Gh (growth hormone) - Rat Genome Database

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Gene: Gh (growth hormone) Mus musculus
Analyze
Symbol: Gh
Name: growth hormone
RGD ID: 10643
MGI Page MGI
Description: Enables growth hormone receptor binding activity. Acts upstream of or within cellular response to insulin stimulus; regulation of growth; and response to food. Located in several cellular components, including extracellular space; secretory granule; and trans-Golgi network. Is expressed in several structures, including early conceptus; gut; hemolymphoid system; male reproductive system; and pituitary gland. Used to study isolated growth hormone deficiency type II. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gh1; Ghb1; growth hormone b1; somatotropin
RGD Orthologs
Human
Rat
Bonobo
Squirrel
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,191,087 - 106,194,529 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,191,097 - 106,192,691 (-)EnsemblGRCm39 Ensembl
GRCm3811106,300,261 - 106,303,703 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,300,271 - 106,301,865 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,161,582 - 106,163,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,116,358 - 106,117,900 (-)NCBIMGSCv36mm8
Celera11118,030,755 - 118,032,297 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-trifluoroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4-hydroxybutyric acid  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-tert-Octylphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apomorphine  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoates  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bromocriptine  (ISO)
butan-1-ol  (ISO)
butan-2-ol  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
CGP 12177  (ISO)
chlormequat chloride  (ISO)
chromium(6+)  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
corticotropin  (ISO)
cortisol  (ISO)
cypermethrin  (ISO)
cyproheptadine  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
disulfiram  (ISO)
dobutamine  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
ethylene glycol  (ISO)
ethylenediaminetetraacetic acid  (ISO)
fenvalerate  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
glucose  (ISO)
Guanfacine  (ISO)
homocysteine  (ISO)
hydrogen sulfide  (EXP)
idazoxan  (ISO)
ionomycin  (ISO)
L-ascorbic acid  (ISO)
lead nitrate  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
lisinopril dihydrate  (ISO)
maneb  (EXP)
mephenytoin  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-N-nitrosourea  (ISO)
naproxen  (ISO)
nicotinic acid  (ISO)
Nivalenol  (ISO)
octreotide  (ISO)
p-tert-Amylphenol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
pentetic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
progesterone  (ISO)
propan-1-ol  (ISO)
propan-2-ol  (ISO)
propane-1,2-diol  (ISO)
pyridoxal 5'-phosphate  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
sirtinol  (ISO)
sodium atom  (ISO)
sulpiride  (ISO)
sumatriptan  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tert-butanol  (ISO)
testosterone  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
thyroxine  (EXP,ISO)
titanium dioxide  (EXP)
triptonide  (EXP)
urethane  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IBA)
bone maturation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cell surface receptor signaling pathway via STAT  (ISO)
cellular response to alkaline pH  (ISO)
cellular response to insulin stimulus  (IDA)
cellular response to thyroid hormone stimulus  (ISO)
cytokine-mediated signaling pathway  (ISO)
female pregnancy  (ISO)
growth hormone receptor signaling pathway  (IBA)
growth hormone receptor signaling pathway via JAK-STAT  (ISO)
lung alveolus development  (ISO)
neuroblast proliferation  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of growth  (IBA,ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (ISO)
positive regulation of multicellular organism growth  (IGI,ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IBA)
regulation of intracellular steroid hormone receptor signaling pathway  (ISO)
regulation of response to nutrient levels  (ISO)
response to cytokine  (ISO)
response to estradiol  (ISO)
response to food  (IDA)
response to light stimulus  (ISO)
response to nutrient levels  (IBA)
response to peptide hormone  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Recombinant human growth hormone treatment in children with thalassemia major. Arcasoy A, etal., Pediatr Int. 1999 Dec;41(6):655-61.
2. Evaluation of anterior pituitary function in patients with posttraumatic diabetes insipidus. Barreca T, etal., J Clin Endocrinol Metab. 1980 Dec;51(6):1279-82.
3. Identification of novel GHRHR and GH1 mutations in patients with isolated growth hormone deficiency. Birla S, etal., Growth Horm IGF Res. 2016 Aug;29:50-6. doi: 10.1016/j.ghir.2016.04.001. Epub 2016 Apr 16.
4. Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production. Bouillon R Verh K Acad Geneeskd Belg. 1992;54(4):365-91; discussion 391-2.
5. Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining. Castagnino HE, etal., Neuro Endocrinol Lett. 2002 Oct-Dec;23(5-6):391-5.
6. Novel neuronal and endocrine autoantibody targets in Autoimmune Polyendocrine Syndrome type 1. Cocco C, etal., Autoimmunity. 2012 Sep;45(6):485-94. doi: 10.3109/08916934.2012.680632. Epub 2012 May 18.
7. Effects of physical training on serum and pituitary growth hormone contents in diabetic rats. de Almeida Leme JA, etal., Pituitary. 2009;12(4):304-8. Epub 2009 Apr 16.
8. Dynamics of growth hormone secretion in patients with osteoporosis and in patients with osteoarthrosis. Dequeker J, etal., Horm Res. 1982;16(6):353-6.
9. Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. Ekenstedt KJ, etal., Arthritis Rheum. 2006 Dec;54(12):3850-8.
10. Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. Flavell DM, etal., EMBO J. 1996 Aug 1;15(15):3871-9.
11. [Experimental and clinical studies of recombinant human growth hormone treatement of hypoproteinemia of liver cirrhosis patients]. Guo X, etal., Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2001 Dec;15(4):339-41.
12. Effects of recombinant human growth hormone (r-hGH) on experimental osteoporotic fracture healing. Hao Y, etal., Chin J Traumatol. 2001 May;4(2):102-5.
13. Growth hormone and somatomedin in insulin-dependent diabetes mellitus. Horner JM, etal., J Clin Endocrinol Metab. 1981 Dec;53(6):1148-53.
14. Growth hormone improves short stature in children with Diamond-Blackfan anemia. Howell JC, etal., Pediatr Blood Cancer. 2015 Mar;62(3):402-8. doi: 10.1002/pbc.25341. Epub 2014 Dec 9.
15. Growth hormone response following growth hormone releasing hormone injection in thalassemia major: influence of pubertal development. Leheup BP, etal., J Endocrinol Invest. 1991 Jan;14(1):37-40.
16. [Effect of recombinant human growth hormone on hypoalbuminemia in peritoneal sepsis: experimental and clinical research]. Li W, etal., Zhonghua Yi Xue Za Zhi. 1998 Jun;78(6):413-5.
17. Effect of growth hormone-releasing stimuli in streptozotocin diabetic rats. Locatelli V, etal., Brain Res. 1985 Aug 19;341(1):35-40.
18. High levels of growth hormone and human placental lactogen in pregnancy complicated by diabetes. Lopez-Espinoza I, etal., Diabetes Res. 1986 Mar;3(3):119-25.
19. A homozygous point mutation in the GH1 promoter (c.-223C>T) leads to reduced GH1 expression in siblings with isolated GH deficiency (IGHD). Madeira JL, etal., Eur J Endocrinol. 2016 Aug;175(2):K7-K15. doi: 10.1530/EJE-15-0149. Epub 2016 Jun 1.
20. Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Marino G, etal., Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16268-73. doi: 10.1073/pnas.1002696107. Epub 2010 Aug 30.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. Suppressed spontaneous secretion of growth hormone in girls after treatment for acute lymphoblastic leukaemia. Moell C, etal., Arch Dis Child. 1989 Feb;64(2):252-8.
25. Isolated growth hormone deficiency in Chilean patients: clinical and molecular analysis. Molina G, etal., J Pediatr Endocrinol Metab. 2003 Oct-Nov;16(8):1143-55.
26. Growth hormone kinetics in diabetic patients. Navalesi R, etal., Diabetes. 1975 Apr;24(4):317-27.
27. Studies on prolactin and growth hormone gene expression in the pituitary gland of spontaneous dwarf rats. Nogami H, etal., Endocrinology. 1989 Aug;125(2):964-70.
28. Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor. Okazaki K, etal., Endocrinology. 1999 Oct;140(10):4821-30.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Retinal laser photocoagulation in diabetic patients causes prolactin, growth hormone and cortisol release. Pontiroli AE, etal., J Endocrinol Invest. 1988 May;11(5):389-91.
33. Mouse MP Annotation Import Pipeline RGD automated import pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Rat mammary carcinoma regressions during suppression of serum growth hormone and prolactin. Rose DP, etal., Anticancer Res. 1983 Sep-Oct;3(5):323-5.
37. Effect of recombinant human growth hormone on peripheral nerve regeneration: experimental work on the ulnar nerve of the rat. Saceda J, etal., Neurosci Lett. 2011 Oct 24;504(2):146-50. doi: 10.1016/j.neulet.2011.09.020. Epub 2011 Sep 17.
38. Growth hormone attenuates skeletal muscle changes in experimental chronic heart failure. Santos DP, etal., Growth Horm IGF Res. 2010 Apr;20(2):149-55. doi: 10.1016/j.ghir.2009.11.007. Epub 2010 Jan 8.
39. Growth hormone responsiveness in vivo and in vitro to growth hormone releasing factor in the spontaneously diabetic BB Wistar rat. Serri O and Brazeau P, Neuroendocrinology. 1987 Aug;46(2):162-6.
40. Advanced rat mammary cancers are growth hormone dependent. Shen Q, etal., Endocrinology. 2007 Oct;148(10):4536-44. Epub 2007 Jun 21.
41. Effect of long-term administration of recombinant human growth hormone (rhGH) on plasma erythropoietin (EPO) and haemoglobin levels in anaemic patients with adult GH deficiency. Sohmiya M and Kato Y, Clin Endocrinol (Oxf). 2001 Dec;55(6):749-54.
42. Effects of sericin on the testicular growth hormone/insulin-like growth factor-1 axis in a rat model of type 2 diabetes. Song CJ, etal., Int J Clin Exp Med. 2015 Jul 15;8(7):10411-9. eCollection 2015.
43. Biologically inactive growth hormone caused by an amino acid substitution. Takahashi Y, etal., J Clin Invest. 1997 Sep 1;100(5):1159-65.
