Fis1 (fission, mitochondrial 1) - Rat Genome Database

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Gene: Fis1 (fission, mitochondrial 1) Mus musculus
Analyze
Symbol: Fis1
Name: fission, mitochondrial 1
RGD ID: 1315414
MGI Page MGI
Description: Predicted to enable identical protein binding activity; lipid binding activity; and molecular adaptor activity. Involved in mitochondrial fission. Located in mitochondrion. Is expressed in heart. Orthologous to human FIS1 (fission, mitochondrial 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010003O14Rik; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog; mitochondrial fission 1 protein; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11; TPR repeat protein 11; Ttc11
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395136,982,129 - 136,995,088 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5136,982,129 - 136,995,088 (+)EnsemblGRCm39 Ensembl
GRCm385136,953,275 - 136,966,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5136,953,275 - 136,966,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv375137,429,145 - 137,442,104 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,246,713 - 137,250,859 (+)NCBIMGSCv36mm8
Celera5133,969,492 - 133,982,284 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-DAMP(1+)  (ISO)
4-phenylbutyric acid  (ISO)
acrolein  (ISO)
aldehydo-D-glucose  (ISO)
angiotensin II  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
captan  (EXP)
carbidopa  (EXP)
carnosic acid  (ISO)
Carnosol  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (EXP)
curcumin  (ISO)
cytochalasin B  (ISO)
D-glucose  (ISO)
desferrioxamine B  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
fenofibrate  (ISO)
fenthion  (EXP)
flutamide  (ISO)
folpet  (EXP)
fructose  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
glafenine  (ISO)
glucose  (ISO)
hexadecanoic acid  (EXP,ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
Ile(5)-angiotensin II  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lanthanum trichloride  (ISO)
lenvatinib  (ISO)
lipoic acid  (EXP)
manganese(II) chloride  (EXP)
melatonin  (ISO)
metformin  (ISO)
methidathion  (EXP)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nitrogen dioxide  (EXP)
nocodazole  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oxidopamine  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phlorizin  (EXP)
ponasterone A  (ISO)
Pseudolaric acid B  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
sarpogrelate  (EXP,ISO)
selenium atom  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium fluoride  (EXP)
spermine  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
T-2 toxin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
trans-cinnamic acid  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. Aparicio-Trejo OE, etal., Biofactors. 2016 Nov 1. doi: 10.1002/biof.1338.
2. Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study. Chitra L and Boopathy R, Br J Pharmacol. 2013 Jul;169(5):1035-47. doi: 10.1111/bph.12179.
3. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
4. PM2.5-Induced Oxidative Stress and Mitochondrial Damage in the Nasal Mucosa of Rats. Guo Z, etal., Int J Environ Res Public Health. 2017 Jan 29;14(2). pii: E134. doi: 10.3390/ijerph14020134.
5. Autophagy signaling in skeletal muscle of infarcted rats. Jannig PR, etal., PLoS One. 2014 Jan 10;9(1):e85820. doi: 10.1371/journal.pone.0085820. eCollection 2014.
6. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
7. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
8. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. Li R, etal., J Hazard Mater. 2015 Apr 28;287:392-401. doi: 10.1016/j.jhazmat.2015.02.006. Epub 2015 Feb 4.
9. High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria. Lionetti L, etal., PLoS One. 2014 Mar 24;9(3):e92753. doi: 10.1371/journal.pone.0092753. eCollection 2014.
10. Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats. Liu Q, etal., PLoS One. 2015 Oct 19;10(10):e0140906. doi: 10.1371/journal.pone.0140906. eCollection 2015.
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
13. Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle. O'Leary MF, etal., Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C422-30. doi: 10.1152/ajpcell.00240.2012. Epub 2012 Dec 5.
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
16. The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress. Qin SL, etal., J Trace Elem Med Biol. 2015 Jan;29:263-8. doi: 10.1016/j.jtemb.2014.06.001. Epub 2014 Jun 9.
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
19. Necrostatin-1 mitigates mitochondrial dysfunction post-spinal cord injury. Wang Y, etal., Neuroscience. 2015 Mar 19;289:224-32. doi: 10.1016/j.neuroscience.2014.12.061. Epub 2015 Jan 13.
20. MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1. Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.
21. Acetyl-L-carnitine ameliorates mitochondrial damage and apoptosis following spinal cord injury in rats. Zhang ZY, etal., Neurosci Lett. 2015 Sep 14;604:18-23. doi: 10.1016/j.neulet.2015.06.021. Epub 2015 Jun 12.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14561759   PMID:14610273   PMID:14996942   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:17035996   PMID:17408615   PMID:18614015   PMID:18799693   PMID:19578372   PMID:21149567   PMID:21267068   PMID:21642619   PMID:21873635   PMID:22510686  
PMID:22639965   PMID:22794259   PMID:23283981   PMID:23921378   PMID:25348719   PMID:26472072   PMID:27166947   PMID:27179109   PMID:27852436   PMID:28378742   PMID:30550751   PMID:30918582  
PMID:30981733   PMID:31526891   PMID:32325033   PMID:32968282   PMID:33398021   PMID:34355730   PMID:35015731   PMID:35067534   PMID:35290083   PMID:35293971   PMID:36293380   PMID:36754021  
PMID:37468472   PMID:38355793   PMID:38588611  


