Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) Mus musculus
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Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
RGD ID: 10439
MGI Page MGI
Description: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including camera-type eye development; cellular response to oxidative stress; and retinoid metabolic process. Acts upstream of or within several processes, including endothelial cell migration; endothelial cell-cell adhesion; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; steroid hormone biosynthetic pathway; tryptophan metabolic pathway; INTERACTS WITH (S)-naringenin; 1,2,3,7,8-Pentachlorodibenzodioxin; 1,4-dihydroxy-2-naphthoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: benz[a]anthracene inducible; CP1B; CYPIB1; cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450CMEF; cytochrome P450EF; hydroperoxy icosatetraenoate dehydratase; P4501b1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,014,369 - 80,022,490 (-)NCBIGRCm39mm39
GRCm39 Ensembl1780,008,966 - 80,022,490 (-)Ensembl
GRCm381779,706,940 - 79,715,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,701,537 - 79,715,061 (-)EnsemblGRCm38mm10GRCm38
MGSCv371780,106,293 - 80,114,381 (-)NCBIGRCm37mm9NCBIm37
MGSCv361779,615,279 - 79,623,367 (-)NCBImm8
Celera1784,018,414 - 84,026,502 (-)NCBICelera
Cytogenetic Map17E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(R)-pantothenic acid  (ISO)
(S)-naringenin  (EXP,ISO)
1,2,3,4,6,7,8-Heptachlorodibenzodioxin  (ISO)
1,2,3,4,6,7,8-Heptachlorodibenzofuran  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (ISO)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,4-dihydroxy-2-naphthoic acid  (EXP,ISO)
1,4-naphthoquinone  (ISO)
1,8-Dinitropyrene  (ISO)
1-hydroxy-2-naphthoic acid  (EXP,ISO)
1-methylphenanthrene  (ISO)
1-naphthol  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2'-deoxyguanosine  (ISO)
2'-hydroxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5,5'-Hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP,ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dichlorophenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxy-17beta-estradiol  (ISO)
2-naphthol  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-Methylchrysene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4',5,7-Trimethoxyflavone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxychalcone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-methoxy-17beta-estradiol  (ISO)
4-Methylchrysene  (ISO)
4-nonylphenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-Hydroxyflavone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxyindole  (EXP)
5-Methylchrysene  (ISO)
6-chrysenamine  (EXP)
6-hydroxyluteolin  (ISO)
6-Methylchrysene  (ISO)
6-Nitrobenzo[a]pyrene  (ISO)
6-Nitrochrysene  (ISO)
6-prenylnaringenin  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-hydroxyflavone  (ISO)
8-Br-cAMP  (ISO)
9-phenanthrol  (ISO)
acenaphthene  (ISO)
acenaphthylene  (EXP,ISO)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
aldehydo-D-glucose  (ISO)
alizarin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
amentoflavone  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
andrographolide  (EXP)
aniline  (ISO)
anthracene  (ISO)
anthraflavic acid  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite ion  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
avobenzone  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (EXP,ISO)
benzo[c]phenanthrene  (ISO)
benzo[e]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
Benzo[j]fluoranthene  (ISO)
Benzo[k]fluoranthene  (EXP,ISO)
bergomottin  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
biochanin A  (EXP,ISO)
biotin  (ISO)
biphenyl  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
brefeldin A  (ISO)
bucladesine  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calyculin a  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
Carnosol  (ISO)
cefaloridine  (ISO)
ceric oxide  (ISO)
chelerythrine  (EXP)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
Chorionic gonadotropin  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (EXP,ISO)
chrysin  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
chrysophanol  (ISO)
cidofovir anhydrous  (ISO)
cirsiliol  (ISO)
cisplatin  (ISO)
citral  (ISO)
clodronic acid  (ISO)
clothianidin  (ISO)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
daidzein  (EXP,ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextromethorphan  (EXP)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibenz[a,c]anthracene  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
Dibenzo[a,e]pyrene  (ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
dibromoacetic acid  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroergotamine  (EXP)
dimethyl sulfoxide  (EXP,ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
Droloxifene  (ISO)
ellagic acid  (EXP)
ellipticine  (EXP,ISO)
emodin  (ISO)
enilconazole  (ISO)
Erucin  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
ethylbenzene  (ISO)
ethylisopropylamiloride  (ISO)
eugenol  (ISO)
eupatorin  (ISO)
filipin III  (ISO)
fingolimod hydrochloride  (ISO)
flavanone  (EXP,ISO)
flavone  (ISO)
flavonol  (ISO)
