(+)-catechin multiple interactions EXP 6480464 Catechin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein] CTD PMID:16753784 (+)-catechin increases expression EXP 6480464 Catechin results in increased expression of PARP1 protein CTD PMID:16753784 (+)-dexrazoxane multiple interactions EXP 6480464 Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 mRNA] and Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 protein] CTD PMID:28973540 (+)-pilocarpine affects expression ISO Parp1 (Rattus norvegicus) 6480464 Pilocarpine affects the expression of PARP1 protein CTD PMID:25101675 (+)-pilocarpine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein] more ... CTD PMID:31396050 (+)-sesamin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 sesamin inhibits the reaction [Glucose results in increased cleavage of PARP1 protein] CTD PMID:22524206 (+)-Tetrandrine increases cleavage ISO PARP1 (Homo sapiens) 6480464 tetrandrine results in increased cleavage of PARP1 protein CTD PMID:26822499 (-)-anisomycin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein and Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]] CTD PMID:28842171 and PMID:34767868 (-)-bornyl-caffeate increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 bornyl caffeate results in increased cleavage of PARP1 protein CTD PMID:24907532 (-)-epigallocatechin 3-gallate increases activity ISO PARP1 (Homo sapiens) 6480464 epigallocatechin gallate results in increased activity of PARP1 protein CTD PMID:15657356 (-)-epigallocatechin 3-gallate affects cleavage ISO PARP1 (Homo sapiens) 6480464 epigallocatechin gallate affects the cleavage of PARP1 protein CTD PMID:23954321 (-)-epigallocatechin 3-gallate affects activity EXP 6480464 epigallocatechin gallate affects the activity of PARP1 protein CTD PMID:25955525 (-)-epigallocatechin 3-gallate multiple interactions ISO PARP1 (Homo sapiens) 6480464 epigallocatechin gallate inhibits the reaction [potassium chromate(VI) results in increased cleavage of and results in increased activity of PARP1 protein] CTD PMID:22079256 (-)-epigallocatechin 3-gallate increases cleavage ISO PARP1 (Homo sapiens) 6480464 epigallocatechin gallate results in increased cleavage of PARP1 protein CTD PMID:15705601 and PMID:15764647 (-)-gambogic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein more ... CTD PMID:19084572 more ... (-)-gambogic acid decreases expression ISO PARP1 (Homo sapiens) 6480464 gambogic acid results in decreased expression of PARP1 mRNA CTD PMID:19084572 (-)-gambogic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 gambogic acid results in increased cleavage of PARP1 protein CTD PMID:19084572 more ... (-)-noscapine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Noscapine results in increased cleavage of PARP1 protein CTD PMID:22848370 (-)-selegiline multiple interactions EXP 6480464 Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein] CTD PMID:12880480 (20R)-protopanaxadiol increases expression ISO PARP1 (Homo sapiens) 6480464 protopanaxadiol results in increased expression of PARP1 mRNA CTD PMID:31805304 (20S)-ginsenoside Rg3 multiple interactions ISO PARP1 (Homo sapiens) 6480464 [ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of PARP1 protein more ... CTD PMID:24793912 more ... (20S)-ginsenoside Rg3 increases cleavage ISO PARP1 (Homo sapiens) 6480464 ginsenoside Rg3 results in increased cleavage of PARP1 protein CTD PMID:22101440 (3,4-dihydroxyphenyl)acetic acid multiple interactions EXP 6480464 [PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:10318960 (aminomethyl)phosphonic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in increased cleavage of PARP1 protein CTD PMID:26006246 (aminomethyl)phosphonic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 1-aminomethylphosphonic acid results in increased cleavage of PARP1 protein CTD PMID:23983455 (aminooxy)acetic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form CTD PMID:25321483 (R)-adrenaline decreases cleavage ISO PARP1 (Homo sapiens) 6480464 Epinephrine results in decreased cleavage of PARP1 protein CTD PMID:36423730 (R)-adrenaline decreases cleavage EXP 6480464 Epinephrine results in decreased cleavage of PARP1 protein CTD PMID:36423730 (R,R,R)-alpha-tocopherol multiple interactions ISO PARP1 (Homo sapiens) 6480464 alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein] CTD PMID:14645110 (R,R,R)-alpha-tocopherol multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 alpha-Tocopherol inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein] CTD PMID:24448832 (S)-colchicine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Colchicine results in increased cleavage of PARP1 protein CTD PMID:33684465 (S)-naringenin increases cleavage ISO PARP1 (Homo sapiens) 6480464 naringenin results in increased cleavage of PARP1 protein CTD PMID:27838343 (S)-naringenin multiple interactions ISO PARP1 (Homo sapiens) 6480464 naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein] CTD PMID:31254498 (S)-nicotine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Nicotine inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form] more ... CTD PMID:20457658 more ... (S)-nicotine decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Nicotine results in decreased expression of PARP1 protein CTD PMID:29972271 (S)-nicotine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Folic Acid inhibits the reaction [Nicotine results in decreased expression of PARP1 protein] CTD PMID:29972271 (S)-ropivacaine multiple interactions ISO PARP1 (Homo sapiens) 6480464 BCL2 protein inhibits the reaction [Ropivacaine results in increased cleavage of PARP1 protein] and CLU protein inhibits the reaction [Ropivacaine results in increased cleavage of PARP1 protein] CTD PMID:15538973 (S)-ropivacaine increases expression ISO PARP1 (Homo sapiens) 6480464 Ropivacaine results in increased expression of PARP1 protein CTD PMID:28079261 (S)-ropivacaine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Ropivacaine results in increased cleavage of PARP1 protein CTD PMID:15538973 1'-acetoxychavicol acetate multiple interactions ISO PARP1 (Homo sapiens) 6480464 1'-acetoxychavicol acetate promotes the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:15905586 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression ISO Parp1 (Rattus norvegicus) 6480464 o and p'-DDT affects the expression of PARP1 mRNA CTD PMID:17984292 1,2-dimethylhydrazine decreases expression ISO Parp1 (Rattus norvegicus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of PARP1 mRNA CTD PMID:32387197 1,2-dimethylhydrazine increases expression EXP 6480464 1 and 2-Dimethylhydrazine results in increased expression of PARP1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions EXP 6480464 Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PARP1 mRNA] CTD PMID:22206623 1,3-dichloropropan-2-ol multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [1 and 3-dichloro-2-propanol results in increased cleavage of PARP1 protein] CTD PMID:29248572 1,3-dichloropropan-2-ol increases cleavage EXP 6480464 1 and 3-dichloro-2-propanol results in increased cleavage of PARP1 protein CTD PMID:29248572 1,3-dinitrobenzene increases cleavage EXP 6480464 3-dinitrobenzene results in increased cleavage of PARP1 protein CTD PMID:19477251 1,3-dinitrobenzene multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [3-dinitrobenzene results in increased cleavage of PARP1 protein] CTD PMID:19477251 1,4-dithiothreitol multiple interactions EXP 6480464 Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:11035063 1,4-dithiothreitol multiple interactions ISO PARP1 (Homo sapiens) 6480464 Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein] and Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein] CTD PMID:18022205 and PMID:20438634 1,4-naphthoquinone increases cleavage ISO PARP1 (Homo sapiens) 6480464 1 and 4-naphthoquinone analog results in increased cleavage of PARP1 protein CTD PMID:30871965 1,4-naphthoquinone multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [1 more ... CTD PMID:30871965 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases cleavage ISO PARP1 (Homo sapiens) 6480464 Citalopram results in increased cleavage of PARP1 protein CTD PMID:10487422 1-chloro-2,4-dinitrobenzene affects binding ISO PARP1 (Homo sapiens) 6480464 Dinitrochlorobenzene binds to PARP1 protein CTD PMID:32991956 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP 6480464 [PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:10318960 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases response to substance EXP 6480464 PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:10318960 1-monopalmitoylglycerol multiple interactions ISO PARP1 (Homo sapiens) 6480464 palmitoyl glycerol results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:37466199 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12 and 14)-prostaglandin J2] results in increased cleavage of PARP1 protein CTD PMID:23973622 15-deoxy-Delta(12,14)-prostaglandin J2 increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased cleavage of PARP1 protein CTD PMID:23973622 15-deoxy-Delta(12,14)-prostaglandin J2 increases cleavage ISO PARP1 (Homo sapiens) 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased cleavage of PARP1 protein CTD PMID:15498850 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PARP1 mRNA CTD PMID:17942748 17beta-estradiol decreases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Estradiol results in decreased cleavage of PARP1 protein CTD PMID:24894866 17beta-estradiol decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Estradiol results in decreased expression of PARP1 mRNA CTD PMID:32145629 17beta-estradiol increases cleavage ISO PARP1 (Homo sapiens) 6480464 Estradiol results in increased cleavage of PARP1 protein CTD PMID:21732360 17beta-estradiol multiple interactions ISO PARP1 (Homo sapiens) 6480464 [ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of PARP1 protein more ... CTD PMID:21732360 more ... 17beta-estradiol multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Estradiol results in decreased cleavage of PARP1 protein] CTD PMID:24894866 17beta-estradiol 3-benzoate increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 estradiol 3-benzoate results in increased cleavage of PARP1 protein CTD PMID:24316378 17beta-estradiol 3-benzoate multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [estradiol 3-benzoate results in increased cleavage of PARP1 protein] CTD PMID:24316378 2,2',4,4',5,5'-hexachlorobiphenyl increases activity ISO PARP1 (Homo sapiens) 6480464 2 more ... CTD PMID:16884709 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Parp1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:30029115 and PMID:31826744 2,2',5,5'-tetrachlorobiphenyl increases activity ISO PARP1 (Homo sapiens) 6480464 2 more ... CTD PMID:19433264 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO PARP1 (Homo sapiens) 6480464 [2 more ... CTD PMID:19433264 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [3-aminobenzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD] more ... CTD PMID:17669606 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Parp1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the expression of PARP1 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein] CTD PMID:25843524 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO PARP1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of PARP1 mRNA CTD PMID:22574217 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PARP1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PARP1 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PARP1 promoter] CTD PMID:17942748 and PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PARP1 mRNA CTD PMID:19465110 2,4-D multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [2 more ... CTD PMID:36085217 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO PARP1 (Homo sapiens) 6480464 Butylated Hydroxytoluene inhibits the reaction [Benzoyl Peroxide results in increased activity of PARP1 protein] and Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein] CTD PMID:2126186 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions EXP 6480464 Verapamil inhibits the reaction [PARP1 gene mutant form results in decreased uptake of Doxorubicin] CTD PMID:15861398 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein more ... CTD PMID:24373880 2-amino-14,16-dimethyloctadecan-3-ol decreases expression ISO PARP1 (Homo sapiens) 6480464 2-amino-14 and 16-dimethyloctadecan-3-ol results in decreased expression of PARP1 protein CTD PMID:32044396 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP 6480464 [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein] which results in increased cleavage of PARP1 protein and gentiopicroside inhibits the reaction [[[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein] which results in increased cleavage of PARP1 protein] CTD PMID:20558151 2-amino-2-deoxy-D-glucopyranose increases cleavage ISO PARP1 (Homo sapiens) 6480464 Glucosamine results in increased cleavage of PARP1 protein CTD PMID:16850161 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO PARP1 (Homo sapiens) 6480464 pepstatin inhibits the reaction [Glucosamine results in increased cleavage of PARP1 protein] CTD PMID:16850161 2-arachidonoylglycerol increases cleavage ISO PARP1 (Homo sapiens) 6480464 glyceryl 2-arachidonate results in increased cleavage of PARP1 protein CTD PMID:29441458 and PMID:32357311 2-arachidonoylglycerol multiple interactions ISO PARP1 (Homo sapiens) 6480464 GSK2656157 inhibits the reaction [glyceryl 2-arachidonate results in increased cleavage of PARP1 protein] CTD PMID:32357311 2-deoxy-D-glucose increases cleavage ISO PARP1 (Homo sapiens) 6480464 Deoxyglucose results in increased cleavage of PARP1 protein CTD PMID:25246272 2-deoxy-D-glucose multiple interactions EXP 6480464 Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]] CTD PMID:29095437 2-deoxy-D-glucose multiple interactions ISO PARP1 (Homo sapiens) 6480464 Deoxyglucose inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein] and Deoxyglucose inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein] CTD PMID:25246272 2-hydroxyethyl methacrylate increases cleavage ISO PARP1 (Homo sapiens) 6480464 hydroxyethyl methacrylate results in increased cleavage of PARP1 protein CTD PMID:28184909 2-hydroxyethyl methacrylate multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased cleavage of PARP1 protein] CTD PMID:28184909 2-methoxy-17beta-estradiol increases expression ISO PARP1 (Homo sapiens) 6480464 2-Methoxyestradiol results in increased expression of PARP1 protein modified form CTD PMID:23967052 2-methyl-6-(phenylethynyl)pyridine multiple interactions EXP 6480464 6-methyl-2-(phenylethynyl)pyridine promotes the reaction [Oxidopamine results in increased cleavage of PARP1 protein] and GOPC protein affects the reaction [6-methyl-2-(phenylethynyl)pyridine promotes the reaction [Oxidopamine results in increased cleavage of PARP1 protein]] CTD PMID:33571554 2-tert-butylhydroquinone multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in increased cleavage of PARP1 protein] CTD PMID:31423616 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO PARP1 (Homo sapiens) 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] and geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] CTD PMID:21910007 20-hydroxyecdysone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Ecdysterone results in increased cleavage of PARP1 protein CTD PMID:33878320 3'-O-(4-Benzoyl)benzoyl ATP increases expression EXP 6480464 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased expression of PARP1 protein CTD PMID:22253048 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO PARP1 (Homo sapiens) 6480464 3 more ... CTD PMID:20840854 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Parp1 (Rattus norvegicus) 6480464 3 more ... CTD PMID:23196670 3,3',4,4',5-pentachlorobiphenyl increases activity ISO PARP1 (Homo sapiens) 6480464 3 more ... CTD PMID:16884709 3,3',4,4'-tetrachlorobiphenyl increases activity ISO PARP1 (Homo sapiens) 6480464 3 more ... CTD PMID:19433264 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO PARP1 (Homo sapiens) 6480464 [3 more ... CTD PMID:19433264 3,3',5,5'-tetrabromobisphenol A decreases expression ISO PARP1 (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of PARP1 protein CTD PMID:31675489 3,3'-diindolylmethane multiple interactions ISO PARP1 (Homo sapiens) 6480464 [3 and 3'-diindolylmethane co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of PARP1 protein CTD PMID:16580691 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PARP1 mRNA CTD PMID:20188158 3,4-methylenedioxymethamphetamine decreases cleavage ISO Parp1 (Rattus norvegicus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased cleavage of PARP1 protein CTD PMID:26068050 3-(1H-indol-3-yl)propanoic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 indolepropionic acid analog results in increased cleavage of PARP1 protein CTD PMID:23499788 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO PARP1 (Homo sapiens) 6480464 bisindolylmaleimide I inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein] CTD PMID:16407847 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions EXP 6480464 bisindolylmaleimide I inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:22155090 3-aminobenzamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [Asbestos more ... CTD PMID:11217149 more ... 3-aminobenzamide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 3-aminobenzamide inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased cleavage of PARP1 protein] and 3-aminobenzamide inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:28283887 3-aminobenzamide decreases activity ISO Parp1 (Rattus norvegicus) 6480464 3-aminobenzamide results in decreased activity of PARP1 protein CTD PMID:18815186 3-aminobenzamide decreases activity EXP 6480464 3-aminobenzamide results in decreased activity of PARP1 protein CTD PMID:27026705 3-aminobenzamide decreases activity ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide results in decreased activity of PARP1 protein CTD PMID:15075382 more ... 3-aminobenzamide multiple interactions EXP 6480464 3-aminobenzamide inhibits the reaction [PARP1 protein results in increased susceptibility to Acetaminophen] CTD PMID:15601672 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 2 more ... CTD PMID:2523799 and PMID:29704545 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine increases cleavage ISO PARP1 (Homo sapiens) 6480464 2-amino-3-methylimidazo(4 and 5-f)quinoline results in increased cleavage of PARP1 protein CTD PMID:35985368 3-methyladenine multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [3 more ... CTD PMID:19116755 more ... 3-methyladenine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 3-methyladenine inhibits the reaction [aristolochic acid I results in increased cleavage of PARP1 protein] and 3-methyladenine promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein] CTD PMID:23939141 and PMID:34374793 3-methyladenine multiple interactions EXP 6480464 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein] CTD PMID:19116755 3-methyladenine increases cleavage ISO PARP1 (Homo sapiens) 6480464 3-methyladenine results in increased cleavage of PARP1 protein CTD PMID:21616090 3-methylcholanthrene multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Methylcholanthrene inhibits the reaction [3-amino-1 more ... CTD PMID:11999409 3-Nitrofluoranthene increases cleavage EXP 6480464 3-nitrofluoranthene results in increased cleavage of PARP1 protein CTD PMID:19041363 3-phenylprop-2-enal increases cleavage ISO PARP1 (Homo sapiens) 6480464 cinnamaldehyde analog results in increased cleavage of PARP1 protein CTD PMID:16343908 4'-epidoxorubicin increases cleavage EXP 6480464 Epirubicin results in increased cleavage of PARP1 protein CTD PMID:26646421 4'-epidoxorubicin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Gossypol co-treated with Epirubicin] results in increased cleavage of PARP1 protein CTD PMID:35872041 4'-epidoxorubicin multiple interactions EXP 6480464 paeonol inhibits the reaction [Epirubicin results in increased cleavage of PARP1 protein] CTD PMID:26646421 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of PARP1 mRNA CTD PMID:18648102 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 4 more ... CTD PMID:28343033 4,4'-sulfonyldiphenol increases expression ISO PARP1 (Homo sapiens) 6480464 bisphenol S results in increased expression of PARP1 protein CTD PMID:34186270 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide increases degradation ISO PARP1 (Homo sapiens) 6480464 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide results in increased degradation of PARP1 protein CTD PMID:20446019 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression ISO PARP1 (Homo sapiens) 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PARP1 mRNA and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PARP1 protein CTD PMID:35435490 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO PARP1 (Homo sapiens) 6480464 NIPBL mRNA alternative form promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PARP1 protein] CTD PMID:35435490 4-amino-1,8-naphthalimide multiple interactions ISO PARP1 (Homo sapiens) 6480464 4-amino-1 and 8-naphthalimide inhibits the reaction [Doxorubicin results in increased activity of PARP1 protein] CTD PMID:15456408 4-amino-1,8-naphthalimide decreases expression ISO PARP1 (Homo sapiens) 6480464 4-amino-1 and 8-naphthalimide results in decreased expression of PARP1 protein CTD PMID:25499136 4-amino-1,8-naphthalimide multiple interactions EXP 6480464 ATM protein affects the reaction [4-amino-1 more ... CTD PMID:16556909 4-amino-1,8-naphthalimide decreases activity EXP 6480464 4-amino-1 and 8-naphthalimide results in decreased activity of PARP1 protein CTD PMID:16556909 4-amino-2,6-dinitrotoluene affects expression ISO Parp1 (Rattus norvegicus) 6480464 4-amino-2 and 6-dinitrotoluene affects the expression of PARP1 mRNA CTD PMID:21346803 4-hydroxynon-2-enal increases degradation ISO PARP1 (Homo sapiens) 6480464 4-hydroxy-2-nonenal results in increased degradation of PARP1 protein CTD PMID:11488593 4-hydroxyphenyl retinamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein] more ... CTD PMID:16230421 more ... 4-hydroxyphenyl retinamide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Fenretinide results in increased cleavage of PARP1 protein CTD PMID:15735044 more ... 4-hydroxyphenyl retinamide decreases cleavage ISO PARP1 (Homo sapiens) 6480464 Fenretinide results in decreased cleavage of PARP1 protein CTD PMID:17159502 4-hydroxyphenyl retinamide affects expression ISO PARP1 (Homo sapiens) 6480464 Fenretinide affects the expression of PARP1 mRNA CTD PMID:16570282 4-Nerolidylcatechol increases cleavage ISO PARP1 (Homo sapiens) 6480464 4-nerolidylcatechol results in increased cleavage of PARP1 protein CTD PMID:32334110 4-phenylbutyric acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein] more ... CTD PMID:27634458 more ... 4-phenylbutyric acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein] CTD PMID:34214594 4-phenylbutyric acid multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form] and 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of PARP1 protein modified form] CTD PMID:27578021 and PMID:32407927 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid multiple interactions EXP 6480464 pyridoxal phosphate-6-azophenyl-2' and 4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein] CTD PMID:22253048 5,7-dihydroxy-4'-methoxyflavone increases expression ISO PARP1 (Homo sapiens) 6480464 acacetin results in increased expression of PARP1 protein CTD PMID:36740148 5-aminolevulinic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 FADD mutant form inhibits the reaction [Aminolevulinic Acid analog results in increased cleavage of PARP1 protein] CTD PMID:21138480 5-aminolevulinic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Aminolevulinic Acid analog results in increased cleavage of PARP1 protein CTD PMID:21138480 5-aza-2'-deoxycytidine decreases expression ISO PARP1 (Homo sapiens) 6480464 Decitabine results in decreased expression of PARP1 protein CTD PMID:32006662 5-aza-2'-deoxycytidine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Decitabine results in increased cleavage of PARP1 protein CTD PMID:23300844 5-aza-2'-deoxycytidine decreases methylation ISO PARP1 (Homo sapiens) 6480464 Decitabine results in decreased methylation of PARP1 gene CTD PMID:20123007 5-aza-2'-deoxycytidine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein more ... CTD PMID:18636160 more ... 5-azacytidine increases cleavage EXP 6480464 Azacitidine results in increased cleavage of PARP1 protein CTD PMID:32278510 5-azacytidine multiple interactions EXP 6480464 Bleomycin inhibits the reaction [Azacitidine results in increased cleavage of PARP1 protein] CTD PMID:32278510 5-fluorouracil multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein] more ... CTD PMID:15896711 more ... 5-fluorouracil increases cleavage EXP 6480464 Fluorouracil results in increased cleavage of PARP1 protein CTD PMID:32270916 5-fluorouracil affects expression ISO PARP1 (Homo sapiens) 6480464 Fluorouracil affects the expression of PARP1 mRNA CTD PMID:34151400 5-fluorouracil multiple interactions EXP 6480464 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein] and Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein CTD PMID:19116755 5-fluorouracil increases expression ISO PARP1 (Homo sapiens) 6480464 Fluorouracil results in increased expression of PARP1 and Fluorouracil results in increased expression of PARP1 mRNA CTD PMID:11300326 and PMID:28599477 5-fluorouracil increases cleavage ISO PARP1 (Homo sapiens) 6480464 Fluorouracil results in increased cleavage of PARP1 protein CTD PMID:15996812 more ... 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole increases cleavage ISO PARP1 (Homo sapiens) 6480464 Omeprazole results in increased cleavage of PARP1 protein CTD PMID:15461867 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [4-cyclohexylmethoxy-5-nitrosopyrimidine-2 and 6-diamine co-treated with 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea] results in increased cleavage of PARP1 protein CTD PMID:26208482 6-aminonicotinamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 6-Aminonicotinamide inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein] CTD PMID:25246272 6-bromoindirubin-3'-oxime multiple interactions ISO PARP1 (Homo sapiens) 6480464 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of PARP1 protein modified form] CTD PMID:28414160 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:24726431 7,12-dimethyltetraphene increases expression ISO Parp1 (Rattus norvegicus) 6480464 9 more ... CTD PMID:23969067 7,12-dimethyltetraphene multiple interactions EXP 6480464 9 more ... CTD PMID:25448685 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:25448685 7,12-dimethyltetraphene decreases expression ISO Parp1 (Rattus norvegicus) 6480464 9 more ... CTD PMID:23969067 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO PARP1 (Homo sapiens) 6480464 Uric Acid inhibits the reaction [sodium arsenite inhibits the reaction [PARP1 protein binds to Zinc]] and Uric Acid inhibits the reaction [sodium arsenite results in decreased activity of and results in increased nitrosation of PARP1 protein] CTD PMID:31152818 7-ketocholesterol increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 7-ketocholesterol results in increased cleavage of PARP1 protein CTD PMID:25845326 7-ketocholesterol multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased cleavage of PARP1 protein] more ... CTD PMID:25845326 8-(4-chlorophenylthio)-cAMP multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Acetylcysteine results in increased susceptibility to 8-((4-chlorophenyl)thio)cyclic-3' and 5'-AMP] which results in increased cleavage of PARP1 protein CTD PMID:38042493 9-cis-retinoic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Alitretinoin results in increased cleavage of PARP1 protein CTD PMID:16449964 [6]-Shogaol multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] more ... CTD PMID:18384088 and PMID:25619640 [6]-Shogaol increases cleavage ISO PARP1 (Homo sapiens) 6480464 shogaol results in increased cleavage of PARP1 protein CTD PMID:18384088 and PMID:25619640 ABT-737 multiple interactions ISO PARP1 (Homo sapiens) 6480464 [[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein more ... CTD PMID:28843007 and PMID:32802178 acadesine multiple interactions ISO PARP1 (Homo sapiens) 6480464 acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein] CTD PMID:33002460 acenaphthylene increases cleavage ISO PARP1 (Homo sapiens) 6480464 acenaphthylene results in increased cleavage of PARP1 protein CTD PMID:21132278 acetaldehyde multiple interactions ISO PARP1 (Homo sapiens) 6480464 Silybin inhibits the reaction [Acetaldehyde results in increased cleavage of PARP1 protein] more ... CTD PMID:35158046 acetaldehyde increases cleavage ISO PARP1 (Homo sapiens) 6480464 Acetaldehyde results in increased cleavage of PARP1 protein CTD PMID:35158046 acetochlor increases cleavage ISO PARP1 (Homo sapiens) 6480464 acetochlor results in increased cleavage of PARP1 protein CTD PMID:25291404 acetochlor multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased cleavage of PARP1 protein] CTD PMID:25291404 acetylleucyl-leucyl-norleucinal multiple interactions EXP 6480464 acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 acetylsalicylic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein more ... CTD PMID:15481331 more ... acetylsalicylic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Aspirin results in increased cleavage of PARP1 protein CTD PMID:11228543 more ... acifluorfen increases expression ISO PARP1 (Homo sapiens) 6480464 acifluorfen results in increased expression of PARP1 protein modified form CTD PMID:25944804 aclacinomycin A affects activity ISO PARP1 (Homo sapiens) 6480464 Aclarubicin affects the activity of PARP1 protein CTD PMID:20399885 acrolein increases cleavage ISO PARP1 (Homo sapiens) 6480464 Acrolein results in increased cleavage of PARP1 protein CTD PMID:19596284 and PMID:29964147 acrolein multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2 and 2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased cleavage of PARP1 protein] CTD PMID:31639409 acrolein increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Acrolein results in increased cleavage of PARP1 protein CTD PMID:31639409 acrolein multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PARP1 mRNA more ... CTD PMID:29964147 and PMID:32699268 acrylamide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Acrylamide results in increased cleavage of PARP1 protein CTD PMID:27634458 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of PARP1 protein CTD PMID:36565847 acrylamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein] and Acetylcysteine inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein] CTD PMID:27634458 acrylonitrile multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Acrylonitrile results in increased cleavage of PARP1 protein] CTD PMID:20981856 acrylonitrile increases cleavage ISO PARP1 (Homo sapiens) 6480464 Acrylonitrile results in increased cleavage of PARP1 protein CTD PMID:20981856 actinomycin D multiple interactions ISO PARP1 (Homo sapiens) 6480464 [TNF co-treated with Dactinomycin] results in increased cleavage of PARP1 protein more ... CTD PMID:14640974 and PMID:16492401 actinomycin D multiple interactions EXP 6480464 PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein] CTD PMID:14640974 Aeroplysinin 1 increases cleavage ISO PARP1 (Homo sapiens) 6480464 aeroplysinin I results in increased cleavage of PARP1 protein CTD PMID:27120392 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of PARP1 mRNA CTD PMID:19770486 aflatoxin B1 increases cleavage ISO PARP1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased cleavage of PARP1 protein CTD PMID:34089297 aflatoxin B1 decreases methylation ISO PARP1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of PARP1 gene CTD PMID:27153756 aflatoxin B1 multiple interactions ISO PARP1 (Homo sapiens) 6480464 CYP2A13 protein promotes the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form] more ... CTD PMID:22743290 aflatoxin B1 increases expression ISO PARP1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of PARP1 protein modified form CTD PMID:22743290 Aflatoxin G1 increases expression ISO PARP1 (Homo sapiens) 6480464 aflatoxin G1 results in increased expression of PARP1 protein modified form CTD PMID:23907605 aflatoxin M1 multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Aflatoxin M1 co-treated with ochratoxin A] results in increased expression of PARP1 protein CTD PMID:34126166 AH23848 multiple interactions ISO PARP1 (Homo sapiens) 6480464 [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased cleavage of and results in increased activity of PARP1 protein CTD PMID:19407222 alantolactone increases cleavage ISO PARP1 (Homo sapiens) 6480464 alantolactone results in increased cleavage of PARP1 protein CTD PMID:22721982 alborixin increases cleavage ISO PARP1 (Homo sapiens) 6480464 alborixin results in increased cleavage of PARP1 protein CTD PMID:27378626 aldehydo-D-glucosamine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Glucosamine results in increased cleavage of PARP1 protein CTD PMID:16850161 aldehydo-D-glucosamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 pepstatin inhibits the reaction [Glucosamine results in increased cleavage of PARP1 protein] CTD PMID:16850161 aldehydo-D-glucose increases acetylation ISO PARP1 (Homo sapiens) 6480464 Glucose results in increased acetylation of PARP1 protein CTD PMID:28478229 aldehydo-D-glucose increases activity ISO PARP1 (Homo sapiens) 6480464 Glucose results in increased activity of PARP1 protein CTD PMID:21031461 and PMID:27288104 aldehydo-D-glucose affects localization ISO PARP1 (Homo sapiens) 6480464 Glucose affects the localization of PARP1 protein CTD PMID:28478229 aldehydo-D-glucose multiple interactions EXP 6480464 Glucose deficiency inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form] and PARP1 protein affects the reaction [Glucose results in increased ADP-ribosylation of GAPDH protein] CTD PMID:14523042 and PMID:29095437 aldehydo-D-glucose increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Glucose results in increased cleavage of PARP1 protein CTD PMID:22524206 aldehydo-D-glucose multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [INS1 protein co-treated with Glucose] results in increased activity of PARP1 protein more ... CTD PMID:18004065 more ... aldehydo-D-glucose increases activity ISO Parp1 (Rattus norvegicus) 6480464 Glucose results in increased