Il33 (interleukin 33) - Rat Genome Database

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Gene: Il33 (interleukin 33) Mus musculus
Analyze
Symbol: Il33
Name: interleukin 33
RGD ID: 1322462
MGI Page MGI
Description: Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; microglial cell activation involved in immune response; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9230117N10Rik; Il-; Il-33; Il1f; Il1f11; interleukin-33; NF-H; NF-HEV; nuclear factor from high endothelial venules
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,902,513 - 29,938,118 (+)NCBIGRCm39mm39
GRCm39 Ensembl1929,902,514 - 29,938,118 (+)Ensembl
GRCm381929,925,113 - 29,960,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,925,114 - 29,960,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,999,604 - 30,035,205 (+)NCBIGRCm37mm9NCBIm37
MGSCv361930,015,647 - 30,026,715 (+)NCBImm8
Celera1930,700,532 - 30,736,141 (+)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myocardial infarction  (ISO)
Alzheimer's disease  (IEA)
angiostrongyliasis  (IDA,IEP)
asthma  (IMP,ISO)
atopic dermatitis  (ISO)
candidiasis  (ISO)
Cardiomegaly  (IEP,ISO)
Cardiovirus Infections  (IEP)
cerebral malaria  (IDA,IEP)
Chronic Hepatitis B  (IDA,ISO)
chronic obstructive pulmonary disease  (IEP)
Chronic Periodontitis  (ISO)
clonorchiasis  (IEP,ISO)
Clostridium difficile colitis  (IEP,IMP)
colitis  (IDA,IEP,ISO)
colon cancer  (ISO)
common cold  (ISO)
cryptococcosis  (IEP)
dengue disease  (IDA)
diabetes mellitus  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (IDA,IEP)
Experimental Liver Cirrhosis  (ISO)
familial hemophagocytic lymphohistiocytosis 2  (IEP)
Fungal Lung Diseases  (IEP)
gout  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Helicobacter Infections  (ISO)
Hemolysis  (ISO)
herpes simplex  (IEP,ISO)
Hookworm Infections  (IEP)
Hyperalgesia  (ISO)
Immediate Hypersensitivity  (ISO)
inflammatory bowel disease  (ISO)
influenza  (IEP)
Intervertebral Disc Displacement  (ISO)
irritable bowel syndrome  (ISO)
kidney disease  (ISO)
listeriosis  (IEP)
liver cirrhosis  (IEP,ISO)
malaria  (IEP)
Nematode Infections  (IEP)
paracoccidioidomycosis  (ISO)
parasitic helminthiasis infectious disease  (IDA)
peptic ulcer disease  (ISO)
periodontitis  (IDA,IEP)
pleural tuberculosis  (ISO)
pneumocystosis  (IDA)
pneumonia  (ISO)
prostate cancer  (ISO)
Pseudomonas Infections  (IEP)
pulmonary edema  (ISO)
pulmonary tuberculosis  (IDA)
respiratory allergy  (IDA)
respiratory syncytial virus infectious disease  (IEP,IMP)
schistosomiasis  (IEP)
Schistosomiasis Japonica  (IDA,IMP,ISO)
Sepsis  (IEP,IMP,ISO)
Staphylococcal Pneumonia  (IEP)
Staphylococcal Skin Infections  (IDA,IEP)
Strongylida Infections  (IEP)
Superinfection  (IDA)
tongue squamous cell carcinoma  (ISO)
tuberculosis  (ISO)
ulcerative colitis  (IEP,ISO)
Viral Bronchiolitis  (ISO)
viral encephalitis  (IEP)
Viral Myocarditis  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetamide  (ISO)
acetic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP)
AM-251  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (EXP)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (EXP)
calcitriol  (ISO)
calycosin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clomipramine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diclofenac  (EXP)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
ferulic acid  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
furan  (ISO)
genistein  (EXP)
glutathione  (ISO)
glyphosate  (EXP)
graphene oxide  (EXP)
hydroquinone  (ISO)
imipramine  (ISO)
imiquimod  (EXP)
indole-3-methanol  (ISO)
irinotecan  (ISO)
ketoconazole  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lysophosphatidylcholine  (ISO)
mechlorethamine  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methoxychlor  (EXP)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pemetrexed  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quinazolines  (ISO)
