Il33 (interleukin 33) - Rat Genome Database

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Gene: Il33 (interleukin 33) Mus musculus
Analyze
Symbol: Il33
Name: interleukin 33
RGD ID: 1322462
MGI Page MGI
Description: Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including antibacterial innate immune response; regulation of gene expression; and regulation of inflammatory response. Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9230117N10Rik; Il-; Il-33; Il1f; Il1f11; interleukin-33; NF-H; NF-HEV; nuclear factor from high endothelial venules
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,902,513 - 29,938,118 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,902,514 - 29,938,118 (+)EnsemblGRCm39 Ensembl
GRCm381929,925,113 - 29,960,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,925,114 - 29,960,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,999,604 - 30,035,205 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,015,647 - 30,026,715 (+)NCBIMGSCv36mm8
Celera1930,700,532 - 30,736,141 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1924.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myocardial infarction  (ISO)
Alzheimer's disease  (IAGP)
angiostrongyliasis  (IDA,IEP)
aortic atherosclerosis  (ISO)
asthma  (IMP,ISO)
atopic dermatitis  (ISO)
candidiasis  (ISO)
Cardiomegaly  (IEP,ISO)
Cardiovirus Infections  (IEP)
cerebral malaria  (IDA,IEP)
chromosome 9p deletion syndrome  (ISO)
Chronic Hepatitis B  (IDA,ISO)
chronic obstructive pulmonary disease  (IEP)
Chronic Periodontitis  (ISO)
clonorchiasis  (IEP,ISO)
Clostridium difficile colitis  (IEP,IMP)
colitis  (IDA,IEP,ISO)
colon cancer  (ISO)
common cold  (ISO)
cryptococcosis  (IEP)
dengue disease  (IDA)
diabetes mellitus  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (IDA,IEP)
Experimental Liver Cirrhosis  (ISO)
familial hemophagocytic lymphohistiocytosis 2  (IEP)
Fungal Lung Diseases  (IEP)
gout  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Helicobacter Infections  (ISO)
Hemolysis  (ISO)
herpes simplex  (IEP,ISO)
Hookworm Infections  (IEP)
Hyperalgesia  (ISO)
Immediate Hypersensitivity  (ISO)
inflammatory bowel disease  (ISO)
influenza  (IEP)
Intervertebral Disc Displacement  (ISO)
irritable bowel syndrome  (ISO)
kidney disease  (ISO)
listeriosis  (IEP)
liver cirrhosis  (IEP,ISO)
malaria  (IEP)
Nematode Infections  (IEP)
paracoccidioidomycosis  (ISO)
parasitic helminthiasis infectious disease  (IDA)
peptic ulcer disease  (ISO)
periodontitis  (IDA,IEP)
pleural tuberculosis  (ISO)
pneumocystosis  (IDA)
pneumonia  (ISO)
prostate cancer  (ISO)
Pseudomonas Infections  (IEP)
pulmonary edema  (ISO)
pulmonary tuberculosis  (IDA)
respiratory allergy  (IDA)
respiratory syncytial virus infectious disease  (IEP,IMP)
schistosomiasis  (IEP)
Schistosomiasis Japonica  (IDA,IMP,ISO)
Sepsis  (IEP,IMP,ISO)
Staphylococcal Pneumonia  (IEP)
Staphylococcal Skin Infections  (IDA,IEP)
Strongylida Infections  (IEP)
Superinfection  (IDA)
tongue squamous cell carcinoma  (ISO)
tuberculosis  (ISO)
ulcerative colitis  (IEP,ISO)
Viral Bronchiolitis  (ISO)
viral encephalitis  (IEP)
Viral Myocarditis  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5'-S-methyl-5'-thioadenosine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetamide  (ISO)
acetic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (EXP)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (EXP)
calcitriol  (ISO)
calycosin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clomipramine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ferric oxide  (EXP)
ferulic acid  (EXP)
flavokawain B  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
furan  (ISO)
genistein  (EXP)
glutathione  (ISO)
glyphosate  (EXP)
graphene oxide  (EXP)
hydroquinone  (ISO)
imipramine  (ISO)
imiquimod  (EXP)
indole-3-methanol  (ISO)
irinotecan  (ISO)
kaempferol  (EXP,ISO)
ketoconazole  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lysophosphatidylcholine  (ISO)