activity of PARP1 protein CTD PMID:18004065 aldehydo-D-glucose decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Glucose results in decreased expression of PARP1 mRNA CTD PMID:21818840 aldehydo-D-glucose increases expression ISO PARP1 (Homo sapiens) 6480464 Glucose results in increased expression of PARP1 mRNA and Glucose results in increased expression of PARP1 protein modified form CTD PMID:22228707 more ... aldehydo-D-glucose multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Glucose co-treated with Oxygen deficiency] results in increased activity of PARP1 protein more ... CTD PMID:14523042 more ... alginic acid multiple interactions EXP 6480464 Alginic Acid results in increased expression of and results in increased cleavage of PARP1 protein CTD PMID:35066102 Alisol B increases cleavage ISO PARP1 (Homo sapiens) 6480464 alisol B results in increased cleavage of PARP1 protein CTD PMID:20197400 all-trans-acitretin increases activity ISO PARP1 (Homo sapiens) 6480464 Acitretin results in increased activity of PARP1 protein CTD PMID:18624760 all-trans-retinal increases cleavage ISO PARP1 (Homo sapiens) 6480464 Retinaldehyde results in increased cleavage of PARP1 protein CTD PMID:25331497 all-trans-retinoic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [IDH1 protein affects the susceptibility to Tretinoin] which affects the cleavage of PARP1 protein more ... CTD PMID:16826196 more ... all-trans-retinoic acid decreases expression ISO PARP1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of PARP1 mRNA CTD PMID:33167477 all-trans-retinoic acid increases cleavage EXP 6480464 Tretinoin results in increased cleavage of PARP1 protein CTD PMID:21626648 and PMID:29767511 all-trans-retinoic acid multiple interactions EXP 6480464 Tretinoin promotes the reaction [pevonedistat results in increased cleavage of and results in increased activity of PARP1 protein] CTD PMID:22110742 all-trans-retinoic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Tretinoin results in increased cleavage of PARP1 protein CTD PMID:14519626 and PMID:17387344 allethrin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Allethrins results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:25072698 alloxan increases degradation ISO Parp1 (Rattus norvegicus) 6480464 Alloxan results in increased degradation of PARP1 protein CTD PMID:21982801 alloxan multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 D-Glucaric acid more ... CTD PMID:21982801 alpha,alpha-trehalose multiple interactions ISO PARP1 (Homo sapiens) 6480464 Trehalose inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] and Trehalose promotes the reaction [ovatodiolide results in increased cleavage of PARP1 protein] CTD PMID:23011206 and PMID:38000454 alpha-mangostin increases cleavage ISO PARP1 (Homo sapiens) 6480464 mangostin results in increased cleavage of PARP1 protein CTD PMID:23954321 alpha-naphthoflavone increases cleavage EXP 6480464 alpha-naphthoflavone results in increased cleavage of PARP1 protein CTD PMID:30508555 alpha-pinene multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PARP1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PARP1 mRNA CTD PMID:32699268 alpinumisoflavone increases cleavage ISO PARP1 (Homo sapiens) 6480464 alpinumisoflavone results in increased cleavage of PARP1 protein CTD PMID:23850732 alprazolam multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein CTD PMID:19490937 alvocidib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of PARP1 protein more ... CTD PMID:10430095 more ... alvocidib increases cleavage ISO PARP1 (Homo sapiens) 6480464 alvocidib results in increased cleavage of PARP1 protein CTD PMID:12170773 more ... AM-251 multiple interactions ISO PARP1 (Homo sapiens) 6480464 AM 251 inhibits the reaction [HU 211 results in increased cleavage of PARP1 protein] CTD PMID:19509271 amiloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] and Okadaic Acid inhibits the reaction [Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] CTD PMID:15607733 and PMID:16059913 aminoguanidine multiple interactions ISO PARP1 (Homo sapiens) 6480464 pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein] CTD PMID:33930484 amiodarone multiple interactions ISO PARP1 (Homo sapiens) 6480464 [3-methyladenine co-treated with Amiodarone] results in increased cleavage of PARP1 protein and [TNFSF10 co-treated with Amiodarone] results in increased cleavage of PARP1 protein CTD PMID:21292685 and PMID:23912912 ammonia affects response to substance ISO Parp1 (Rattus norvegicus) 6480464 PARP1 protein affects the susceptibility to Ammonia CTD PMID:15147502 ammonium acetate multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Cycloheximide inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein] and Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein] CTD PMID:15147502 ammonium acetate increases expression ISO Parp1 (Rattus norvegicus) 6480464 ammonium acetate results in increased expression of PARP1 protein CTD PMID:15147502 ammonium chloride multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 (1 more ... CTD PMID:14535961 ammonium chloride increases cleavage EXP 6480464 Ammonium Chloride results in increased cleavage of PARP1 protein CTD PMID:31310755 ammonium chloride affects expression ISO Parp1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of PARP1 mRNA CTD PMID:16483693 ammonium chloride increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Ammonium Chloride results in increased cleavage of PARP1 protein CTD PMID:14535961 amosite asbestos multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [Asbestos more ... CTD PMID:11217149 amosite asbestos increases activity ISO PARP1 (Homo sapiens) 6480464 Asbestos and Amosite results in increased activity of PARP1 protein CTD PMID:11217149 amphetamine decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Amphetamine results in decreased expression of PARP1 mRNA CTD PMID:30779732 anandamide increases cleavage ISO PARP1 (Homo sapiens) 6480464 anandamide results in increased cleavage of PARP1 protein CTD PMID:29441458 andrographolide increases cleavage ISO PARP1 (Homo sapiens) 6480464 andrographolide results in increased cleavage of PARP1 protein CTD PMID:35917943 anethole multiple interactions ISO PARP1 (Homo sapiens) 6480464 anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:10871845 anthocyanin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein] CTD PMID:28856781 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO PARP1 (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [1 more ... CTD PMID:14724571 more ... anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PARP1 protein] more ... CTD PMID:17292878 more ... anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [3-dinitrobenzene results in increased cleavage of PARP1 protein] CTD PMID:19477251 Antimony trioxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 antimony trioxide results in increased cleavage of PARP1 protein CTD PMID:16112521 Antimony trioxide multiple interactions ISO PARP1 (Homo sapiens) 6480464 Glutathione deficiency promotes the reaction [antimony trioxide results in increased cleavage of PARP1 protein] CTD PMID:16112521 antimycin A multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Antimycin A co-treated with Paraquat] results in increased cleavage of PARP1 protein and Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of PARP1 protein] CTD PMID:16237197 and PMID:32662599 antimycin A increases cleavage ISO PARP1 (Homo sapiens) 6480464 Antimycin A results in increased cleavage of PARP1 protein CTD PMID:16237197 and PMID:32662599 Antrocin increases cleavage ISO PARP1 (Homo sapiens) 6480464 antrocin results in increased cleavage of PARP1 protein CTD PMID:21158420 apigenin multiple interactions EXP 6480464 Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of PARP1 protein] more ... CTD PMID:20493918 and PMID:22155090 apigenin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Apigenin results in increased cleavage of PARP1 protein CTD PMID:24148603 apigenin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Apigenin co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile] results in increased cleavage of PARP1 protein more ... CTD PMID:24070738 more ... apocynin multiple interactions EXP 6480464 acetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein] and acetovanillone inhibits the reaction [zinc chloride results in increased activity of PARP1 protein] CTD PMID:15502880 and PMID:18509044 apocynin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein] CTD PMID:24932781 apocynin multiple interactions ISO PARP1 (Homo sapiens) 6480464 acetovanillone inhibits the reaction [arsenite results in increased oxidation of PARP1 protein] and acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein] CTD PMID:29111459 and PMID:34798142 arachidonic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 1 more ... CTD PMID:19540902 and PMID:30626086 arachidonic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Arachidonic Acid results in increased cleavage of PARP1 protein CTD PMID:19540902 and PMID:21132278 arachidonic acid increases cleavage EXP 6480464 Arachidonic Acid results in increased cleavage of PARP1 protein CTD PMID:10403056 arachidonyl-2'-chloroethylamide multiple interactions EXP 6480464 arachidonyl-2-chloroethylamide inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:31256211 aristolochic acid A multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 3-methyladenine inhibits the reaction [aristolochic acid I results in increased cleavage of PARP1 protein] and ATG5 affects the reaction [aristolochic acid I results in increased cleavage of PARP1 protein] CTD PMID:23939141 aristolochic acid A increases expression EXP 6480464 aristolochic acid I results in increased expression of PARP1 protein modified form CTD PMID:26656393 aristolochic acid A increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 aristolochic acid I results in increased cleavage of PARP1 protein CTD PMID:23939141 arjunolic acid multiple interactions EXP 6480464 arjunolic acid inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21420465 Aroclor 1254 increases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of PARP1 mRNA CTD PMID:25113976 arsane multiple interactions ISO PARP1 (Homo sapiens) 6480464 [[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein more ... CTD PMID:21332098 more ... arsane increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Arsenic results in increased cleavage of PARP1 protein CTD PMID:28903487 arsane multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased cleavage of PARP1 protein more ... CTD PMID:28903487 and PMID:31542844 arsane decreases expression ISO PARP1 (Homo sapiens) 6480464 Arsenic results in decreased expression of PARP1 mRNA and Arsenic results in decreased expression of PARP1 protein CTD PMID:21332098 and PMID:35490796 arsenic atom decreases expression ISO PARP1 (Homo sapiens) 6480464 Arsenic results in decreased expression of PARP1 mRNA and Arsenic results in decreased expression of PARP1 protein CTD PMID:21332098 and PMID:35490796 arsenic atom increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Arsenic results in increased cleavage of PARP1 protein CTD PMID:28903487 arsenic atom multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased cleavage of PARP1 protein more ... CTD PMID:28903487 and PMID:31542844 arsenic atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein more ... CTD PMID:21332098 more ... arsenite(3-) multiple interactions ISO PARP1 (Homo sapiens) 6480464 [arsenite results in decreased activity of PARP1 protein] which affects the localization of AIFM1 protein more ... CTD PMID:18392098 more ... arsenite(3-) increases oxidation ISO PARP1 (Homo sapiens) 6480464 arsenite results in increased oxidation of PARP1 protein CTD PMID:34798142 arsenite(3-) increases cleavage EXP 6480464 arsenite results in increased cleavage of PARP1 protein CTD PMID:23396362 and PMID:32980394 arsenite(3-) multiple interactions EXP 6480464 MIR190A affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased cleavage of PARP1 protein]] more ... CTD PMID:23396362 and PMID:32980394 arsenite(3-) increases expression ISO PARP1 (Homo sapiens) 6480464 arsenite results in increased expression of PARP1 protein CTD PMID:18392098 arsenite(3-) increases cleavage ISO PARP1 (Homo sapiens) 6480464 arsenite results in increased cleavage of PARP1 protein CTD PMID:20083129 and PMID:22260869 arsenite(3-) decreases activity ISO PARP1 (Homo sapiens) 6480464 arsenite results in decreased activity of PARP1 protein CTD PMID:17011244 more ... arsenite(3-) affects response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the susceptibility to arsenite CTD PMID:22387748 arsenite(3-) decreases cleavage ISO PARP1 (Homo sapiens) 6480464 arsenite results in decreased cleavage of PARP1 protein CTD PMID:22387748 arsenous acid increases activity EXP 6480464 Arsenic Trioxide results in increased activity of PARP1 protein CTD PMID:24157283 arsenous acid increases cleavage EXP 6480464 Arsenic Trioxide results in increased cleavage of PARP1 protein CTD PMID:15761769 more ... arsenous acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein] and salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein] CTD PMID:24634002 and PMID:28391263 arsenous acid affects localization ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide affects the localization of PARP1 protein modified form CTD PMID:15131059 arsenous acid increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased cleavage of PARP1 protein CTD PMID:24634002 and PMID:32096187 arsenous acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased cleavage of PARP1 protein CTD PMID:10382944 more ... arsenous acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein] more ... CTD PMID:12883035 more ... arsenous acid increases expression ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of PARP1 protein and Arsenic Trioxide results in increased expression of PARP1 protein modified form CTD PMID:25972196 and PMID:27430728 arsenous acid decreases expression ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of PARP1 protein CTD PMID:19695276 and PMID:25419056 arsenous acid increases degradation ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased degradation of PARP1 protein CTD PMID:16166054 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of PARP1 protein modified form CTD PMID:29095437 arsenous acid increases expression ISO Parp1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of PARP1 protein CTD PMID:28391263 arsenous acid increases activity ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased activity of PARP1 protein CTD PMID:11304686 arsenous acid multiple interactions EXP 6480464 [Genistein co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein more ... CTD PMID:21078540 more ... artesunate increases cleavage ISO PARP1 (Homo sapiens) 6480464 Artesunate results in increased cleavage of PARP1 protein CTD PMID:24704559 and PMID:33002460 artesunate multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein] more ... CTD PMID:33002460 asbestos multiple interactions ISO PARP1 (Homo sapiens) 6480464 Asbestos results in increased expression of and results in decreased activity of PARP1 protein CTD PMID:21543585 asbestos increases expression ISO PARP1 (Homo sapiens) 6480464 Asbestos results in increased expression of PARP1 mRNA CTD PMID:21543585 Aspidin increases expression ISO PARP1 (Homo sapiens) 6480464 aspidin BB results in increased expression of PARP1 protein modified form CTD PMID:23628508 astilbin multiple interactions ISO PARP1 (Homo sapiens) 6480464 astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:29471006 atorvastatin calcium multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in increased cleavage of PARP1 protein] more ... CTD PMID:18172863 more ... atorvastatin calcium increases cleavage EXP 6480464 Atorvastatin results in increased cleavage of PARP1 protein CTD PMID:20876807 atorvastatin calcium multiple interactions EXP 6480464 ATG5 mutant form promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein] CTD PMID:20876807 atorvastatin calcium increases cleavage ISO PARP1 (Homo sapiens) 6480464 Atorvastatin results in increased cleavage of PARP1 protein CTD PMID:16470222 more ... ATP increases expression EXP 6480464 Adenosine Triphosphate results in increased expression of PARP1 protein CTD PMID:22253048 ATP multiple interactions ISO PARP1 (Homo sapiens) 6480464 PARP1 mutant form inhibits the reaction [Cadmium results in decreased abundance of Adenosine Triphosphate] CTD PMID:21767558 ATP multiple interactions EXP 6480464 PARP1 protein affects the reaction [pyrithione zinc results in decreased abundance of Adenosine Triphosphate] and PARP1 protein affects the reaction [Zinc results in decreased abundance of Adenosine Triphosphate] CTD PMID:17728843 and PMID:19809895 Atranorin increases cleavage EXP 6480464 atranorin results in increased cleavage of PARP1 protein CTD PMID:26969521 atrazine multiple interactions EXP 6480464 Melatonin inhibits the reaction [Atrazine results in increased cleavage of PARP1 protein] CTD PMID:25259610 atrazine increases cleavage EXP 6480464 Atrazine results in increased cleavage of PARP1 protein CTD PMID:25259610 aucubin multiple interactions EXP 6480464 aucubin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:32504734 auranofin decreases activity ISO PARP1 (Homo sapiens) 6480464 Auranofin results in decreased activity of PARP1 protein CTD PMID:21370912 auranofin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Auranofin results in increased cleavage of PARP1 protein CTD PMID:15159275 aurantiamide acetate affects binding ISO PARP1 (Homo sapiens) 6480464 N-benzoylphenylalanylphenylalinol acetate binds to PARP1 protein CTD PMID:24876881 Auriculasin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein and TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein] CTD PMID:30817944 bafilomycin A1 multiple interactions EXP 6480464 bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 bafilomycin A1 multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 bafilomycin A1 promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein] CTD PMID:34374793 bafilomycin A1 increases cleavage EXP 6480464 bafilomycin A1 results in increased cleavage of PARP1 protein CTD PMID:31310755 bafilomycin A1 increases expression ISO PARP1 (Homo sapiens) 6480464 bafilomycin A1 results in increased expression of PARP1 protein modified form CTD PMID:28063998 bafilomycin A1 increases cleavage ISO PARP1 (Homo sapiens) 6480464 bafilomycin A1 results in increased cleavage of PARP1 protein CTD PMID:21616090 more ... bafilomycin A1 multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein] more ... CTD PMID:20876807 more ... BAPTA multiple interactions ISO PARP1 (Homo sapiens) 6480464 1 more ... CTD PMID:24752504 BAPTA multiple interactions EXP 6480464 1 more ... CTD PMID:29111403 Bardoxolone methyl increases cleavage ISO PARP1 (Homo sapiens) 6480464 bardoxolone methyl results in increased cleavage of PARP1 protein CTD PMID:17363558 and PMID:25246272 belinostat increases cleavage ISO PARP1 (Homo sapiens) 6480464 belinostat results in increased cleavage of PARP1 protein CTD PMID:18223231 and PMID:25537862 belinostat increases expression EXP 6480464 belinostat results in increased expression of PARP1 mRNA and belinostat results in increased expression of PARP1 protein CTD PMID:29733868 belinostat multiple interactions ISO PARP1 (Homo sapiens) 6480464 Bortezomib promotes the reaction [belinostat results in increased cleavage of PARP1 protein] CTD PMID:18223231 bellidifolin decreases expression ISO PARP1 (Homo sapiens) 6480464 bellidifolin results in decreased expression of PARP1 protein CTD PMID:33299414 benomyl increases cleavage ISO PARP1 (Homo sapiens) 6480464 Benomyl results in increased cleavage of PARP1 protein CTD PMID:16903866 benzalkonium chloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Benzalkonium Compounds analog results in increased cleavage of PARP1 protein] CTD PMID:31982400 benzalkonium chloride increases cleavage ISO PARP1 (Homo sapiens) 6480464 Benzalkonium Compounds analog results in increased cleavage of PARP1 protein CTD PMID:31982400 benzamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [benzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD] more ... CTD PMID:17669606 and PMID:19447888 benzamide decreases expression EXP 6480464 benzamide results in decreased expression of PARP1 protein CTD PMID:19998477 benzamide decreases activity ISO Parp1 (Rattus norvegicus) 6480464 benzamide results in decreased activity of PARP1 protein CTD PMID:12411406 benzamide decreases activity EXP 6480464 benzamide results in decreased activity of PARP1 protein CTD PMID:11593040 benzamide multiple interactions EXP 6480464 [benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Hydrogen Peroxide more ... CTD PMID:11593040 benzamide decreases activity ISO PARP1 (Homo sapiens) 6480464 benzamide results in decreased activity of PARP1 protein CTD PMID:17669606 and PMID:18695944 benzatropine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cuprizone co-treated with Benztropine] results in increased expression of PARP1 protein CTD PMID:34122009 benzatropine decreases expression ISO PARP1 (Homo sapiens) 6480464 Benztropine results in decreased expression of PARP1 protein CTD PMID:34122009 benzene increases cleavage ISO PARP1 (Homo sapiens) 6480464 Benzene analog results in increased cleavage of PARP1 protein CTD PMID:15826604 benzene increases methylation ISO PARP1 (Homo sapiens) 6480464 Benzene results in increased methylation of PARP1 promoter CTD PMID:20230882 benzene multiple interactions ISO PARP1 (Homo sapiens) 6480464 decitabine inhibits the reaction [Benzene results in decreased expression of PARP1 mRNA] more ... CTD PMID:20230882 benzene decreases expression ISO PARP1 (Homo sapiens) 6480464 Benzene results in decreased expression of PARP1 mRNA CTD PMID:20230882 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to PARP1 promoter] and Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:19654925 and PMID:32061149 benzo[a]pyrene increases methylation ISO PARP1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of PARP1 promoter CTD PMID:27901495 benzo[a]pyrene decreases methylation EXP 6480464 Benzo(a)pyrene results in decreased methylation of PARP1 exon and Benzo(a)pyrene results in decreased methylation of PARP1 intron CTD PMID:27901495 benzo[a]pyrene increases cleavage ISO PARP1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased cleavage of PARP1 protein CTD PMID:20840854 and PMID:24685774 benzo[a]pyrene increases expression ISO PARP1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of PARP1 protein CTD PMID:24664296 benzo[a]pyrene multiple interactions ISO PARP1 (Homo sapiens) 6480464 2 more ... CTD PMID:20840854 more ... benzo[a]pyrene increases cleavage EXP 6480464 Benzo(a)pyrene results in increased cleavage of PARP1 protein CTD PMID:19041363 and PMID:32061149 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of PARP1 mRNA CTD PMID:19770486 benzo[a]pyrene decreases response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein results in decreased susceptibility to Benzo(a)pyrene CTD PMID:19247804 benzo[a]pyrene decreases expression ISO PARP1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of PARP1 mRNA and Benzo(a)pyrene results in decreased expression of PARP1 protein CTD PMID:20064835 and PMID:33278487 Benzo[a]pyrene-7,8-diol multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzo(a)pyrene 7 and 8-dihydrodiol results in increased cleavage of PARP1 protein] CTD PMID:15572374 Benzo[a]pyrene-7,8-diol increases cleavage ISO PARP1 (Homo sapiens) 6480464 benzo(a)pyrene 7 and 8-dihydrodiol results in increased cleavage of PARP1 protein CTD PMID:15572374 benzo[b]fluoranthene increases cleavage ISO PARP1 (Homo sapiens) 6480464 benzo(b)fluoranthene results in increased cleavage of PARP1 protein CTD PMID:21132278 Benzo[ghi]perylene increases cleavage ISO PARP1 (Homo sapiens) 6480464 1 and 12-benzoperylene results in increased cleavage of PARP1 protein CTD PMID:21132278 Benzo[k]fluoranthene increases cleavage ISO PARP1 (Homo sapiens) 6480464 benzo(k)fluoranthene results in increased cleavage of PARP1 protein CTD PMID:21132278 benzoates increases cleavage ISO PARP1 (Homo sapiens) 6480464 Benzoates analog results in increased cleavage of PARP1 protein CTD PMID:29472718 Benzoyl peroxide increases activity ISO PARP1 (Homo sapiens) 6480464 Benzoyl Peroxide results in increased activity of PARP1 protein CTD PMID:2120135 and PMID:2126186 Benzoyl peroxide multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [Benzoyl Peroxide results in increased activity of PARP1 protein] more ... CTD PMID:2120135 and PMID:2126186 berberine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Berberine results in increased cleavage of PARP1 protein CTD PMID:16505103 berberine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein more ... CTD PMID:26712469 and PMID:36070022 beta-carboline increases cleavage ISO PARP1 (Homo sapiens) 6480464 norharman results in increased cleavage of PARP1 protein CTD PMID:35985368 beta-cyclodextrin multiple interactions EXP 6480464 betadex inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:11035063 beta-D-glucosamine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Glucosamine results in increased cleavage of PARP1 protein CTD PMID:16850161 beta-D-glucosamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 pepstatin inhibits the reaction [Glucosamine results in increased cleavage of PARP1 protein] CTD PMID:16850161 beta-Elemonic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 beta-elemonic acid results in increased cleavage of PARP1 protein CTD PMID:33878321 beta-ionone increases cleavage ISO PARP1 (Homo sapiens) 6480464 beta-ionone results in increased cleavage of PARP1 protein CTD PMID:36843289 beta-ionone multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein] more ... CTD PMID:36843289 betulin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [betulin co-treated with Oxygen] results in increased cleavage of PARP1 protein more ... CTD PMID:26540049 more ... betulin increases cleavage ISO PARP1 (Homo sapiens) 6480464 betulin results in increased cleavage of PARP1 protein CTD PMID:32190974 and PMID:33181113 betulinic acid increases expression ISO PARP1 (Homo sapiens) 6480464 Betulinic Acid results in increased expression of PARP1 protein modified form CTD PMID:26540049 betulinic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Betulinic Acid co-treated with Oxygen] results in increased cleavage of PARP1 protein and Betulinic Acid promotes the reaction [Gefitinib results in increased cleavage of PARP1 protein] CTD PMID:30136359 and PMID:33181113 betulinic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Betulinic Acid results in increased cleavage of PARP1 protein CTD PMID:30136359 and PMID:33181113 bicalutamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form] CTD PMID:28500234 bilirubin IXalpha multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form] CTD PMID:27578021 bilirubin IXalpha increases expression ISO PARP1 (Homo sapiens) 6480464 Bilirubin results in increased expression of PARP1 protein modified form CTD PMID:27578021 biochanin A increases cleavage ISO PARP1 (Homo sapiens) 6480464 biochanin A results in increased cleavage of PARP1 protein CTD PMID:12791511 bis(2-chloroethyl) sulfide multiple interactions ISO PARP1 (Homo sapiens) 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mustard Gas results in increased cleavage of PARP1 protein] more ... CTD PMID:11886524 more ... bis(2-chloroethyl) sulfide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Mustard Gas results in increased cleavage of PARP1 protein CTD PMID:11886524 more ... bis(2-chloroethyl) sulfide decreases expression ISO PARP1 (Homo sapiens) 6480464 Mustard Gas results in decreased expression of PARP1 mRNA CTD PMID:25102026 bis(2-chloroethyl) sulfide increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Mustard Gas results in increased cleavage of PARP1 protein CTD PMID:20659490 bis(2-chloroethyl) sulfide multiple interactions EXP 6480464 PARP1 protein inhibits the reaction [Mustard Gas results in increased activity of CASP3 protein] CTD PMID:11886524 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased cleavage of PARP1 protein] and PRDX5 protein inhibits the reaction [Diethylhexyl Phthalate results in increased cleavage of PARP1 protein] CTD PMID:31408635 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of PARP1 mRNA CTD PMID:36423848 bis(2-ethylhexyl) phthalate increases cleavage EXP 6480464 Diethylhexyl Phthalate results in increased cleavage of PARP1 protein CTD PMID:31408635 bisphenol A affects expression ISO Parp1 (Rattus norvegicus) 6480464 bisphenol A affects the expression of PARP1 mRNA CTD PMID:25181051 bisphenol A increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 bisphenol A results in increased cleavage of PARP1 protein CTD PMID:35567931 and PMID:35887390 bisphenol A multiple interactions EXP 6480464 bisphenol A promotes the reaction [Cholesterol results in increased cleavage of PARP1 protein] and Resveratrol inhibits the reaction [bisphenol A promotes the reaction [Cholesterol results in increased cleavage of PARP1 protein]] CTD PMID:33239236 bisphenol A increases expression ISO PARP1 (Homo sapiens) 6480464 bisphenol A results in increased expression of PARP1 protein CTD PMID:34186270 bisphenol A decreases expression ISO PARP1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of PARP1 mRNA and bisphenol A results in decreased expression of PARP1 protein CTD PMID:29275510 more ... bisphenol A affects expression ISO PARP1 (Homo sapiens) 6480464 bisphenol A affects the expression of PARP1 mRNA CTD PMID:30903817 bisphenol A decreases expression ISO Parp1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of PARP1 mRNA and bisphenol A results in decreased expression of PARP1 protein CTD PMID:27189055 and PMID:34947998 bisphenol A increases methylation ISO Parp1 (Rattus norvegicus) 6480464 bisphenol A results in increased methylation of PARP1 gene CTD PMID:28505145 bisphenol A multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [bisphenol A co-treated with tributyltin] results in increased expression of PARP1 mRNA and Genistein inhibits the reaction [bisphenol A results in decreased cleavage of PARP1 protein] CTD PMID:24884420 and PMID:31129395 bisphenol A decreases cleavage ISO Parp1 (Rattus norvegicus) 6480464 bisphenol A results in decreased cleavage of PARP1 protein CTD PMID:24884420 bisphenol F increases expression ISO PARP1 (Homo sapiens) 6480464 bisphenol F results in increased expression of PARP1 protein CTD PMID:34186270 bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of PARP1 protein CTD PMID:16317386 bleomycin A2 multiple interactions EXP 6480464 Bleomycin inhibits the reaction [Azacitidine results in increased cleavage of PARP1 protein] CTD PMID:32278510 bleomycin A2 increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Bleomycin results in increased cleavage of PARP1 protein CTD PMID:15371238 bortezomib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [alvocidib co-treated with Bortezomib] results in increased cleavage of PARP1 protein more ... CTD PMID:12893773 more ... bortezomib increases cleavage EXP 6480464 Bortezomib results in increased cleavage of PARP1 protein CTD PMID:29384525 bortezomib increases expression ISO PARP1 (Homo sapiens) 6480464 Bortezomib results in increased expression of PARP1 protein CTD PMID:17156654 bortezomib increases cleavage ISO PARP1 (Homo sapiens) 6480464 Bortezomib results in increased cleavage of PARP1 protein CTD PMID:16617327 more ... bosutinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [bosutinib co-treated with linsidomine] affects the expression of PARP1 protein and bosutinib affects the reaction [linsidomine results in increased cleavage of PARP1 protein] CTD PMID:34519134 brassinin increases cleavage ISO PARP1 (Homo sapiens) 6480464 brassinin analog results in increased cleavage of PARP1 protein CTD PMID:24747292 brazilin increases expression ISO PARP1 (Homo sapiens) 6480464 brazilin results in increased expression of PARP1 protein modified form CTD PMID:28063998 brazilin multiple interactions ISO PARP1 (Homo sapiens) 6480464 bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form] and BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form] CTD PMID:28063998 brefeldin A multiple interactions EXP 6480464 Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of PARP1 protein] CTD PMID:20493918 brefeldin A increases cleavage EXP 6480464 Brefeldin A results in increased cleavage of PARP1 protein CTD PMID:20493918 Brusatol increases cleavage ISO PARP1 (Homo sapiens) 6480464 brusatol results in increased cleavage of PARP1 protein CTD PMID:33465425 bufalin multiple interactions ISO PARP1 (Homo sapiens) 6480464 HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein] CTD PMID:23091618 bufalin increases cleavage ISO PARP1 (Homo sapiens) 6480464 bufalin results in increased cleavage of PARP1 protein CTD PMID:23091618 busulfan multiple interactions ISO PARP1 (Homo sapiens) 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of PARP1 protein more ... CTD PMID:19732952 and PMID:20933509 busulfan increases cleavage ISO PARP1 (Homo sapiens) 6480464 Busulfan results in increased cleavage of PARP1 protein CTD PMID:18339423 butein increases cleavage ISO PARP1 (Homo sapiens) 6480464 butein results in increased cleavage of PARP1 protein CTD PMID:24931875 butylated hydroxyanisole multiple interactions ISO PARP1 (Homo sapiens) 6480464 Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein] CTD PMID:16407847 butyric acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Butyric Acid results in increased cleavage of PARP1 protein CTD PMID:27830268 C.I. Natural Red 20 multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [shikonin results in increased cleavage of PARP1 protein] CTD PMID:24463199 C.I. Natural Red 20 increases cleavage ISO PARP1 (Homo sapiens) 6480464 shikonin results in increased cleavage of PARP1 protein CTD PMID:24463199 and PMID:37268198 cadmium atom multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] more ... CTD PMID:19433269 more ... cadmium atom increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cadmium results in increased cleavage of PARP1 protein CTD PMID:28507149 more ... cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of PARP1 mRNA CTD PMID:26187450 cadmium atom increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Cadmium results in increased cleavage of PARP1 protein CTD PMID:19433269 more ... cadmium atom multiple interactions EXP 6480464 1 more ... CTD PMID:29111403 more ... cadmium atom increases cleavage EXP 6480464 Cadmium results in increased