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Gene: Lta4h (leukotriene A4 hydrolase) Mus musculus
Symbol: Lta4h
Name: leukotriene A4 hydrolase
Description: The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: leukotriene A-4 hydrolase; LTA-4 hydrolase; LTA4 hydrodase
Homo sapiens (human) : LTA4H (leukotriene A4 hydrolase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lta4h (leukotriene A4 hydrolase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lta4h (leukotriene A4 hydrolase)
Pan paniscus (bonobo/pygmy chimpanzee) : LTA4H (leukotriene A4 hydrolase)
Canis lupus familiaris (dog) : LTA4H (leukotriene A4 hydrolase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lta4h (leukotriene A4 hydrolase)
Sus scrofa (pig) : LTA4H (leukotriene A4 hydrolase)
more info ...
Related Pseudogenes: Gm4854  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381093,453,396 - 93,484,896 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371092,916,141 - 92,947,641 (+)NCBIGRCm37mm9NCBIm37
MGSCv361092,883,229 - 92,914,633 (+)NCBImm8
Celera1095,436,799 - 95,470,679 (+)NCBICelera
Cytogenetic Map10 C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lta4h
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322732
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.