fluoranthene  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
formononetin  (ISO)
fructose  (EXP)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (ISO)
geranial  (ISO)
geraniol  (ISO)
glucaric acid  (EXP)
glucoerucin  (ISO)
glucoerucin(1-)  (ISO)
glucoraphanin  (ISO)
glucose  (ISO)
glutathione  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (ISO)
homoeriodictyol  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
ICI 118551  (ISO)
ifosfamide  (ISO)
imperatorin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (ISO)
indoles  (ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
isoflavones  (EXP)
isoimperatorin  (ISO)
isoliquiritigenin  (ISO)
isopimpinellin  (ISO)
isoprenaline  (EXP,ISO)
isoproturon  (EXP)
isorhamnetin  (ISO)
ivermectin  (EXP,ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
KN-93  (ISO)
kynurenine  (ISO)
L-methionine  (EXP)
L-tryptophan  (ISO)
lansoprazole  (ISO)
laquinimod  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone A  (ISO)
linuron  (EXP,ISO)
lithocholic acid  (EXP)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (EXP)
medroxyprogesterone acetate  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
menadione  (ISO)
mephenytoin  (EXP)
mercury atom  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methoxsalen  (EXP)
methoxychlor  (EXP,ISO)
methylmercury chloride  (ISO)
midazolam  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
monocrotaline  (EXP)
monoethyl phthalate  (EXP)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desmethylclozapine  (ISO)
N-Desmethyltamoxifen  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
naringin  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nifedipine  (EXP)
nimesulide  (ISO)
nobiletin  (ISO)
NS-398  (ISO)
O-methyleugenol  (ISO)
o-xylene  (ISO)
okadaic acid  (ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
organoselenium compound  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paricalcitol  (ISO)
perfluorononanoic acid  (ISO)
phenanthrene  (ISO)
phenanthrenes  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
primaquine  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
purpurin  (ISO)
pyrene  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
quinidine  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
Rutecarpine  (ISO)
rutin  (ISO)
salicylamide  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
scutellarein  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sinensetin  (ISO)
skatole  (ISO)
sodium acetate trihydrate  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium propionate  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilbenoid  (ISO)
Sudan I  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
suramin  (ISO)
tamoxifen  (EXP,ISO)
tangeretin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
tetrahydrocurcumin  (EXP)
tetraphene  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (ISO)
tranilast  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclocarban  (EXP,ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
troglitazone  (EXP,ISO)
Tungsten carbide  (ISO)
undecane  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (EXP)
verapamil  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
angiogenesis  (IMP)
arachidonic acid metabolic process  (IDA,ISO)
benzene-containing compound metabolic process  (ISO)
blood vessel morphogenesis  (IMP)
cell adhesion  (IMP)
cellular aromatic compound metabolic process  (IDA,IMP,ISO)
cellular response to cAMP  (ISO)
cellular response to cortisol stimulus  (ISO)
cellular response to hydrogen peroxide  (IMP)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
collagen fibril organization  (IMP)
dibenzo-p-dioxin metabolic process  (IMP)
DNA modification  (ISO)
endothelial cell migration  (IMP)
endothelial cell-cell adhesion  (IMP)
estrogen metabolic process  (IDA,ISO)
estrous cycle  (ISO)
fatty acid metabolic process  (IEA)
ganglion development  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IMP)
lipid metabolic process  (IEA)
male gonad development  (ISO)
membrane lipid catabolic process  (IMP)
negative regulation of cell adhesion mediated by integrin  (IMP)
negative regulation of cell migration  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of NF-kappaB transcription factor activity  (IMP)
nitric oxide biosynthetic process  (IMP)
positive regulation of angiogenesis  (IMP)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IMP)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of translation  (ISO)
positive regulation of vascular endothelial growth factor production  (IMP)
regulation of reactive oxygen species metabolic process  (IMP)
response to arsenic-containing substance  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to indole-3-methanol  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (IMP,ISO)
retina vasculature development in camera-type eye  (IMP)
retinal blood vessel morphogenesis  (IMP)
retinal metabolic process  (IDA,ISO)
retinol metabolic process  (IDA,ISO)
steroid metabolic process  (ISO)
toxin metabolic process  (IMP)
trabecular meshwork development  (IMP)
xenobiotic metabolic process  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Alfadhli S, etal., Am J Ophthalmol. 2006 Mar;141(3):512-6.