cleavage of PARP1 protein CTD PMID:29111403 cadmium atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein more ... CTD PMID:21767558 more ... cadmium dichloride multiple interactions EXP 6480464 1 more ... CTD PMID:18850067 more ... cadmium dichloride increases expression ISO Parp1 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased expression of PARP1 mRNA and Cadmium Chloride results in increased expression of PARP1 protein modified form CTD PMID:28283887 more ... cadmium dichloride increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased cleavage of PARP1 protein CTD PMID:21544200 more ... cadmium dichloride increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cadmium Chloride results in increased cleavage of PARP1 protein CTD PMID:21544200 more ... cadmium dichloride increases expression ISO PARP1 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of PARP1 protein modified form CTD PMID:24291162 cadmium dichloride affects cleavage EXP 6480464 Cadmium Chloride affects the cleavage of PARP1 protein CTD PMID:18506790 cadmium dichloride increases cleavage EXP 6480464 Cadmium Chloride results in increased cleavage of PARP1 protein CTD PMID:18850067 and PMID:21420465 cadmium dichloride multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 1 more ... CTD PMID:18703135 more ... cadmium dichloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 1 more ... CTD PMID:18703135 more ... cadmium sulfate multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased cleavage of PARP1 protein] more ... CTD PMID:14687664 cadmium sulfate increases cleavage EXP 6480464 cadmium sulfate results in increased cleavage of PARP1 protein CTD PMID:14687664 caffeine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein more ... CTD PMID:16522534 more ... caffeine increases phosphorylation ISO PARP1 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of PARP1 protein CTD PMID:35688186 caffeine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Caffeine inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] CTD PMID:30377735 caffeine decreases response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein results in decreased susceptibility to Caffeine CTD PMID:21840268 caffeine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Caffeine results in increased cleavage of PARP1 protein CTD PMID:21229324 caffeine affects cleavage ISO PARP1 (Homo sapiens) 6480464 Caffeine affects the cleavage of PARP1 protein CTD PMID:19242509 calciol affects expression ISO PARP1 (Homo sapiens) 6480464 Cholecalciferol affects the expression of PARP1 protein CTD PMID:18628207 calciol multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of PARP1 protein modified form more ... CTD PMID:22940495 calcium atom multiple interactions EXP 6480464 PARP1 protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium] CTD PMID:20878536 calcium(0) multiple interactions EXP 6480464 PARP1 protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium] CTD PMID:20878536 Calpeptin multiple interactions EXP 6480464 calpeptin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 Calpeptin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 calpeptin inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein] CTD PMID:25947082 camptothecin multiple interactions ISO PARP1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:15585644 more ... camptothecin decreases response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 results in decreased susceptibility to Camptothecin CTD PMID:27694308 camptothecin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein] CTD PMID:25843524 camptothecin increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Camptothecin results in increased cleavage of PARP1 protein CTD PMID:25843524 camptothecin affects response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the susceptibility to Camptothecin CTD PMID:27694308 and PMID:35778544 camptothecin increases cleavage EXP 6480464 Camptothecin results in increased cleavage of PARP1 protein CTD PMID:18506790 and PMID:29384525 camptothecin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Camptothecin results in increased cleavage of PARP1 protein CTD PMID:11741290 more ... camptothecin multiple interactions EXP 6480464 [Camptothecin co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased cleavage of PARP1 protein and [veliparib results in decreased activity of PARP1 protein] which results in increased susceptibility to Camptothecin CTD PMID:22158865 and PMID:25449198 cannabidiol increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cannabidiol results in increased cleavage of PARP1 protein CTD PMID:29441458 more ... cannabidiol multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of PARP1 mRNA more ... CTD PMID:30096889 and PMID:31699976 cannabidiol decreases expression ISO PARP1 (Homo sapiens) 6480464 Cannabidiol results in decreased expression of PARP1 mRNA CTD PMID:33244087 cantharidic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 cantharidic acid results in increased cleavage of PARP1 protein CTD PMID:29159945 more ... cantharidin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cantharidin results in increased cleavage of PARP1 protein CTD PMID:27113412 capillarisin multiple interactions ISO PARP1 (Homo sapiens) 6480464 Bortezomib promotes the reaction [capillarisin results in increased cleavage of PARP1 protein] more ... CTD PMID:24333736 capillarisin increases cleavage ISO PARP1 (Homo sapiens) 6480464 capillarisin results in increased cleavage of PARP1 protein CTD PMID:24333736 capsaicin multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein] more ... CTD PMID:22200406 and PMID:22226932 capsaicin increases cleavage EXP 6480464 Capsaicin results in increased cleavage of PARP1 protein CTD PMID:17295509 capsaicin increases expression ISO PARP1 (Homo sapiens) 6480464 Capsaicin results in increased expression of PARP1 protein CTD PMID:22226932 capsaicin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Capsaicin results in increased cleavage of PARP1 protein CTD PMID:17505005 and PMID:19855437 capsaicin increases ADP-ribosylation ISO PARP1 (Homo sapiens) 6480464 Capsaicin results in increased ADP-ribosylation of PARP1 protein modified form CTD PMID:22226932 carbamazepine affects expression ISO PARP1 (Homo sapiens) 6480464 Carbamazepine affects the expression of PARP1 mRNA CTD PMID:24752500 and PMID:25979313 carbon nanotube increases cleavage EXP 6480464 Nanotubes and Carbon results in increased cleavage of PARP1 protein CTD PMID:24929217 carboplatin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Carboplatin results in increased cleavage of PARP1 protein CTD PMID:15996812 Cardamonin increases cleavage ISO PARP1 (Homo sapiens) 6480464 cardamonin results in increased cleavage of PARP1 protein CTD PMID:37268255 carmustine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Disulfiram promotes the reaction [Carmustine results in increased cleavage of PARP1 protein] CTD PMID:24193513 carmustine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Carmustine results in increased cleavage of PARP1 protein CTD PMID:24193513 carnosic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [salvin results in increased cleavage of PARP1 protein] more ... CTD PMID:25446857 more ... carnosic acid decreases expression ISO PARP1 (Homo sapiens) 6480464 salvin results in decreased expression of PARP1 protein CTD PMID:28918123 carnosic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 salvin results in increased cleavage of PARP1 protein CTD PMID:28918123 carnosic acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein] CTD PMID:25446857 carnosine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Carnosine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 Carnosol multiple interactions EXP 6480464 carnosol inhibits the reaction [Dietary Fats results in increased expression of PARP1 protein modified form] more ... CTD PMID:34678374 carteolol affects expression ISO PARP1 (Homo sapiens) 6480464 Carteolol affects the expression of PARP1 mRNA CTD PMID:37120125 casticin increases expression EXP 6480464 casticin results in increased expression of PARP1 protein CTD PMID:32270916 CDP-choline decreases expression ISO PARP1 (Homo sapiens) 6480464 Cytidine Diphosphate Choline results in decreased expression of PARP1 protein modified form CTD PMID:12443983 celastrol multiple interactions ISO PARP1 (Homo sapiens) 6480464 [TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein more ... CTD PMID:20605676 celastrol increases cleavage ISO PARP1 (Homo sapiens) 6480464 celastrol results in increased cleavage of PARP1 protein CTD PMID:31715269 celecoxib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Atorvastatin co-treated with Celecoxib] results in increased cleavage of PARP1 protein more ... CTD PMID:15572759 more ... celecoxib multiple interactions EXP 6480464 Celecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of PARP1 protein] CTD PMID:16230411 celecoxib increases cleavage ISO PARP1 (Homo sapiens) 6480464 Celecoxib results in increased cleavage of PARP1 protein CTD PMID:15572759 more ... celecoxib increases activity ISO PARP1 (Homo sapiens) 6480464 Celecoxib results in increased activity of PARP1 protein CTD PMID:12824303 celecoxib affects cleavage ISO PARP1 (Homo sapiens) 6480464 Celecoxib analog affects the cleavage of PARP1 protein CTD PMID:18485224 cepharanthine decreases expression ISO PARP1 (Homo sapiens) 6480464 cepharanthine results in decreased expression of PARP1 protein CTD PMID:31255635 cetylpyridinium multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Cetylpyridinium results in increased cleavage of PARP1 protein] CTD PMID:31982400 cetylpyridinium increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cetylpyridinium results in increased cleavage of PARP1 protein CTD PMID:31982400 chalcone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Chalcone results in increased cleavage of PARP1 protein CTD PMID:20620131 chalcone multiple interactions ISO PARP1 (Homo sapiens) 6480464 MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein] CTD PMID:20620131 chalcones increases cleavage ISO PARP1 (Homo sapiens) 6480464 Chalcones analog results in increased cleavage of PARP1 protein CTD PMID:30576621 chalcones multiple interactions ISO PARP1 (Homo sapiens) 6480464 BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of PARP1 protein] CTD PMID:30576621 chenodeoxycholic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Chenodeoxycholic Acid co-treated with ursodoxicoltaurine] results in increased cleavage of PARP1 protein CTD PMID:14976352 chenodeoxycholic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Chenodeoxycholic Acid results in increased cleavage of PARP1 protein CTD PMID:14976352 chloramphenicol multiple interactions ISO PARP1 (Homo sapiens) 6480464 CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]] and Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein] CTD PMID:15905168 chlordecone increases expression EXP 6480464 Chlordecone results in increased expression of PARP1 mRNA CTD PMID:33711761 chloroacetic acid increases cleavage EXP 6480464 chloroacetic acid results in increased cleavage of PARP1 protein CTD PMID:23103613 chloropicrin multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [chloropicrin results in increased cleavage of PARP1 protein] CTD PMID:31884112 chloropicrin increases cleavage ISO PARP1 (Homo sapiens) 6480464 chloropicrin results in increased cleavage of PARP1 protein CTD PMID:31884112 chloroquine multiple interactions EXP 6480464 Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 chloroquine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein more ... CTD PMID:28906492 more ... chloroquine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Chloroquine results in increased cleavage of PARP1 protein CTD PMID:28906492 more ... chloroquine increases cleavage EXP 6480464 Chloroquine results in increased cleavage of PARP1 protein CTD PMID:31310755 chloroquine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Chloroquine promotes the reaction [Cadmium results in increased cleavage of PARP1 protein] and Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein] CTD PMID:27658547 and PMID:34374793 chlorpyrifos multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 mRNA more ... CTD PMID:22714038 more ... chlorpyrifos increases cleavage EXP 6480464 Chlorpyrifos results in increased cleavage of PARP1 protein CTD PMID:34289071 and PMID:36252918 chlorpyrifos increases expression ISO Parp1 (Rattus norvegicus) 6480464 Chlorpyrifos results in increased expression of PARP1 mRNA and Chlorpyrifos results in increased expression of PARP1 protein CTD PMID:33908150 chlorpyrifos increases cleavage ISO PARP1 (Homo sapiens) 6480464 Chlorpyrifos results in increased cleavage of PARP1 protein CTD PMID:24793810 chlorpyrifos increases expression ISO PARP1 (Homo sapiens) 6480464 Chlorpyrifos results in increased expression of PARP1 mRNA more ... CTD PMID:23416140 and PMID:28887667 chlorpyrifos increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Chlorpyrifos results in increased cleavage of PARP1 protein CTD PMID:22714038 and PMID:29859868 cholesterol increases cleavage EXP 6480464 Cholesterol results in increased cleavage of PARP1 protein CTD PMID:33239236 cholesterol multiple interactions EXP 6480464 bisphenol A promotes the reaction [Cholesterol results in increased cleavage of PARP1 protein] and Resveratrol inhibits the reaction [bisphenol A promotes the reaction [Cholesterol results in increased cleavage of PARP1 protein]] CTD PMID:33239236 chromium atom increases cleavage EXP 6480464 Chromium results in increased cleavage of PARP1 protein CTD PMID:12423593 chromium atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein and Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein] CTD PMID:29115570 chromium(6+) multiple interactions ISO PARP1 (Homo sapiens) 6480464 Ascorbic Acid promotes the reaction [chromium hexavalent ion results in increased cleavage of PARP1 protein] more ... CTD PMID:15831465 more ... chromium(6+) affects expression EXP 6480464 chromium hexavalent ion affects the expression of PARP1 mRNA CTD PMID:28472532 chromium(6+) increases cleavage ISO PARP1 (Homo sapiens) 6480464 chromium hexavalent ion results in increased cleavage of PARP1 protein CTD PMID:15831465 more ... chromone multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form] and benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form] CTD PMID:30256521 chromone increases expression ISO PARP1 (Homo sapiens) 6480464 4-chromone analog results in increased expression of PARP1 protein modified form CTD PMID:30256521 chrysin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein and benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein] CTD PMID:25770930 chrysin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 chrysin inhibits the reaction [Cyclophosphamide results in increased expression of PARP1 protein] CTD PMID:37263553 chrysin increases cleavage ISO PARP1 (Homo sapiens) 6480464 chrysin results in increased cleavage of PARP1 protein CTD PMID:18455702 and PMID:25770930 ciglitazone multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ciglitazone promotes the reaction [Niflumic Acid results in increased cleavage of PARP1 protein]] more ... CTD PMID:15492468 and PMID:21067863 ciglitazone increases cleavage ISO PARP1 (Homo sapiens) 6480464 ciglitazone results in increased cleavage of PARP1 protein CTD PMID:21067863 cinchocaine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Dibucaine inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein] CTD PMID:25947082 Cinobufagin increases expression ISO PARP1 (Homo sapiens) 6480464 cinobufagin results in increased expression of PARP1 protein modified form CTD PMID:23164673 Cinobufagin multiple interactions ISO PARP1 (Homo sapiens) 6480464 GSK3B protein mutant form inhibits the reaction [cinobufagin results in increased expression of PARP1 protein modified form] and SB 216763 promotes the reaction [cinobufagin results in increased expression of PARP1 protein modified form] CTD PMID:23164673 ciprofloxacin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Ciprofloxacin results in increased cleavage of PARP1 protein CTD PMID:10741713 cisplatin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FAM168A results in decreased susceptibility to Cisplatin]] which results in increased cleavage of PARP1 protein more ... CTD PMID:15496615 more ... cisplatin increases expression ISO Parp1 (Rattus norvegicus) 6480464 Cisplatin results in increased expression of PARP1 protein CTD PMID:29599129 cisplatin increases activity ISO PARP1 (Homo sapiens) 6480464 Cisplatin results in increased activity of PARP1 protein CTD PMID:18468580 and PMID:25806124 cisplatin increases activity EXP 6480464 Cisplatin results in increased activity of PARP1 protein CTD PMID:25806124 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of PARP1 protein CTD PMID:26723870 cisplatin increases cleavage ISO PARP1 (Homo sapiens) 127284886 cisplatin increases cleavage of PARP1 protein in stomach RGD cisplatin multiple interactions EXP 6480464 [Nicotinamide Mononucleotide co-treated with Cisplatin] results in decreased expression of PARP1 protein more ... CTD PMID:24560772 more ... cisplatin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cisplatin results in increased cleavage of PARP1 protein CTD PMID:15496615 more ... cisplatin decreases response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein results in decreased susceptibility to Cisplatin CTD PMID:20798217 and PMID:21447800 cisplatin decreases activity ISO PARP1 (Homo sapiens) 6480464 Cisplatin results in decreased activity of PARP1 protein CTD PMID:21370912 cisplatin increases expression ISO PARP1 (Homo sapiens) 6480464 Cisplatin results in increased expression of PARP1 protein and Cisplatin results in increased expression of PARP1 protein modified form CTD PMID:21274007 more ... cisplatin increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Cisplatin results in increased cleavage of PARP1 protein CTD PMID:23628706 more ... cisplatin increases cleavage EXP 6480464 Cisplatin results in increased cleavage of PARP1 protein CTD PMID:23628706 more ... cisplatin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 5-aminoisoquinoline inhibits the reaction [Cisplatin results in increased expression of PARP1 protein] more ... CTD PMID:24973089 more ... citalopram increases cleavage ISO PARP1 (Homo sapiens) 6480464 Citalopram results in increased cleavage of PARP1 protein CTD PMID:10487422 cladribine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein and [Cladribine co-treated with Cyclophosphamide] results in decreased expression of PARP1 protein CTD PMID:15582267 cladribine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cladribine results in increased cleavage of PARP1 protein CTD PMID:15582267 and PMID:21679466 clobetasol decreases expression EXP 6480464 Clobetasol results in decreased expression of PARP1 mRNA CTD PMID:27462272 clofarabine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of PARP1 protein more ... CTD PMID:20933509 more ... clofibric acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PARP1 mRNA CTD PMID:17602206 clomipramine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Clomipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 cobalt atom increases cleavage EXP 6480464 Cobalt results in increased cleavage of PARP1 protein CTD PMID:12423593 cobalt atom affects binding ISO PARP1 (Homo sapiens) 6480464 PARP1 protein modified form binds to Cobalt CTD PMID:25549802 cobalt dichloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Chromium Alloys co-treated with cobaltous chloride] results in increased cleavage of PARP1 protein more ... CTD PMID:19714248 more ... cobalt dichloride increases cleavage ISO PARP1 (Homo sapiens) 6480464 cobaltous chloride results in increased cleavage of PARP1 protein CTD PMID:21882223 and PMID:22172632 cobalt dichloride increases activity ISO PARP1 (Homo sapiens) 6480464 cobaltous chloride results in increased activity of PARP1 protein CTD PMID:25125499 cobalt dichloride decreases expression ISO PARP1 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of PARP1 mRNA CTD PMID:19320972 cobimetinib increases cleavage ISO PARP1 (Homo sapiens) 6480464 cobimetinib results in increased cleavage of PARP1 protein CTD PMID:22084396 cobimetinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3 more ... CTD PMID:22084396 cocaine affects expression EXP 6480464 Cocaine affects the expression of PARP1 mRNA CTD PMID:15681117 cocaine increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Cocaine results in increased cleavage of PARP1 protein CTD PMID:17084983 colforsin daropate hydrochloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein] CTD PMID:9454737 colforsin daropate hydrochloride increases cleavage ISO PARP1 (Homo sapiens) 6480464 Colforsin results in increased cleavage of PARP1 protein CTD PMID:31278978 colistin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein CTD PMID:28842171 concanamycin A multiple interactions ISO PARP1 (Homo sapiens) 6480464 [lapatinib co-treated with concanamycin A] results in increased cleavage of PARP1 protein CTD PMID:25981168 copper atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of PARP1 mRNA more ... CTD PMID:17079463 more ... copper atom multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in increased cleavage of PARP1 protein CTD PMID:24690739 copper(0) multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of PARP1 mRNA more ... CTD PMID:17079463 more ... copper(0) multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in increased cleavage of PARP1 protein CTD PMID:24690739 copper(II) chloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Disulfiram co-treated with cupric chloride] results in increased cleavage of PARP1 protein and [prolinedithiocarbamate analog co-treated with cupric chloride] results in increased cleavage of PARP1 protein CTD PMID:19789329 and PMID:21035945 copper(II) chloride increases expression EXP 6480464 cupric chloride results in increased expression of PARP1 protein CTD PMID:23313662 copper(II) sulfate decreases expression ISO PARP1 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of PARP1 mRNA CTD PMID:19549813 cordycepin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein] more ... CTD PMID:24704558 cordycepin increases cleavage ISO PARP1 (Homo sapiens) 6480464 cordycepin results in increased cleavage of PARP1 protein CTD PMID:23941773 and PMID:35732609 cordycepin increases cleavage EXP 6480464 cordycepin results in increased cleavage of PARP1 protein CTD PMID:26303320 cordycepin increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 cordycepin results in increased cleavage of PARP1 protein CTD PMID:24704558 coumarin decreases activity ISO PARP1 (Homo sapiens) 6480464 coumarin results in decreased activity of PARP1 protein CTD PMID:17669606 coumarin decreases expression ISO PARP1 (Homo sapiens) 6480464 coumarin analog results in decreased expression of PARP1 mRNA CTD PMID:32578917 coumarin increases cleavage ISO PARP1 (Homo sapiens) 6480464 coumarin analog results in increased cleavage of PARP1 protein CTD PMID:31199928 coumarin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD] and [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP] CTD PMID:17669606 coumarins increases cleavage ISO PARP1 (Homo sapiens) 6480464 Coumarins analog results in increased cleavage of PARP1 protein CTD PMID:25231984 coumestrol multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 crizotinib increases cleavage ISO PARP1 (Homo sapiens) 6480464 Crizotinib results in increased cleavage of PARP1 protein CTD PMID:31639374 and PMID:31706006 crizotinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Crizotinib results in increased cleavage of PARP1 protein] CTD PMID:31706006 crocidolite asbestos increases cleavage ISO PARP1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased cleavage of PARP1 protein CTD PMID:17191120 and PMID:19783790 crocidolite asbestos decreases expression ISO PARP1 (Homo sapiens) 6480464 Asbestos more ... CTD PMID:32006662 crocidolite asbestos increases expression ISO PARP1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of PARP1 mRNA CTD PMID:20616036 crocidolite asbestos multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [Asbestos more ... CTD PMID:20616036 and PMID:21543585 crocin-1 multiple interactions ISO PARP1 (Homo sapiens) 6480464 MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein] CTD PMID:30672053 crocin-1 increases cleavage ISO PARP1 (Homo sapiens) 6480464 crocin results in increased cleavage of PARP1 protein CTD PMID:30672053 Cryptotanshinone increases cleavage ISO PARP1 (Homo sapiens) 6480464 cryptotanshinone results in increased cleavage of PARP1 protein CTD PMID:26564229 crystal violet increases cleavage ISO PARP1 (Homo sapiens) 6480464 Gentian Violet results in increased cleavage of PARP1 protein CTD PMID:24535435 cucurbitacin E multiple interactions ISO PARP1 (Homo sapiens) 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein] and Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein] CTD PMID:27106530 cucurbitacin E increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 cucurbitacin E results in increased cleavage of PARP1 protein CTD PMID:27363783 cucurbitacin E increases cleavage ISO PARP1 (Homo sapiens) 6480464 cucurbitacin E results in increased cleavage of PARP1 protein CTD PMID:27106530 cucurbitacin I increases cleavage ISO PARP1 (Homo sapiens) 6480464 cucurbitacin I results in increased cleavage of PARP1 protein CTD PMID:24858077 Cuprizon multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cuprizone co-treated with Benztropine] results in increased expression of PARP1 protein CTD PMID:34122009 curcumin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Curcumin co-treated with Bortezomib] results in increased cleavage of PARP1 protein more ... CTD PMID:14724571 more ... curcumin increases expression ISO PARP1 (Homo sapiens) 6480464 Curcumin results in increased expression of PARP1 protein modified form CTD PMID:27430728 curcumin decreases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Curcumin results in decreased cleavage of PARP1 protein CTD PMID:26612707 curcumin decreases expression ISO PARP1 (Homo sapiens) 6480464 Curcumin analog results in decreased expression of PARP1 mRNA CTD PMID:26409325 curcumin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Curcumin results in increased cleavage of PARP1 protein CTD PMID:14555224 more ... curcumin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased cleavage of PARP1 protein] more ... CTD PMID:15569404 more ... curcumin multiple interactions EXP 6480464 [Doxorubicin co-treated with Curcumin] results in increased cleavage of PARP1 protein and Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:11035063 and PMID:18006147 curcumin increases cleavage EXP 6480464 Curcumin results in increased cleavage of PARP1 protein CTD PMID:21594647 curcumin increases degradation ISO PARP1 (Homo sapiens) 6480464 Curcumin results in increased degradation of PARP1 CTD PMID:21595920 CX-5461 increases cleavage ISO PARP1 (Homo sapiens) 6480464 CX 5461 results in increased cleavage of PARP1 protein CTD PMID:32799625 cycloheximide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cycloheximide co-treated with TNF protein] results in increased cleavage of PARP1 protein more ... CTD PMID:12925536 and PMID:18222423 cycloheximide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Cycloheximide inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein] CTD PMID:15147502 cycloheximide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cycloheximide results in increased cleavage of PARP1 protein CTD PMID:16051428 cyclophosphamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein and [Cladribine co-treated with Cyclophosphamide] results in decreased expression of PARP1 protein CTD PMID:15582267 cyclophosphamide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 chrysin inhibits the reaction [Cyclophosphamide results in increased expression of PARP1 protein] CTD PMID:37263553 cyclophosphamide increases expression ISO Parp1 (Rattus norvegicus) 6480464 Cyclophosphamide results in increased expression of PARP1 mRNA and Cyclophosphamide results in increased expression of PARP1 protein CTD PMID:11599041 and PMID:37263553 cyclophosphamide increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Cyclophosphamide results in increased cleavage of PARP1 protein CTD PMID:11723234 cyclophosphamide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cyclophosphamide results in increased cleavage of PARP1 protein CTD PMID:17898787 cyclophosphamide decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Cyclophosphamide results in decreased expression of PARP1 mRNA CTD PMID:11906922 cyclosporin A increases cleavage ISO PARP1 (Homo sapiens) 6480464 Cyclosporine results in increased cleavage of PARP1 protein CTD PMID:22155090 cyclosporin A multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Cyclosporine inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein] CTD PMID:25947082 cyclosporin A decreases expression ISO PARP1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of PARP1 mRNA CTD PMID:25562108 cyclosporin A increases cleavage EXP 6480464 Cyclosporine results in increased cleavage of PARP1 protein CTD PMID:22155090 cyclosporin A multiple interactions EXP 6480464 2-dimethylamino-4 more ... CTD PMID:22155090 cyclosporin A multiple interactions ISO PARP1 (Homo sapiens) 6480464 salubrinal inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:22155090 cylindrospermopsin increases cleavage ISO PARP1 (Homo sapiens) 6480464 cylindrospermopsin results in increased cleavage of PARP1 protein CTD PMID:30500929 cypermethrin multiple interactions ISO PARP1 (Homo sapiens) 6480464 cypermethrin inhibits the reaction [Docosahexaenoic Acids results in increased degradation of PARP1 protein] CTD PMID:11341974 cypermethrin decreases expression ISO PARP1 (Homo sapiens) 6480464 cypermethrin results in decreased expression of PARP1 mRNA CTD PMID:27704156 cytarabine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cytarabine co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein more ... CTD PMID:12780785 and PMID:8840993 cytarabine increases degradation ISO PARP1 (Homo sapiens) 6480464 Cytarabine results in increased degradation of PARP1 protein CTD PMID:8840993 D-cycloserine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Cycloserine inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 D-glucose multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [INS1 protein co-treated with Glucose] results in increased activity of PARP1 protein more ... CTD PMID:18004065 more ... D-glucose increases acetylation ISO PARP1 (Homo sapiens) 6480464 Glucose results in increased acetylation of PARP1 protein CTD PMID:28478229 D-glucose multiple interactions EXP 6480464 Glucose deficiency inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form] and PARP1 protein affects the reaction [Glucose results in increased ADP-ribosylation of GAPDH protein] CTD PMID:14523042 and PMID:29095437 D-glucose increases activity ISO PARP1 (Homo sapiens) 6480464 Glucose results in increased activity of PARP1 protein CTD PMID:21031461 and PMID:27288104 D-glucose affects localization ISO PARP1 (Homo sapiens) 6480464 Glucose affects the localization of PARP1 protein CTD PMID:28478229 D-glucose increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Glucose results in increased cleavage of PARP1 protein CTD PMID:22524206 D-glucose decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Glucose results in decreased expression of PARP1 mRNA CTD PMID:21818840 D-glucose increases activity ISO Parp1 (Rattus norvegicus) 6480464 Glucose results in increased activity of PARP1 protein CTD PMID:18004065 D-glucose increases expression ISO PARP1 (Homo sapiens) 6480464 Glucose results in increased expression of PARP1 mRNA and Glucose results in increased expression of PARP1 protein modified form CTD PMID:22228707 more ... D-glucose multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Glucose co-treated with Oxygen deficiency] results in increased activity of PARP1 protein more ... CTD PMID:14523042 more ... D-penicillamine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Penicillamine results in increased cleavage of PARP1 protein CTD PMID:22843330 dactolisib increases cleavage ISO PARP1 (Homo sapiens) 6480464 dactolisib results in increased cleavage of PARP1 protein CTD PMID:21464613 daidzein increases cleavage ISO PARP1 (Homo sapiens) 6480464 daidzein results in increased cleavage of PARP1 protein CTD PMID:12791511 daunorubicin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Daunorubicin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein CTD PMID:12780785 daunorubicin affects expression ISO PARP1 (Homo sapiens) 6480464 Daunorubicin affects the expression of PARP1 mRNA CTD PMID:27780733 daunorubicin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Daunorubicin results in increased cleavage of PARP1 protein CTD PMID:10766178 more ... DDE increases activity ISO PARP1 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in increased activity of PARP1 protein CTD PMID:19545618 decabromodiphenyl ether decreases expression ISO PARP1 (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of PARP1 protein CTD PMID:31675489 Decursin increases cleavage ISO PARP1 (Homo sapiens) 6480464 decursin results in increased cleavage of PARP1 protein CTD PMID:17723170 deguelin increases expression ISO PARP1 (Homo sapiens) 6480464 deguelin metabolite results in increased expression of PARP1 protein modified form and deguelin results in increased expression of PARP1 protein modified form CTD PMID:19139008 deguelin increases cleavage ISO PARP1 (Homo sapiens) 6480464 deguelin results in increased cleavage of PARP1 protein CTD PMID:17035597 and PMID:22986522 deguelin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein and deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:17015749 and PMID:25242579 delphinidin decreases activity ISO PARP1 (Homo sapiens) 6480464 delphinidin results in decreased activity of PARP1 protein CTD PMID:17884996 delphinidin increases cleavage ISO PARP1 (Homo sapiens) 6480464 delphinidin results in increased cleavage of PARP1 protein CTD PMID:29451351 demethoxycurcumin multiple interactions ISO PARP1 (Homo sapiens) 6480464 Wortmannin promotes the reaction [demethoxycurcumin results in increased cleavage of PARP1 protein] CTD PMID:34291863 demethoxycurcumin increases cleavage ISO PARP1 (Homo sapiens) 6480464 demethoxycurcumin results in increased cleavage of PARP1 protein CTD PMID:34291863 demethoxyfumitremorgin C increases cleavage ISO PARP1 (Homo sapiens) 6480464 demethoxyfumitremorgin C results in increased cleavage of PARP1 protein CTD