mechlorethamine  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methoxychlor  (EXP)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pemetrexed  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quartz  (EXP)
quinazolines  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
trichloroethene  (ISO)
triclosan  (EXP,ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
Vinpocetine  (EXP)
WIN 55212-2  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial innate immune response  (IDA)
cellular response to mechanical stimulus  (IEA,ISO)
defense response to virus  (IDA)
extrinsic apoptotic signaling pathway  (IGI)
gene expression  (IDA)
interleukin-33-mediated signaling pathway  (IDA)
macrophage activation involved in immune response  (IDA)
macrophage differentiation  (IDA)
microglial cell activation involved in immune response  (IDA)
microglial cell proliferation  (IDA)
negative regulation of immunoglobulin production  (IGI)
negative regulation of inflammatory response to wounding  (IDA,ISO)
negative regulation of leukocyte migration  (IGI)
negative regulation of macrophage proliferation  (IDA)
negative regulation of T-helper 1 type immune response  (IGI)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of type II interferon production  (IGI)
positive regulation of CD80 production  (IDA)
positive regulation of CD86 production  (IDA)
positive regulation of cellular defense response  (IMP)
positive regulation of chemokine production  (IDA,ISO)
positive regulation of cytokine production  (IBA)
positive regulation of gene expression  (IDA)
positive regulation of immunoglobulin production  (IGI)
positive regulation of inflammatory response  (IBA,IDA)
positive regulation of interleukin-13 production  (IGI)
positive regulation of interleukin-4 production  (IGI)
positive regulation of interleukin-5 production  (IGI)
positive regulation of interleukin-6 production  (IDA,IGI)
positive regulation of macrophage activation  (IDA,ISO)
positive regulation of MHC class I biosynthetic process  (IDA)
positive regulation of MHC class II biosynthetic process  (IDA)
positive regulation of oligodendrocyte differentiation  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IDA,IGI)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of tumor necrosis factor production  (IDA)
positive regulation of type 2 immune response  (IDA,IGI)
protein import into nucleus  (IDA)
response to wounding  (IDA)
type 2 immune response  (IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal coat/ hair morphology  (IEA)
abnormal double-strand DNA break repair  (IAGP)
abnormal habituation to a new environment  (IAGP)
abnormal immune cell physiology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
decreased airway responsiveness  (IAGP)
decreased corpora lutea number  (IAGP)
decreased eosinophil cell number  (IAGP)
decreased heart rate  (IEA)
decreased IgE level  (IAGP)
decreased inflammatory response  (IAGP)
decreased interleukin-1 alpha secretion  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased respiratory mucosa goblet cell number  (IAGP)
decreased superovulation rate  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
early reproductive senescence  (IAGP)
hippocampal neuron degeneration  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
impaired passive avoidance behavior  (IAGP)
increased airway responsiveness  (IAGP)
increased locomotor activity  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased vertical activity  (IAGP)
lung inflammation  (IAGP)
neurodegeneration  (IAGP)
prolonged RR interval  (IEA)
tau protein deposits  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Differential production of interleukin-1 family cytokines (IL-1β, IL-18, IL-33 and IL-37) in patients with paracoccidioidomycosis: correlation with clinical form and antifungal therapy. Alves ABRM, etal., Med Mycol. 2018 Apr 1;56(3):332-343. doi: 10.1093/mmy/myx050.
2. A potential role for interleukin-33 and gamma-epithelium sodium channel in the pathogenesis of human malaria associated lung injury. Ampawong S, etal., Malar J. 2015 Oct 5;14:389. doi: 10.1186/s12936-015-0922-x.