rac-lactic acid  (ISO)
silicon dioxide  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
trichloroethene  (ISO)
triclosan  (EXP,ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
Vinpocetine  (EXP)
WIN 55212-2  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to mechanical stimulus  (ISO)
defense response to virus  (IDA)
extrinsic apoptotic signaling pathway  (IGI)
gene expression  (IDA)
interleukin-33-mediated signaling pathway  (IDA)
macrophage activation involved in immune response  (IDA)
microglial cell activation involved in immune response  (IDA)
microglial cell proliferation  (IDA)
negative regulation of immunoglobulin production  (IGI)
negative regulation of interferon-gamma production  (IGI)
negative regulation of leukocyte migration  (IGI)
negative regulation of macrophage proliferation  (IDA)
negative regulation of T-helper 1 type immune response  (IGI)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of CD80 production  (IDA)
positive regulation of CD86 production  (IDA)
positive regulation of cellular defense response  (IMP)
positive regulation of chemokine production  (IDA,ISO)
positive regulation of cytokine production  (IBA)
positive regulation of gene expression  (IDA)
positive regulation of immunoglobulin production  (IGI)
positive regulation of inflammatory response  (IBA,IDA)
positive regulation of interleukin-13 production  (IGI)
positive regulation of interleukin-4 production  (IGI)
positive regulation of interleukin-5 production  (IGI)
positive regulation of interleukin-6 production  (IDA,IGI)
positive regulation of macrophage activation  (IDA,ISO)
positive regulation of MHC class I biosynthetic process  (IDA)
positive regulation of MHC class II biosynthetic process  (IDA)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IDA,IGI)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of tumor necrosis factor production  (IDA)
positive regulation of type 2 immune response  (IDA,IGI)
regulation of sensory perception of pain  (ISO)
type 2 immune response  (IDA)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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Additional References at PubMed
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PMID:16286016   PMID:16602821   PMID:17185418   PMID:17623648   PMID:17675517   PMID:17881510   PMID:18003919   PMID:18023358   PMID:18250453   PMID:18268038   PMID:18450470   PMID:18566365  
PMID:18603409   PMID:18667700   PMID:18799693   PMID:18802081   PMID:19248109   PMID:19451398   PMID:19465481   PMID:19508382   PMID:19553541   PMID:19559631   PMID:19661270   PMID:19666510  
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PMID:20534524   PMID:20634488   PMID:20689814   PMID:20693421   PMID:20937871   PMID:20939024   PMID:21190867   PMID:21239713   PMID:21239718   PMID:21267068   PMID:21268000   PMID:21281751  
PMID:21308681   PMID:21349253   PMID:21357533   PMID:21422152   PMID:21454686   PMID:21469105   PMID:21494550   PMID:21515798   PMID:21557213   PMID:21642589   PMID:21646790   PMID:21677750  
PMID:21703183   PMID:21703403   PMID:21734074   PMID:21797940   PMID:21835205   PMID:21873635   PMID:21887788   PMID:21945667   PMID:21949025   PMID:21949094   PMID:21972019   PMID:22013230  
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PMID:22371395   PMID:22460070   PMID:22542450   PMID:22585447   PMID:22634619   PMID:22660580   PMID:22665806   PMID:22686327   PMID:22689946   PMID:22702477   PMID:22782692   PMID:22802353  
PMID:22922818   PMID:23006545   PMID:23071771   PMID:23093619   PMID:23132931   PMID:23162017   PMID:23169007   PMID:23248269   PMID:23300625   PMID:23323935   PMID:23324173   PMID:23347081  
PMID:23363980   PMID:23397250   PMID:23403558   PMID:23418608   PMID:23496815   PMID:23499895   PMID:23523996   PMID:23547117   PMID:23555875   PMID:23582173   PMID:23585480   PMID:23630360  