PMID:28359723 deoxycholic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PARP1 protein] and cobaltiprotoporphyrin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PARP1 protein] CTD PMID:17644113 and PMID:21362092 deoxycholic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Deoxycholic Acid results in increased cleavage of PARP1 protein CTD PMID:17644113 and PMID:21362092 deoxynivalenol increases cleavage EXP 6480464 deoxynivalenol results in increased cleavage of PARP1 protein CTD PMID:19410639 deoxynivalenol increases expression ISO PARP1 (Homo sapiens) 6480464 deoxynivalenol results in increased expression of PARP1 mRNA CTD PMID:34677630 deoxynivalenol multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in decreased expression of and results in increased cleavage of PARP1 protein] more ... CTD PMID:35925383 deoxynivalenol multiple interactions EXP 6480464 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone affects the reaction [deoxynivalenol affects the expression of and results in increased cleavage of PARP1 protein] and deoxynivalenol affects the expression of and results in increased cleavage of PARP1 protein CTD PMID:35925383 desferrioxamine B increases cleavage ISO PARP1 (Homo sapiens) 6480464 Deferoxamine results in increased cleavage of PARP1 protein CTD PMID:21882223 desferrioxamine B multiple interactions ISO PARP1 (Homo sapiens) 6480464 Indomethacin promotes the reaction [Deferoxamine results in increased cleavage of PARP1 protein] and Sulindac promotes the reaction [Deferoxamine results in increased cleavage of PARP1 protein] CTD PMID:21882223 desloratadine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [desloratadine results in increased susceptibility to Sorafenib] which results in increased cleavage of PARP1 protein and [Sorafenib results in increased susceptibility to desloratadine] which results in increased cleavage of PARP1 protein CTD PMID:36617552 desloratadine increases cleavage ISO PARP1 (Homo sapiens) 6480464 desloratadine results in increased cleavage of PARP1 protein CTD PMID:36617552 Destruxin B increases cleavage ISO PARP1 (Homo sapiens) 6480464 destruxin B results in increased cleavage of PARP1 protein CTD PMID:22465936 dexamethasone multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of PARP1 protein modified form more ... CTD PMID:16144937 more ... dexamethasone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Dexamethasone results in increased cleavage of PARP1 protein CTD PMID:25447644 dexamethasone multiple interactions EXP 6480464 2 more ... CTD PMID:16644695 more ... dexamethasone increases cleavage EXP 6480464 Dexamethasone results in increased cleavage of PARP1 protein CTD PMID:16644695 dexamethasone phosphate increases cleavage ISO PARP1 (Homo sapiens) 6480464 dexamethasone 21-phosphate results in increased cleavage of PARP1 protein CTD PMID:25447644 dextran sulfate increases cleavage EXP 6480464 Dextran Sulfate results in increased cleavage of PARP1 protein CTD PMID:21989142 dextran sulfate multiple interactions EXP 6480464 [Camptothecin co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased cleavage of PARP1 protein more ... CTD PMID:21989142 and PMID:25449198 Diacetoxyscirpenol decreases expression EXP 6480464 diacetoxyscirpenol results in decreased expression of PARP1 mRNA CTD PMID:31836554 diallyl disulfide multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] and diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:30677442 diallyl trisulfide multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of PARP1 protein] CTD PMID:22578287 diallyl trisulfide increases cleavage ISO PARP1 (Homo sapiens) 6480464 diallyl trisulfide results in increased cleavage of PARP1 protein CTD PMID:20055834 more ... diarsenic trioxide increases cleavage EXP 6480464 Arsenic Trioxide results in increased cleavage of PARP1 protein CTD PMID:15761769 more ... diarsenic trioxide increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased cleavage of PARP1 protein CTD PMID:24634002 and PMID:32096187 diarsenic trioxide increases activity EXP 6480464 Arsenic Trioxide results in increased activity of PARP1 protein CTD PMID:24157283 diarsenic trioxide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein] and salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein] CTD PMID:24634002 and PMID:28391263 diarsenic trioxide multiple interactions ISO PARP1 (Homo sapiens) 6480464 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein] more ... CTD PMID:12883035 more ... diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of PARP1 protein modified form CTD PMID:29095437 diarsenic trioxide increases activity ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased activity of PARP1 protein CTD PMID:11304686 diarsenic trioxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased cleavage of PARP1 protein CTD PMID:10382944 more ... diarsenic trioxide increases expression ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of PARP1 protein and Arsenic Trioxide results in increased expression of PARP1 protein modified form CTD PMID:25972196 and PMID:27430728 diarsenic trioxide decreases expression ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of PARP1 protein CTD PMID:19695276 and PMID:25419056 diarsenic trioxide multiple interactions EXP 6480464 [Genistein co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein more ... CTD PMID:21078540 more ... diarsenic trioxide affects localization ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide affects the localization of PARP1 protein modified form CTD PMID:15131059 diarsenic trioxide increases degradation ISO PARP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased degradation of PARP1 protein CTD PMID:16166054 diarsenic trioxide increases expression ISO Parp1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of PARP1 protein CTD PMID:28391263 dibenziodolium multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased cleavage of PARP1 protein] CTD PMID:14687664 dibenziodolium multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 diphenyleneiodonium inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein] CTD PMID:25947082 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of PARP1 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of PARP1 mRNA CTD PMID:21266533 dichloroacetic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Dichloroacetic Acid results in increased expression of and results in increased cleavage of PARP1 protein CTD PMID:25630799 dichlorvos increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Dichlorvos results in increased cleavage of PARP1 protein CTD PMID:24231740 dichlorvos multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 N-(oxo-5 more ... CTD PMID:24231740 dichlorvos increases activity ISO Parp1 (Rattus norvegicus) 6480464 Dichlorvos results in increased activity of PARP1 protein CTD PMID:24231740 diclofenac affects expression ISO PARP1 (Homo sapiens) 6480464 Diclofenac affects the expression of PARP1 mRNA CTD PMID:24752500 Dictamnine multiple interactions ISO PARP1 (Homo sapiens) 6480464 dictamnine results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:34861243 Didecyldimethylammonium decreases expression ISO PARP1 (Homo sapiens) 6480464 didecyldimethylammonium results in decreased expression of PARP1 protein CTD PMID:32763356 dieldrin increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Dieldrin results in increased cleavage of PARP1 protein CTD PMID:15183012 dieldrin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Dieldrin results in increased cleavage of PARP1 protein] CTD PMID:15183012 diepoxybutane increases cleavage ISO PARP1 (Homo sapiens) 6480464 diepoxybutane results in increased cleavage of PARP1 protein CTD PMID:14998682 diethyl fumarate increases cleavage ISO PARP1 (Homo sapiens) 6480464 diethyl fumarate results in increased cleavage of PARP1 protein CTD PMID:21105742 diethyl maleate increases cleavage ISO PARP1 (Homo sapiens) 6480464 diethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 diethyl phthalate multiple interactions EXP 6480464 diethyl phthalate results in increased expression of and results in increased cleavage of PARP1 protein CTD PMID:37942807 dihydrogen multiple interactions ISO PARP1 (Homo sapiens) 6480464 Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 dihydroxyacetone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Dihydroxyacetone results in increased cleavage of PARP1 protein CTD PMID:29193605 dimethyl maleate increases cleavage ISO PARP1 (Homo sapiens) 6480464 dimethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 dimethyl sulfoxide increases cleavage EXP 6480464 Dimethyl Sulfoxide results in increased cleavage of PARP1 protein CTD PMID:22535522 dimethylarsinous acid decreases activity ISO PARP1 (Homo sapiens) 6480464 dimethylarsinous acid results in decreased activity of PARP1 protein CTD PMID:17011244 dimethylarsinous acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein more ... CTD PMID:17011244 and PMID:29774349 dioscin multiple interactions EXP 6480464 dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein] CTD PMID:24146112 dioscin decreases expression ISO PARP1 (Homo sapiens) 6480464 dioscin results in decreased expression of PARP1 mRNA and dioscin results in decreased expression of PARP1 protein CTD PMID:33359023 dioscin increases expression ISO PARP1 (Homo sapiens) 6480464 dioscin results in increased expression of PARP1 mRNA CTD PMID:29990575 dioscin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein] CTD PMID:24146112 diosmetin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form] more ... CTD PMID:35191607 diosmin multiple interactions EXP 6480464 Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 dioxygen increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Oxygen deficiency results in increased cleavage of PARP1 protein CTD PMID:11042672 dioxygen multiple interactions EXP 6480464 PARP1 gene mutant form inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CXCL1 protein] CTD PMID:15696051 dioxygen increases activity ISO PARP1 (Homo sapiens) 6480464 Oxygen deficiency results in increased activity of PARP1 protein CTD PMID:27288104 dioxygen increases expression ISO PARP1 (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of PARP1 protein modified form CTD PMID:26540049 dioxygen increases cleavage ISO PARP1 (Homo sapiens) 6480464 Oxygen deficiency results in increased cleavage of PARP1 protein and Oxygen results in increased cleavage of PARP1 protein CTD PMID:20530905 and PMID:25831079 dioxygen multiple interactions ISO PARP1 (Homo sapiens) 6480464 [betulin co-treated with Oxygen] results in increased cleavage of PARP1 protein more ... CTD PMID:20530905 more ... dioxygen multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [N-(oxo-5 more ... CTD PMID:11042672 more ... diprotium multiple interactions ISO PARP1 (Homo sapiens) 6480464 Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 diquat increases cleavage ISO PARP1 (Homo sapiens) 6480464 Diquat results in increased cleavage of PARP1 protein CTD PMID:25693864 disodium selenite increases cleavage ISO PARP1 (Homo sapiens) 6480464 Sodium Selenite results in increased cleavage of PARP1 protein CTD PMID:15845651 and PMID:28161410 disodium selenite decreases activity ISO Parp1 (Rattus norvegicus) 6480464 Sodium Selenite results in decreased activity of PARP1 protein CTD PMID:18209489 disodium selenite increases expression ISO PARP1 (Homo sapiens) 6480464 Sodium Selenite results in increased expression of PARP1 mRNA CTD PMID:18175754 disulfiram multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Copper co-treated with Disulfiram] results in increased cleavage of PARP1 protein more ... CTD PMID:17079463 more ... disulfiram multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in increased cleavage of PARP1 protein CTD PMID:24690739 disulfiram increases cleavage ISO PARP1 (Homo sapiens) 6480464 Disulfiram results in increased cleavage of PARP1 protein CTD PMID:17079463 more ... divinyl sulfone increases cleavage ISO PARP1 (Homo sapiens) 6480464 divinyl sulfone analog results in increased cleavage of PARP1 protein CTD PMID:24875536 divinyl sulfone multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [divinyl sulfone analog results in increased cleavage of PARP1 protein] and Acetylcysteine inhibits the reaction [divinyl sulfone analog results in increased cleavage of PARP1 protein] CTD PMID:24875536 dizocilpine maleate multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein] CTD PMID:15147502 dopamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of PARP1 protein] more ... CTD PMID:15198987 more ... dopamine multiple interactions EXP 6480464 [PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:10318960 dopamine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Dopamine results in increased cleavage of PARP1 protein CTD PMID:15198987 more ... dorsomorphin increases cleavage ISO PARP1 (Homo sapiens) 6480464 dorsomorphin results in increased cleavage of PARP1 protein CTD PMID:23274516 and PMID:31900833 dorsomorphin multiple interactions ISO PARP1 (Homo sapiens) 6480464 dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein] more ... CTD PMID:23274516 more ... doxorubicin increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Doxorubicin results in increased cleavage of PARP1 protein CTD PMID:16687611 more ... doxorubicin decreases expression ISO PARP1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of PARP1 mRNA CTD PMID:36634904 doxorubicin increases expression ISO PARP1 (Homo sapiens) 6480464 Doxorubicin results in increased expression of PARP1 mRNA and Doxorubicin results in increased expression of PARP1 protein modified form CTD PMID:29803840 more ... doxorubicin affects expression ISO PARP1 (Homo sapiens) 6480464 Doxorubicin affects the expression of PARP1 mRNA CTD PMID:27780733 doxorubicin increases cleavage EXP 6480464 Doxorubicin results in increased cleavage of PARP1 protein CTD PMID:10704466 more ... doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of PARP1 protein CTD PMID:20144634 and PMID:31174020 doxorubicin increases expression ISO Parp1 (Rattus norvegicus) 6480464 Doxorubicin results in increased expression of PARP1 protein and Doxorubicin results in increased expression of PARP1 protein modified form CTD PMID:12967636 more ... doxorubicin decreases activity EXP 6480464 Doxorubicin results in decreased activity of PARP1 protein CTD PMID:20656019 doxorubicin increases uptake EXP 6480464 PARP1 protein results in increased uptake of Doxorubicin CTD PMID:15861398 doxorubicin affects response to substance EXP 6480464 PARP1 protein affects the susceptibility to Doxorubicin CTD PMID:11861791 doxorubicin increases activity EXP 6480464 Doxorubicin results in increased activity of PARP1 protein CTD PMID:19286953 doxorubicin multiple interactions EXP 6480464 5 more ... CTD PMID:15861398 more ... doxorubicin increases degradation ISO PARP1 (Homo sapiens) 6480464 Doxorubicin results in increased degradation of PARP1 protein CTD PMID:17418594 doxorubicin increases activity ISO PARP1 (Homo sapiens) 6480464 Doxorubicin results in increased activity of PARP1 protein CTD PMID:15456408 doxorubicin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Doxorubicin analog results in increased cleavage of PARP1 protein and Doxorubicin results in increased cleavage of PARP1 protein CTD PMID:10766178 more ... doxorubicin affects cleavage ISO PARP1 (Homo sapiens) 6480464 Doxorubicin affects the cleavage of PARP1 protein CTD PMID:15870702 doxorubicin multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3 more ... CTD PMID:15456408 more ... doxorubicin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] more ... CTD PMID:12967636 more ... Echimidine multiple interactions ISO PARP1 (Homo sapiens) 6480464 echimidine results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:29458164 edaravone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Edaravone analog results in increased cleavage of PARP1 protein CTD PMID:25684395 elemental selenium multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Doxorubicin co-treated with Selenium] results in increased degradation of PARP1 protein more ... CTD PMID:17339365 ellagic acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Ellagic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:25247703 ellipticine increases cleavage ISO PARP1 (Homo sapiens) 6480464 ellipticine results in increased cleavage of PARP1 protein CTD PMID:21843585 embelin increases cleavage ISO PARP1 (Homo sapiens) 6480464 embelin results in increased cleavage of PARP1 protein CTD PMID:24694877 and PMID:28722333 embelin multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein] CTD PMID:28722333 emetine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Emetine results in increased cleavage of PARP1 protein CTD PMID:21256112 emodin increases activity ISO PARP1 (Homo sapiens) 6480464 Emodin results in increased activity of PARP1 protein CTD PMID:23848338 emodin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Emodin results in increased cleavage of PARP1 protein CTD PMID:27032576 more ... emodin multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein] more ... CTD PMID:27032576 Enterolactone multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PARP1 mRNA CTD PMID:19167446 enzalutamide decreases cleavage ISO PARP1 (Homo sapiens) 6480464 enzalutamide results in decreased cleavage of PARP1 protein CTD PMID:32184358 enzalutamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [enzalutamide co-treated with GSK-2816126] results in increased cleavage of PARP1 protein more ... CTD PMID:30940724 more ... enzyme inhibitor multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PARP1 protein CTD PMID:23301498 epalrestat multiple interactions EXP 6480464 epalrestat analog inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] and epalrestat inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] CTD PMID:37257577 epothilone A multiple interactions ISO PARP1 (Homo sapiens) 6480464 [epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA more ... CTD PMID:29117515 epothilone A increases expression ISO PARP1 (Homo sapiens) 6480464 epothilone A results in increased expression of PARP1 mRNA CTD PMID:29117515 epoxomicin increases cleavage ISO PARP1 (Homo sapiens) 6480464 epoxomicin results in increased cleavage of PARP1 protein CTD PMID:20153345 epoxomicin multiple interactions ISO PARP1 (Homo sapiens) 6480464 quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [epoxomicin results in increased cleavage of PARP1 protein] CTD PMID:20153345 erdosteine multiple interactions EXP 6480464 erdosteine inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:26193055 erdosteine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 erdosteine affects the reaction [Isoproterenol results in increased expression of PARP1 protein] CTD PMID:33210414 erlotinib hydrochloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 [TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of PARP1 protein more ... CTD PMID:25895606 and PMID:30171258 erlotinib hydrochloride increases expression ISO PARP1 (Homo sapiens) 6480464 Erlotinib Hydrochloride results in increased expression of PARP1 protein modified form CTD PMID:25895606 erlotinib hydrochloride increases cleavage ISO PARP1 (Homo sapiens) 6480464 Erlotinib Hydrochloride results in increased cleavage of PARP1 protein CTD PMID:23125191 and PMID:30171258 esculetin increases cleavage ISO PARP1 (Homo sapiens) 6480464 esculetin results in increased cleavage of PARP1 protein CTD PMID:26388407 and PMID:31313495 etacrynic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein more ... CTD PMID:23082001 ethanol multiple interactions ISO PARP1 (Homo sapiens) 6480464 Ethanol results in increased expression of and results in increased cleavage of PARP1 protein more ... CTD PMID:21410490 more ... ethanol affects splicing EXP 6480464 Ethanol affects the splicing of PARP1 mRNA CTD PMID:30319688 ethanol increases activity EXP 6480464 Ethanol results in increased activity of PARP1 protein CTD PMID:27984176 ethanol increases activity ISO Parp1 (Rattus norvegicus) 6480464 Ethanol results in increased activity of PARP1 protein CTD PMID:30368987 ethanol increases cleavage ISO PARP1 (Homo sapiens) 6480464 Ethanol results in increased cleavage of PARP1 protein CTD PMID:21410490 more ... ethanol increases expression EXP 6480464 Ethanol results in increased expression of PARP1 protein CTD PMID:24146112 and PMID:29317476 ethanol multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [2 more ... CTD PMID:24146112 more ... ethanol multiple interactions EXP 6480464 5-aminoisoquinolinone inhibits the reaction [Ethanol results in increased activity of PARP1 protein] more ... CTD PMID:24146112 more ... ethanol increases cleavage EXP 6480464 Ethanol results in increased cleavage of PARP1 protein CTD PMID:22535522 and PMID:34116071 ethanol increases expression ISO Parp1 (Rattus norvegicus) 6480464 Ethanol results in increased expression of PARP1 mRNA and Ethanol results in increased expression of PARP1 protein CTD PMID:15353170 more ... ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions EXP 6480464 [1 more ... CTD PMID:29111403 ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21544200 ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21544200 etoposide increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Etoposide results in increased cleavage of PARP1 protein CTD PMID:17516866 etoposide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Etoposide results in increased cleavage of PARP1 protein CTD PMID:12690110 more ... etoposide multiple interactions ISO PARP1 (Homo sapiens) 6480464 3' more ... CTD PMID:16014620 more ... etoposide increases degradation ISO PARP1 (Homo sapiens) 6480464 Etoposide results in increased degradation of PARP1 protein CTD PMID:8840993 etoposide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Niacin deficiency affects the reaction [Etoposide results in increased cleavage of PARP1 protein] CTD PMID:17516866 eugenol multiple interactions EXP 6480464 Eugenol affects the reaction [Methylnitronitrosoguanidine affects the cleavage of PARP1 protein] CTD PMID:20434464 EUK-134 multiple interactions ISO PARP1 (Homo sapiens) 6480464 EUK-134 inhibits the reaction [evodiamine results in increased cleavage of PARP1 protein] CTD PMID:34808100 everolimus multiple interactions ISO PARP1 (Homo sapiens) 6480464 [navitoclax co-treated with Everolimus] results in increased cleavage of PARP1 protein CTD PMID:28947240 Evodiamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 EUK-134 inhibits the reaction [evodiamine results in increased cleavage of PARP1 protein] more ... CTD PMID:15710601 and PMID:34808100 Evodiamine increases cleavage ISO PARP1 (Homo sapiens) 6480464 evodiamine results in increased cleavage of PARP1 protein CTD PMID:34808100 excitatory amino acid agonist increases activity ISO Parp1 (Rattus norvegicus) 6480464 Excitatory Amino Acid Agonists results in increased activity of PARP1 protein CTD PMID:19288225 excitatory amino acid agonist decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Excitatory Amino Acid Agonists results in decreased expression of PARP1 protein CTD PMID:19288225 excitatory amino acid agonist multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Niacinamide inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of PARP1 protein] more ... CTD PMID:19288225 and PMID:24675465 excitatory amino acid agonist increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Excitatory Amino Acid Agonists results in increased cleavage of PARP1 protein CTD PMID:24675465 fangchinoline increases cleavage ISO PARP1 (Homo sapiens) 6480464 fangchinoline results in increased cleavage of PARP1 protein CTD PMID:28754437 fenvalerate multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 CAT protein inhibits the reaction [fenvalerate results in increased cleavage of PARP1 protein] CTD PMID:30307764 fenvalerate increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 fenvalerate results in increased cleavage of PARP1 protein CTD PMID:30307764 ferric ammonium citrate multiple interactions ISO PARP1 (Homo sapiens) 6480464 [ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein more ... CTD PMID:34826546 ferric oxide multiple interactions EXP 6480464 ferric oxide results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:28993115 ferric oxide increases cleavage EXP 6480464 ferric oxide results in increased cleavage of PARP1 protein CTD PMID:26991130 ferric oxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 ferric oxide analog results in increased cleavage of PARP1 protein CTD PMID:27270449 ferrosoferric oxide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of PARP1 protein CTD PMID:30098274 fingolimod hydrochloride increases cleavage ISO PARP1 (Homo sapiens) 6480464 Fingolimod Hydrochloride results in increased cleavage of PARP1 protein CTD PMID:25939952 fingolimod hydrochloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein] more ... CTD PMID:25939952 fisetin decreases activity ISO PARP1 (Homo sapiens) 6480464 fisetin results in decreased activity of PARP1 protein CTD PMID:17884996 flavanone increases cleavage ISO PARP1 (Homo sapiens) 6480464 flavanone results in increased cleavage of PARP1 protein CTD PMID:22056764 flavanones multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine promotes the reaction [Flavanones results in increased cleavage of PARP1 protein] more ... CTD PMID:21616090 flavanones increases cleavage ISO PARP1 (Homo sapiens) 6480464 Flavanones results in increased cleavage of PARP1 protein CTD PMID:21616090 flavokawain B multiple interactions ISO PARP1 (Homo sapiens) 6480464 [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein more ... CTD PMID:30025493 flavone increases cleavage ISO PARP1 (Homo sapiens) 6480464 flavone results in increased cleavage of PARP1 protein CTD PMID:15289867 flavone decreases activity ISO PARP1 (Homo sapiens) 6480464 flavone results in decreased activity of PARP1 protein CTD PMID:17643414 flavonoids increases cleavage ISO PARP1 (Homo sapiens) 6480464 Flavonoids results in increased cleavage of PARP1 protein CTD PMID:23063593 flavonoids increases expression ISO Parp1 (Rattus norvegicus) 6480464 Flavonoids results in increased expression of PARP1 mRNA CTD PMID:18035473 flavonoids decreases expression ISO PARP1 (Homo sapiens) 6480464 Flavonoids results in decreased expression of PARP1 mRNA CTD PMID:15465739 floxuridine decreases response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein results in decreased susceptibility to Floxuridine CTD PMID:21613406 fludioxonil increases expression ISO PARP1 (Homo sapiens) 6480464 fludioxonil results in increased expression of PARP1 protein CTD PMID:23052036 fluoranthene increases cleavage ISO PARP1 (Homo sapiens) 6480464 fluoranthene results in increased cleavage of PARP1 protein CTD PMID:21132278 flutamide increases expression ISO Parp1 (Rattus norvegicus) 6480464 Flutamide results in increased expression of PARP1 mRNA CTD PMID:24136188 folic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Folic Acid results in increased cleavage of PARP1 protein CTD PMID:16728583 folic acid decreases expression ISO PARP1 (Homo sapiens) 6480464 Folic Acid results in decreased expression of PARP1 mRNA CTD PMID:36354958 folic acid multiple interactions EXP 6480464 Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PARP1 mRNA] CTD PMID:22206623 folic acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Folic Acid inhibits the reaction [Methotrexate results in increased cleavage of PARP1 protein] and Folic Acid inhibits the reaction [Nicotine results in decreased expression of PARP1 protein] CTD PMID:29972271 and PMID:30502384 formaldehyde decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Formaldehyde results in decreased expression of PARP1 mRNA CTD PMID:17285311 formaldehyde increases expression ISO PARP1 (Homo sapiens) 6480464 Formaldehyde results in increased expression of PARP1 protein modified form CTD PMID:24140967 FR900359 increases phosphorylation ISO PARP1 (Homo sapiens) 6480464 FR900359 results in increased phosphorylation of PARP1 protein CTD PMID:37730182 frenolicin B increases cleavage ISO PARP1 (Homo sapiens) 6480464 frenolicin B results in increased cleavage of PARP1 protein CTD PMID:30661989 frenolicin B multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [frenolicin B results in increased cleavage of PARP1 protein] CTD PMID:30661989 fructose increases expression EXP 6480464 Fructose results in increased expression of PARP1 protein CTD PMID:28257781 fulvestrant multiple interactions ISO PARP1 (Homo sapiens) 6480464 fulvestrant inhibits the reaction [Estradiol results in increased cleavage of PARP1 protein] and fulvestrant inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein] CTD PMID:21732360 fumonisin B1 multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 fumonisin B1 inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein] CTD PMID:24448832 fumonisin B1 decreases cleavage ISO PARP1 (Homo sapiens) 6480464 fumonisin B1 results in decreased cleavage of PARP1 protein CTD PMID:25800559 furazolidone multiple interactions ISO PARP1 (Homo sapiens) 6480464 CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein] CTD PMID:26687534 furazolidone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Furazolidone results in increased cleavage of PARP1 protein CTD PMID:26687534 galangin increases cleavage ISO PARP1 (Homo sapiens) 6480464 galangin results in increased cleavage of PARP1 protein CTD PMID:18455702 gallic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Gallic Acid results in increased cleavage of PARP1 protein CTD PMID:27060209 gallic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 1 more ... CTD PMID:27060209 gamma-linolenic acid increases cleavage EXP 6480464 gamma-Linolenic Acid results in increased cleavage of PARP1 protein CTD PMID:10403056 Garcinol increases cleavage ISO PARP1 (Homo sapiens) 6480464 garcinol results in increased cleavage of PARP1 protein CTD PMID:16052481 gardenin B increases cleavage ISO PARP1 (Homo sapiens) 6480464 gardenin B results in increased cleavage of PARP1 protein CTD PMID:27423764 gefitinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 Betulinic Acid promotes the reaction [Gefitinib results in increased cleavage of PARP1 protein] and Gefitinib affects the reaction [Oxaliplatin results in increased cleavage of PARP1 protein] CTD PMID:16243822 and PMID:30136359 gefitinib multiple interactions EXP 6480464 [Gefitinib results in increased secretion of CCL2 protein] inhibits the reaction [Gefitinib results in increased expression of PARP1 protein modified form] CTD PMID:33248157 gefitinib increases expression EXP 6480464 Gefitinib results in increased expression of PARP1 protein modified form CTD PMID:33248157 gefitinib increases cleavage ISO PARP1 (Homo sapiens) 6480464 gefitinib results in increased cleavage of PARP1 protein CTD PMID:23523951 geldanamycin multiple interactions ISO PARP1 (Homo sapiens) 6480464 geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] and Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein] CTD PMID:16311509 and PMID:17293044 geldanamycin increases degradation ISO PARP1 (Homo sapiens) 6480464 geldanamycin results in increased degradation of PARP1 protein CTD PMID:17293044 gemcitabine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [alvocidib co-treated with Gemcitabine] results in increased cleavage of PARP1 protein more ... CTD PMID:15770523 more ... gemcitabine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Gemcitabine results in increased cleavage of PARP1 protein CTD PMID:17146438 and PMID:26894857 genistein multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Fluorouracil co-treated with Genistein] results in increased cleavage of PARP1 protein and [Genistein co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein CTD PMID:15896711 and PMID:21078540 genistein increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Genistein results in increased cleavage of PARP1 protein CTD PMID:24884420 genistein multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Genistein inhibits the reaction [bisphenol A results in decreased cleavage of PARP1 protein] CTD PMID:24884420 genistein increases cleavage EXP 6480464 Genistein results in increased cleavage of PARP1 protein CTD PMID:21078540 and PMID:25756279 genistein increases cleavage ISO PARP1 (Homo sapiens) 6480464 Genistein results in increased cleavage of PARP1 protein CTD PMID:12791511 and PMID:21078540 genistein multiple interactions EXP 6480464 [Genistein co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein CTD PMID:21078540 gentamycin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Gentamicins results in increased activity of PARP1 protein] CTD PMID:11470263 gentamycin increases activity ISO Parp1 (Rattus norvegicus) 6480464 Gentamicins results in increased activity of PARP1 protein CTD PMID:11470263 gentamycin increases expression ISO Parp1 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of PARP1 mRNA CTD PMID:22061828 Gentiopicrin multiple interactions EXP 6480464 gentiopicroside inhibits the reaction [[[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein] which results in increased cleavage of PARP1 protein] CTD PMID:20558151 Geraniin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Geraniin results in increased cleavage of PARP1 protein CTD PMID:27097871 gingerol multiple interactions ISO PARP1 (Homo sapiens) 6480464 [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein and Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein] CTD PMID:25034532 Ginkgoic acid increases cleavage ISO PARP1 (Homo sapiens) 127284886 Ginkgoic acid increases cleavage of PARP1 protein in stomach RGD ginsenoside Re multiple interactions ISO PARP1 (Homo sapiens) 6480464 ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein] CTD PMID:25523949 glabridin increases cleavage ISO PARP1 (Homo sapiens) 6480464 glabridin results in increased cleavage of PARP1 protein CTD PMID:29663662 glucose multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [INS1 protein co-treated with Glucose] results in increased activity of PARP1 protein more ... CTD PMID:18004065 more ... glucose increases acetylation ISO PARP1 (Homo sapiens) 6480464 Glucose results in increased acetylation of PARP1 protein CTD PMID:28478229 glucose increases activity ISO PARP1 (Homo sapiens) 6480464 Glucose results in increased activity of PARP1 protein CTD PMID:21031461 and PMID:27288104 glucose affects localization ISO PARP1 (Homo sapiens) 6480464 Glucose affects the localization of PARP1 protein CTD PMID:28478229 glucose multiple interactions EXP 6480464 Glucose deficiency inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form] and PARP1 protein affects the reaction [Glucose results