3. New Host-Directed Therapeutics for the Treatment of Clostridioides difficile Infection. Andersson JA, etal., mBio. 2020 Mar 10;11(2). pii: mBio.00053-20. doi: 10.1128/mBio.00053-20.
4. The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity. Aoki R, etal., J Invest Dermatol. 2016 Jun;136(6):1290-1292. doi: 10.1016/j.jid.2016.01.030. Epub 2016 Feb 9.
5. Decreased circulating interleukin-33 concentration in Helicobacter pylori-infected patients with peptic ulcer: Evaluation of its association with a cytokine gene polymorphism, gender of patients and bacterial virulence factor CagA. Bassagh A, etal., Microb Pathog. 2019 Nov;136:103708. doi: 10.1016/j.micpath.2019.103708. Epub 2019 Sep 3.
6. IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. Besnard AG, etal., PLoS Pathog. 2015 Feb 6;11(2):e1004607. doi: 10.1371/journal.ppat.1004607. eCollection 2015 Feb.
7. Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection. Blériot C, etal., Immunity. 2015 Jan 20;42(1):145-58. doi: 10.1016/j.immuni.2014.12.020. Epub 2014 Dec 25.
8. ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms. Bouchery T, etal., Nat Commun. 2015 Apr 27;6:6970. doi: 10.1038/ncomms7970.
9. Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation. Callejas BE, etal., Int J Cancer. 2019 Dec 1;145(11):3126-3139. doi: 10.1002/ijc.32626. Epub 2019 Aug 30.
10. Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33. Castanhinha S, etal., J Allergy Clin Immunol. 2015 Aug;136(2):312-22.e7. doi: 10.1016/j.jaci.2015.01.016. Epub 2015 Mar 5.
11. [Changes in plasma interleukin-33 concentration in sepsis and its correlation with seriousness of sepsis]. Chang D, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Feb;27(2):138-42. doi: 10.3760/cma.j.issn.2095-4352.2015.02.012.
12. [Correlation between acute schistosomiasis japonica and serum interleukin-33 levels]. Chen RQ, etal., Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2012 Feb;24(1):32-4, 39.
13. Group 2 Innate Lymphoid Cells (ILC2s) Are Key Mediators of the Inflammatory Response in Polymicrobial Sepsis. Chun TT, etal., Am J Pathol. 2018 Sep;188(9):2097-2108. doi: 10.1016/j.ajpath.2018.05.009. Epub 2018 Jun 20.
14. Arginase-1 and Treg Profile Appear to Modulate Inflammatory Process in Patients with Chronic Gastritis: IL-33 May Be the Alarm Cytokine in H. pylori-Positive Patients. da Silva EAW, etal., Mediators Inflamm. 2019 Jun 20;2019:2536781. doi: 10.1155/2019/2536781. eCollection 2019.
15. IL-33 mediates the expressions of IL-5 and IL-13 in Angiostrongylus cantonensis-infected mice. Du WY, etal., Exp Parasitol. 2013 Nov;135(3):587-94. doi: 10.1016/j.exppara.2013.09.012. Epub 2013 Sep 27.
16. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. Franca RF, etal., J Neuroinflammation. 2016 Jun 22;13(1):159. doi: 10.1186/s12974-016-0628-1.
17. Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis. García-García ML, etal., Medicine (Baltimore). 2017 May;96(18):e6787. doi: 10.1097/MD.0000000000006787.
18. Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis. Gimenes JA, etal., Clin Sci (Lond). 2019 Apr 29;133(8):983-996. doi: 10.1042/CS20181088. Print 2019 Apr 30.
19. Group 2 innate lymphoid cells exhibit progressively higher levels of activation during worsening of liver fibrosis. Gonzalez-Polo V, etal., Ann Hepatol. 2019 Mar - Apr;18(2):366-372. doi: 10.1016/j.aohep.2018.12.001. Epub 2019 Apr 25.