Genomics

Comparative Map Data
Fis1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395136,982,129 - 136,995,088 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5136,982,129 - 136,995,088 (+)EnsemblGRCm39 Ensembl
GRCm385136,953,275 - 136,966,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5136,953,275 - 136,966,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv375137,429,145 - 137,442,104 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,246,713 - 137,250,859 (+)NCBIMGSCv36mm8
Celera5133,969,492 - 133,982,284 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.06NCBI
FIS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,239,472 - 101,245,081 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,239,458 - 101,252,316 (-)EnsemblGRCh38hg38GRCh38
GRCh377100,882,753 - 100,888,362 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,669,613 - 100,675,091 (-)NCBINCBI36Build 36hg18NCBI36
Build 347100,476,327 - 100,481,801NCBI
Celera795,892,051 - 95,897,529 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,475,936 - 95,481,415 (-)NCBIHuRef
CHM1_17100,813,303 - 100,818,781 (-)NCBICHM1_1
T2T-CHM13v2.07102,562,935 - 102,568,544 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,241,280 - 100,246,758 (-)NCBI
Fis1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,345,239 - 25,360,135 (-)NCBIGRCr8
mRatBN7.21219,708,560 - 19,723,392 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,708,558 - 19,723,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,847,143 - 20,862,230 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,459,848 - 21,474,937 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,524,895 - 20,540,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,750,485 - 22,765,324 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,750,485 - 22,765,308 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,760,051 - 24,774,751 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,806,840 - 20,821,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,807,273 - 20,811,373 (+)NCBI
Celera1221,483,983 - 21,498,749 (-)NCBICelera
Cytogenetic Map12q12NCBI
Fis1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,038,221 - 16,060,623 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545616,057,158 - 16,060,623 (+)NCBIChiLan1.0ChiLan1.0
FIS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,252,931 - 119,260,623 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,517,560 - 167,523,003 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,381,058 - 93,386,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,621,211 - 106,626,612 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,621,211 - 106,626,683 (-)Ensemblpanpan1.1panPan2
FIS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,642,014 - 8,645,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,642,039 - 8,648,851 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,339,369 - 10,343,166 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,461,512 - 8,465,308 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,458,742 - 8,465,308 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,417,290 - 8,421,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,392,322 - 8,396,123 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,557,014 - 8,560,797 (+)NCBIUU_Cfam_GSD_1.0
Fis1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,919,990 - 132,923,784 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,112,742 - 1,116,518 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,112,746 - 1,116,521 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FIS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,937,453 - 8,946,955 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,938,250 - 8,942,102 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FIS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12811,934,848 - 11,940,230 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2811,934,821 - 11,941,901 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660704,412,698 - 4,418,083 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fis1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,052,820 - 16,057,098 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,052,777 - 16,056,438 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fis1
388 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1437
Count of miRNA genes:357
Interacting mature miRNAs:397
Transcripts:ENSMUST00000019198, ENSMUST00000111094, ENSMUST00000111097, ENSMUST00000138610, ENSMUST00000147557, ENSMUST00000152658
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse

Markers in Region
ksks97  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385136,965,160 - 136,965,599UniSTSGRCm38
MGSCv375137,441,030 - 137,441,469UniSTSGRCm37
Celera5133,981,220 - 133,981,649UniSTS
Cytogenetic Map5G1UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000019198   ⟹   ENSMUSP00000019198
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5136,990,931 - 136,995,088 (+)Ensembl
GRCm38.p6 Ensembl5136,962,077 - 136,966,234 (+)Ensembl
Ensembl Acc Id: ENSMUST00000111094   ⟹   ENSMUSP00000106723
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5136,982,129 - 136,995,086 (+)Ensembl
GRCm38.p6 Ensembl5136,953,275 - 136,966,232 (+)Ensembl
Ensembl Acc Id: ENSMUST00000111097   ⟹   ENSMUSP00000106726
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5136,982,260 - 136,995,003 (+)Ensembl
GRCm38.p6 Ensembl5136,953,406 - 136,966,149 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138610
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5136,991,287 - 136,994,811 (+)Ensembl
GRCm38.p6 Ensembl5136,962,433 - 136,965,957 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147557
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5136,991,298 - 136,994,964 (+)Ensembl
GRCm38.p6 Ensembl5136,962,444 - 136,966,110 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152658
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5136,991,699 - 136,994,865 (+)Ensembl
GRCm38.p6 Ensembl5136,962,845 - 136,966,011 (+)Ensembl
RefSeq Acc Id: NM_001163243   ⟹   NP_001156715
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395136,982,129 - 136,995,088 (+)NCBI
GRCm385136,953,275 - 136,966,234 (+)NCBI
MGSCv375137,429,145 - 137,442,104 (+)RGD
Celera5133,969,492 - 133,982,284 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001347504   ⟹   NP_001334433
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395136,982,129 - 136,995,088 (+)NCBI
GRCm385136,953,275 - 136,966,234 (+)NCBI
Sequence:
RefSeq Acc Id: NM_025562   ⟹   NP_079838
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395136,990,931 - 136,995,088 (+)NCBI
GRCm385136,962,077 - 136,966,234 (+)NCBI
MGSCv375137,429,145 - 137,442,104 (+)RGD
Celera5133,969,492 - 133,982,284 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_079838   ⟸   NM_025562
- Peptide Label: isoform 1
- UniProtKB: Q9CQ92 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156715   ⟸   NM_001163243
- Peptide Label: isoform 2
- UniProtKB: G3X9U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001334433   ⟸   NM_001347504
- Peptide Label: isoform 3
- UniProtKB: D3YZ32 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000106726   ⟸   ENSMUST00000111097
Ensembl Acc Id: ENSMUSP00000106723   ⟸   ENSMUST00000111094
Ensembl Acc Id: ENSMUSP00000019198   ⟸   ENSMUST00000019198

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQ92-F1-model_v2 AlphaFold Q9CQ92 1-152 view protein structure

Promoters
RGD ID:6888386
Promoter ID:EPDNEW_M7644
Type:initiation region
Name:Fis1_2
Description:Mus musculus fission, mitochondrial 1 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7645  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385136,953,276 - 136,953,336EPDNEW
RGD ID:6888388
Promoter ID:EPDNEW_M7645
Type:initiation region
Name:Fis1_1
Description:Mus musculus fission, mitochondrial 1 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7644  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385136,962,106 - 136,962,166EPDNEW
RGD ID:6837522
Promoter ID:MM_KWN:44432
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000111097,   NM_001163243
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365137,428,806 - 137,429,306 (+)MPROMDB
RGD ID:6837524
Promoter ID:MM_KWN:44433
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000056794,   OTTMUST00000056803,   OTTMUST00000056804,   OTTMUST00000056805
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365137,437,351 - 137,438,977 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913687 AgrOrtholog
Ensembl Genes ENSMUSG00000019054 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019198 ENTREZGENE
  ENSMUST00000019198.7 UniProtKB/Swiss-Prot
  ENSMUST00000111094 ENTREZGENE
  ENSMUST00000111094.8 UniProtKB/TrEMBL
  ENSMUST00000111097 ENTREZGENE
  ENSMUST00000111097.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fis1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fis1_cytosol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fis1_TPR_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fis1_TPR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66437 UniProtKB/Swiss-Prot
MGD MGI:1913687 ENTREZGENE
NCBI Gene 66437 ENTREZGENE
PANTHER MITOCHONDRIAL FISSION 1 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13247 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fis1_TPR_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fis1_TPR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fis1 PhenoGen
PIRSF TPR_repeat_11_Fis1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YZ32 ENTREZGENE, UniProtKB/TrEMBL
  FIS1_MOUSE UniProtKB/Swiss-Prot
  G3X9U9 ENTREZGENE, UniProtKB/TrEMBL
  Q9CQ92 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Fis1  fission, mitochondrial 1    fission 1 (mitochondrial outer membrane) homolog (yeast)  Symbol and/or name change 5135510 APPROVED