in increased ADP-ribosylation of GAPDH protein] CTD PMID:14523042 and PMID:29095437 glucose increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Glucose results in increased cleavage of PARP1 protein CTD PMID:22524206 glucose increases expression ISO PARP1 (Homo sapiens) 6480464 Glucose results in increased expression of PARP1 mRNA and Glucose results in increased expression of PARP1 protein modified form CTD PMID:22228707 more ... glucose decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Glucose results in decreased expression of PARP1 mRNA CTD PMID:21818840 glucose increases activity ISO Parp1 (Rattus norvegicus) 6480464 Glucose results in increased activity of PARP1 protein CTD PMID:18004065 glucose multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Glucose co-treated with Oxygen deficiency] results in increased activity of PARP1 protein more ... CTD PMID:14523042 more ... glutathione multiple interactions ISO PARP1 (Homo sapiens) 6480464 Glutathione deficiency promotes the reaction [antimony trioxide results in increased cleavage of PARP1 protein] more ... CTD PMID:14660655 more ... Glutathione ethyl ester multiple interactions ISO PARP1 (Homo sapiens) 6480464 S-ethyl glutathione inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein] more ... CTD PMID:22733624 more ... glycerol 2-phosphate multiple interactions EXP 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of PARP1 mRNA more ... CTD PMID:26492236 glycerol 2-phosphate multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of PARP1 protein modified form more ... CTD PMID:22940495 glycochenodeoxycholic acid increases cleavage EXP 6480464 Glycochenodeoxycholic Acid results in increased cleavage of PARP1 protein CTD PMID:25125499 glyphosate decreases expression ISO PARP1 (Homo sapiens) 6480464 Glyphosate results in decreased expression of PARP1 mRNA CTD PMID:31295307 glyphosate increases cleavage EXP 6480464 Glyphosate results in increased cleavage of PARP1 protein CTD PMID:29908847 glyphosate multiple interactions EXP 6480464 XAF1 protein affects the reaction [Glyphosate results in increased cleavage of PARP1 protein] CTD PMID:29908847 Goe 6976 multiple interactions ISO PARP1 (Homo sapiens) 6480464 Go 6976 inhibits the reaction [[cholix toxin and Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein] CTD PMID:28087840 gold atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 Organogold Compounds promotes the reaction [Gold binds to PARP1 protein] CTD PMID:21370912 gold atom decreases expression ISO PARP1 (Homo sapiens) 6480464 Gold analog results in decreased expression of PARP1 mRNA CTD PMID:36057382 gold(0) multiple interactions ISO PARP1 (Homo sapiens) 6480464 Organogold Compounds promotes the reaction [Gold binds to PARP1 protein] CTD PMID:21370912 gold(0) decreases expression ISO PARP1 (Homo sapiens) 6480464 Gold analog results in decreased expression of PARP1 mRNA CTD PMID:36057382 gossypetin decreases activity ISO PARP1 (Homo sapiens) 6480464 gossypetin results in decreased activity of PARP1 protein CTD PMID:17884996 gossypetin multiple interactions ISO PARP1 (Homo sapiens) 6480464 gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein and human results in increased cleavage of PARP1 protein] CTD PMID:25622137 gossypin increases cleavage ISO PARP1 (Homo sapiens) 6480464 gossypin results in increased cleavage of PARP1 protein CTD PMID:30536456 gossypol multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Gossypol co-treated with Epirubicin] results in increased cleavage of PARP1 protein CTD PMID:35872041 GSK2656157 multiple interactions ISO PARP1 (Homo sapiens) 6480464 GSK2656157 inhibits the reaction [glyceryl 2-arachidonate results in increased cleavage of PARP1 protein] CTD PMID:32357311 GSK690693 multiple interactions ISO PARP1 (Homo sapiens) 6480464 GSK690693 promotes the reaction [1 and 4-naphthoquinone analog results in increased cleavage of PARP1 protein] CTD PMID:30871965 GW 3965 multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 GW 3965 inhibits the reaction [Palmitates results in increased cleavage of PARP1 protein] CTD PMID:21209018 GW 4064 decreases phosphorylation EXP 6480464 GW 4064 results in decreased phosphorylation of PARP1 protein CTD PMID:23178280 GW 501516 multiple interactions ISO PARP1 (Homo sapiens) 6480464 GW 501516 promotes the reaction [Indomethacin results in increased cleavage of PARP1 protein] CTD PMID:21400612 harman increases cleavage ISO PARP1 (Homo sapiens) 6480464 harman results in increased cleavage of PARP1 protein CTD PMID:35985368 harmine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:30171258 Heliotrine decreases expression ISO PARP1 (Homo sapiens) 6480464 heliotrine results in decreased expression of PARP1 protein CTD PMID:29458164 hellebrigenin increases activity ISO PARP1 (Homo sapiens) 6480464 hellebrigenin results in increased activity of PARP1 protein CTD PMID:24954031 heparin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Heparin promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein] CTD PMID:30377735 herbimycin increases cleavage EXP 6480464 herbimycin results in increased cleavage of PARP1 protein CTD PMID:11035063 hesperidin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 mRNA more ... CTD PMID:30368987 and PMID:33908150 hexadecanoic acid increases cleavage EXP 6480464 Palmitic Acid results in increased cleavage of PARP1 protein CTD PMID:30208301 hexadecanoic acid increases expression EXP 6480464 Palmitic Acid results in increased expression of PARP1 protein modified form CTD PMID:34678374 hexadecanoic acid increases expression ISO Parp1 (Rattus norvegicus) 6480464 Palmitic Acid results in increased expression of PARP1 mRNA and Palmitic Acid results in increased expression of PARP1 protein CTD PMID:19513971 hexadecanoic acid multiple interactions EXP 6480464 carnosol inhibits the reaction [Palmitic Acid results in increased expression of PARP1 protein modified form] more ... CTD PMID:30208301 and PMID:34678374 homoeriodictyol multiple interactions ISO PARP1 (Homo sapiens) 6480464 homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:29902531 homovanillic acid multiple interactions EXP 6480464 [PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:10318960 Honokiol increases cleavage ISO PARP1 (Homo sapiens) 6480464 honokiol results in increased cleavage of PARP1 protein CTD PMID:15802533 hydralazine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of PARP1 mRNA CTD PMID:17183730 hydrogen peroxide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Rotenone results in increased abundance of Hydrogen Peroxide] which results in increased cleavage of PARP1 protein more ... CTD PMID:14505808 more ... hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of PARP1 protein CTD PMID:26218895 hydrogen peroxide affects expression ISO PARP1 (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of PARP1 protein CTD PMID:17961220 hydrogen peroxide increases ADP-ribosylation ISO PARP1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased ADP-ribosylation of PARP1 protein CTD PMID:27694308 hydrogen peroxide increases expression ISO PARP1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of PARP1 protein modified form CTD PMID:16709600 and PMID:23726866 hydrogen peroxide increases response to substance EXP 6480464 PARP1 protein results in increased susceptibility to Hydrogen Peroxide CTD PMID:20878536 and PMID:26218895 hydrogen peroxide increases cleavage EXP 6480464 Hydrogen Peroxide results in increased cleavage of PARP1 protein CTD PMID:15876423 more ... hydrogen peroxide increases activity EXP 6480464 Hydrogen Peroxide results in increased activity of PARP1 protein CTD PMID:11593040 and PMID:24814482 hydrogen peroxide increases expression ISO Parp1 (Rattus norvegicus) 6480464 Hydrogen Peroxide results in increased expression of PARP1 protein modified form CTD PMID:22081883 hydrogen peroxide increases degradation ISO Parp1 (Rattus norvegicus) 6480464 Hydrogen Peroxide results in increased degradation of PARP1 protein CTD PMID:16157298 hydrogen peroxide decreases response to substance EXP 6480464 PARP1 gene mutant form results in decreased susceptibility to Hydrogen Peroxide CTD PMID:17438151 hydrogen peroxide multiple interactions EXP 6480464 [benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Hydrogen Peroxide more ... CTD PMID:11593040 more ... hydrogen peroxide affects response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the susceptibility to Hydrogen Peroxide CTD PMID:19111594 and PMID:27694308 hydrogen peroxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased cleavage of PARP1 protein CTD PMID:19815691 more ... hydrogen peroxide increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Hydrogen Peroxide results in increased cleavage of PARP1 protein CTD PMID:14505808 more ... hydrogen peroxide increases activity ISO PARP1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased activity of PARP1 protein CTD PMID:11217149 more ... hydrogen peroxide multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein] more ... CTD PMID:11217149 more ... hydroquinone increases cleavage ISO PARP1 (Homo sapiens) 6480464 hydroquinone results in increased cleavage of PARP1 protein CTD PMID:19064679 more ... hydroquinone decreases expression ISO PARP1 (Homo sapiens) 6480464 hydroquinone results in decreased expression of PARP1 protein CTD PMID:26822515 hydroquinone increases degradation ISO PARP1 (Homo sapiens) 6480464 hydroquinone results in increased degradation of PARP1 protein CTD PMID:35302183 hydroquinone increases expression ISO PARP1 (Homo sapiens) 6480464 hydroquinone results in increased expression of PARP1 protein CTD PMID:28263894 more ... hydroquinone affects response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the susceptibility to hydroquinone CTD PMID:26335980 and PMID:28444915 hydroquinone affects expression ISO PARP1 (Homo sapiens) 6480464 hydroquinone affects the expression of PARP1 protein CTD PMID:26047893 hydroquinone increases response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein results in increased susceptibility to hydroquinone CTD PMID:26047893 hydroquinone multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [hydroquinone results in increased expression of PARP1 protein] more ... CTD PMID:19064679 more ... hydroxamic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Hydroxamic Acids results in increased cleavage of PARP1 protein CTD PMID:27163855 hydroxychloroquine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Hydroxychloroquine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein] CTD PMID:36843289 icariside II increases cleavage ISO PARP1 (Homo sapiens) 6480464 baohuoside I results in increased cleavage of PARP1 protein CTD PMID:19289254 and PMID:22687635 icariside II multiple interactions ISO PARP1 (Homo sapiens) 6480464 Dinoprostone inhibits the reaction [baohuoside I results in increased cleavage of PARP1 protein] and PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein] CTD PMID:19289254 idarubicin multiple interactions EXP 6480464 Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 mRNA] and Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 protein] CTD PMID:28973540 idarubicin increases expression EXP 6480464 Idarubicin results in increased expression of PARP1 mRNA and Idarubicin results in increased expression of PARP1 protein CTD PMID:28973540 idelalisib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein CTD PMID:23676220 Ilimaquinone multiple interactions ISO PARP1 (Homo sapiens) 6480464 [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein and ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:24930757 Ilimaquinone increases cleavage ISO PARP1 (Homo sapiens) 6480464 ilimaquinone results in increased cleavage of PARP1 protein CTD PMID:24930757 imipramine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Imipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 Indeno[1,2,3-cd]pyrene increases cleavage ISO PARP1 (Homo sapiens) 6480464 indeno(1 more ... CTD PMID:21132278 indole-3-butyric acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 indolebutyric acid analog results in increased cleavage of PARP1 protein CTD PMID:23499788 indole-3-methanol multiple interactions ISO PARP1 (Homo sapiens) 6480464 indole-3-carbinol promotes the reaction [TNF protein results in increased cleavage of PARP1 protein] and indole-3-carbinol results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:15811958 and PMID:29992829 indole-3-methanol increases cleavage EXP 6480464 indole-3-carbinol results in increased cleavage of PARP1 protein CTD PMID:29775573 indometacin multiple interactions ISO PARP1 (Homo sapiens) 6480464 (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1 more ... CTD PMID:17873517 more ... indometacin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Indomethacin results in increased cleavage of PARP1 protein CTD PMID:11532860 more ... iodoacetic acid increases expression ISO PARP1 (Homo sapiens) 6480464 Iodoacetic Acid results in increased expression of PARP1 protein modified form CTD PMID:25944804 irinotecan increases expression ISO PARP1 (Homo sapiens) 6480464 Irinotecan results in increased expression of PARP1 protein CTD PMID:30612311 irinotecan multiple interactions ISO PARP1 (Homo sapiens) 6480464 rucaparib inhibits the reaction [Irinotecan results in increased expression of PARP1 protein] CTD PMID:30612311 iron atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein more ... CTD PMID:30626086 more ... iron(0) multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein more ... CTD PMID:30626086 more ... isoalantolactone increases cleavage ISO PARP1 (Homo sapiens) 6480464 isoalantolactone results in increased cleavage of PARP1 protein CTD PMID:29800641 isoalantolactone multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form] more ... CTD PMID:29800641 isoalantolactone increases expression ISO PARP1 (Homo sapiens) 6480464 isoalantolactone results in increased expression of PARP1 protein modified form CTD PMID:29800641 isobavachalcone increases cleavage ISO PARP1 (Homo sapiens) 6480464 isobavachalcone results in increased cleavage of PARP1 protein CTD PMID:30890322 Isoliensinine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [isoliensinine results in increased cleavage of PARP1 protein] more ... CTD PMID:26219228 Isoliensinine increases cleavage ISO PARP1 (Homo sapiens) 6480464 isoliensinine results in increased cleavage of PARP1 protein CTD PMID:26219228 isoliquiritigenin increases cleavage ISO PARP1 (Homo sapiens) 6480464 isoliquiritigenin results in increased cleavage of PARP1 protein CTD PMID:23747687 isoliquiritigenin multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of PARP1 protein] CTD PMID:23747687 isoprenaline multiple interactions EXP 6480464 BMP10 protein inhibits the reaction [Isoproterenol results in increased cleavage of PARP1 protein] CTD PMID:31712309 isoprenaline multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 erdosteine affects the reaction [Isoproterenol results in increased expression of PARP1 protein] CTD PMID:33210414 isoprenaline increases expression ISO Parp1 (Rattus norvegicus) 6480464 Isoproterenol results in increased expression of PARP1 protein CTD PMID:33210414 isoprenaline decreases expression ISO PARP1 (Homo sapiens) 6480464 Isoproterenol results in decreased expression of PARP1 protein CTD PMID:29438734 isoprenaline increases cleavage EXP 6480464 Isoproterenol results in increased cleavage of PARP1 protein CTD PMID:31712309 isoquinoline-1,5-diol multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 1 and 5-dihydroxyisoquinoline inhibits the reaction [Vancomycin results in increased expression of PARP1 protein] CTD PMID:19833176 isoquinoline-1,5-diol multiple interactions ISO PARP1 (Homo sapiens) 6480464 1 more ... CTD PMID:25517228 isoquinoline-1,5-diol decreases activity ISO PARP1 (Homo sapiens) 6480464 1 and 5-dihydroxyisoquinoline results in decreased activity of PARP1 protein CTD PMID:25517228 isoquinoline-1,5-diol decreases expression ISO Parp1 (Rattus norvegicus) 6480464 1 and 5-dihydroxyisoquinoline results in decreased expression of PARP1 protein CTD PMID:12824290 isorhamnetin increases cleavage ISO PARP1 (Homo sapiens) 6480464 3-methylquercetin results in increased cleavage of PARP1 protein CTD PMID:22992727 ivermectin decreases expression ISO PARP1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of PARP1 protein CTD PMID:32959892 ivermectin increases expression ISO PARP1 (Homo sapiens) 6480464 Ivermectin results in increased expression of PARP1 protein modified form CTD PMID:28811376 jaceosidin multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein] more ... CTD PMID:27729209 jaceosidin increases cleavage ISO PARP1 (Homo sapiens) 6480464 jaceosidin results in increased cleavage of PARP1 protein CTD PMID:27729209 JBIR-99 decreases expression ISO PARP1 (Homo sapiens) 6480464 JBIR-99 results in decreased expression of PARP1 protein CTD PMID:31433962 juglone multiple interactions ISO PARP1 (Homo sapiens) 6480464 [juglone co-treated with Ascorbic Acid] results in increased degradation of PARP1 protein CTD PMID:29992683 kaempferol multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] CTD PMID:22155320 kaempferol increases cleavage ISO PARP1 (Homo sapiens) 6480464 kaempferol results in increased cleavage of PARP1 protein CTD PMID:16014620 kaempferol multiple interactions ISO PARP1 (Homo sapiens) 6480464 3' and 4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of PARP1 protein] CTD PMID:16014620 kahweol multiple interactions ISO PARP1 (Homo sapiens) 6480464 kahweol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:31306736 kahweol increases cleavage ISO PARP1 (Homo sapiens) 6480464 kahweol results in increased cleavage of PARP1 protein CTD PMID:30205135 kainic acid increases activity ISO Parp1 (Rattus norvegicus) 6480464 Kainic Acid results in increased activity of PARP1 protein CTD PMID:28704930 ketoconazole increases expression ISO PARP1 (Homo sapiens) 6480464 Ketoconazole results in increased expression of PARP1 mRNA CTD PMID:36621641 L-1,4-dithiothreitol multiple interactions EXP 6480464 Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:11035063 L-1,4-dithiothreitol multiple interactions ISO PARP1 (Homo sapiens) 6480464 Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein] and Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein] CTD PMID:18022205 and PMID:20438634 L-ascorbic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [juglone co-treated with Ascorbic Acid] results in increased degradation of PARP1 protein more ... CTD PMID:16407847 more ... L-ascorbic acid multiple interactions EXP 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of PARP1 mRNA more ... CTD PMID:26492236 L-ascorbic acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Ascorbic Acid inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] and Ascorbic Acid inhibits the reaction [Potassium Dichromate results in increased cleavage of PARP1 protein] CTD PMID:19433269 and PMID:21262251 L-ascorbic acid 2-phosphate multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of PARP1 protein modified form more ... CTD PMID:22940495 L-gamma-glutamyl-L-cysteine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 AKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]] more ... CTD PMID:34767868 lactulose multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Lactulose inhibits the reaction [Methamphetamine results in increased expression of PARP1 protein modified form] CTD PMID:30450033 lapatinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Lapatinib results in increased cleavage of PARP1 protein] more ... CTD PMID:25981168 more ... lapatinib increases cleavage ISO PARP1 (Homo sapiens) 6480464 Lapatinib results in increased cleavage of PARP1 protein CTD PMID:25221644 and PMID:29387217 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of PARP1 mRNA CTD PMID:21829687 lead diacetate increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 lead acetate results in increased cleavage of PARP1 protein CTD PMID:28283887 lead diacetate multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [[lead acetate co-treated with Cadmium Chloride] results in increased expression of PARP1 mRNA] more ... CTD PMID:28283887 lead diacetate increases expression ISO Parp1 (Rattus norvegicus) 6480464 lead acetate results in increased expression of PARP1 mRNA CTD PMID:28283887 lead(0) affects expression ISO PARP1 (Homo sapiens) 6480464 Lead affects the expression of PARP1 mRNA CTD PMID:28903495 lead(0) multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein and Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein] CTD PMID:29115570 LGK974 multiple interactions ISO PARP1 (Homo sapiens) 6480464 LGK974 inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein] CTD PMID:30205152 Licochalcone A increases cleavage ISO PARP1 (Homo sapiens) 6480464 licochalcone A results in increased cleavage of PARP1 protein CTD PMID:30983163 Licochalcone B multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [licochalcone B results in increased cleavage of PARP1 protein] more ... CTD PMID:35948134 Licochalcone B increases cleavage ISO PARP1 (Homo sapiens) 6480464 licochalcone B results in increased cleavage of PARP1 protein CTD PMID:35948134 licoricidin increases cleavage ISO PARP1 (Homo sapiens) 6480464 licoricidin results in increased cleavage of PARP1 protein CTD PMID:37013980 lignan increases cleavage ISO PARP1 (Homo sapiens) 6480464 Lignans analog results in increased cleavage of PARP1 protein CTD PMID:26620693 linsidomine multiple interactions EXP 6480464 Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein] CTD PMID:12880480 linsidomine increases cleavage ISO PARP1 (Homo sapiens) 6480464 linsidomine results in increased cleavage of PARP1 protein CTD PMID:34519134 linsidomine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [bosutinib co-treated with linsidomine] affects the expression of PARP1 protein more ... CTD PMID:31152818 and PMID:34519134 linsidomine decreases folding ISO PARP1 (Homo sapiens) 6480464 linsidomine results in decreased folding of PARP1 protein CTD PMID:31152818 linsidomine decreases activity ISO PARP1 (Homo sapiens) 6480464 linsidomine results in decreased activity of PARP1 protein CTD PMID:31152818 linsidomine decreases expression EXP 6480464 linsidomine results in decreased expression of PARP1 protein CTD PMID:12880480 lipopolysaccharide multiple interactions EXP 6480464 [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein] which results in increased cleavage of PARP1 protein more ... CTD PMID:11818323 more ... lipopolysaccharide multiple interactions ISO PARP1 (Homo sapiens) 6480464 3 more ... CTD PMID:23011206 lipopolysaccharide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Sialic Acids inhibits the reaction [Lipopolysaccharides results in increased expression of PARP1 protein] CTD PMID:24973090 lipopolysaccharide increases expression ISO Parp1 (Rattus norvegicus) 6480464 Lipopolysaccharides results in increased expression of PARP1 protein CTD PMID:24973090 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of PARP1 protein modified form CTD PMID:23170834 lithium atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 Lithium inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:17849503 lithium chloride multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein] more ... CTD PMID:27658547 more ... lithium chloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 Lithium Chloride inhibits the reaction [hydroquinone results in increased cleavage of PARP1 protein] and Lithium Chloride inhibits the reaction [quinocetone results in increased expression of PARP1 protein modified form] CTD PMID:28343033 and PMID:28886972 lithium hydride multiple interactions ISO PARP1 (Homo sapiens) 6480464 Lithium inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:17849503 lithocholic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [Lithocholic Acid analog results in increased activity of PARP1 protein] CTD PMID:2120135 lithocholic acid increases activity ISO PARP1 (Homo sapiens) 6480464 Lithocholic Acid analog results in increased activity of PARP1 protein CTD PMID:2120135 LM-1685 multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[LM-1685 co-treated with carboxyamido-triazole] results in increased cleavage of PARP1 protein] CTD PMID:15867384 Longikaurin A increases expression ISO PARP1 (Homo sapiens) 6480464 longikaurin A results in increased expression of PARP1 protein modified form CTD PMID:28801140 losartan multiple interactions EXP 6480464 Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein] CTD PMID:15502880 losartan multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein] CTD PMID:21613793 lovastatin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Lovastatin analog results in increased cleavage of PARP1 protein CTD PMID:26863638 Lupiwighteone increases cleavage ISO PARP1 (Homo sapiens) 6480464 lupiwighteone results in increased cleavage of PARP1 protein CTD PMID:31604113 luteolin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Luteolin results in increased cleavage of PARP1 protein CTD PMID:12168845 more ... luteolin multiple interactions EXP 6480464 Luteolin inhibits the reaction [Tunicamycin results in increased expression of PARP1 protein modified form] CTD PMID:32407927 luteolin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Luteolin co-treated with Paclitaxel] results in decreased expression of PARP1 protein more ... CTD PMID:24525192 more ... luteolin increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Luteolin results in increased cleavage of PARP1 protein CTD PMID:31201582 luteolin 7-O-beta-D-glucoside multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [luteolin-7-glucoside results in increased cleavage of PARP1 protein] more ... CTD PMID:34165247 luteolin 7-O-beta-D-glucoside increases cleavage ISO PARP1 (Homo sapiens) 6480464 luteolin-7-glucoside results in increased cleavage of PARP1 protein CTD PMID:34165247 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased cleavage of PARP1 protein] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein] CTD PMID:14687664 and PMID:23143138 LY294002 increases cleavage ISO PARP1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of PARP1 protein CTD PMID:14688022 more ... LY294002 multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:27658547 LY294002 multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein] more ... CTD PMID:19261616 more ... lycopene multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 lycopene inhibits the reaction [decamethrin results in increased activity of PARP1 protein] CTD PMID:23076637 lysophosphatidylethanolamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of PARP1 protein] CTD PMID:25125499 Maduramicin increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 maduramicin results in increased cleavage of PARP1 protein CTD PMID:29047155 Maduramicin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [maduramicin results in increased cleavage of PARP1 protein] CTD PMID:29047155 malathion multiple interactions EXP 6480464 Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein] CTD PMID:29027213 malathion increases cleavage EXP 6480464 Malathion results in increased cleavage of PARP1 protein CTD PMID:29027213 malvidin increases cleavage ISO PARP1 (Homo sapiens) 6480464 malvidin results in increased cleavage of PARP1 protein CTD PMID:15964118 manganese atom multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein more ... CTD PMID:25791630 manganese atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein and Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein] CTD PMID:29115570 manganese atom increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Manganese results in increased cleavage of PARP1 protein CTD PMID:25448048 and PMID:25791630 manganese(0) increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Manganese results in increased cleavage of PARP1 protein CTD PMID:25448048 and PMID:25791630 manganese(0) multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein and Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein] CTD PMID:29115570 manganese(0) multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein more ... CTD PMID:25791630 manganese(II) chloride increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 manganese chloride results in increased cleavage of PARP1 protein CTD PMID:21704098 manganese(II) chloride multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [manganese chloride results in increased cleavage of PARP1 protein] CTD PMID:21704098 manganese(II) chloride multiple interactions EXP 6480464 [Plant Extracts co-treated with manganese chloride] affects the cleavage of PARP1 protein CTD PMID:26064043 manumycin A increases cleavage ISO PARP1 (Homo sapiens) 6480464 manumycin results in increased cleavage of PARP1 and manumycin results in increased cleavage of PARP1 protein CTD PMID:14625852 and PMID:19409983 manumycin A multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [manumycin results in increased cleavage of PARP1] and Quercetin promotes the reaction [manumycin results in increased cleavage of PARP1 protein] CTD PMID:14625852 and PMID:19409983 Melarsoprol increases cleavage ISO PARP1 (Homo sapiens) 6480464 Melarsoprol results in increased cleavage of PARP1 protein CTD PMID:15314284 melatonin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Melatonin inhibits the reaction [Doxorubicin results in increased expression of PARP1 protein modified form] CTD PMID:29966675 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Atrazine results in increased cleavage of PARP1 protein] CTD PMID:25259610 melittin multiple interactions EXP 6480464 Melitten inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein] CTD PMID:21871910 menadione multiple interactions ISO PARP1 (Homo sapiens) 6480464 [sodium arsenite co-treated with Vitamin K 3] results in increased cleavage of PARP1 protein CTD PMID:19082730 menadione affects response to substance EXP 6480464 PARP1 protein affects the susceptibility to Vitamin K 3 CTD PMID:21124846 menaquinone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Vitamin K 2 results in increased cleavage of PARP1 protein CTD PMID:29432837 mercury atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein and Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein] CTD PMID:29115570 mercury dichloride increases cleavage ISO PARP1 (Homo sapiens) 6480464 Mercuric Chloride results in increased cleavage of PARP1 protein CTD PMID:11068922 more ... mercury dichloride multiple interactions EXP 6480464 [Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of PARP1 protein and Acetylcysteine inhibits the reaction [[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of PARP1 protein] CTD PMID:22909951 mercury(0) multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein and Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein] CTD PMID:29115570 mesalamine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Mesalamine results in increased cleavage of PARP1 protein CTD PMID:12663503 metformin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of PARP1 protein] CTD PMID:27551045 metformin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Metformin results in increased cleavage of PARP1 protein CTD PMID:35350904 metformin multiple interactions EXP 6480464 Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]] and Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form] CTD PMID:29095437 metformin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA more ... CTD PMID:29117515 and PMID:35350904 metformin increases expression ISO PARP1 (Homo sapiens) 6480464 Metformin results in increased expression of PARP1 mRNA CTD PMID:29117515 methamphetamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 BBC3 protein affects the reaction [Methamphetamine results in decreased cleavage of PARP1 protein] more ... CTD PMID:25523949 more ... methamphetamine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Methamphetamine results in increased cleavage of PARP1 protein CTD PMID:25523949 and PMID:31059759 methamphetamine increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Methamphetamine results in increased cleavage of PARP1 protein CTD PMID:25631491 more ... methamphetamine increases activity ISO Parp1 (Rattus norvegicus) 6480464 Methamphetamine results in increased activity of PARP1 protein CTD PMID:25127757 methamphetamine decreases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Methamphetamine results in decreased cleavage of PARP1 protein CTD PMID:26524635 methamphetamine increases expression ISO Parp1 (Rattus norvegicus) 6480464 Methamphetamine results in increased expression of PARP1 protein modified form CTD PMID:26825372 more ... methamphetamine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 3-methyladenine promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein] more ... CTD PMID:25127757 more ... methamphetamine decreases cleavage ISO PARP1 (Homo sapiens) 6480464 Methamphetamine results in decreased cleavage of PARP1 protein CTD PMID:26524635 methotrexate multiple interactions ISO PARP1 (Homo sapiens) 6480464 ESRRA protein inhibits the reaction [Methotrexate results in increased cleavage of PARP1 protein] CTD PMID:24967384 methotrexate multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 DHFR protein inhibits the reaction [Methotrexate results in increased cleavage of PARP1 protein] and Folic Acid inhibits the reaction [Methotrexate results in increased cleavage of PARP1 protein] CTD PMID:30502384 methotrexate increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Methotrexate results in increased cleavage of PARP1 protein CTD PMID:30502384 methotrexate increases cleavage ISO PARP1 (Homo sapiens) 6480464 Methotrexate results in increased cleavage of PARP1 protein CTD PMID:17286800 and PMID:24967384 methoxsalen multiple interactions ISO PARP1 (Homo sapiens) 6480464 Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form] CTD PMID:22743290 methoxyacetic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in increased cleavage of PARP1 protein CTD PMID:26006246 methyl beta-cyclodextrin multiple interactions ISO PARP1 (Homo sapiens) 6480464 methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein] CTD PMID:21362627 methyl caffeate multiple interactions ISO PARP1 (Homo sapiens) 6480464 methyl caffeate binds to and results in increased activity of PARP1 protein CTD PMID:26415618 methyl methanesulfonate affects response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the susceptibility to Methyl Methanesulfonate CTD PMID:19111594 methyl methanesulfonate decreases expression ISO PARP1 (Homo sapiens) 6480464 Methyl Methanesulfonate results in decreased expression of PARP1 mRNA CTD PMID:23649840 methylglyoxal increases cleavage ISO PARP1 (Homo