20. NFATc1-E2F1-LMCD1-Mediated IL-33 Expression by Thrombin Is Required for Injury-Induced Neointima Formation. Govatati S, etal., Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1212-1226. doi: 10.1161/ATVBAHA.119.312729.
21. Natural helper cells mediate respiratory syncytial virus-induced airway inflammation by producing type 2 cytokines in an IL-33-dependent manner. Han X, etal., Immunotherapy. 2017 Aug;9(9):715-722. doi: 10.2217/imt-2017-0037. Epub 2017 Aug 3.
22. Down-regulation of microRNA-203-3p initiates type 2 pathology during schistosome infection via elevation of interleukin-33. He X, etal., PLoS Pathog. 2018 Mar 19;14(3):e1006957. doi: 10.1371/journal.ppat.1006957. eCollection 2018 Mar.
23. Lung epithelium is the major source of IL-33 and is regulated by IL-33-dependent and IL-33-independent mechanisms in pulmonary cryptococcosis. Heyen L, etal., Pathog Dis. 2016 Oct;74(7). pii: ftw086. doi: 10.1093/femspd/ftw086. Epub 2016 Sep 4.
24. Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. Huan SL, etal., BMC Infect Dis. 2016 May 16;16:200. doi: 10.1186/s12879-016-1543-x.
25. IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation. Huang SJ, etal., J Neuroinflammation. 2018 Jan 12;15(1):12. doi: 10.1186/s12974-017-1021-4.
26. Induction of IL-33 expression and activity in central nervous system glia. Hudson CA, etal., J Leukoc Biol. 2008 Sep;84(3):631-43. doi: 10.1189/jlb.1207830. Epub 2008 Jun 13.
27. Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue. Ishikawa K, etal., Auris Nasus Larynx. 2014 Dec;41(6):552-7. doi: 10.1016/j.anl.2014.08.007. Epub 2014 Sep 2.
28. IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha. Jackson-Jones LH, etal., Eur J Immunol. 2016 Oct;46(10):2311-2321. doi: 10.1002/eji.201646442.
29. IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals. Le HT, etal., J Immunol. 2012 Jul 1;189(1):287-95. doi: 10.4049/jimmunol.1103564. Epub 2012 Jun 1.
30. Association between elevated pleural interleukin-33 levels and tuberculous pleurisy. Lee KS, etal., Ann Lab Med. 2013 Jan;33(1):45-51. doi: 10.3343/alm.2013.33.1.45. Epub 2012 Dec 17.
31. Combined detections of interleukin-33 and adenosine deaminase for diagnosis of tuberculous pleural effusion. Li D, etal., Int J Clin Exp Pathol. 2015 Jan 1;8(1):888-93. eCollection 2015.
32. Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression. Li ZY, etal., Parasit Vectors. 2019 Jun 14;12(1):302. doi: 10.1186/s13071-019-3542-4.
33. Natural helper cells contribute to pulmonary eosinophilia by producing IL-13 via IL-33/ST2 pathway in a murine model of respiratory syncytial virus infection. Liu J, etal., Int Immunopharmacol. 2015 Sep;28(1):337-43. doi: 10.1016/j.intimp.2015.05.035. Epub 2015 Jun 1.
34. Virus-like particles presenting interleukin-33 molecules: immunization characteristics and potentials of blockingIL-33/ST2 pathway in allergic airway inflammation. Long Q, etal., Hum Vaccin Immunother. 2014;10(8):2303-11. doi: 10.4161/hv.29425.
35. IL-33 Exacerbates Periodontal Disease through Induction of RANKL. Malcolm J, etal., J Dent Res. 2015 Jul;94(7):968-75. doi: 10.1177/0022034515577815. Epub 2015 Mar 25.
36. Interleukin-33 contributes to disease severity in Dengue virus infection in mice. Marques RE, etal., Immunology. 2018 Dec;155(4):477-490. doi: 10.1111/imm.12988. Epub 2018 Sep 10.
