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Gene: Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) Mus musculus
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Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Description: Exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including blood vessel morphogenesis; collagen fibril organization; and retinoid metabolic process. Localizes to the mitochondrion. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Peters anomaly; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1); PARTICIPATES IN steroid hormone biosynthetic pathway; tryptophan metabolic pathway; INTERACTS WITH 1,2,3,7,8-Pentachlorodibenzodioxin; 1,4-dihydroxy-2-naphthoic acid; 1-hydroxy-2-naphthoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: benz[a]anthracene inducible; CP1B; CYPIB1; cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450CMEF; cytochrome P450EF; hydroperoxy icosatetraenoate dehydratase; P4501b1
Orthologs:
Homo sapiens (human) : CYP1B1 (cytochrome P450 family 1 subfamily B member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102009223 (cytochrome P450 1B1)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100989599 (cytochrome P450 1B1)
Canis lupus familiaris (dog) : CYP1B1 (cytochrome P450 family 1 subfamily B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101970101 (cytochrome P450 1B1)
Sus scrofa (pig) : LOC100625479 (cytochrome P450 1B1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381779,706,940 - 79,715,061 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371780,106,293 - 80,114,381 (-)NCBIGRCm37mm9NCBIm37
MGSCv361779,615,279 - 79,623,367 (-)NCBImm8
Celera1784,018,414 - 84,026,502 (-)NCBICelera
Cytogenetic Map17 E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cyp1b1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10439
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.