PMID:23662055   PMID:23683462   PMID:23733876   PMID:23810766   PMID:23837438   PMID:23894196   PMID:23911389   PMID:23918359   PMID:23945235   PMID:23954132   PMID:23960191   PMID:24028396  
PMID:24043894   PMID:24045639   PMID:24058536   PMID:24076135   PMID:24105680   PMID:24194600   PMID:24205109   PMID:24220317   PMID:24257755   PMID:24323357   PMID:24356538   PMID:24446518  
PMID:24459820   PMID:24551140   PMID:24556514   PMID:24586149   PMID:24613091   PMID:24619410   PMID:24675360   PMID:24730559   PMID:24786898   PMID:24837103   PMID:24860117   PMID:24860190  
PMID:24892809   PMID:24982172   PMID:24985397   PMID:25015831   PMID:25022964   PMID:25043027   PMID:25143444   PMID:25153903   PMID:25172162   PMID:25278425   PMID:25313073   PMID:25429071  
PMID:25458701   PMID:25472995   PMID:25500143   PMID:25504587   PMID:25505285   PMID:25533952   PMID:25543045   PMID:25573803   PMID:25599561   PMID:25617223   PMID:25617473   PMID:25660244  
PMID:25661185   PMID:25676669   PMID:25683166   PMID:25692703   PMID:25693767   PMID:25714839   PMID:25739051   PMID:25786179   PMID:25795135   PMID:25807992   PMID:25814531   PMID:25829541  
PMID:25847973   PMID:25857925   PMID:25870243   PMID:25918379   PMID:25926677   PMID:25930197   PMID:25941360   PMID:25997709   PMID:26011644   PMID:26018806   PMID:26047701   PMID:26079807  
PMID:26092469   PMID:26100084   PMID:26129648   PMID:26200013   PMID:26230091   PMID:26243875   PMID:26244295   PMID:26249267   PMID:26251474   PMID:26272855   PMID:26277897   PMID:26310268  
PMID:26311113   PMID:26322482   PMID:26342029   PMID:26352378   PMID:26363151   PMID:26365875   PMID:26386119   PMID:26417439   PMID:26425820   PMID:26428949   PMID:26473724   PMID:26489077  
PMID:26490658   PMID:26514775   PMID:26566691   PMID:26597162   PMID:26598236   PMID:26602156   PMID:26603638   PMID:26673140   PMID:26755704   PMID:26771472   PMID:26802241   PMID:26811463  
PMID:26813347   PMID:26830114   PMID:26864308   PMID:26872699   PMID:26908008   PMID:26936882   PMID:26943125   PMID:26987428   PMID:26991049   PMID:27001956   PMID:27053610   PMID:27056266  
PMID:27062360   PMID:27067050   PMID:27091974   PMID:27102638   PMID:27120577   PMID:27126934   PMID:27155324   PMID:27184849   PMID:27222019   PMID:27222477   PMID:27233150   PMID:27236500  
PMID:27300306   PMID:27310495   PMID:27317338   PMID:27318792   PMID:27340126   PMID:27358001   PMID:27372570   PMID:27421703   PMID:27421705   PMID:27453471   PMID:27492144   PMID:27545879  
PMID:27548066   PMID:27559047   PMID:27608599   PMID:27626380   PMID:27653694   PMID:27683753   PMID:27697499   PMID:27701734   PMID:27731325   PMID:27749840   PMID:27775548   PMID:27811142  
PMID:27821781   PMID:27839630   PMID:27918564   PMID:27994070   PMID:28002730   PMID:28011865   PMID:28095415   PMID:28096407   PMID:28137851   PMID:28194023   PMID:28196763   PMID:28196875  
PMID:28198366   PMID:28228256   PMID:28258042   PMID:28259547   PMID:28341741   PMID:28373582   PMID:28389473   PMID:28439013   PMID:28448566   PMID:28448579   PMID:28450225   PMID:28494352  
PMID:28532656   PMID:28539382   PMID:28552763   PMID:28576981   PMID:28607531   PMID:28611297   PMID:28637902   PMID:28637954   PMID:28656964   PMID:28675392   PMID:28697404   PMID:28701507  
PMID:28710436   PMID:28730605   PMID:28801624   PMID:28802996   PMID:28855579   PMID:28878285   PMID:28889151   PMID:28921511   PMID:29032512   PMID:29045819   PMID:29045902   PMID:29045903  
PMID:29070568   PMID:29120743   PMID:29132961   PMID:29146574   PMID:29147584   PMID:29166590   PMID:29208683   PMID:29222107   PMID:29242561   PMID:29247993   PMID:29288203   PMID:29309756  
PMID:29331643   PMID:29346765   PMID:29368135   PMID:29379874   PMID:29392836   PMID:29420261   PMID:29436517   PMID:29452935   PMID:29463593   PMID:29463838   PMID:29467297   PMID:29534857  
PMID:29556000   PMID:29596938   PMID:29610934   PMID:29621782   PMID:29630123   PMID:29671873   PMID:29674622   PMID:29691371   PMID:29728120   PMID:29728508   PMID:29729112   PMID:29784508  