sapiens) 6480464 Pyruvaldehyde results in increased cleavage of PARP1 protein CTD PMID:31254498 and PMID:33930484 methylglyoxal multiple interactions ISO PARP1 (Homo sapiens) 6480464 naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein] more ... CTD PMID:31254498 and PMID:33930484 methylisothiazolinone increases cleavage ISO PARP1 (Homo sapiens) 6480464 2-methyl-4-isothiazolin-3-one results in increased cleavage of PARP1 protein CTD PMID:29110394 methylmercury chloride increases cleavage ISO PARP1 (Homo sapiens) 6480464 methylmercuric chloride results in increased cleavage of PARP1 protein CTD PMID:11068922 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of PARP1 protein modified form CTD PMID:31330229 methylmercury chloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of PARP1 protein] and AKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased expression of PARP1 protein modified form] CTD PMID:31330229 methylseleninic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [2 more ... CTD PMID:16204082 more ... methylseleninic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 methylselenic acid results in increased cleavage of PARP1 protein CTD PMID:15845651 more ... methylseleninic acid increases cleavage EXP 6480464 methylselenic acid results in increased cleavage of PARP1 protein CTD PMID:19276161 metipranolol multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Metipranolol inhibits the reaction [Zinc results in decreased expression of PARP1 protein] and Metipranolol inhibits the reaction [Zinc Sulfate results in decreased expression of PARP1 protein] CTD PMID:16799065 metoclopramide multiple interactions EXP 6480464 Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein] and Metoclopramide inhibits the reaction [Paraoxon results in increased cleavage of PARP1 protein] CTD PMID:29027213 mevalonic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] more ... CTD PMID:20045437 and PMID:21910007 Mezerein multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [mezerein results in increased activity of PARP1 protein] CTD PMID:2120135 Mezerein increases activity ISO PARP1 (Homo sapiens) 6480464 mezerein results in increased activity of PARP1 protein CTD PMID:2120135 and PMID:2126186 microcystin-LR increases cleavage EXP 6480464 cyanoginosin LR results in increased cleavage of PARP1 protein CTD PMID:21684301 microcystin-LR multiple interactions ISO PARP1 (Homo sapiens) 6480464 [cyanoginosin LR inhibits the reaction [PARP1 protein binds to TIMELESS protein]] promotes the reaction [CGAS protein binds to PARP1 protein] more ... CTD PMID:36435412 microcystin-LR multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein] CTD PMID:31157505 microcystin-LR increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 cyanoginosin LR results in increased cleavage of PARP1 protein CTD PMID:31157505 microcystin-LR multiple interactions EXP 6480464 sulforaphane inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein] CTD PMID:21684301 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone results in increased cleavage of PARP1 protein] CTD PMID:16644695 mifepristone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Mifepristone results in increased cleavage of PARP1 protein CTD PMID:16525653 mitomycin C multiple interactions ISO PARP1 (Homo sapiens) 6480464 CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]] more ... CTD PMID:15905168 and PMID:24124520 mitomycin C decreases response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein results in decreased susceptibility to Mitomycin CTD PMID:28757444 mitomycin C increases cleavage ISO PARP1 (Homo sapiens) 6480464 Mitomycin results in increased cleavage of PARP1 protein CTD PMID:24124520 mitomycin C increases activity ISO PARP1 (Homo sapiens) 6480464 Mitomycin results in increased activity of PARP1 protein CTD PMID:15905168 mitoxantrone multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein more ... CTD PMID:15582267 and PMID:8840993 MK-2206 multiple interactions ISO PARP1 (Homo sapiens) 6480464 [mirdametinib co-treated with MK 2206] results in increased cleavage of PARP1 protein more ... CTD PMID:27634878 monensin A increases cleavage ISO PARP1 (Homo sapiens) 6480464 Monensin results in increased cleavage of PARP1 protein CTD PMID:30718715 monocrotophos increases expression ISO PARP1 (Homo sapiens) 6480464 Monocrotophos results in increased expression of PARP1 mRNA and Monocrotophos results in increased expression of PARP1 protein CTD PMID:28887667 morin increases expression ISO PARP1 (Homo sapiens) 6480464 morin results in increased expression of PARP1 mRNA CTD PMID:28689916 morpholines multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Morpholines analog results in increased cleavage of PARP1 protein] and Acetylcysteine inhibits the reaction [Morpholines analog results in increased cleavage of PARP1 protein] CTD PMID:24875536 morpholines increases cleavage ISO PARP1 (Homo sapiens) 6480464 Morpholines analog results in increased cleavage of PARP1 protein CTD PMID:24875536 morusin multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of PARP1 protein] more ... CTD PMID:33035517 morusin increases cleavage ISO PARP1 (Homo sapiens) 6480464 morusin results in increased cleavage of PARP1 protein CTD PMID:33035517 and PMID:37443484 myo-inositol hexakisphosphate multiple interactions ISO PARP1 (Homo sapiens) 6480464 Phytic Acid inhibits the reaction [Asbestos more ... CTD PMID:11217149 myricetin increases cleavage ISO PARP1 (Homo sapiens) 6480464 myricetin results in increased cleavage of PARP1 protein CTD PMID:15748703 and PMID:29698783 myricetin decreases activity ISO PARP1 (Homo sapiens) 6480464 myricetin results in decreased activity of PARP1 protein CTD PMID:17884996 myriocin multiple interactions ISO PARP1 (Homo sapiens) 6480464 thermozymocidin inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 myristicin increases cleavage ISO PARP1 (Homo sapiens) 6480464 myristicin results in increased cleavage of PARP1 protein CTD PMID:24792648 N(gamma)-nitro-L-arginine methyl ester multiple interactions EXP 6480464 NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein] CTD PMID:15502880 N(omega)-methyl-L-arginine multiple interactions ISO PARP1 (Homo sapiens) 6480464 omega-N-Methylarginine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine decreases activity ISO PARP1 (Homo sapiens) 6480464 N more ... CTD PMID:24275069 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine multiple interactions EXP 6480464 N more ... CTD PMID:22253048 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 N more ... CTD PMID:15966574 more ... N,N-dimethylformamide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Dimethylformamide co-treated with Carbon Tetrachloride] results in increased cleavage of PARP1 protein CTD PMID:20097184 N,N-dimethylsphingosine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Bortezomib co-treated with N and N-dimethylsphingosine] results in increased cleavage of PARP1 protein CTD PMID:21195056 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [1 more ... CTD PMID:14687664 more ... N-acetyl-L-cysteine decreases expression ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine results in decreased expression of PARP1 protein modified form CTD PMID:31433961 N-acetyl-L-cysteine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased cleavage of PARP1 protein] more ... CTD PMID:11470263 more ... N-acetyl-L-cysteine multiple interactions ISO PARP1 (Homo sapiens) 127284846 N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of PARP protein in the stomach) RGD N-acetyl-L-cysteine increases cleavage EXP 6480464 Acetylcysteine results in increased cleavage of PARP1 protein CTD PMID:15375156 N-acetyl-L-cysteine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] more ... CTD PMID:14660655 more ... N-acetylsphingosine increases activity ISO PARP1 (Homo sapiens) 6480464 N-acetylsphingosine results in increased activity of PARP1 protein CTD PMID:24420784 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases cleavage EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of PARP1 protein CTD PMID:20100472 and PMID:34418242 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases cleavage ISO PARP1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of PARP1 protein CTD PMID:15498850 more ... N-methyl-4-phenylpyridinium increases cleavage ISO PARP1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein CTD PMID:20946892 more ... N-methyl-4-phenylpyridinium increases expression ISO PARP1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PARP1 protein modified form CTD PMID:28481321 and PMID:31342299 N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 8-phenyl-6a more ... CTD PMID:20946892 N-methyl-4-phenylpyridinium multiple interactions ISO PARP1 (Homo sapiens) 6480464 8-phenyl-6a more ... CTD PMID:20946892 more ... N-methyl-4-phenylpyridinium increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein CTD PMID:24875324 N-methyl-4-phenylpyridinium multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Plant Preparations inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein] and Polysaccharides inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein] CTD PMID:24875324 N-methyl-4-phenylpyridinium increases cleavage EXP 6480464 1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein CTD PMID:20946892 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PARP1 protein CTD PMID:26558463 N-methyl-D-aspartic acid increases ADP-ribosylation ISO Parp1 (Rattus norvegicus) 6480464 N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 [benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Methylnitronitrosoguanidine more ... CTD PMID:11593040 more ... N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of PARP1 protein CTD PMID:26954031 N-methyl-N'-nitro-N-nitrosoguanidine increases response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein results in increased susceptibility to Methylnitronitrosoguanidine CTD PMID:22001597 N-methyl-N'-nitro-N-nitrosoguanidine affects cleavage EXP 6480464 Methylnitronitrosoguanidine affects the cleavage of PARP1 protein CTD PMID:20434464 N-methyl-N'-nitro-N-nitrosoguanidine increases activity EXP 6480464 Methylnitronitrosoguanidine results in increased activity of PARP1 protein CTD PMID:11593040 N-methyl-N-nitrosourea increases response to substance EXP 6480464 PARP1 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:15282315 N-methyl-N-nitrosourea multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Niacinamide inhibits the reaction [Methylnitrosourea results in increased activity of PARP1 protein] CTD PMID:16168987 N-methyl-N-nitrosourea increases activity ISO Parp1 (Rattus norvegicus) 6480464 Methylnitrosourea results in increased activity of PARP1 protein CTD PMID:16168987 N-methyl-N-nitrosourea affects response to substance EXP 6480464 PARP1 protein affects the susceptibility to Methylnitrosourea CTD PMID:11850828 N-methyl-N-nitrosourea multiple interactions EXP 6480464 PARP1 protein affects the reaction [Methylnitrosourea affects the activity of TRP53 protein] more ... CTD PMID:11850828 and PMID:16052507 N-methylnicotinate multiple interactions ISO PARP1 (Homo sapiens) 6480464 [trigonelline co-treated with Cisplatin] results in increased cleavage of PARP1 protein and [trigonelline co-treated with Etoposide] results in increased cleavage of PARP1 protein CTD PMID:33148531 N-methylnicotinate multiple interactions EXP 6480464 trigonelline inhibits the reaction [Palmitic Acid results in increased cleavage of PARP1 protein] CTD PMID:30208301 N-Nitrosodi-n-butylamine increases cleavage ISO PARP1 (Homo sapiens) 6480464 dibutylnitrosamine results in increased cleavage of PARP1 protein CTD PMID:17929238 N-nitrosodiethylamine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PARP1 mRNA CTD PMID:17602206 N-nitrosopiperidine increases cleavage ISO PARP1 (Homo sapiens) 6480464 N-nitrosopiperidine results in increased cleavage of PARP1 protein CTD PMID:17929238 N-tosyl-L-phenylalanyl chloromethyl ketone multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of PARP1 protein] CTD PMID:19679660 N-tosyl-L-phenylalanyl chloromethyl ketone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of PARP1 protein CTD PMID:19679660 N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Ranitidine inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:19723537 NAD zwitterion multiple interactions ISO PARP1 (Homo sapiens) 6480464 [2 more ... CTD PMID:17669606 more ... NAD zwitterion multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 5-chloro-2-(3-(4-phenyl-3 and 6-dihydro-1(2H)-pyridinyl)propyl)-4(3H)-quinazolinone inhibits the reaction [PARP1 protein results in decreased abundance of NAD] CTD PMID:15075382 NAD zwitterion decreases abundance ISO Parp1 (Rattus norvegicus) 6480464 PARP1 protein results in decreased abundance of NAD CTD PMID:15075382 NAD zwitterion affects abundance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein mutant form affects the abundance of NAD CTD PMID:27694308 NAD zwitterion affects abundance ISO Parp1 (Rattus norvegicus) 6480464 PARP1 protein affects the abundance of NAD CTD PMID:15147502 NAD zwitterion multiple interactions EXP 6480464 [Hydrogen Peroxide results in increased activity of PARP1 protein] which results in decreased abundance of NAD more ... CTD PMID:11593040 NAD(+) multiple interactions ISO PARP1 (Homo sapiens) 6480464 [2 more ... CTD PMID:17669606 more ... NAD(+) decreases abundance ISO Parp1 (Rattus norvegicus) 6480464 PARP1 protein results in decreased abundance of NAD CTD PMID:15075382 NAD(+) multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 5-chloro-2-(3-(4-phenyl-3 and 6-dihydro-1(2H)-pyridinyl)propyl)-4(3H)-quinazolinone inhibits the reaction [PARP1 protein results in decreased abundance of NAD] CTD PMID:15075382 NAD(+) affects abundance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein mutant form affects the abundance of NAD CTD PMID:27694308 NAD(+) affects abundance ISO Parp1 (Rattus norvegicus) 6480464 PARP1 protein affects the abundance of NAD CTD PMID:15147502 NAD(+) multiple interactions EXP 6480464 [Hydrogen Peroxide results in increased activity of PARP1 protein] which results in decreased abundance of NAD more ... CTD PMID:11593040 NADP zwitterion multiple interactions ISO PARP1 (Homo sapiens) 6480464 [3-aminobenzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP] more ... CTD PMID:17669606 NADP(+) multiple interactions ISO PARP1 (Homo sapiens) 6480464 [3-aminobenzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP] more ... CTD PMID:17669606 navitoclax multiple interactions ISO PARP1 (Homo sapiens) 6480464 [MTOR protein affects the susceptibility to navitoclax] which affects the cleavage of PARP1 protein more ... CTD PMID:28947240 and PMID:32927276 navitoclax increases cleavage ISO PARP1 (Homo sapiens) 6480464 navitoclax results in increased cleavage of PARP1 protein CTD PMID:28947240 and PMID:32927276 neoastilbin multiple interactions ISO PARP1 (Homo sapiens) 6480464 astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:29471006 nickel atom decreases expression ISO PARP1 (Homo sapiens) 6480464 Nickel results in decreased expression of PARP1 mRNA CTD PMID:23195993 nickel atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein and Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein] CTD PMID:29115570 nickel atom affects binding ISO PARP1 (Homo sapiens) 6480464 PARP1 protein modified form binds to Nickel CTD PMID:25549802 nickel dichloride multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 alpha-Tocopherol inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein] more ... CTD PMID:21843586 and PMID:24448832 nickel dichloride increases cleavage ISO PARP1 (Homo sapiens) 6480464 nickel chloride results in increased cleavage of PARP1 protein CTD PMID:21828359 more ... nickel dichloride increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 nickel chloride results in increased cleavage of PARP1 protein CTD PMID:21843586 and PMID:24448832 nickel dichloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 [TP53 mutant form results in decreased susceptibility to nickel chloride] which results in decreased cleavage of PARP1 protein more ... CTD PMID:22172632 and PMID:23566959 nickel sulfate increases cleavage ISO PARP1 (Homo sapiens) 6480464 nickel sulfate results in increased cleavage of PARP1 protein CTD PMID:19135467 nickel sulfate multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [PARP1 protein results in increased susceptibility to [Potassium Dichromate co-treated with nickel sulfate]] more ... CTD PMID:20493934 nickel sulfate increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 nickel sulfate results in increased cleavage of PARP1 protein CTD PMID:19135467 niclosamide increases expression ISO PARP1 (Homo sapiens) 6480464 Niclosamide results in increased expression of PARP1 protein modified form CTD PMID:28500234 niclosamide decreases expression ISO PARP1 (Homo sapiens) 6480464 Niclosamide results in decreased expression of PARP1 protein CTD PMID:26917416 niclosamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 1 more ... CTD PMID:24750999 more ... niclosamide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Niclosamide results in increased cleavage of PARP1 protein CTD PMID:24750999 more ... niclosamide multiple interactions EXP 6480464 [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein CTD PMID:30258081 nicotinamide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Niacinamide inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of PARP1 protein] more ... CTD PMID:16168987 more ... nicotinamide increases expression ISO PARP1 (Homo sapiens) 6480464 Niacinamide results in increased expression of PARP1 mRNA and Niacinamide results in increased expression of PARP1 protein CTD PMID:29143419 nicotinamide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein and Niacinamide inhibits the reaction [sodium arsenite results in decreased expression of PARP1 protein] CTD PMID:26712469 and PMID:36958258 nicotinamide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Niacinamide results in increased cleavage of PARP1 protein CTD PMID:26712469 nicotinamide decreases activity ISO Parp1 (Rattus norvegicus) 6480464 Niacinamide results in decreased activity of PARP1 protein CTD PMID:19288225 nicotine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Nicotine inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form] more ... CTD PMID:20457658 more ... nicotine decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Nicotine results in decreased expression of PARP1 protein CTD PMID:29972271 nicotine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Folic Acid inhibits the reaction [Nicotine results in decreased expression of PARP1 protein] CTD PMID:29972271 nicotinic acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Niacin deficiency affects the reaction [Etoposide results in increased cleavage of PARP1 protein] CTD PMID:17516866 nicotinic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein CTD PMID:18377693 Niflumic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Niflumic Acid results in increased cleavage of PARP1 protein CTD PMID:21067863 Niflumic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ciglitazone promotes the reaction [Niflumic Acid results in increased cleavage of PARP1 protein]] more ... CTD PMID:21067863 nilotinib increases cleavage ISO PARP1 (Homo sapiens) 6480464 nilotinib results in increased cleavage of PARP1 protein CTD PMID:26549707 nilotinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [nilotinib results in increased cleavage of PARP1 protein] and benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [nilotinib results in increased cleavage of PARP1 protein] CTD PMID:26549707 nimesulide increases cleavage ISO PARP1 (Homo sapiens) 6480464 nimesulide results in increased cleavage of PARP1 protein CTD PMID:19360361 nimesulide increases expression ISO Parp1 (Rattus norvegicus) 6480464 nimesulide results in increased expression of PARP1 mRNA CTD PMID:24136188 niraparib multiple interactions ISO PARP1 (Homo sapiens) 6480464 niraparib binds to and results in decreased activity of PARP1 protein CTD PMID:28001384 nirogacestat increases cleavage ISO PARP1 (Homo sapiens) 6480464 nirogacestat results in increased cleavage of PARP1 protein CTD PMID:30940724 nirogacestat multiple interactions ISO PARP1 (Homo sapiens) 6480464 [nirogacestat results in increased susceptibility to enzalutamide] which results in increased cleavage of PARP1 protein CTD PMID:30940724 nitric oxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Nitric Oxide results in increased cleavage of PARP1 protein CTD PMID:15126337 and PMID:16024610 nitric oxide multiple interactions EXP 6480464 PARP1 gene mutant form inhibits the reaction [S100B protein results in increased secretion of Nitric Oxide] CTD PMID:27444121 nitric oxide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]] CTD PMID:10811113 nitroglycerin decreases expression ISO PARP1 (Homo sapiens) 6480464 Nitroglycerin results in decreased expression of PARP1 protein alternative form CTD PMID:17322376 nitroprusside multiple interactions ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:30296409 Nivalenol increases cleavage EXP 6480464 nivalenol results in increased cleavage of PARP1 protein CTD PMID:19410639 NMN zwitterion affects abundance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the abundance of Nicotinamide Mononucleotide CTD PMID:19426698 NMN zwitterion multiple interactions EXP 6480464 [Nicotinamide Mononucleotide co-treated with Cisplatin] results in decreased expression of PARP1 protein CTD PMID:34089817 nobiletin multiple interactions ISO PARP1 (Homo sapiens) 6480464 AGN 193109 inhibits the reaction [nobiletin results in decreased expression of and results in increased cleavage of PARP1 protein] and nobiletin results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:33058988 nocodazole multiple interactions ISO PARP1 (Homo sapiens) 6480464 TYMP inhibits the reaction [Nocodazole results in increased cleavage of PARP1 protein] CTD PMID:15907805 nocodazole increases cleavage ISO PARP1 (Homo sapiens) 6480464 Nocodazole analog results in increased cleavage of PARP1 protein and Nocodazole results in increased cleavage of PARP1 protein CTD PMID:15907805 more ... Nonidet P-40 decreases expression ISO PARP1 (Homo sapiens) 6480464 Nonidet P-40 results in decreased expression of PARP1 mRNA CTD PMID:26552463 Nonylphenol multiple interactions EXP 6480464 U 0126 inhibits the reaction [nonylphenol results in increased cleavage of PARP1 protein] CTD PMID:23677851 Nonylphenol increases cleavage EXP 6480464 nonylphenol results in increased cleavage of PARP1 protein CTD PMID:23677851 NORCANTHARIDIN increases expression ISO PARP1 (Homo sapiens) 6480464 norcantharidin results in increased expression of PARP1 protein modified form CTD PMID:34272796 NORCANTHARIDIN multiple interactions ISO PARP1 (Homo sapiens) 6480464 [norcantharidin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein more ... CTD PMID:34272796 notoginsenoside R1 multiple interactions EXP 6480464 notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of PARP1 protein modified form] CTD PMID:23170834 NS-398 multiple interactions EXP 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of PARP1 protein] CTD PMID:16230411 Nutlin-3 multiple interactions ISO PARP1 (Homo sapiens) 6480464 TP53 mutant form inhibits the reaction [nutlin 3 results in increased cleavage of PARP1 protein] CTD PMID:22260869 Nutlin-3 increases cleavage ISO PARP1 (Homo sapiens) 6480464 nutlin 3 results in increased cleavage of PARP1 protein CTD PMID:22260869 O-methyleugenol increases cleavage ISO PARP1 (Homo sapiens) 6480464 methyleugenol results in increased cleavage of PARP1 protein CTD PMID:28818686 ochratoxin A increases cleavage ISO PARP1 (Homo sapiens) 6480464 ochratoxin A results in increased cleavage of PARP1 protein CTD PMID:25002221 ochratoxin A decreases expression ISO PARP1 (Homo sapiens) 6480464 ochratoxin A results in decreased expression of PARP1 mRNA CTD PMID:34481902 ochratoxin A multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Aflatoxin M1 co-treated with ochratoxin A] results in increased expression of PARP1 protein CTD PMID:34126166 ochratoxin A increases expression ISO PARP1 (Homo sapiens) 6480464 ochratoxin A results in increased expression of PARP1 protein CTD PMID:34126166 okadaic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Okadaic Acid inhibits the reaction [Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] CTD PMID:16059913 olaparib multiple interactions EXP 6480464 olaparib inhibits the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein] CTD PMID:24814482 olaparib increases cleavage ISO PARP1 (Homo sapiens) 6480464 olaparib results in increased cleavage of PARP1 protein CTD PMID:29567272 olaparib multiple interactions ISO PARP1 (Homo sapiens) 6480464 (+)-JQ1 compound promotes the reaction [olaparib results in increased cleavage of PARP1 protein] more ... CTD PMID:29567272 and PMID:35396826 olaparib decreases binding ISO PARP1 (Homo sapiens) 151356754 olaparib decreases binding of PARP1 to Cp promoter region in human lymphoblastoid cell lines RGD olaparib decreases activity ISO PARP1 (Homo sapiens) 6480464 olaparib results in decreased activity of PARP1 protein CTD PMID:28001384 oleanolic acid multiple interactions EXP 6480464 Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:31306688 oleanolic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Ascorbic Acid inhibits the reaction [Oleanolic Acid results in increased cleavage of PARP1 protein] and Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:22678527 and PMID:31306688 oleanolic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Oleanolic Acid analog results in increased cleavage of PARP1 protein and Oleanolic Acid results in increased cleavage of PARP1 protein CTD PMID:22678527 more ... oleic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Oleic Acid results in increased cleavage of PARP1 protein CTD PMID:21132278 oleic acid multiple interactions EXP 6480464 N-(oxo-5 more ... CTD PMID:30165350 oleic acid increases activity ISO PARP1 (Homo sapiens) 6480464 Oleic Acid results in increased activity of PARP1 protein CTD PMID:25536389 oleic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [NAD co-treated with Oleic Acid] results in increased activity of PARP1 protein more ... CTD PMID:25536389 oleic acid increases activity EXP 6480464 Oleic Acid results in increased activity of PARP1 protein CTD PMID:30165350 oligopeptide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Oligopeptides analog results in increased cleavage of PARP1 protein CTD PMID:24875536 oligopeptide multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein] more ... CTD PMID:24875536 omeprazole increases cleavage ISO PARP1 (Homo sapiens) 6480464 Omeprazole results in increased cleavage of PARP1 protein CTD PMID:15461867 omipalisib decreases phosphorylation ISO PARP1 (Homo sapiens) 6480464 omipalisib results in decreased phosphorylation of PARP1 protein CTD PMID:21464613 omipalisib increases cleavage ISO PARP1 (Homo sapiens) 6480464 omipalisib results in increased cleavage of PARP1 protein CTD PMID:21464613 organoselenium compound increases cleavage ISO PARP1 (Homo sapiens) 6480464 Organoselenium Compounds results in increased cleavage of PARP1 protein CTD PMID:24905917 oridonin increases cleavage ISO PARP1 (Homo sapiens) 6480464 oridonin results in increased cleavage of PARP1 protein CTD PMID:16019488 oridonin multiple interactions ISO PARP1 (Homo sapiens) 6480464 oridonin analog results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:31594861 orlistat increases cleavage ISO PARP1 (Homo sapiens) 6480464 orlistat results in increased cleavage of PARP1 protein CTD PMID:15870086 and PMID:17283163 orlistat multiple interactions ISO PARP1 (Homo sapiens) 6480464 [orlistat co-treated with Thapsigargin] results in increased cleavage of PARP1 protein CTD PMID:17283163 oroxylin A increases degradation ISO PARP1 (Homo sapiens) 6480464 5 and 7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased degradation of PARP1 protein CTD PMID:19135124 osimertinib increases cleavage ISO PARP1 (Homo sapiens) 6480464 osimertinib results in increased cleavage of PARP1 protein CTD PMID:30171258 osimertinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of PARP1 protein more ... CTD PMID:28237877 more ... osimertinib increases expression ISO PARP1 (Homo sapiens) 6480464 osimertinib results in increased expression of PARP1 protein modified form CTD PMID:28237877 osthole increases cleavage ISO PARP1 (Homo sapiens) 6480464 osthol results in increased cleavage of PARP1 protein CTD PMID:29319219 osthole decreases expression ISO PARP1 (Homo sapiens) 6480464 osthol results in decreased expression of PARP1 protein CTD PMID:31870840 osthole multiple interactions ISO PARP1 (Homo sapiens) 6480464 osthol results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:31870840 ouabain multiple interactions ISO PARP1 (Homo sapiens) 6480464 Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein] and Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein] CTD PMID:24124520 ouabain increases cleavage ISO PARP1 (Homo sapiens) 6480464 Ouabain results in increased cleavage of PARP1 protein CTD PMID:24124520 and PMID:31436044 oxaliplatin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of PARP1 protein more ... CTD PMID:16243822 more ... oxaliplatin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PARP1 mRNA CTD PMID:25729387 oxaliplatin increases cleavage ISO PARP1 (Homo sapiens) 6480464 oxaliplatin results in increased cleavage of PARP1 protein CTD PMID:16243822 oxidopamine increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Oxidopamine results in increased cleavage of PARP1 protein CTD PMID:25446857 oxidopamine increases expression ISO PARP1 (Homo sapiens) 6480464 Oxidopamine results in increased expression of PARP1 protein CTD PMID:31176653 oxidopamine increases activity ISO Parp1 (Rattus norvegicus) 6480464 Oxidopamine results in increased activity of PARP1 protein CTD PMID:21397656 oxidopamine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Oxidopamine results in increased cleavage of PARP1 protein CTD PMID:25446857 more ... oxidopamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]] more ... CTD PMID:19815691 more ... oxidopamine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 5 more ... CTD PMID:21397656 and PMID:25446857 oxidopamine multiple interactions EXP 6480464 2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine results in increased cleavage of PARP1 protein] more ... CTD PMID:33571554 oxidopamine increases cleavage EXP 6480464 Oxidopamine results in increased cleavage of PARP1 protein CTD PMID:10397638 and PMID:33571554 ozone multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PARP1 mRNA more ... CTD PMID:32699268 paclitaxel multiple interactions ISO PARP1 (Homo sapiens) 6480464 [3 more ... CTD PMID:10075725 more ... paclitaxel increases expression ISO PARP1 (Homo sapiens) 6480464 Paclitaxel results in increased expression of PARP1 protein modified form CTD PMID:34272796 paclitaxel multiple interactions EXP 6480464 [rottlerin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein CTD PMID:35995259 paclitaxel affects response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the susceptibility to Paclitaxel CTD PMID:19426673 paclitaxel increases cleavage ISO PARP1 (Homo sapiens) 6480464 Paclitaxel results in increased cleavage of PARP1 protein CTD PMID:10075725 more ... Paeonol multiple interactions EXP 6480464 paeonol inhibits the reaction [Epirubicin results in increased cleavage of PARP1 protein] CTD PMID:26646421 palbociclib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein more ... CTD PMID:22751436 and PMID:23676220 pamidronate increases cleavage ISO PARP1 (Homo sapiens) 6480464 pamidronate results in increased cleavage of PARP1 protein CTD PMID:10780527 and PMID:15346059 pamidronate multiple interactions EXP 6480464 [pamidronate co-treated with ultra-high molecular weight polyethylene] results in increased cleavage of PARP1 protein CTD PMID:12507583 Panduratin A increases cleavage ISO PARP1 (Homo sapiens) 6480464 panduratin A results in increased cleavage of PARP1 protein CTD PMID:16497706 panobinostat multiple interactions ISO PARP1 (Homo sapiens) 6480464 [resveratrol co-treated with panobinostat] results in increased cleavage of PARP1 protein CTD PMID:22923501 paracetamol increases cleavage ISO PARP1 (Homo sapiens) 6480464 Acetaminophen results in increased cleavage of PARP1 and Acetaminophen results in increased cleavage of PARP1 protein CTD PMID:12005112 and PMID:14725611 paracetamol increases expression ISO PARP1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of PARP1 mRNA CTD PMID:33971260 paracetamol multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein more ... CTD PMID:31678598 and PMID:33971260 paracetamol decreases expression ISO PARP1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of PARP1 mRNA CTD PMID:21420995 paracetamol increases expression ISO Parp1 (Rattus norvegicus) 6480464 Acetaminophen results in increased expression of PARP1 mRNA CTD PMID:16751229 paracetamol increases response to substance EXP 6480464 PARP1 protein results in increased susceptibility to Acetaminophen CTD PMID:15601672 paracetamol increases activity EXP 6480464 Acetaminophen results in increased activity of PARP1 protein CTD PMID:15601672 paracetamol multiple interactions EXP 6480464 3-aminobenzamide inhibits the reaction [PARP1 protein results in increased susceptibility to Acetaminophen] more ... CTD PMID:15601672 and PMID:29540258 paraoxon increases cleavage EXP 6480464 Paraoxon results in increased cleavage of PARP1 protein CTD PMID:29027213 paraoxon multiple interactions EXP 6480464 Metoclopramide inhibits the reaction [Paraoxon results in increased cleavage of PARP1 protein] CTD PMID:29027213 paraquat multiple interactions ISO PARP1 (Homo sapiens) 6480464 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of PARP1 protein modified form] more ... CTD PMID:16237197 more ... paraquat multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 calpeptin inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein] more ... CTD PMID:25947082 paraquat increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Paraquat results in increased cleavage of PARP1 protein CTD PMID:25947082 paraquat increases expression ISO PARP1 (Homo sapiens) 6480464 Paraquat results in increased expression of PARP1 protein modified form CTD PMID:27003823 and PMID:28414160 paraquat increases cleavage ISO PARP1 (Homo sapiens) 6480464 Paraquat results in increased cleavage of PARP1 protein CTD PMID:17018646 more ... paraquat increases activity ISO PARP1 (Homo sapiens) 6480464 Paraquat results