ISO,ISS)
positive regulation of fibroblast proliferation  (ISO,ISS)
positive regulation of innate immune response  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of mitotic nuclear division  (IBA,IDA,ISO,ISS)
positive regulation of phosphorylation  (ISO,ISS)
positive regulation of protein kinase activity  (ISO,ISS)
positive regulation of smooth muscle cell proliferation  (ISO,ISS)
primary follicle stage  (ISO,ISS)
response to peptide hormone  (IEA,ISO)

Cellular Component
extracellular space  (IBA,IDA,IGI,ISO,ISS)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Polymorphism in the EREG gene confers susceptibility to tuberculosis. Cao W, etal., BMC Med Genet. 2019 Jan 11;20(1):7. doi: 10.1186/s12881-018-0729-z.
2. Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury. Hsu D, etal., Lab Invest. 2010 Sep;90(9):1295-305. doi: 10.1038/labinvest.2010.100. Epub 2010 May 24.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
13. Expression of the epidermal growth factor system in human middle ear cholesteatoma. Thorup MB, etal., Acta Otolaryngol. 2014 Feb;134(2):124-34. doi: 10.3109/00016489.2013.847282. Epub 2013 Nov 21.
14. Epiregulin (EREG) variation is associated with susceptibility to tuberculosis. Thuong NT, etal., Genes Immun. 2012 Apr;13(3):275-81. doi: 10.1038/gene.2011.83. Epub 2011 Dec 15.
15. Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer. Xie Y, etal., PLoS One. 2013 Jun 21;8(6):e67819. doi: 10.1371/journal.pone.0067819. Print 2013.
Additional References at PubMed
PMID:7706296   PMID:8549764   PMID:9337852   PMID:9344537   PMID:9419975   PMID:9556621   PMID:9990076   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12573256  
PMID:14726596   PMID:15365177   PMID:15456865   PMID:15489334   PMID:15651060   PMID:16141072   PMID:16141073   PMID:16182244   PMID:16338791   PMID:16857964   PMID:17194751   PMID:18069687  
PMID:19267999   PMID:19321658   PMID:19330024   PMID:19884258   PMID:21041656   PMID:21123517   PMID:21233255   PMID:21237132   PMID:21512138   PMID:21738714   PMID:21873635   PMID:21946538  
PMID:22427548   PMID:22682244   PMID:22951731   PMID:23549083   PMID:24043783   PMID:24488930   PMID:24812054   PMID:24825892   PMID:24952961   PMID:26627827   PMID:26764350   PMID:26894620  
PMID:28360101   PMID:28472347   PMID:28492365   PMID:28783046   PMID:28898113   PMID:29129684   PMID:30400011   PMID:31761787   PMID:31889361   PMID:32700456   PMID:34292881   PMID:36915679  
PMID:37070602   PMID:38514807  