PMID:29900561   PMID:29906552   PMID:29950152   PMID:29954866   PMID:30001716   PMID:30011081   PMID:30030493   PMID:30108595   PMID:30145369   PMID:30159930   PMID:30170813   PMID:30185824  
PMID:30192340   PMID:30224451   PMID:30269028   PMID:30275536   PMID:30316823   PMID:30333314   PMID:30446384   PMID:30463004   PMID:30467418   PMID:30515155   PMID:30518915   PMID:30530480  
PMID:30539029   PMID:30574145   PMID:30575775   PMID:30576068   PMID:30602786   PMID:30635396   PMID:30642984   PMID:30651000   PMID:30682073   PMID:30763587   PMID:30778250   PMID:30779711  
PMID:30780005   PMID:30801682   PMID:30824323   PMID:30831322   PMID:30838872   PMID:30856600   PMID:30872761   PMID:30913260   PMID:30913451   PMID:30926166   PMID:30988052   PMID:30999922  
PMID:31027995   PMID:31053654   PMID:31053655   PMID:31087583   PMID:31112061   PMID:31146104   PMID:31165473   PMID:31165767   PMID:31173201   PMID:31221971   PMID:31227713   PMID:31235844  
PMID:31269440   PMID:31334837   PMID:31391233   PMID:31421832   PMID:31471525   PMID:31507610   PMID:31562870   PMID:31578269   PMID:31582416   PMID:31591231   PMID:31616416   PMID:31622507  
PMID:31641224   PMID:31656879   PMID:31674275   PMID:31796062   PMID:31801068   PMID:31801092   PMID:31816636   PMID:31844326   PMID:31847374   PMID:31900341   PMID:31922608   PMID:31940364  
PMID:31975538   PMID:31988179   PMID:31990689   PMID:32028244   PMID:32060135   PMID:32102434   PMID:32103173   PMID:32108542   PMID:32122655   PMID:32130902   PMID:32140881   PMID:32144162  
PMID:32156776   PMID:32160524   PMID:32240120   PMID:32240600   PMID:32241531   PMID:32268121   PMID:32272082   PMID:32296080   PMID:32306382   PMID:32326950   PMID:32340025   PMID:32360132  
PMID:32410845   PMID:32424229   PMID:32432676   PMID:32484881   PMID:32486265   PMID:32520308   PMID:32571430   PMID:32573494   PMID:32582171   PMID:32644975   PMID:32648964   PMID:32690653  
PMID:32700362   PMID:32728764   PMID:32768188   PMID:32793232   PMID:32807943   PMID:32817520   PMID:32841733   PMID:32853659   PMID:32931477   PMID:32977238   PMID:32977946   PMID:32989331  
PMID:33023944   PMID:33072128   PMID:33104171   PMID:33132030   PMID:33153107   PMID:33178181   PMID:33188058   PMID:33204337   PMID:33220232   PMID:33245913   PMID:33314772   PMID:33351862  
PMID:33400692   PMID:33420328   PMID:33427298   PMID:33431701   PMID:33432186   PMID:33443211   PMID:33444291   PMID:33456562   PMID:33482904   PMID:33507882   PMID:33547321   PMID:33571420  
PMID:33600797   PMID:33616251   PMID:33654214   PMID:33665576   PMID:33723298   PMID:33884963   PMID:33902297   PMID:33929319   PMID:33953267   PMID:33964300   PMID:33992109   PMID:33997712  
PMID:34088769   PMID:34093589   PMID:34198027   PMID:34266437   PMID:34299063   PMID:34324507   PMID:34354077   PMID:34358967   PMID:34380650   PMID:34411293   PMID:34493712   PMID:34531316  
PMID:34531562   PMID:34547141   PMID:34560104   PMID:34624652   PMID:34638904   PMID:34650552   PMID:34822949   PMID:34860143   PMID:34942481   PMID:34948083   PMID:34982959   PMID:35022276  
PMID:35181439   PMID:35191758   PMID:35387873  


Genomics

Comparative Map Data
Il33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,902,513 - 29,938,118 (+)NCBIGRCm39mm39
GRCm39 Ensembl1929,902,514 - 29,938,118 (+)Ensembl
GRCm381929,925,113 - 29,960,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,925,114 - 29,960,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,999,604 - 30,035,205 (+)NCBIGRCm37mm9NCBIm37
MGSCv361930,015,647 - 30,026,715 (+)NCBImm8
Celera1930,700,532 - 30,736,141 (+)NCBICelera
Cytogenetic Map19C1NCBI
IL33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3896,215,149 - 6,257,983 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl96,215,786 - 6,257,983 (+)EnsemblGRCh38hg38GRCh38