in increased activity of PARP1 protein CTD PMID:24130211 paraquat multiple interactions EXP 6480464 [Paraquat co-treated with ST2825] results in increased expression of PARP1 protein and PARK7 protein affects the reaction [Paraquat results in increased cleavage of PARP1 protein] CTD PMID:21300143 and PMID:34811946 paraquat increases cleavage EXP 6480464 Paraquat results in increased cleavage of PARP1 protein CTD PMID:21300143 and PMID:28428137 Parthenin increases cleavage ISO PARP1 (Homo sapiens) 6480464 parthenin analog results in increased cleavage of PARP1 protein CTD PMID:25196075 PCB138 multiple interactions EXP 6480464 2 more ... CTD PMID:29704545 PD 0325901 multiple interactions ISO PARP1 (Homo sapiens) 6480464 [mirdametinib co-treated with MK 2206] results in increased cleavage of PARP1 protein more ... CTD PMID:24576621 more ... PD 0325901 increases cleavage ISO PARP1 (Homo sapiens) 6480464 mirdametinib results in increased cleavage of PARP1 protein CTD PMID:27634878 and PMID:32268164 PD173074 multiple interactions ISO PARP1 (Homo sapiens) 6480464 [arsenic trioxide co-treated with PD 173074] results in increased expression of PARP1 protein modified form more ... CTD PMID:27794399 Pendulone multiple interactions ISO PARP1 (Homo sapiens) 6480464 4-phenylbutyric acid inhibits the reaction [pendulone results in increased cleavage of PARP1 protein] and Acetylcysteine inhibits the reaction [pendulone results in increased cleavage of PARP1 protein] CTD PMID:35288263 Pendulone increases cleavage ISO PARP1 (Homo sapiens) 6480464 pendulone results in increased cleavage of PARP1 protein CTD PMID:35288263 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of PARP1 mRNA CTD PMID:23892564 pentetic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Pentetic Acid inhibits the reaction [pyrithione zinc results in increased activity of PARP1 protein] CTD PMID:21424779 Pentoxifylline multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Pentoxifylline co-treated with Doxorubicin] results in increased cleavage of PARP1 protein and Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:20804743 and PMID:33775688 Pentoxifylline increases cleavage ISO PARP1 (Homo sapiens) 6480464 Pentoxifylline results in increased cleavage of PARP1 protein CTD PMID:18851957 and PMID:33775688 pepstatin A multiple interactions ISO PARP1 (Homo sapiens) 6480464 pepstatin inhibits the reaction [Glucosamine results in increased cleavage of PARP1 protein] CTD PMID:16850161 perfluorooctane-1-sulfonic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in increased cleavage of PARP1 protein CTD PMID:26844784 and PMID:34006824 perfluorooctane-1-sulfonic acid increases cleavage EXP 6480464 perfluorooctane sulfonic acid results in increased cleavage of PARP1 protein CTD PMID:34006824 perfluorooctane-1-sulfonic acid increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 perfluorooctane sulfonic acid results in increased cleavage of PARP1 protein CTD PMID:26844784 more ... perfluorooctane-1-sulfonic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 MIR155 mRNA promotes the reaction [perfluorooctane sulfonic acid results in increased cleavage of PARP1 protein] CTD PMID:26844784 perfluorooctanoic acid increases cleavage EXP 6480464 perfluorooctanoic acid results in increased cleavage of PARP1 protein CTD PMID:35066053 perifosine increases cleavage ISO PARP1 (Homo sapiens) 6480464 perifosine results in increased cleavage of PARP1 protein CTD PMID:32587277 perifosine multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [perifosine results in increased cleavage of PARP1 protein] and LAT2 protein inhibits the reaction [perifosine results in increased cleavage of PARP1 protein] CTD PMID:32587277 peroxynitrous acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [PARP1 protein results in decreased susceptibility to Peroxynitrous Acid] which results in decreased phosphorylation of BAD protein more ... CTD PMID:18239155 peroxynitrous acid increases activity ISO PARP1 (Homo sapiens) 6480464 Peroxynitrous Acid results in increased activity of PARP1 protein CTD PMID:18239155 pevonedistat multiple interactions EXP 6480464 pevonedistat results in increased cleavage of and results in increased activity of PARP1 protein and Tretinoin promotes the reaction [pevonedistat results in increased cleavage of and results in increased activity of PARP1 protein] CTD PMID:22110742 pevonedistat increases cleavage ISO PARP1 (Homo sapiens) 6480464 pevonedistat results in increased cleavage of PARP1 protein CTD PMID:24634471 phenanthrene increases cleavage ISO PARP1 (Homo sapiens) 6480464 phenanthrene results in increased cleavage of PARP1 protein CTD PMID:21132278 phenanthridone decreases activity ISO Parp1 (Rattus norvegicus) 6480464 phenanthridone results in decreased activity of PARP1 protein CTD PMID:12411406 phenanthridone multiple interactions ISO PARP1 (Homo sapiens) 6480464 [eprenetapopt co-treated with phenanthridone] results in increased cleavage of PARP1 protein CTD PMID:29416738 phenethyl isothiocyanate increases cleavage ISO PARP1 (Homo sapiens) 6480464 phenethyl isothiocyanate results in increased cleavage of PARP1 protein CTD PMID:25246272 phenethyl isothiocyanate multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of PARP1 protein] CTD PMID:25246272 phenobarbital increases expression ISO Parp1 (Rattus norvegicus) 6480464 Phenobarbital results in increased expression of PARP1 mRNA CTD PMID:19162173 phenobarbital affects expression ISO PARP1 (Homo sapiens) 6480464 Phenobarbital affects the expression of PARP1 mRNA CTD PMID:19159669 phenylarsine oxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 oxophenylarsine results in increased cleavage of PARP1 protein CTD PMID:10515888 phenylephrine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Phenylephrine inhibits the reaction [Oxygen deficiency results in increased cleavage of PARP1 protein] CTD PMID:11042672 phloroglucinol increases cleavage ISO PARP1 (Homo sapiens) 6480464 Phloroglucinol analog results in increased cleavage of PARP1 protein and Phloroglucinol metabolite results in increased cleavage of PARP1 protein CTD PMID:22796323 and PMID:23178381 phorbol 13-acetate 12-myristate multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein] more ... CTD PMID:17309078 more ... phorbol 13-acetate 12-myristate affects response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the susceptibility to Tetradecanoylphorbol Acetate CTD PMID:16323285 phorbol 13-acetate 12-myristate increases activity ISO PARP1 (Homo sapiens) 6480464 Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein CTD PMID:2120135 and PMID:2126186 phosphoramide mustard affects expression ISO Parp1 (Rattus norvegicus) 6480464 phosphoramide mustard affects the expression of PARP1 mRNA CTD PMID:25497287 phosphoramide mustard increases expression ISO Parp1 (Rattus norvegicus) 6480464 phosphoramide mustard results in increased expression of PARP1 mRNA and phosphoramide mustard results in increased expression of PARP1 protein CTD PMID:25497287 and PMID:26708502 phytosphingosine multiple interactions ISO PARP1 (Homo sapiens) 6480464 3 more ... CTD PMID:17237268 phytosphingosine increases cleavage ISO PARP1 (Homo sapiens) 6480464 phytosphingosine results in increased cleavage of PARP1 protein CTD PMID:37956922 phytosphingosine increases activity ISO PARP1 (Homo sapiens) 6480464 phytosphingosine results in increased activity of PARP1 protein CTD PMID:15486061 pifithrin-? multiple interactions ISO PARP1 (Homo sapiens) 6480464 [pifithrin co-treated with Arsenic Trioxide] results in decreased expression of PARP1 protein more ... CTD PMID:16777994 more ... pifithrin-? multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein] more ... CTD PMID:16687611 more ... piperine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [piperine analog co-treated with Paclitaxel] results in increased cleavage of PARP1 protein CTD PMID:37244399 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of PARP1 mRNA CTD PMID:18301758 pirinixic acid decreases expression ISO Parp1 (Rattus norvegicus) 6480464 pirinixic acid results in decreased expression of PARP1 mRNA CTD PMID:16940010 pitavastatin increases cleavage ISO PARP1 (Homo sapiens) 6480464 pitavastatin results in increased cleavage of PARP1 protein CTD PMID:37956312 pitavastatin(1-) increases cleavage ISO PARP1 (Homo sapiens) 6480464 pitavastatin results in increased cleavage of PARP1 protein CTD PMID:37956312 Plantamajoside multiple interactions ISO PARP1 (Homo sapiens) 6480464 plantamajoside promotes the reaction [Metformin results in increased cleavage of PARP1 protein] CTD PMID:35350904 platinum multiple interactions ISO PARP1 (Homo sapiens) 6480464 Cisplatin promotes the reaction [Platinum binds to PARP1 protein] CTD PMID:21370912 platinum(0) multiple interactions ISO PARP1 (Homo sapiens) 6480464 Cisplatin promotes the reaction [Platinum binds to PARP1 protein] CTD PMID:21370912 platycodin D increases cleavage ISO PARP1 (Homo sapiens) 6480464 platycodin D results in increased cleavage of PARP1 protein CTD PMID:23236765 more ... platycodin D increases activity ISO PARP1 (Homo sapiens) 6480464 platycodin D results in increased activity of PARP1 protein CTD PMID:18804340 and PMID:20412017 platycodin D multiple interactions ISO PARP1 (Homo sapiens) 6480464 [platycodin D co-treated with Imatinib Mesylate] results in increased cleavage of and results in decreased expression of PARP1 protein CTD PMID:29552859 plumbagin decreases expression ISO PARP1 (Homo sapiens) 6480464 plumbagin results in decreased expression of PARP1 mRNA and plumbagin results in decreased expression of PARP1 protein CTD PMID:36336213 podophyllotoxin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Podophyllotoxin results in increased cleavage of PARP1 protein CTD PMID:21916509 ponatinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 (+)-JQ1 compound promotes the reaction [ponatinib results in increased cleavage of PARP1 protein] and ponatinib promotes the reaction [(+)-JQ1 compound results in increased cleavage of PARP1 protein] CTD PMID:25053825 ponatinib increases cleavage ISO PARP1 (Homo sapiens) 6480464 ponatinib results in increased cleavage of PARP1 protein CTD PMID:21482694 more ... potassium chromate multiple interactions ISO PARP1 (Homo sapiens) 6480464 epigallocatechin gallate inhibits the reaction [potassium chromate(VI) results in increased cleavage of and results in increased activity of PARP1 protein] and potassium chromate(VI) results in increased cleavage of and results in increased activity of PARP1 protein CTD PMID:22079256 potassium chromate increases cleavage ISO PARP1 (Homo sapiens) 6480464 potassium chromate(VI) results in increased cleavage of PARP1 protein CTD PMID:25977998 potassium dichromate multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Ascorbic Acid inhibits the reaction [Potassium Dichromate results in increased cleavage of PARP1 protein] CTD PMID:21262251 potassium dichromate multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [PARP1 protein results in increased susceptibility to [Potassium Dichromate co-treated with nickel sulfate]] more ... CTD PMID:20493934 potassium dichromate increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Potassium Dichromate results in increased cleavage of PARP1 protein CTD PMID:21262251 potassium iodide increases expression ISO Parp1 (Rattus norvegicus) 6480464 Potassium Iodide results in increased expression of PARP1 protein modified form CTD PMID:32593569 probenecid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Probenecid promotes the reaction [10-nitro-oleic acid results in increased cleavage of PARP1 protein] CTD PMID:29158255 prodigiosin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Prodigiosin results in increased cleavage of PARP1 protein CTD PMID:15746575 and PMID:19133282 propofol multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Propofol results in increased susceptibility to STA 9090] which results in increased cleavage of PARP1 protein CTD PMID:24784839 prostaglandin D2 increases cleavage ISO PARP1 (Homo sapiens) 6480464 Prostaglandin D2 results in increased cleavage of PARP1 protein CTD PMID:15843042 prostaglandin D2 increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Prostaglandin D2 results in increased cleavage of PARP1 protein CTD PMID:23973622 prostaglandin E2 multiple interactions ISO PARP1 (Homo sapiens) 6480464 Dinoprostone inhibits the reaction [baohuoside I results in increased cleavage of PARP1 protein] CTD PMID:19289254 prostaglandin J2 increases cleavage ISO PARP1 (Homo sapiens) 6480464 9-deoxy-delta-9-prostaglandin D2 results in increased cleavage of PARP1 protein CTD PMID:15843042 prostaglandin J2 multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12 and 14)-prostaglandin J2] results in increased cleavage of PARP1 protein CTD PMID:23973622 protein kinase inhibitor increases cleavage ISO PARP1 (Homo sapiens) 6480464 Protein Kinase Inhibitors results in increased cleavage of PARP1 protein CTD PMID:21878655 Pseudolaric acid B increases cleavage EXP 6480464 pseudolaric acid B results in increased cleavage of PARP1 protein CTD PMID:37244295 pterostilbene increases expression ISO PARP1 (Homo sapiens) 6480464 pterostilbene results in increased expression of PARP1 protein modified form CTD PMID:19549798 pterostilbene multiple interactions ISO PARP1 (Homo sapiens) 6480464 pterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein] CTD PMID:33930484 puerarin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 puerarin inhibits the reaction [cadmium acetate results in increased cleavage of PARP1 protein] CTD PMID:27717697 puerarin multiple interactions EXP 6480464 puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PARP1 protein] and puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PARP1 protein] CTD PMID:27318789 and PMID:31273855 pyrene increases cleavage ISO PARP1 (Homo sapiens) 6480464 pyrene results in increased cleavage of PARP1 protein CTD PMID:21132278 pyrethrins increases cleavage ISO PARP1 (Homo sapiens) 6480464 Pyrethrins results in increased cleavage of PARP1 protein CTD PMID:27939866 pyridaben increases cleavage ISO PARP1 (Homo sapiens) 6480464 pyridaben results in increased cleavage of PARP1 protein CTD PMID:16237197 pyridaben multiple interactions ISO PARP1 (Homo sapiens) 6480464 [pyridaben co-treated with Paraquat] results in increased cleavage of PARP1 protein CTD PMID:16237197 pyrimidifen increases expression ISO PARP1 (Homo sapiens) 6480464 pyrimidifen results in increased expression of PARP1 mRNA CTD PMID:33512557 pyrroloquinoline quinone multiple interactions EXP 6480464 PQQ Cofactor analog results in decreased expression of and results in increased cleavage of PARP1 protein and PQQ Cofactor results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:32068067 quercetin decreases expression ISO PARP1 (Homo sapiens) 6480464 Quercetin results in decreased expression of PARP1 mRNA CTD PMID:20596804 and PMID:30152185 quercetin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein] more ... CTD PMID:14505808 more ... quercetin multiple interactions ISO PARP1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein] more ... CTD PMID:14625852 more ... quercetin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Quercetin metabolite results in increased cleavage of PARP1 protein and Quercetin results in increased cleavage of PARP1 protein CTD PMID:12168845 more ... quercetin increases cleavage EXP 6480464 Quercetin results in increased cleavage of PARP1 protein CTD PMID:26076811 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:15876423 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of PARP1 protein CTD PMID:17039455 quercetin increases degradation ISO PARP1 (Homo sapiens) 6480464 Quercetin results in increased degradation of PARP1 protein CTD PMID:16059641 quercetin decreases activity ISO PARP1 (Homo sapiens) 6480464 Quercetin results in decreased activity of PARP1 protein CTD PMID:17884996 quercetin increases expression ISO PARP1 (Homo sapiens) 6480464 Quercetin metabolite results in increased expression of PARP1 protein and Quercetin results in increased expression of PARP1 protein modified form CTD PMID:16280456 more ... quercetin 3-O-beta-D-galactopyranoside multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Quercetin co-treated with hyperoside] results in increased cleavage of PARP1 protein CTD PMID:24173369 and PMID:25354548 quercitrin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein] CTD PMID:23138875 quinacrine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Quinacrine results in increased cleavage of PARP1 protein CTD PMID:28867437 quinolines increases cleavage ISO PARP1 (Homo sapiens) 6480464 Quinolines analog results in increased cleavage of PARP1 protein CTD PMID:15826604 quizartinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 (+)-JQ1 compound promotes the reaction [quizartinib results in increased cleavage of PARP1 protein] and quizartinib promotes the reaction [(+)-JQ1 compound results in increased cleavage of PARP1 protein] CTD PMID:25053825 quizartinib increases cleavage ISO PARP1 (Homo sapiens) 6480464 quizartinib results in increased cleavage of PARP1 protein CTD PMID:25053825 rac-1-monopalmitoylglycerol multiple interactions ISO PARP1 (Homo sapiens) 6480464 palmitoyl glycerol results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:37466199 raloxifene increases cleavage ISO PARP1 (Homo sapiens) 6480464 Raloxifene Hydrochloride results in increased cleavage of PARP1 protein CTD PMID:22965848 raloxifene multiple interactions ISO PARP1 (Homo sapiens) 6480464 [ESR1 protein co-treated with ESR2 protein] affects the reaction [Raloxifene Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:22965848 ranitidine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Ranitidine inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:19723537 Reactive blue 2 multiple interactions EXP 6480464 Cibacron Blue F 3GA inhibits the reaction [zinc chloride results in increased expression of PARP1 protein] CTD PMID:22253048 reactive oxygen species multiple interactions ISO PARP1 (Homo sapiens) 6480464 [2 more ... CTD PMID:24100277 more ... reactive oxygen species increases cleavage EXP 6480464 Reactive Oxygen Species results in increased cleavage of PARP1 protein CTD PMID:16412576 reactive oxygen species decreases expression ISO PARP1 (Homo sapiens) 6480464 Reactive Oxygen Species results in decreased expression of PARP1 mRNA CTD PMID:25800948 regorafenib increases cleavage ISO PARP1 (Homo sapiens) 6480464 regorafenib results in increased cleavage of PARP1 protein CTD PMID:30801954 remdesivir increases expression ISO PARP1 (Homo sapiens) 6480464 remdesivir results in increased expression of PARP1 protein CTD PMID:35417658 resveratrol multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Sirolimus co-treated with resveratrol] results in increased cleavage of PARP1 protein more ... CTD PMID:24304514 more ... resveratrol decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Resveratrol results in decreased expression of PARP1 mRNA CTD PMID:33775663 resveratrol decreases cleavage ISO Parp1 (Rattus norvegicus) 6480464 resveratrol results in decreased cleavage of PARP1 protein CTD PMID:24675465 resveratrol increases cleavage ISO PARP1 (Homo sapiens) 6480464 resveratrol analog results in increased cleavage of PARP1 protein and resveratrol results in increased cleavage of PARP1 protein CTD PMID:12690110 more ... resveratrol increases cleavage EXP 6480464 Resveratrol results in increased cleavage of PARP1 protein CTD PMID:16675471 more ... resveratrol increases ADP-ribosylation EXP 6480464 resveratrol results in increased ADP-ribosylation of PARP1 protein CTD PMID:25533949 resveratrol increases ADP-ribosylation ISO PARP1 (Homo sapiens) 6480464 resveratrol results in increased ADP-ribosylation of PARP1 protein CTD PMID:25533949 resveratrol increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 resveratrol results in increased cleavage of PARP1 protein CTD PMID:24304514 and PMID:24894866 resveratrol increases degradation ISO PARP1 (Homo sapiens) 6480464 resveratrol results in increased degradation of PARP1 protein CTD PMID:20028382 resveratrol increases expression ISO PARP1 (Homo sapiens) 6480464 resveratrol results in increased expression of PARP1 protein modified form CTD PMID:9680369 resveratrol multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]] more ... CTD PMID:14749477 more ... resveratrol multiple interactions EXP 6480464 1-(4-dimethylaminomethylphenyl)-8 more ... CTD PMID:21224254 more ... riboflavin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein CTD PMID:18377693 riboflavin increases cleavage EXP 6480464 Riboflavin analog results in increased cleavage of PARP1 protein CTD PMID:20688149 rifampicin multiple interactions ISO PARP1 (Homo sapiens) 6480464 Rifampin inhibits the reaction [[Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein] CTD PMID:31678598 rimonabant decreases expression ISO PARP1 (Homo sapiens) 6480464 Rimonabant results in decreased expression of PARP1 protein CTD PMID:19479993 ritonavir increases cleavage ISO PARP1 (Homo sapiens) 6480464 Ritonavir results in increased cleavage of PARP1 protein CTD PMID:19386116 and PMID:21270666 rocaglamide decreases expression ISO PARP1 (Homo sapiens) 6480464 rocaglamide results in decreased expression of PARP1 protein CTD PMID:31433962 romidepsin increases cleavage ISO PARP1 (Homo sapiens) 6480464 romidepsin results in increased cleavage of PARP1 protein CTD PMID:18223231 and PMID:27634878 romidepsin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [romidepsin co-treated with MK 2206] results in increased cleavage of PARP1 protein more ... CTD PMID:18223231 and PMID:27634878 rotenone multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]] more ... CTD PMID:14976342 more ... rotenone increases expression ISO PARP1 (Homo sapiens) 6480464 Rotenone results in increased expression of PARP1 protein modified form CTD PMID:29371327 rotenone increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Rotenone results in increased cleavage of PARP1 protein CTD PMID:25247703 rotenone multiple interactions EXP 6480464 Rotenone inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form] and SNCAIP protein inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:19857556 and PMID:29095437 rotenone increases cleavage EXP 6480464 Rotenone results in increased cleavage of PARP1 protein CTD PMID:19857556 rotenone multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Rotenone results in increased abundance of Hydrogen Peroxide] which results in increased cleavage of PARP1 protein more ... CTD PMID:25247703 and PMID:25304210 rotenone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Rotenone results in increased cleavage of PARP1 protein CTD PMID:14976342 more ... rottlerin increases cleavage ISO PARP1 (Homo sapiens) 6480464 rottlerin results in increased cleavage of PARP1 protein CTD PMID:22902833 rottlerin multiple interactions EXP 6480464 [rottlerin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein CTD PMID:35995259 rottlerin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 rottlerin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:27658547 rubimaillin increases degradation ISO PARP1 (Homo sapiens) 6480464 rubimaillin results in increased degradation of PARP1 protein CTD PMID:19716835 rubimaillin multiple interactions ISO PARP1 (Homo sapiens) 6480464 BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] and benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] CTD PMID:19716835 rucaparib decreases expression ISO PARP1 (Homo sapiens) 6480464 rucaparib results in decreased expression of PARP1 protein CTD PMID:30612311 rucaparib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [rucaparib co-treated with Dasatinib co-treated with CPI-0610] results in increased cleavage of PARP1 protein more ... CTD PMID:28001384 more ... ruthenium atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) promotes the reaction [Ruthenium binds to PARP1 protein] and RAPTA-T promotes the reaction [Ruthenium binds to PARP1 protein] CTD PMID:21370912 S-(1,2-dichlorovinyl)-L-cysteine increases cleavage ISO PARP1 (Homo sapiens) 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased cleavage of PARP1 protein CTD PMID:15967204 S-adenosyl-L-methioninate multiple interactions ISO PARP1 (Homo sapiens) 6480464 S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA] CTD PMID:35490796 S-adenosyl-L-methionine multiple interactions ISO PARP1 (Homo sapiens) 6480464 S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA] CTD PMID:35490796 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Buthionine Sulfoximine promotes the reaction [O(2)-(2 more ... CTD PMID:20962031 and PMID:22733624 S-nitroso-N-acetyl-D-penicillamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]] CTD PMID:10811113 Salinomycin increases cleavage ISO PARP1 (Homo sapiens) 6480464 salinomycin results in increased cleavage of PARP1 protein CTD PMID:30273566 salubrinal multiple interactions ISO PARP1 (Homo sapiens) 6480464 salubrinal inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] and salubrinal inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:21809093 and PMID:22155090 Salvianolic acid A multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 salvianolic acid A inhibits the reaction [arsenic trioxide results in increased expression of PARP1 protein] CTD PMID:28391263 Sanggenon C multiple interactions ISO PARP1 (Homo sapiens) 6480464 [sanggenone C co-treated with Temozolomide] results in increased expression of and results in increased cleavage of PARP1 protein more ... CTD PMID:37346933 sappanchalcone increases cleavage ISO PARP1 (Homo sapiens) 6480464 sappanchalcone results in increased cleavage of PARP1 protein CTD PMID:32590072 Satratoxin H increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 satratoxin H results in increased cleavage of PARP1 protein CTD PMID:22863859 SB 203580 multiple interactions ISO PARP1 (Homo sapiens) 6480464 SB 203580 inhibits the reaction [1 more ... CTD PMID:14645110 more ... SB 415286 multiple interactions EXP 6480464 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2 and 5-dione inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:22155090 scoparone increases cleavage ISO PARP1 (Homo sapiens) 6480464 scoparone results in increased cleavage of PARP1 protein CTD PMID:37449671 Se-methyl-L-selenocysteine increases expression ISO PARP1 (Homo sapiens) 6480464 selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form CTD PMID:25321483 Se-methyl-L-selenocysteine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form and BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form] CTD PMID:25321483 Se-methylselenocysteine increases expression ISO PARP1 (Homo sapiens) 6480464 selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form CTD PMID:25321483 Se-methylselenocysteine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form and BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form] CTD PMID:25321483 selenium atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Doxorubicin co-treated with Selenium] results in increased degradation of PARP1 protein more ... CTD PMID:17339365 selumetinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of PARP1 protein]] CTD PMID:27222248 selumetinib increases cleavage EXP 6480464 AZD 6244 results in increased cleavage of PARP1 protein CTD PMID:17876044 selumetinib multiple interactions EXP 6480464 Doxorubicin promotes the reaction [AZD 6244 results in increased cleavage of PARP1 protein] CTD PMID:17876044 senecionine decreases expression ISO PARP1 (Homo sapiens) 6480464 senecionine results in decreased expression of PARP1 protein CTD PMID:29458164 senecionine decreases expression EXP 6480464 senecionine results in decreased expression of PARP1 protein CTD PMID:35357534 sepantronium increases cleavage ISO PARP1 (Homo sapiens) 6480464 sepantronium results in increased cleavage of PARP1 protein CTD PMID:31837377 sepantronium multiple interactions ISO PARP1 (Homo sapiens) 6480464 [venetoclax co-treated with sepantronium] results in increased cleavage of PARP1 protein and sepantronium promotes the reaction [PI-3065 results in increased cleavage of PARP1 protein] CTD PMID:31837377 and PMID:36623716 serotonin affects abundance ISO PARP1 (Homo sapiens) 6480464 PARP1 affects the abundance of Serotonin CTD PMID:21990073 sesquiterpene increases cleavage ISO PARP1 (Homo sapiens) 6480464 Sesquiterpenes results in increased cleavage of PARP1 protein CTD PMID:18070620 Shikonin multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [shikonin results in increased cleavage of PARP1 protein] CTD PMID:24463199 Shikonin increases cleavage ISO PARP1 (Homo sapiens) 6480464 shikonin results in increased cleavage of PARP1 protein CTD PMID:24463199 and PMID:37268198 silibinin multiple interactions ISO PARP1 (Homo sapiens) 6480464 benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Silybin results in increased cleavage of PARP1 protein] more ... CTD PMID:16777994 more ... silibinin increases expression ISO PARP1 (Homo sapiens) 6480464 Silybin results in increased expression of PARP1 protein CTD PMID:27402681 silibinin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Silybin results in increased cleavage of PARP1 protein CTD PMID:24440808 silicon dioxide multiple interactions ISO PARP1 (Homo sapiens) 6480464 Decitabine inhibits the reaction [Silicon Dioxide results in decreased expression of PARP1 mRNA] more ... CTD PMID:20123007 more ... silicon dioxide increases expression ISO PARP1 (Homo sapiens) 6480464 Silicon Dioxide results in increased expression of PARP1 protein modified form CTD PMID:31082419 silicon dioxide decreases response to substance ISO PARP1 (Homo sapiens) 6480464 PARP1 protein results in decreased susceptibility to Silicon Dioxide CTD PMID:28757444 silicon dioxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Silicon Dioxide results in increased cleavage of PARP1 protein CTD PMID:19783790 silicon dioxide increases methylation ISO PARP1 (Homo sapiens) 6480464 Silicon Dioxide results in increased methylation of PARP1 promoter CTD PMID:22265868 silicon dioxide decreases expression ISO PARP1 (Homo sapiens) 6480464 Silicon Dioxide results in decreased expression of PARP1 mRNA and Silicon Dioxide results in decreased expression of PARP1 protein CTD PMID:20123007 and PMID:22265868 simvastatin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Simvastatin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein more ... CTD PMID:20045437 more ... simvastatin multiple interactions EXP 6480464 IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein] CTD PMID:27734117 simvastatin increases cleavage EXP 6480464 Simvastatin results in increased cleavage of PARP1 protein CTD PMID:27734117 simvastatin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Simvastatin results in increased cleavage of PARP1 protein CTD PMID:20045437 more ... simvastatin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Simvastatin inhibits the reaction [Glucose results in increased activity of PARP1 protein] CTD PMID:18004065 simvastatin decreases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Simvastatin results in decreased cleavage of PARP1 mRNA CTD PMID:16054375 sirolimus multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Sirolimus co-treated with ovatodiolide] results in increased cleavage of PARP1 protein more ... CTD PMID:19682553 more ... sirolimus increases cleavage ISO PARP1 (Homo sapiens) 6480464 Sirolimus results in increased cleavage of PARP1 protein CTD PMID:25307878 sirolimus multiple interactions EXP 6480464 Sirolimus promotes the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 sirolimus multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Sirolimus co-treated with Resveratrol] results in increased cleavage of PARP1 protein more ... CTD PMID:24304514 and PMID:34374793 sirolimus increases expression ISO Parp1 (Rattus norvegicus) 6480464 Sirolimus results in increased expression of PARP1 protein modified form CTD PMID:26825372 skatole increases cleavage ISO PARP1 (Homo sapiens) 6480464 Skatole results in increased cleavage of PARP1 protein CTD PMID:19700606 SM-164 multiple interactions ISO PARP1 (Homo sapiens) 6480464 [TNF protein co-treated with SM 164] results in increased cleavage of PARP1 protein and benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with SM 164] results in increased cleavage of PARP1 protein] CTD PMID:34523043 sodium arsenite multiple interactions ISO PARP1 (Homo sapiens) 6480464 3-aminobenzamide inhibits the reaction [sodium arsenite results in decreased expression of PARP1 protein] more ... CTD PMID:12614848 more ... sodium arsenite increases activity ISO PARP1 (Homo sapiens) 6480464 sodium arsenite results in increased activity of PARP1 protein CTD PMID:36958258 sodium arsenite affects expression ISO PARP1 (Homo sapiens) 6480464 sodium arsenite affects the expression of PARP1 mRNA CTD PMID:34032870 sodium arsenite decreases cleavage ISO PARP1 (Homo sapiens) 6480464 sodium arsenite results in decreased cleavage of PARP1 protein CTD PMID:32890875 sodium arsenite increases expression ISO Parp1 (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of PARP1 mRNA and sodium arsenite results in increased expression of PARP1 protein CTD PMID:28283887 and PMID:31163222 sodium arsenite increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 sodium arsenite results in increased cleavage of PARP1 protein CTD PMID:19616567 and PMID:28283887 sodium arsenite multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride] results in increased expression of PARP1 mRNA] more ... CTD PMID:19616567 more ... sodium arsenite increases degradation ISO Parp1 (Rattus norvegicus) 6480464 sodium arsenite results in increased degradation of PARP1 protein CTD PMID:20830294 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of PARP1 mRNA and sodium arsenite results in increased expression of PARP1 protein modified form CTD PMID:20643705 and PMID:23143138 sodium arsenite increases cleavage EXP 6480464 sodium arsenite results in increased cleavage of PARP1 protein CTD PMID:11035063 more ... sodium arsenite decreases activity EXP 6480464 sodium arsenite results in decreased activity of PARP1 protein CTD PMID:26443841 sodium arsenite increases response to substance EXP 6480464 PARP1 gene mutant form results in increased susceptibility to sodium arsenite CTD PMID:16322246 sodium arsenite multiple interactions EXP 6480464 benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] more ... CTD PMID:11035063 more ... sodium arsenite increases expression ISO PARP1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of PARP1 mRNA and sodium arsenite results in increased expression of PARP1 protein CTD PMID:20036271 and PMID:28595984 sodium arsenite increases