37. MGDs mouse GO annotations MGD data from the GO Consortium
38. The effect of diabetes on ovaries in a rat model: the role of interleukin-33 and apoptosis. Nayki C, etal., Gynecol Endocrinol. 2017 Sep;33(9):708-711. doi: 10.1080/09513590.2017.1313971. Epub 2017 Apr 17.
39. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. Nelson MP, etal., J Immunol. 2011 Feb 15;186(4):2372-81. doi: 10.4049/jimmunol.1002558. Epub 2011 Jan 10.
40. Critical role of IL-33 receptor ST2 in experimental cerebral malaria development. Palomo J, etal., Eur J Immunol. 2015 May;45(5):1354-65. doi: 10.1002/eji.201445206. Epub 2015 Mar 20.
41. Interleukin 33 mediates type 2 immunity and inflammation in the central nervous system of mice infected with Angiostrongylus cantonensis. Peng H, etal., J Infect Dis. 2013 Mar 1;207(5):860-9. doi: 10.1093/infdis/jis682. Epub 2012 Nov 12.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
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44. Mouse MP Annotation Import Pipeline RGD automated import pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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50. IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut. Sattler S, etal., J Autoimmun. 2014 May;50:107-22. doi: 10.1016/j.jaut.2014.01.032. Epub 2014 Feb 1.
51. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Sedhom MA, etal., Gut. 2013 Dec;62(12):1714-23. doi: 10.1136/gutjnl-2011-301785. Epub 2012 Nov 21.
52. IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis. Seidelin JB, etal., J Gastroenterol. 2015 Feb;50(2):180-90. doi: 10.1007/s00535-014-0982-7. Epub 2014 Aug 12.
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54. IL-33 Ameliorates the Development of MSU-Induced Inflammation Through Expanding MDSCs-Like Cells. Shang K, etal., Front Endocrinol (Lausanne). 2019 Feb 26;10:36. doi: 10.3389/fendo.2019.00036. eCollection 2019.
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Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12819012   PMID:15475267   PMID:15489334   PMID:16141072   PMID:16141073  
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Genomics

Comparative Map Data
Il33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,902,513 - 29,938,118 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,902,514 - 29,938,118 (+)EnsemblGRCm39 Ensembl
GRCm381929,925,113 - 29,960,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,925,114 - 29,960,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,999,604 - 30,035,205 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,015,647 - 30,026,715 (+)NCBIMGSCv36mm8
Celera1930,700,532 - 30,736,141 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1924.56NCBI
IL33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3896,215,149 - 6,257,983 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl96,215,786 - 6,257,983 (+)EnsemblGRCh38hg38GRCh38
GRCh3796,215,149 - 6,257,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3696,231,678 - 6,247,982 (+)NCBINCBI36Build 36hg18NCBI36
Build 3496,231,677 - 6,247,982NCBI
Celera96,179,137 - 6,195,439 (+)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef96,171,374 - 6,213,493 (+)NCBIHuRef
CHM1_196,216,394 - 6,258,768 (+)NCBICHM1_1
T2T-CHM13v2.096,220,289 - 6,263,045 (+)NCBIT2T-CHM13v2.0
Il33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,115,478 - 237,149,897 (+)NCBIGRCr8
mRatBN7.21227,701,964 - 227,736,374 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,721,435 - 227,736,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,123,222 - 236,138,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,052,907 - 243,067,851 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,869,667 - 235,884,579 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,112,611 - 248,147,030 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,132,090 - 248,147,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,382,760 - 255,397,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,670,801 - 233,685,798 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11233,834,823 - 233,849,820 (+)NCBI
Celera1224,871,607 - 224,886,518 (+)NCBICelera
Cytogenetic Map1q52NCBI