GRCh3796,215,149 - 6,257,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3696,231,678 - 6,247,982 (+)NCBINCBI36hg18NCBI36
Build 3496,231,677 - 6,247,982NCBI
Celera96,179,137 - 6,195,439 (+)NCBI
Cytogenetic Map9p24.1NCBI
HuRef96,171,374 - 6,213,493 (+)NCBIHuRef
CHM1_196,216,394 - 6,258,768 (+)NCBICHM1_1
Il33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21227,701,964 - 227,736,374 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1227,721,435 - 227,736,373 (+)Ensembl
Rnor_6.01248,112,611 - 248,147,030 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,132,090 - 248,147,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,382,760 - 255,397,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,670,801 - 233,685,798 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11233,834,823 - 233,849,820 (+)NCBI
Celera1224,871,607 - 224,886,518 (+)NCBICelera
Cytogenetic Map1q52NCBI
Il33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543410,171,812 - 10,188,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543410,145,449 - 10,187,595 (+)NCBIChiLan1.0ChiLan1.0
IL33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.196,208,479 - 6,250,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl96,234,178 - 6,248,624 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v096,027,014 - 6,069,540 (+)NCBIMhudiblu_PPA_v0panPan3
IL33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11127,219,878 - 27,256,723 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1127,219,878 - 27,256,721 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1125,988,860 - 26,025,714 (+)NCBI
ROS_Cfam_1.01128,069,676 - 28,106,564 (+)NCBI
ROS_Cfam_1.0 Ensembl1128,069,663 - 28,108,194 (+)Ensembl
UMICH_Zoey_3.11126,788,250 - 26,825,127 (+)NCBI
UNSW_CanFamBas_1.01126,610,673 - 26,647,647 (+)NCBI
UU_Cfam_GSD_1.01127,281,817 - 27,318,668 (+)NCBI
Il33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947142,170,523 - 142,338,788 (+)NCBI
SpeTri2.0NW_004936539763,755 - 791,461 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,899,435 - 215,941,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,899,830 - 215,941,944 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,454,091 - 241,496,130 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11273,235,585 - 73,283,665 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1273,237,406 - 73,252,436 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603861,612,048 - 61,659,928 (-)NCBIVero_WHO_p1.0
Il33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473610,733,944 - 10,786,188 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AV028447  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381929,960,570 - 29,960,708UniSTSGRCm38
MGSCv371930,035,060 - 30,035,198UniSTSGRCm37
Celera1930,735,996 - 30,736,134UniSTS
Cytogenetic Map19C2UniSTS
Whitehead/MRC_RH19302.82UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192777198535295381Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1001
Count of miRNA genes:460
Interacting mature miRNAs:491
Transcripts:ENSMUST00000025724, ENSMUST00000120388, ENSMUST00000136850, ENSMUST00000144528, ENSMUST00000177518
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025724   ⟹   ENSMUSP00000025724
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,923,190 - 29,938,104 (+)Ensembl
GRCm38.p6 Ensembl1929,945,790 - 29,960,704 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120388   ⟹   ENSMUSP00000113829
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,902,514 - 29,938,118 (+)Ensembl
GRCm38.p6 Ensembl1929,925,114 - 29,960,718 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136850   ⟹   ENSMUSP00000135324
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,929,216 - 29,930,213 (+)Ensembl
GRCm38.p6 Ensembl1929,951,816 - 29,952,813 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144528   ⟹   ENSMUSP00000122319
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,902,515 - 29,929,477 (+)Ensembl