2. Bar-Yosef U, etal., J Glaucoma. 2010 Jan;19(1):35-8. doi: 10.1097/IJG.0b013e3181a98b6f.
3. Bhattacharjee A, etal., Mol Vis. 2008 May 8;14:841-50.
4. Bhattacharyya KK, etal., J Biol Chem 1995 May 12;270(19):11595-602.
5. Chakrabarti S, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5439-44.
6. Devlin AH, etal., Mol Carcinog. 2009 Feb;48(2):110-7. doi: 10.1002/mc.20459.
7. Edward D, etal., Ophthalmic Genet. 2004 Dec;25(4):257-70.
8. El-Gayar S, etal., Mol Vis. 2009 Jul 8;15:1325-31.
9. Hilal L, etal., Mol Vis. 2010 Jul 2;16:1215-26.
10. Jennings BL, etal., Hypertension. 2010 Oct;56(4):667-74. doi: 10.1161/HYPERTENSIONAHA.110.154518. Epub 2010 Aug 30.
11. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
12. Kumar A, etal., Mol Vis. 2007 Apr 30;13:667-76.
13. Libby RT, etal., Science 2003 Mar 7;299(5612):1578-81.
14. Lu J, etal., J Biol Chem 2005 Feb 11;280(6):4834-41. Epub 2004 Nov 19.
15. Melki R, etal., Mol Vis. 2005 Nov 23;11:1012-7.
16. MGD and Homologene mouse data transfer
17. MGD data from the GO Consortium
18. Milla E, etal., Mol Vis. 2013 Aug 4;19:1707-22. Print 2013.
19. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
20. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. OMIM Disease Annotation Pipeline
22. Pipeline to import KEGG annotations from KEGG into RGD
23. Plasilova M, etal., J Med Genet. 1999 Apr;36(4):290-4.
24. Putluri N, etal., Cancer Res. 2011 Dec 15;71(24):7376-86. doi: 10.1158/0008-5472.CAN-11-1154. Epub 2011 Oct 11.
25. RGD automated import pipeline
26. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. RGD automated import pipeline for gene-chemical interactions