Il33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543410,171,812 - 10,188,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543410,145,449 - 10,187,595 (+)NCBIChiLan1.0ChiLan1.0
IL33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211118,322,326 - 118,364,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19118,328,274 - 118,370,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v096,027,014 - 6,069,540 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.196,208,479 - 6,250,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl96,234,178 - 6,248,624 (+)Ensemblpanpan1.1panPan2
IL33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11127,219,878 - 27,256,723 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1127,219,878 - 27,256,721 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1125,988,860 - 26,025,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01128,069,676 - 28,106,564 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1128,069,663 - 28,108,194 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11126,788,250 - 26,825,127 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01126,610,673 - 26,647,647 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01127,281,817 - 27,318,668 (+)NCBIUU_Cfam_GSD_1.0
Il33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947142,170,523 - 142,338,788 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936539623,248 - 791,470 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936539763,755 - 791,461 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,899,436 - 215,941,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,899,830 - 215,941,944 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,454,091 - 241,496,130 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11273,235,585 - 73,283,665 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1273,237,406 - 73,252,436 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603861,612,048 - 61,659,928 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473610,764,486 - 10,784,864 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473610,733,944 - 10,786,188 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il33
1317 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1001
Count of miRNA genes:460
Interacting mature miRNAs:491
Transcripts:ENSMUST00000025724, ENSMUST00000120388, ENSMUST00000136850, ENSMUST00000144528, ENSMUST00000177518
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192777198535295381Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
AV028447  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381929,960,570 - 29,960,708UniSTSGRCm38
MGSCv371930,035,060 - 30,035,198UniSTSGRCm37
Celera1930,735,996 - 30,736,134UniSTS
Cytogenetic Map19C2UniSTS
Whitehead/MRC_RH19302.82UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025724   ⟹   ENSMUSP00000025724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,923,190 - 29,938,104 (+)Ensembl
GRCm38.p6 Ensembl1929,945,790 - 29,960,704 (+)Ensembl
Ensembl Acc Id: ENSMUST00000120388   ⟹   ENSMUSP00000113829
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,902,514 - 29,938,118 (+)Ensembl
GRCm38.p6 Ensembl1929,925,114 - 29,960,718 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136850   ⟹   ENSMUSP00000135324
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,929,216 - 29,930,213 (+)Ensembl
GRCm38.p6 Ensembl1929,951,816 - 29,952,813 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144528   ⟹   ENSMUSP00000122319
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,902,515 - 29,929,477 (+)Ensembl
GRCm38.p6 Ensembl1929,925,115 - 29,952,077 (+)Ensembl
Ensembl Acc Id: ENSMUST00000177518   ⟹   ENSMUSP00000135854
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1929,902,532 - 29,936,375 (+)Ensembl
GRCm38.p6 Ensembl1929,925,132 - 29,958,975 (+)Ensembl
RefSeq Acc Id: NM_001164724   ⟹   NP_001158196
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,923,190 - 29,938,118 (+)NCBI
GRCm381929,945,790 - 29,960,718 (+)NCBI
MGSCv371929,999,604 - 30,035,205 (+)RGD
Celera1930,700,532 - 30,736,141 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001360725   ⟹   NP_001347654