GRCm38.p6 Ensembl1929,925,115 - 29,952,077 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177518   ⟹   ENSMUSP00000135854
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,902,532 - 29,936,375 (+)Ensembl
GRCm38.p6 Ensembl1929,925,132 - 29,958,975 (+)Ensembl
RefSeq Acc Id: NM_001164724   ⟹   NP_001158196
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,923,190 - 29,938,118 (+)NCBI
GRCm381929,945,790 - 29,960,718 (+)NCBI
MGSCv371929,999,604 - 30,035,205 (+)RGD
Celera1930,700,532 - 30,736,141 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001360725   ⟹   NP_001347654
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,902,513 - 29,938,118 (+)NCBI
GRCm381929,925,113 - 29,960,718 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133775   ⟹   NP_598536
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,902,513 - 29,938,118 (+)NCBI
GRCm381929,925,113 - 29,960,718 (+)NCBI
MGSCv371929,999,604 - 30,035,205 (+)RGD
Celera1930,700,532 - 30,736,141 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527463   ⟹   XP_006527526
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,925,881 - 29,938,104 (+)NCBI
GRCm381929,948,443 - 29,960,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161730   ⟹   XP_036017623
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,903,755 - 29,938,104 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598536   ⟸   NM_133775
- UniProtKB: Q8BVZ5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001158196   ⟸   NM_001164724
- UniProtKB: Q8BVZ5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006527526   ⟸   XM_006527463
- Peptide Label: isoform X1
- UniProtKB: Q8BVZ5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001347654   ⟸   NM_001360725
RefSeq Acc Id: ENSMUSP00000122319   ⟸   ENSMUST00000144528
RefSeq Acc Id: ENSMUSP00000135854   ⟸   ENSMUST00000177518
RefSeq Acc Id: ENSMUSP00000113829   ⟸   ENSMUST00000120388
RefSeq Acc Id: ENSMUSP00000025724   ⟸   ENSMUST00000025724
RefSeq Acc Id: ENSMUSP00000135324   ⟸   ENSMUST00000136850
RefSeq Acc Id: XP_036017623   ⟸   XM_036161730
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BVZ5-F1-model_v2 AlphaFold Q8BVZ5 1-266 view protein structure

Promoters
RGD ID:13679236
Promoter ID:EPDNEW_M23767
Type:single initiation site
Name:Il33_1
Description:Mus musculus interleukin 33 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23768  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381929,925,115 - 29,925,175EPDNEW
RGD ID:13679238
Promoter ID:EPDNEW_M23768
Type:multiple initiation site
Name:Il33_2
Description:Mus musculus interleukin 33 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23767  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381929,945,790 - 29,945,850EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924375 AgrOrtholog
Ensembl Genes ENSMUSG00000024810 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025724 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000113829 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000122319 UniProtKB/TrEMBL
  ENSMUSP00000135324 UniProtKB/TrEMBL
  ENSMUSP00000135854 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025724 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000120388 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000136850 UniProtKB/TrEMBL
  ENSMUST00000144528 UniProtKB/TrEMBL
  ENSMUST00000177518 UniProtKB/TrEMBL
InterPro IL-33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:77125 UniProtKB/Swiss-Prot
MGD MGI:1924375 ENTREZGENE
NCBI Gene 77125 ENTREZGENE
PANTHER PTHR21114 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il33 PhenoGen
UniProt D3Z6T7_MOUSE UniProtKB/TrEMBL
  E9M2E8_MOUSE UniProtKB/TrEMBL
  H3BKB5_MOUSE UniProtKB/TrEMBL
  H3BLN5_MOUSE UniProtKB/TrEMBL
  IL33_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q2YEJ4 UniProtKB/Swiss-Prot
  Q3TQN0 UniProtKB/Swiss-Prot
  Q99L46 UniProtKB/Swiss-Prot