28. Soley GC, etal., J Glaucoma. 2003 Feb;12(1):27-30.
29. Stoilov I, etal., Hum Mol Genet. 1997 Apr;6(4):641-7.
30. Trombino AF, etal., Breast Cancer Res Treat. 2000 Sep;63(2):117-31.
31. Watanabe J, etal., Pharmacogenetics. 2000 Feb;10(1):25-33.
32. Xue X, etal., Nephrol Dial Transplant. 2008 Oct;23(10):3074-81. doi: 10.1093/ndt/gfn262. Epub 2008 May 21.
33. Yang M, etal., Mol Vis. 2009;15:432-7. Epub 2009 Feb 27.
Additional References at PubMed
PMID:1910294   PMID:7505439   PMID:7772257   PMID:8195121   PMID:9367523   PMID:9377560   PMID:9772216   PMID:10051580   PMID:10349636   PMID:10464095   PMID:10503904   PMID:10725249  
PMID:10871058   PMID:10910056   PMID:11042159   PMID:11076861   PMID:11577022   PMID:11673863   PMID:12464254   PMID:12477932   PMID:12745259   PMID:14681479   PMID:14740995   PMID:15028720  
PMID:15258110   PMID:15359218   PMID:15580705   PMID:15582647   PMID:15752708   PMID:15843505   PMID:16141072   PMID:16141073   PMID:16377763   PMID:16636061   PMID:17166882   PMID:17325023  
PMID:17560947   PMID:17709388   PMID:17914928   PMID:17997381   PMID:18287559   PMID:18372398   PMID:18391535   PMID:18452486   PMID:18779384   PMID:18953896   PMID:19005183   PMID:19138945  
PMID:19208226   PMID:19576202   PMID:20032512   PMID:20088394   PMID:21303932   PMID:21386911   PMID:21389345   PMID:21677750   PMID:21785971   PMID:21873635   PMID:22184325   PMID:22859684  
PMID:22960141   PMID:23047765   PMID:23108654   PMID:23112163   PMID:23275542   PMID:23276798   PMID:23376040   PMID:23519266   PMID:23568032   PMID:23692925   PMID:23776235   PMID:23821647  
PMID:23956430   PMID:23979599   PMID:24088896   PMID:24497629   PMID:24639079   PMID:24684199   PMID:25233073   PMID:25233930   PMID:25261715   PMID:25315223   PMID:25694484   PMID:25703193  
PMID:25868132   PMID:25870196   PMID:26049101   PMID:26573711   PMID:26893163   PMID:26928804   PMID:26990437   PMID:27036855   PMID:27113764   PMID:27235555   PMID:27301358   PMID:28146477  
PMID:28251434   PMID:28416584   PMID:28583802   PMID:30352686   PMID:30371217   PMID:30372497   PMID:30550785   PMID:30576387   PMID:30728831   PMID:30892936   PMID:30923189   PMID:31112136  
PMID:31220272   PMID:31852820   PMID:31948482   PMID:32027669   PMID:32330152   PMID:33748124  


Genomics

Comparative Map Data
Cyp1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,014,369 - 80,022,490 (-)NCBIGRCm39mm39
GRCm39 Ensembl1780,008,966 - 80,022,490 (-)Ensembl
GRCm381779,706,940 - 79,715,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,701,537 - 79,715,061 (-)EnsemblGRCm38mm10GRCm38
MGSCv371780,106,293 - 80,114,381 (-)NCBIGRCm37mm9NCBIm37
MGSCv361779,615,279 - 79,623,367 (-)NCBImm8
Celera1784,018,414 - 84,026,502 (-)NCBICelera
Cytogenetic Map17E3NCBI
CYP1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl238,066,973 - 38,109,902 (-)EnsemblGRCh38hg38GRCh38
GRCh38238,067,509 - 38,076,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37238,294,652 - 38,303,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36238,148,250 - 38,156,796 (-)NCBINCBI36hg18NCBI36
Build 34238,206,396 - 38,214,943NCBI
Celera238,135,623 - 38,144,201 (-)NCBI
Cytogenetic Map2p22.2NCBI
HuRef238,034,680 - 38,043,258 (-)NCBIHuRef
CHM1_1238,224,106 - 38,232,684 (-)NCBICHM1_1
Cyp1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2615,342,312 - 15,350,886 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl615,342,344 - 15,350,917 (+)Ensembl
Rnor_6.062,308,179 - 2,316,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl62,307,808 - 2,316,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.062,294,952 - 2,300,644 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.462,548,224 - 2,553,767 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.162,545,648 - 2,553,767 (-)NCBI
Celera615,009,941 - 15,015,671 (+)NCBICelera
Cytogenetic Map6q11NCBI
LOC102009223
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554415,803,032 - 5,812,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554415,803,397 - 5,812,131 (-)NCBIChiLan1.0ChiLan1.0
CYP1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A38,851,000 - 38,859,883 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A38,851,000 - 38,859,824 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A38,087,863 - 38,096,529 (-)NCBIMhudiblu_PPA_v0panPan3
CYP1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11730,273,281 - 30,278,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1730,272,749 - 30,278,554 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1730,086,594 - 30,091,868 (-)NCBI
ROS_Cfam_1.01730,923,029 - 30,928,301 (-)NCBI
UMICH_Zoey_3.11730,148,312 - 30,153,581 (-)NCBI
UNSW_CanFamBas_1.01730,216,274 - 30,221,549 (-)NCBI
UU_Cfam_GSD_1.01730,431,572 - 30,436,860 (-)NCBI
LOC101970101
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629241,681,103 - 41,689,696 (+)NCBI
SpeTri2.0NW_004936663345,021 - 355,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3102,195,741 - 102,206,750 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13102,195,743 - 102,205,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11469,318,713 - 69,327,277 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1469,319,495 - 69,324,157 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604542,635,474 - 42,644,623 (-)NCBIVero_WHO_p1.0
LOC101701066
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473819,639,215 - 19,647,807 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381779,713,430 - 79,714,277UniSTSGRCm38
MGSCv371780,112,770 - 80,113,617UniSTSGRCm37
Celera1784,024,891 - 84,025,738UniSTS
Cytogenetic Map17E3UniSTS
cM Map17 UniSTS
U03283  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381779,707,205 - 79,707,341UniSTSGRCm38