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,902,513 - 29,938,118 (+)NCBI
GRCm381929,925,113 - 29,960,718 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133775   ⟹   NP_598536
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,902,513 - 29,938,118 (+)NCBI
GRCm381929,925,113 - 29,960,718 (+)NCBI
MGSCv371929,999,604 - 30,035,205 (+)RGD
Celera1930,700,532 - 30,736,141 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527463   ⟹   XP_006527526
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,925,881 - 29,938,104 (+)NCBI
GRCm381929,948,443 - 29,960,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161730   ⟹   XP_036017623
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,903,755 - 29,938,104 (+)NCBI
Sequence:
RefSeq Acc Id: NP_598536   ⟸   NM_133775
- Peptide Label: isoform 1
- UniProtKB: Q3TQN0 (UniProtKB/Swiss-Prot),   Q2YEJ4 (UniProtKB/Swiss-Prot),   Q99L46 (UniProtKB/Swiss-Prot),   Q8BVZ5 (UniProtKB/Swiss-Prot),   H3BLN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001158196   ⟸   NM_001164724
- Peptide Label: isoform 1
- UniProtKB: Q3TQN0 (UniProtKB/Swiss-Prot),   Q2YEJ4 (UniProtKB/Swiss-Prot),   Q99L46 (UniProtKB/Swiss-Prot),   Q8BVZ5 (UniProtKB/Swiss-Prot),   H3BLN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006527526   ⟸   XM_006527463
- Peptide Label: isoform X1
- UniProtKB: Q3TQN0 (UniProtKB/Swiss-Prot),   Q2YEJ4 (UniProtKB/Swiss-Prot),   Q99L46 (UniProtKB/Swiss-Prot),   Q8BVZ5 (UniProtKB/Swiss-Prot),   H3BLN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001347654   ⟸   NM_001360725
- Peptide Label: isoform 1
- UniProtKB: Q8BVZ5 (UniProtKB/Swiss-Prot),   Q3TQN0 (UniProtKB/Swiss-Prot),   Q2YEJ4 (UniProtKB/Swiss-Prot),   Q99L46 (UniProtKB/Swiss-Prot),   H3BLN5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000122319   ⟸   ENSMUST00000144528
Ensembl Acc Id: ENSMUSP00000135854   ⟸   ENSMUST00000177518
Ensembl Acc Id: ENSMUSP00000113829   ⟸   ENSMUST00000120388
Ensembl Acc Id: ENSMUSP00000025724   ⟸   ENSMUST00000025724
Ensembl Acc Id: ENSMUSP00000135324   ⟸   ENSMUST00000136850
RefSeq Acc Id: XP_036017623   ⟸   XM_036161730
- Peptide Label: isoform X1
- UniProtKB: Q8BVZ5 (UniProtKB/Swiss-Prot),   Q3TQN0 (UniProtKB/Swiss-Prot),   Q2YEJ4 (UniProtKB/Swiss-Prot),   Q99L46 (UniProtKB/Swiss-Prot),   H3BLN5 (UniProtKB/TrEMBL)
Protein Domains
Interleukin 33 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BVZ5-F1-model_v2 AlphaFold Q8BVZ5 1-266 view protein structure

Promoters
RGD ID:13679236
Promoter ID:EPDNEW_M23767
Type:single initiation site
Name:Il33_1
Description:Mus musculus interleukin 33 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23768  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381929,925,115 - 29,925,175EPDNEW
RGD ID:13679238
Promoter ID:EPDNEW_M23768
Type:multiple initiation site
Name:Il33_2
Description:Mus musculus interleukin 33 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23767  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381929,945,790 - 29,945,850EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924375 AgrOrtholog
Ensembl Genes ENSMUSG00000024810 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025724 ENTREZGENE
  ENSMUST00000025724.9 UniProtKB/Swiss-Prot
  ENSMUST00000120388 ENTREZGENE
  ENSMUST00000120388.9 UniProtKB/Swiss-Prot
  ENSMUST00000136850.2 UniProtKB/TrEMBL
  ENSMUST00000144528.8 UniProtKB/TrEMBL
  ENSMUST00000177518.8 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IL-33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL33_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:77125 UniProtKB/Swiss-Prot
MGD MGI:1924375 ENTREZGENE
NCBI Gene 77125 ENTREZGENE
PANTHER INTERLEUKIN-33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21114 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il33 PhenoGen
UniProt D3Z6T7_MOUSE UniProtKB/TrEMBL
  E9M2E8_MOUSE UniProtKB/TrEMBL
  H3BKB5_MOUSE UniProtKB/TrEMBL
  H3BLN5 ENTREZGENE, UniProtKB/TrEMBL
  IL33_MOUSE UniProtKB/Swiss-Prot
  Q2YEJ4 ENTREZGENE
  Q3TQN0 ENTREZGENE
  Q8BVZ5 ENTREZGENE
  Q99L46 ENTREZGENE
UniProt Secondary Q2YEJ4 UniProtKB/Swiss-Prot
  Q3TQN0 UniProtKB/Swiss-Prot
  Q99L46 UniProtKB/Swiss-Prot