degradation ISO PARP1 (Homo sapiens) 6480464 sodium arsenite results in increased degradation of PARP1 protein CTD PMID:12614848 sodium arsenite increases cleavage ISO PARP1 (Homo sapiens) 6480464 sodium arsenite results in increased cleavage of PARP1 protein CTD PMID:15028728 more ... sodium arsenite decreases activity ISO PARP1 (Homo sapiens) 6480464 sodium arsenite results in decreased activity of PARP1 protein CTD PMID:19056730 more ... sodium dichromate multiple interactions EXP 6480464 CAT protein inhibits the reaction [sodium bichromate results in increased cleavage of PARP1 protein] and TRP53 mutant form inhibits the reaction [sodium bichromate results in increased cleavage of PARP1 protein] CTD PMID:20298709 sodium dichromate increases cleavage ISO PARP1 (Homo sapiens) 6480464 sodium bichromate results in increased cleavage of PARP1 protein CTD PMID:28624442 sodium dichromate multiple interactions ISO PARP1 (Homo sapiens) 6480464 FBP1 protein promotes the reaction [sodium bichromate results in increased cleavage of PARP1 protein] CTD PMID:28624442 sodium dichromate affects expression ISO Parp1 (Rattus norvegicus) 6480464 sodium bichromate affects the expression of PARP1 mRNA CTD PMID:11960910 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of PARP1 mRNA CTD PMID:22155349 sodium dichromate increases cleavage EXP 6480464 sodium bichromate results in increased cleavage of PARP1 protein CTD PMID:20298709 sodium fluoride multiple interactions EXP 6480464 resveratrol inhibits the reaction [Sodium Fluoride results in increased cleavage of PARP1 protein] CTD PMID:24296261 sodium fluoride increases cleavage ISO PARP1 (Homo sapiens) 6480464 Sodium Fluoride results in increased cleavage of PARP1 protein CTD PMID:28962382 sodium fluoride increases expression ISO Parp1 (Rattus norvegicus) 6480464 Sodium Fluoride results in increased expression of PARP1 protein CTD PMID:29758312 sodium fluoride multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 protocatechuic acid methyl ester inhibits the reaction [Sodium Fluoride results in increased expression of PARP1 protein] CTD PMID:29758312 sodium fluoride increases cleavage EXP 6480464 Sodium Fluoride results in increased cleavage of PARP1 protein CTD PMID:24296261 and PMID:30130527 Sodium salicylate increases cleavage ISO PARP1 (Homo sapiens) 6480464 Sodium Salicylate results in increased cleavage of PARP1 protein CTD PMID:10090950 and PMID:9694730 Sodium salicylate increases expression ISO PARP1 (Homo sapiens) 6480464 Sodium Salicylate results in increased expression of PARP1 mRNA CTD PMID:29117515 Sodium salicylate multiple interactions ISO PARP1 (Homo sapiens) 6480464 Sodium Salicylate inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA] and Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA] CTD PMID:29117515 solasodine multiple interactions ISO PARP1 (Homo sapiens) 6480464 solasodine results in increased cleavage of and results in decreased expression of PARP1 protein CTD PMID:37121296 Soman decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Soman results in decreased expression of PARP1 mRNA CTD PMID:19281266 sorafenib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Bortezomib co-treated with Sorafenib] results in increased cleavage of PARP1 protein more ... CTD PMID:16985072 more ... sorafenib increases cleavage ISO PARP1 (Homo sapiens) 6480464 sorafenib results in increased cleavage of PARP1 protein CTD PMID:20054642 and PMID:26911335 staurosporine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Staurosporine results in increased cleavage of PARP1 protein CTD PMID:18451153 more ... staurosporine increases expression ISO Parp1 (Rattus norvegicus) 6480464 Staurosporine results in increased expression of PARP1 protein modified form CTD PMID:22639866 staurosporine multiple interactions ISO PARP1 (Homo sapiens) 6480464 EOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein] more ... CTD PMID:27539959 and PMID:35158046 staurosporine increases cleavage EXP 6480464 Staurosporine results in increased cleavage of PARP1 protein CTD PMID:10704466 more ... staurosporine multiple interactions EXP 6480464 SOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein] and Staurosporine affects the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:11035063 and PMID:24740755 streptozocin increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Streptozocin results in increased cleavage of PARP1 protein CTD PMID:25541178 and PMID:28856781 streptozocin multiple interactions EXP 6480464 N-(oxo-5 more ... CTD PMID:27288104 and PMID:28478229 streptozocin increases activity EXP 6480464 Streptozocin results in increased activity of PARP1 protein CTD PMID:27288104 streptozocin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein] and Curcumin inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein] CTD PMID:25541178 and PMID:28856781 styrene oxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 styrene oxide results in increased cleavage of PARP1 protein CTD PMID:11929631 styrene oxide increases cleavage EXP 6480464 styrene oxide results in increased cleavage of PARP1 protein CTD PMID:17662326 succimer multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Succimer inhibits the reaction [sodium arsenite results in increased expression of PARP1 protein] CTD PMID:31163222 sulfonyldimethane increases expression ISO PARP1 (Homo sapiens) 6480464 dimethyl sulfone results in increased expression of PARP1 mRNA CTD PMID:32562081 sulfonyldimethane multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Doxorubicin co-treated with dimethyl sulfone] results in increased expression of PARP1 mRNA more ... CTD PMID:32562081 sulfonyldimethane affects cleavage ISO PARP1 (Homo sapiens) 6480464 dimethyl sulfone affects the cleavage of PARP1 protein CTD PMID:32562081 sulforaphane multiple interactions EXP 6480464 sulforaphane inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein] CTD PMID:21684301 sulforaphane increases expression ISO PARP1 (Homo sapiens) 6480464 sulforaphane results in increased expression of PARP1 protein modified form CTD PMID:33894213 sulforaphane multiple interactions ISO PARP1 (Homo sapiens) 6480464 [sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein more ... CTD PMID:22922937 and PMID:29792947 sulindac multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein more ... CTD PMID:18281123 and PMID:21882223 sulindac increases activity ISO PARP1 (Homo sapiens) 6480464 Sulindac results in increased activity of PARP1 protein CTD PMID:15713900 sulindac sulfide multiple interactions ISO PARP1 (Homo sapiens) 6480464 (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1 and 3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid promotes the reaction [sulindac sulfide results in increased cleavage of PARP1 protein] CTD PMID:21400612 sulindac sulfide decreases expression ISO PARP1 (Homo sapiens) 6480464 sulindac sulfide results in decreased expression of PARP1 mRNA CTD PMID:16184548 sulindac sulfide increases cleavage ISO PARP1 (Homo sapiens) 6480464 sulindac sulfide results in increased cleavage of PARP1 protein CTD PMID:12663503 more ... sulindac sulfide increases cleavage EXP 6480464 sulindac sulfide results in increased cleavage of PARP1 protein CTD PMID:16886631 sunitinib decreases expression ISO PARP1 (Homo sapiens) 6480464 Sunitinib results in decreased expression of PARP1 mRNA CTD PMID:31533062 surfactin increases cleavage ISO PARP1 (Homo sapiens) 6480464 surfactin peptide results in increased cleavage of PARP1 protein CTD PMID:34850538 surfactin C increases cleavage ISO PARP1 (Homo sapiens) 6480464 surfactin peptide results in increased cleavage of PARP1 protein CTD PMID:34850538 T-2 toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of PARP1 mRNA and T-2 Toxin results in increased expression of PARP1 protein CTD PMID:28697680 and PMID:29432840 tamoxifen multiple interactions ISO PARP1 (Homo sapiens) 6480464 alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein] and SB 203580 inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein] CTD PMID:14645110 tamoxifen increases cleavage ISO PARP1 (Homo sapiens) 6480464 Tamoxifen results in increased cleavage of PARP1 protein CTD PMID:14645110 tanespimycin increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 tanespimycin results in increased cleavage of PARP1 protein CTD PMID:22810956 tanespimycin increases cleavage ISO PARP1 (Homo sapiens) 6480464 tanespimycin results in increased cleavage of PARP1 protein CTD PMID:22810956 tangeretin multiple interactions ISO PARP1 (Homo sapiens) 6480464 AGN 193109 inhibits the reaction [tangeretin results in decreased expression of and results in increased cleavage of PARP1 protein] and tangeretin results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:33058988 Tanshinone I increases cleavage ISO PARP1 (Homo sapiens) 6480464 tanshinone results in increased cleavage of PARP1 protein CTD PMID:26203587 Tanshinone I multiple interactions ISO PARP1 (Homo sapiens) 6480464 [TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein more ... CTD PMID:26203587 taraxasterol increases cleavage ISO PARP1 (Homo sapiens) 6480464 taraxasterol results in increased cleavage of PARP1 protein CTD PMID:35128947 taurine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Taurine inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] and Taurine inhibits the reaction [sodium arsenite results in increased degradation of PARP1 protein] CTD PMID:19616567 and PMID:20830294 tauroursodeoxycholic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Chenodeoxycholic Acid co-treated with ursodoxicoltaurine] results in increased cleavage of PARP1 protein CTD PMID:14976352 Tautomycin multiple interactions ISO PARP1 (Homo sapiens) 6480464 tautomycin inhibits the reaction [Docosahexaenoic Acids results in increased degradation of PARP1 protein] CTD PMID:11341974 temozolomide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [sanggenone C co-treated with Temozolomide] results in increased expression of and results in increased cleavage of PARP1 protein more ... CTD PMID:19825992 more ... temozolomide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Temozolomide results in increased cleavage of PARP1 protein CTD PMID:34328678 temozolomide decreases response to substance EXP 6480464 PARP1 protein results in decreased susceptibility to temozolomide CTD PMID:21555580 teprenone multiple interactions ISO PARP1 (Homo sapiens) 6480464 geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein] CTD PMID:34732784 tert-butyl hydroperoxide multiple interactions EXP 6480464 Catechin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein] CTD PMID:16753784 tert-butyl hydroperoxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased cleavage of PARP1 protein CTD PMID:27050144 more ... tert-butyl hydroperoxide multiple interactions ISO PARP1 (Homo sapiens) 6480464 1-(3 more ... CTD PMID:27050144 more ... tert-butyl hydroperoxide decreases expression ISO PARP1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of PARP1 protein CTD PMID:28733231 tert-butyl hydroperoxide increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 tert-Butylhydroperoxide results in increased cleavage of PARP1 protein CTD PMID:15569404 tert-butyl hydroperoxide multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein] CTD PMID:15569404 tert-butyl hydroperoxide increases cleavage EXP 6480464 tert-Butylhydroperoxide results in increased cleavage of PARP1 protein CTD PMID:16753784 testosterone multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Testosterone results in increased expression of PARP1 protein] CTD PMID:25714330 testosterone increases expression ISO Parp1 (Rattus norvegicus) 6480464 Testosterone results in increased expression of PARP1 protein CTD PMID:25714330 tetrachloromethane multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [Dimethylformamide co-treated with Carbon Tetrachloride] results in increased cleavage of PARP1 protein CTD PMID:20097184 tetrachloromethane multiple interactions EXP 6480464 N-(oxo-5 more ... CTD PMID:27318789 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of PARP1 protein CTD PMID:27318789 tetramethylpyrazine multiple interactions ISO PARP1 (Homo sapiens) 6480464 tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:26404762 tetraphene increases cleavage ISO PARP1 (Homo sapiens) 6480464 benz(a)anthracene results in increased cleavage of PARP1 protein CTD PMID:21132278 thalidomide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein CTD PMID:19372569 thalidomide increases cleavage ISO PARP1 (Homo sapiens) 6480464 Thalidomide analog results in increased cleavage of PARP1 protein CTD PMID:15858615 thapsigargin increases cleavage EXP 6480464 Thapsigargin results in increased cleavage of PARP1 protein CTD PMID:20493918 thapsigargin decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Thapsigargin results in decreased expression of PARP1 protein CTD PMID:35544339 thapsigargin multiple interactions EXP 6480464 Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of PARP1 protein] CTD PMID:20493918 thapsigargin multiple interactions ISO PARP1 (Homo sapiens) 6480464 [orlistat co-treated with Thapsigargin] results in increased cleavage of PARP1 protein CTD PMID:17283163 Theaflavin 3,3'-digallate increases cleavage ISO PARP1 (Homo sapiens) 6480464 theaflavin-3 and 3'-digallate results in increased cleavage of PARP1 protein CTD PMID:30769778 theophylline affects binding ISO PARP1 (Homo sapiens) 6480464 Theophylline binds to PARP1 protein CTD PMID:18951874 theophylline multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein] CTD PMID:9454737 Thiotepa multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Niacinamide inhibits the reaction [Thiotepa results in increased cleavage of PARP1 protein] CTD PMID:22164206 Thiotepa increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Thiotepa results in increased cleavage of PARP1 protein CTD PMID:22164206 thymoquinone increases expression ISO PARP1 (Homo sapiens) 6480464 thymoquinone results in increased expression of PARP1 protein modified form CTD PMID:31433961 thymoquinone increases cleavage ISO PARP1 (Homo sapiens) 6480464 thymoquinone results in increased cleavage of PARP1 protein CTD PMID:29981725 more ... thymoquinone multiple interactions ISO PARP1 (Homo sapiens) 6480464 4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein] more ... CTD PMID:29981725 more ... Tiron multiple interactions ISO PARP1 (Homo sapiens) 6480464 1 more ... CTD PMID:22002103 titanium dioxide increases expression ISO PARP1 (Homo sapiens) 6480464 titanium dioxide results in increased expression of PARP1 mRNA CTD PMID:20362650 titanium dioxide decreases expression ISO PARP1 (Homo sapiens) 6480464 titanium dioxide results in decreased expression of PARP1 protein CTD PMID:30098274 titanium dioxide multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of PARP1 protein CTD PMID:30098274 titanium dioxide increases cleavage ISO PARP1 (Homo sapiens) 6480464 titanium dioxide results in increased cleavage of PARP1 protein CTD PMID:20362650 and PMID:30126039 Tomentosin multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [tomentosin results in increased cleavage of PARP1 protein] CTD PMID:30917517 Tomentosin increases cleavage ISO PARP1 (Homo sapiens) 6480464 tomentosin results in increased cleavage of PARP1 protein CTD PMID:27922187 and PMID:30917517 toosendanin increases expression ISO PARP1 (Homo sapiens) 6480464 toosendanin results in increased expression of PARP1 protein modified form CTD PMID:23111283 topotecan multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PARP1 mRNA CTD PMID:25729387 topotecan multiple interactions ISO PARP1 (Homo sapiens) 6480464 [N-(oxo-5 more ... CTD PMID:23376119 and PMID:25667043 topotecan increases cleavage ISO PARP1 (Homo sapiens) 6480464 Topotecan results in increased cleavage of PARP1 protein CTD PMID:25667043 trametinib multiple interactions ISO PARP1 (Homo sapiens) 6480464 trametinib promotes the reaction [physapubescin B results in increased cleavage of PARP1 protein] CTD PMID:33035574 tranexamic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:19539006 trans-anethole multiple interactions ISO PARP1 (Homo sapiens) 6480464 anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:10871845 trans-chalcone multiple interactions ISO PARP1 (Homo sapiens) 6480464 MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein] CTD PMID:20620131 trans-chalcone increases cleavage ISO PARP1 (Homo sapiens) 6480464 Chalcone results in increased cleavage of PARP1 protein CTD PMID:20620131 triazoles increases cleavage ISO PARP1 (Homo sapiens) 6480464 Triazoles analog results in increased cleavage of PARP1 protein CTD PMID:32217108 tributylstannane increases cleavage ISO PARP1 (Homo sapiens) 6480464 tributyltin results in increased cleavage of PARP1 protein CTD PMID:31401084 tributylstannane multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 [bisphenol A co-treated with tributyltin] results in increased expression of PARP1 mRNA CTD PMID:31129395 tributylstannane multiple interactions ISO PARP1 (Homo sapiens) 6480464 DFFB protein promotes the reaction [tributyltin results in increased cleavage of PARP1 protein] CTD PMID:31401084 tricetin decreases activity ISO PARP1 (Homo sapiens) 6480464 tricetin results in decreased activity of PARP1 protein CTD PMID:17884996 tricetin multiple interactions ISO PARP1 (Homo sapiens) 6480464 tricetin inhibits the reaction [Oxidopamine results in increased expression of PARP1 protein] CTD PMID:31176653 trichloroethene decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Trichloroethylene results in decreased expression of PARP1 mRNA CTD PMID:33387578 trichostatin A multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Bortezomib co-treated with trichostatin A] results in increased cleavage of and results in increased activity of PARP1 protein more ... CTD PMID:16904634 more ... trichostatin A increases acetylation ISO PARP1 (Homo sapiens) 6480464 trichostatin A results in increased acetylation of PARP1 protein CTD PMID:27064363 trichostatin A increases expression ISO PARP1 (Homo sapiens) 6480464 trichostatin A results in increased expression of PARP1 protein modified form CTD PMID:23770000 trichostatin A increases degradation ISO PARP1 (Homo sapiens) 6480464 trichostatin A results in increased degradation of PARP1 protein CTD PMID:16010430 trichostatin A increases cleavage ISO PARP1 (Homo sapiens) 6480464 trichostatin A results in increased cleavage of PARP1 protein CTD PMID:17431121 triciribine increases expression ISO PARP1 (Homo sapiens) 6480464 triciribine results in increased expression of PARP1 mRNA CTD PMID:29117515 triciribine multiple interactions ISO PARP1 (Homo sapiens) 6480464 triciribine inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA] and triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA] CTD PMID:29117515 trifluoperazine multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21544200 trifluoperazine multiple interactions ISO PARP1 (Homo sapiens) 6480464 Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21544200 trifluridine increases cleavage ISO PARP1 (Homo sapiens) 6480464 Trifluridine results in increased cleavage of PARP1 protein CTD PMID:19816940 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of PARP1 mRNA CTD PMID:19042947 triphenyl phosphate affects expression ISO Parp1 (Rattus norvegicus) 6480464 triphenyl phosphate affects the expression of PARP1 mRNA CTD PMID:30589522 Triptolide increases cleavage ISO PARP1 (Homo sapiens) 6480464 triptolide results in increased cleavage of PARP1 protein CTD PMID:12533674 more ... Triptolide multiple interactions EXP 6480464 [triptolide co-treated with Lipopolysaccharides] results in increased expression of PARP1 protein modified form more ... CTD PMID:30633930 and PMID:30836114 Triptolide increases cleavage EXP 6480464 triptolide results in increased cleavage of PARP1 protein CTD PMID:30836114 Triptolide increases expression EXP 6480464 triptolide results in increased expression of PARP1 protein CTD PMID:26990902 triptonide increases cleavage ISO PARP1 (Homo sapiens) 6480464 triptonide results in increased cleavage of PARP1 protein CTD PMID:28666825 triptonide decreases expression EXP 6480464 triptonide results in decreased expression of PARP1 mRNA CTD PMID:33045310 troglitazone multiple interactions ISO PARP1 (Homo sapiens) 6480464 Aspirin promotes the reaction [troglitazone results in increased cleavage of PARP1 protein] and troglitazone promotes the reaction [Aspirin results in increased cleavage of PARP1 protein] CTD PMID:19908241 troglitazone increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Troglitazone results in increased cleavage of PARP1 protein CTD PMID:28283887 troglitazone increases expression ISO Parp1 (Rattus norvegicus) 6480464 Troglitazone results in increased expression of PARP1 mRNA CTD PMID:28283887 troglitazone multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [Troglitazone results in increased expression of PARP1 mRNA] more ... CTD PMID:28283887 troglitazone increases expression ISO PARP1 (Homo sapiens) 6480464 troglitazone results in increased expression of PARP1 CTD PMID:12680223 troglitazone increases cleavage ISO PARP1 (Homo sapiens) 6480464 troglitazone results in increased cleavage of PARP1 protein CTD PMID:19908241 trovafloxacin increases cleavage ISO PARP1 (Homo sapiens) 6480464 trovafloxacin results in increased cleavage of PARP1 protein CTD PMID:33609687 trovafloxacin multiple interactions ISO PARP1 (Homo sapiens) 6480464 ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of PARP1 protein] CTD PMID:33609687 tungsten decreases expression EXP 6480464 Tungsten results in decreased expression of PARP1 mRNA CTD PMID:30912803 tunicamycin increases expression EXP 6480464 Tunicamycin results in increased expression of PARP1 protein modified form CTD PMID:31330229 and PMID:32407927 tunicamycin multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of PARP1 protein modified form] and Luteolin inhibits the reaction [Tunicamycin results in increased expression of PARP1 protein modified form] CTD PMID:32407927 tyrphostin B42 multiple interactions ISO PARP1 (Homo sapiens) 127284886 tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases cleavage of PARP1 protein in stomach] RGD ubiquinones multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein CTD PMID:18377693 ursodeoxycholic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of PARP1 protein more ... CTD PMID:19728331 and PMID:21362627 ursodeoxycholic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Ursodeoxycholic Acid results in increased cleavage of PARP1 protein CTD PMID:21362627 ursolic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 Ursolic Acid results in increased cleavage of PARP1 protein CTD PMID:16012738 usnic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 usnic acid results in increased cleavage of PARP1 protein CTD PMID:31715134 valdecoxib increases expression ISO Parp1 (Rattus norvegicus) 6480464 valdecoxib results in increased expression of PARP1 mRNA CTD PMID:24136188 valproic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of PARP1 mRNA CTD PMID:17183730 valproic acid multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 Vitamin U inhibits the reaction [Valproic Acid results in decreased cleavage of PARP1 protein] CTD PMID:34420476 valproic acid decreases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Valproic Acid results in decreased cleavage of PARP1 protein CTD PMID:34420476 valproic acid increases cleavage EXP 6480464 Valproic Acid results in increased cleavage of PARP1 protein CTD PMID:24913804 vancomycin multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 1 and 5-dihydroxyisoquinoline inhibits the reaction [Vancomycin results in increased expression of PARP1 protein] CTD PMID:19833176 vancomycin increases expression ISO Parp1 (Rattus norvegicus) 6480464 Vancomycin results in increased expression of PARP1 protein CTD PMID:19833176 veliparib increases expression ISO PARP1 (Homo sapiens) 6480464 [veliparib results in increased expression of PARP1 protein] which results in increased expression of H2AX protein more ... CTD PMID:17505006 more ... veliparib multiple interactions ISO PARP1 (Homo sapiens) 6480464 PARP1 protein affects the susceptibility to [Temozolomide co-treated with veliparib] more ... CTD PMID:19825992 more ... veliparib multiple interactions EXP 6480464 [veliparib results in decreased activity of PARP1 protein] which results in increased susceptibility to Camptothecin CTD PMID:22158865 veliparib decreases activity ISO PARP1 (Homo sapiens) 6480464 veliparib results in decreased activity of PARP1 protein CTD PMID:17505006 more ... veliparib decreases activity EXP 6480464 veliparib results in decreased activity of PARP1 protein CTD PMID:22158865 vemurafenib multiple interactions ISO PARP1 (Homo sapiens) 6480464 [KRAS protein mutant form affects the susceptibility to Vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of PARP1 protein] more ... CTD PMID:27222248 and PMID:35648318 venetoclax multiple interactions ISO PARP1 (Homo sapiens) 6480464 [mivebresib co-treated with venetoclax] results in increased cleavage of PARP1 protein more ... CTD PMID:30647404 more ... venetoclax increases cleavage ISO PARP1 (Homo sapiens) 6480464 venetoclax results in increased cleavage of PARP1 protein CTD PMID:34861246 venom increases cleavage ISO PARP1 (Homo sapiens) 6480464 Viper Venoms results in increased cleavage of PARP1 protein CTD PMID:27613483 verapamil multiple interactions EXP 6480464 Verapamil inhibits the reaction [PARP1 gene mutant form results in decreased uptake of Doxorubicin] CTD PMID:15861398 verapamil multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein more ... CTD PMID:24373880 verteporfin increases cleavage ISO PARP1 (Homo sapiens) 6480464 Verteporfin results in increased cleavage of PARP1 protein CTD PMID:31494105 vincaleukoblastine multiple interactions ISO PARP1 (Homo sapiens) 6480464 CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]] and Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein] CTD PMID:16545138 vinclozolin decreases expression ISO Parp1 (Rattus norvegicus) 6480464 vinclozolin results in decreased expression of PARP1 mRNA CTD PMID:23034163 vincristine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [CEP 33779 results in increased susceptibility to Vincristine] which results in increased cleavage of PARP1 protein and [NVP-BSK805 results in increased susceptibility to Vincristine] which results in increased cleavage of PARP1 protein CTD PMID:28669723 vitamin E multiple interactions ISO PARP1 (Homo sapiens) 6480464 Vitamin E inhibits the reaction [Benzo(a)pyrene results in increased expression of PARP1 protein] and Vitamin E inhibits the reaction [osimertinib results in increased expression of PARP1 protein modified form] CTD PMID:24664296 and PMID:28237877 vitamin E increases expression ISO PARP1 (Homo sapiens) 6480464 Vitamin E results in increased expression of PARP1 mRNA CTD PMID:19244175 Voacamine multiple interactions ISO PARP1 (Homo sapiens) 6480464 [voacamine co-treated with Paclitaxel] results in increased cleavage of PARP1 protein CTD PMID:34856211 vorinostat increases expression EXP 6480464 Vorinostat results in increased expression of PARP1 mRNA CTD PMID:32512035 vorinostat increases cleavage ISO PARP1 (Homo sapiens) 6480464 vorinostat results in increased cleavage of PARP1 protein CTD PMID:15897598 more ... vorinostat multiple interactions ISO PARP1 (Homo sapiens) 6480464 [(+)-JQ1 compound co-treated with vorinostat] results in increased cleavage of PARP1 protein more ... CTD PMID:12893773 more ... warfarin increases expression ISO PARP1 (Homo sapiens) 6480464 Warfarin results in increased expression of PARP1 protein modified form CTD PMID:26206560 wedelolactone multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 wedelolactone inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein] CTD PMID:25631491 wedelolactone increases cleavage ISO PARP1 (Homo sapiens) 6480464 wedelolactone results in increased cleavage of PARP1 protein CTD PMID:22733624 wedelolactone multiple interactions ISO PARP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein] more ... CTD PMID:22733624 WIN 55212-2 decreases expression ISO PARP1 (Homo sapiens) 6480464 (3R)-((2 more ... CTD PMID:30776504 withaferin A increases cleavage ISO PARP1 (Homo sapiens) 6480464 withaferin A results in increased cleavage of PARP1 protein CTD PMID:20438634 and PMID:24019090 withaferin A multiple interactions ISO PARP1 (Homo sapiens) 6480464 Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein] and MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] CTD PMID:20438634 and PMID:24019090 wortmannin multiple interactions ISO PARP1 (Homo sapiens) 6480464 AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]] more ... CTD PMID:12614848 more ... wortmannin multiple interactions EXP 6480464 wortmannin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:22155090 xanthohumol increases cleavage ISO PARP1 (Homo sapiens) 6480464 xanthohumol results in increased cleavage of PARP1 protein CTD PMID:15995977 and PMID:35229981 XAV939 multiple interactions ISO PARP1 (Homo sapiens) 6480464 XAV939 binds to and results in decreased activity of PARP1 protein CTD PMID:28001384 Y-27632 decreases expression EXP 6480464 Y 27632 results in decreased expression of PARP1 protein CTD PMID:24676941 ytterbium increases cleavage ISO PARP1 (Homo sapiens) 6480464 Ytterbium analog results in increased cleavage of PARP1 protein CTD PMID:19632212 zearalenone increases cleavage ISO Parp1 (Rattus norvegicus) 6480464 Zearalenone results in increased cleavage of PARP1 protein CTD PMID:24530352 zearalenone decreases expression EXP 6480464 Zearalenone results in decreased expression of PARP1 protein CTD PMID:28089945 zebularine increases cleavage ISO PARP1 (Homo sapiens) 6480464 pyrimidin-2-one beta-ribofuranoside results in increased cleavage of PARP1 protein CTD PMID:19459041 zerumbone increases cleavage ISO PARP1 (Homo sapiens) 6480464 zerumbone analog results in increased cleavage of PARP1 protein and zerumbone results in increased cleavage of PARP1 protein CTD PMID:16007145 and PMID:28987329 zerumbone decreases expression ISO PARP1 (Homo sapiens) 6480464 zerumbone results in decreased expression of PARP1 mRNA CTD PMID:36122806 zinc atom multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 6-hydroxy-2 more ... CTD PMID:16799065 and PMID:31542844 zinc atom increases folding ISO PARP1 (Homo sapiens) 6480464 Zinc results in increased folding of PARP1 protein CTD PMID:31152818 zinc atom affects binding ISO PARP1 (Homo sapiens) 6480464 PARP1 protein binds to Zinc more ... CTD PMID:24275069 more ... zinc atom multiple interactions EXP 6480464 PARP1 protein affects the reaction [Zinc results in decreased abundance of Adenosine Triphosphate] more ... CTD PMID:17728843 and PMID:26443841 zinc atom increases cleavage ISO PARP1 (Homo sapiens) 6480464 Zinc deficiency results in increased cleavage of PARP1 protein and Zinc results in increased cleavage of PARP1 protein CTD PMID:16472982 more ... zinc atom multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein more ... CTD PMID:15966574 more ... zinc atom decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Zinc results in decreased expression of PARP1 protein CTD PMID:16799065 zinc dichloride multiple interactions ISO PARP1 (Homo sapiens) 6480464 zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]] more ... CTD PMID:19056730 more ... zinc dichloride increases expression EXP 6480464 zinc chloride results in increased expression of PARP1 protein CTD PMID:22253048 zinc dichloride increases activity EXP 6480464 zinc chloride results in increased activity of PARP1 protein CTD PMID:18509044 zinc dichloride increases response to substance EXP 6480464 PARP1 results in increased susceptibility to zinc chloride CTD PMID:18509044 zinc dichloride multiple interactions EXP 6480464 1 more ... CTD PMID:18509044 and PMID:22253048 zinc oxide multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of PARP1 protein] CTD PMID:24614525 zinc oxide increases cleavage EXP 6480464 Zinc Oxide analog results in increased cleavage of PARP1 protein CTD PMID:24614525 zinc pyrithione multiple interactions ISO PARP1 (Homo sapiens) 6480464 Pentetic Acid inhibits the reaction [pyrithione zinc results in increased activity of PARP1 protein] CTD PMID:21424779 zinc pyrithione increases activity ISO PARP1 (Homo sapiens) 6480464 pyrithione zinc results in increased activity of PARP1 protein CTD PMID:21424779 zinc pyrithione affects response to substance EXP 6480464 PARP1 protein affects the susceptibility to pyrithione zinc CTD PMID:19809895 zinc pyrithione multiple interactions EXP 6480464 PARP1 protein affects the reaction [pyrithione zinc results in decreased abundance of Adenosine Triphosphate] CTD PMID:19809895 zinc sulfate increases cleavage ISO PARP1 (Homo sapiens) 6480464 Zinc Sulfate results in increased cleavage of PARP1 protein CTD PMID:16799065 zinc sulfate decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Zinc Sulfate results in decreased expression of PARP1 protein CTD PMID:16799065 zinc sulfate multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 6-hydroxy-2 more ... CTD PMID:16799065 zinc(0) multiple interactions ISO Parp1 (Rattus norvegicus) 6480464 6-hydroxy-2 more ... CTD PMID:16799065 and PMID:31542844 zinc(0) increases folding ISO PARP1 (Homo sapiens) 6480464 Zinc results in increased folding of PARP1 protein CTD PMID:31152818 zinc(0) decreases expression ISO Parp1 (Rattus norvegicus) 6480464 Zinc results in decreased expression of PARP1 protein CTD PMID:16799065 zinc(0) multiple interactions ISO PARP1 (Homo sapiens) 6480464 [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein more ... CTD PMID:15966574 more ... zinc(0) increases cleavage ISO PARP1 (Homo sapiens) 6480464 Zinc deficiency results in increased cleavage of PARP1 protein and Zinc results in increased cleavage of PARP1 protein CTD PMID:16472982 more ... zinc(0) multiple interactions EXP 6480464 PARP1 protein affects the reaction [Zinc results in decreased abundance of Adenosine Triphosphate] more ... CTD PMID:17728843 and PMID:26443841 zinc(0) affects binding ISO PARP1 (Homo sapiens) 6480464 PARP1 protein binds to Zinc more ... CTD PMID:24275069 more ... zoledronic acid increases expression ISO PARP1 (Homo sapiens) 6480464 zoledronic acid results in increased expression of PARP1 mRNA CTD PMID:24714768 zoledronic acid increases cleavage ISO PARP1 (Homo sapiens) 6480464 zoledronic acid results in increased cleavage of PARP1 protein CTD PMID:10780527 and PMID:20977926 zoledronic acid multiple interactions ISO PARP1 (Homo sapiens) 6480464 arsenic trioxide promotes the reaction [zoledronic acid results in increased cleavage of PARP1 protein] CTD PMID:20977926