MGSCv371780,106,545 - 80,106,681UniSTSGRCm37
Celera1784,018,666 - 84,018,802UniSTS
Cytogenetic Map17E3UniSTS
Whitehead/MRC_RH17920.68UniSTS
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E3UniSTS
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E3UniSTS
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E3UniSTS
Cyp1b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174620000082100000Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined174989696283897108Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175145143085451617Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175145143085451617Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175680065690800808Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175680065690800808Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175680065690800808Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175680065690800808Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175680065690800808Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175680065690800808Mouse
4142201Obrq15_mobesity resistance QTL 15 (mouse)Not determined5722744780578347Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175722744793199751Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5728209491282202Mouse
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176199358194987271Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176199358194987271Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176357811994987271Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176490750994987271Mouse
14928308Manh82_mmandible shape 82 (mouse)176600781494987271Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176863389194987271Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177039377094987271Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177039377094987271Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177039377094987271Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177039377094987271Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177308770494987271Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177308770494987271Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7380065693199751Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177428209490087842Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177428209490087842Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir27bmmu-miR-27b-3pOncomiRDBexternal_infoNANA16982751

Predicted Target Of
Summary Value
Count of predictions:801
Count of miRNA genes:532
Interacting mature miRNAs:608
Transcripts:ENSMUST00000024894
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024894   ⟹   ENSMUSP00000024894
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1780,014,382 - 80,022,470 (-)Ensembl
GRCm38.p6 Ensembl1779,706,953 - 79,715,041 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234361   ⟹   ENSMUSP00000157049
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1780,014,323 - 80,022,490 (-)Ensembl
GRCm38.p6 Ensembl1779,706,894 - 79,715,061 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234927   ⟹   ENSMUSP00000157101
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1780,008,966 - 80,021,084 (-)Ensembl
GRCm38.p6 Ensembl1779,701,537 - 79,713,655 (-)Ensembl
RefSeq Acc Id: NM_001364889   ⟹   NP_001351818
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391780,014,369 - 80,022,490 (-)NCBI
GRCm381779,706,940 - 79,715,061 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009994   ⟹   NP_034124
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391780,014,369 - 80,022,490 (-)NCBI
GRCm381779,706,940 - 79,715,061 (-)NCBI
MGSCv371780,106,293 - 80,114,381 (-)RGD
Celera1784,018,414 - 84,026,502 (-)RGD
cM Map17 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034124   ⟸   NM_009994
- Peptide Label: isoform 1
- UniProtKB: Q64429 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001351818   ⟸   NM_001364889
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000024894   ⟸   ENSMUST00000024894
RefSeq Acc Id: ENSMUSP00000157101   ⟸   ENSMUST00000234927
RefSeq Acc Id: ENSMUSP00000157049   ⟸   ENSMUST00000234361

Promoters
RGD ID:13676832
Promoter ID:EPDNEW_M22565
Type:initiation region
Name:Cyp1b1_1
Description:Mus musculus cytochrome P450, family 1, subfamily b, polypeptide1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381779,715,058 - 79,715,118EPDNEW
RGD ID:6827964
Promoter ID:MM_KWN:24259
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   MEF_B4,   MEF_B6
Transcripts:NM_009994,   UC008DQB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361780,114,064 - 80,114,564 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88590 AgrOrtholog
Ensembl Genes ENSMUSG00000024087 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000024894 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000157049 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000157101 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024894 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000234361 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000234927 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CYP1B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13078 UniProtKB/Swiss-Prot
MGD MGI:88590 ENTREZGENE
NCBI Gene 13078 ENTREZGENE
PANTHER PTHR24299:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP1B1 RGD
PhenoGen Cyp1b1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3Q4L2V1_MOUSE UniProtKB/TrEMBL
  CP1B1_MOUSE UniProtKB/Swiss-Prot
  Q3UTK2_MOUSE UniProtKB/TrEMBL
  Q64429 ENTREZGENE
  Q80V82_MOUSE UniProtKB/TrEMBL
  Q8BRY0_MOUSE UniProtKB/TrEMBL
  Q9CUA1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UVA8 UniProtKB/Swiss-Prot
  Q60593 UniProtKB/Swiss-Prot
  Q64461 UniProtKB/Swiss-Prot