Genomics

Comparative Map Data
Ereg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,222,476 - 91,241,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,222,481 - 91,241,505 (+)EnsemblGRCm39 Ensembl
GRCm38591,074,617 - 91,093,649 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl591,074,622 - 91,093,646 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,503,643 - 91,522,675 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36592,149,822 - 92,168,846 (+)NCBIMGSCv36mm8
Celera589,212,781 - 89,230,978 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
EREG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,365,145 - 74,388,749 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,365,145 - 74,388,749 (+)EnsemblGRCh38hg38GRCh38
GRCh37475,230,862 - 75,254,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,449,724 - 75,473,341 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,595,894 - 75,619,512NCBI
Celera472,591,116 - 72,614,730 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef471,041,824 - 71,065,447 (+)NCBIHuRef
CHM1_1475,266,712 - 75,290,347 (+)NCBICHM1_1
T2T-CHM13v2.0477,708,788 - 77,732,398 (+)NCBIT2T-CHM13v2.0
Ereg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,311,485 - 17,325,260 (-)NCBIGRCr8
mRatBN7.21417,027,287 - 17,041,062 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,027,287 - 17,041,062 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,029,016 - 17,042,901 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,347,942 - 18,361,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,040,063 - 17,053,944 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,577,620 - 18,591,395 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,576,355 - 18,591,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,486,956 - 18,500,731 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,521,069 - 18,534,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,521,068 - 18,534,844 (-)NCBI
Celera1416,405,096 - 16,418,803 (-)NCBICelera
Cytogenetic Map14p22NCBI
Ereg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474612,440 - 627,606 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474612,440 - 627,606 (+)NCBIChiLan1.0ChiLan1.0
EREG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2355,672,126 - 55,720,786 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1455,861,183 - 55,909,825 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0449,806,505 - 49,827,961 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,641,014 - 55,660,568 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,641,014 - 55,660,568 (-)Ensemblpanpan1.1panPan2
EREG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,857,325 - 62,877,831 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,856,709 - 62,877,760 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,545,018 - 62,568,011 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,687,189 - 63,710,239 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,687,115 - 63,707,828 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11363,301,985 - 63,325,016 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,783,802 - 62,806,817 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,926,759 - 63,949,788 (+)NCBIUU_Cfam_GSD_1.0
Ereg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528512,874,664 - 12,893,710 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,328,803 - 1,344,360 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,328,803 - 1,336,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EREG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,351,311 - 70,372,569 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,351,316 - 70,372,530 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,502,143 - 74,521,363 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EREG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,898,998 - 22,924,922 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,901,862 - 22,920,678 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660371,191,580 - 1,214,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ereg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247301,339,518 - 1,353,429 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247301,339,017 - 1,353,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1005
Count of miRNA genes:558
Interacting mature miRNAs:686
Transcripts:ENSMUST00000031324
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
Ereg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E1UniSTS
cM Map5 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031324   ⟹   ENSMUSP00000031324
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl591,222,481 - 91,241,505 (+)Ensembl
GRCm38.p6 Ensembl591,074,622 - 91,093,646 (+)Ensembl
RefSeq Acc Id: NM_007950   ⟹   NP_031976
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39591,222,476 - 91,241,508 (+)NCBI
GRCm38591,074,617 - 91,093,649 (+)ENTREZGENE
MGSCv37591,503,643 - 91,522,675 (+)RGD
Celera589,212,781 - 89,230,978 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_031976 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH27838 (Get FASTA)   NCBI Sequence Viewer  
  BAA06446 (Get FASTA)   NCBI Sequence Viewer  
  EDL05296 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000031324
  ENSMUSP00000031324.5
GenBank Protein Q61521 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031976   ⟸   NM_007950
- Peptide Label: preproprotein
- UniProtKB: Q7M0A8 (UniProtKB/Swiss-Prot),   Q61521 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000031324   ⟸   ENSMUST00000031324
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61521-F1-model_v2 AlphaFold Q61521 1-162 view protein structure

Promoters
RGD ID:6887136
Promoter ID:EPDNEW_M7019
Type:multiple initiation site
Name:Ereg_1
Description:Mus musculus epiregulin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38591,074,622 - 91,074,682EPDNEW
RGD ID:6837467
Promoter ID:MM_KWN:42854
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4,   MEF_B6
Transcripts:NM_007950
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36591,503,051 - 91,503,722 (+)MPROMDB
RGD ID:6837015
Promoter ID:MM_KWN:42855
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   MEF_B4
Transcripts:UC008YBR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36591,503,509 - 91,504,009 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107508 AgrOrtholog
Ensembl Genes ENSMUSG00000029377 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031324 ENTREZGENE
  ENSMUST00000031324.6 UniProtKB/Swiss-Prot
Gene3D-CATH Laminin UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
KEGG Report mmu:13874 UniProtKB/Swiss-Prot
MGD MGI:107508 ENTREZGENE
NCBI Gene 13874 ENTREZGENE
PANTHER PROEPIREGULIN UniProtKB/Swiss-Prot
  PTHR10740 UniProtKB/Swiss-Prot
PharmGKB EREG RGD
PhenoGen Ereg PhenoGen
PRINTS EGFTGF UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
UniProt EREG_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q7M0A8 ENTREZGENE
UniProt Secondary Q7M0A8 UniProtKB/Swiss-Prot