44. Molecular mechanism of growth hormone (GH) deficiency in the spontaneous dwarf rat: detection of abnormal splicing of GH messenger ribonucleic acid by the polymerase chain reaction. Takeuchi T, etal., Endocrinology. 1990 Jan;126(1):31-8.
45. Changes in growth hormone (GH), GH receptor, and GH signal transduction in hippocampus of congenital hypothyroid rats. Tang H, etal., J Neurosci Res. 2011 Feb;89(2):248-55. doi: 10.1002/jnr.22540. Epub 2010 Dec 8.
46. Effects of intravenous TRH on growth hormone and cortisol serum levels in children and adolescents with insulin dependent diabetes mellitus. Vanelli M, etal., J Endocrinol Invest. 1986 Aug;9(4):293-7.
47. The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly. Wassenaar MJ, etal., J Clin Endocrinol Metab. 2009 Dec;94(12):4671-8. doi: 10.1210/jc.2009-1172. Epub 2009 Oct 28.
48. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Wei L, etal., Biochem Cell Biol. 2010 Aug;88(4):723-30. doi: 10.1139/O10-022.
49. Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Wolf N, etal., Exp Eye Res. 2005 Sep;81(3):276-85.
50. Growth hormone reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation. Yigiter M, etal., Eur J Obstet Gynecol Reprod Biol. 2011 Jul;157(1):94-100. doi: 10.1016/j.ejogrb.2011.02.012. Epub 2011 Mar 25.
51. Vitreous growth hormone and visual dysfunction. Ziaei M, etal., Neurosci Lett. 2009 Aug 21;460(1):87-91. Epub 2009 May 20.
Additional References at PubMed
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PMID:9144201   PMID:9175714   PMID:9177778   PMID:9247269   PMID:9275086   PMID:9333128   PMID:9388186   PMID:9546108   PMID:9556071   PMID:9620855   PMID:9624169   PMID:10049363  
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PMID:26134413   PMID:26292757   PMID:26296153   PMID:26442444   PMID:26465715   PMID:26651607   PMID:26697363   PMID:26762506   PMID:26764381   PMID:26812162   PMID:26862561   PMID:26887678  
PMID:26997624   PMID:27079169   PMID:27184910   PMID:27226307   PMID:27226320   PMID:27558671   PMID:27616671   PMID:27626380   PMID:27631552   PMID:27771355   PMID:27776119   PMID:27810956  
PMID:27825319   PMID:28506993   PMID:28807898   PMID:28911172   PMID:28938441   PMID:29180744   PMID:29263200   PMID:29578405   PMID:29796621   PMID:30085028   PMID:30307165   PMID:30333823  
PMID:30400015   PMID:30811539   PMID:30910968   PMID:30982661   PMID:31099824   PMID:31436800   PMID:31479305   PMID:31781038   PMID:31913463   PMID:32100023   PMID:32423821   PMID:32556100  
PMID:32644973   PMID:32844436   PMID:33108146   PMID:33112796   PMID:33248443   PMID:33368660   PMID:33539533   PMID:33772537   PMID:33795686   PMID:34023483   PMID:34564702   PMID:34721302  
PMID:34737342   PMID:34971379   PMID:35049495   PMID:35652338   PMID:35951005   PMID:36619565   PMID:36762426   PMID:36800350   PMID:36976763   PMID:37168577   PMID:37625855   PMID:38241182  
PMID:38355793  


Genomics

Comparative Map Data
Gh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,191,087 - 106,194,529 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,191,097 - 106,192,691 (-)EnsemblGRCm39 Ensembl
GRCm3811106,300,261 - 106,303,703 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,300,271 - 106,301,865 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,161,582 - 106,163,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,116,358 - 106,117,900 (-)NCBIMGSCv36mm8
Celera11118,030,755 - 118,032,297 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
GH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,917,203 - 63,918,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,917,200 - 63,918,839 (-)EnsemblGRCh38hg38GRCh38
GRCh371761,994,563 - 61,996,199 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,348,295 - 59,349,930 (-)NCBINCBI36Build 36hg18NCBI36
Build 341759,348,294 - 59,349,930NCBI
Celera1756,382,602 - 56,384,237 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,362,255 - 57,363,890 (-)NCBIHuRef
CHM1_11762,058,482 - 62,060,117 (-)NCBICHM1_1
T2T-CHM13v2.01764,787,962 - 64,789,598 (-)NCBIT2T-CHM13v2.0
Gh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,727,883 - 91,729,860 (-)NCBIGRCr8
mRatBN7.21091,228,102 - 91,230,079 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,228,103 - 91,230,078 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,282,748 - 96,284,726 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,745,913 - 95,747,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,156,493 - 91,158,471 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,486,204 - 94,488,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,486,205 - 94,488,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,237,414 - 94,239,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,692,240 - 95,694,117 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11095,708,476 - 95,710,261 (-)NCBI
Celera1089,903,834 - 89,905,811 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
LOC100971425
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,100,098 - 80,103,160 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,920,431 - 84,923,465 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,010,848 - 58,013,421 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,103,339 - 63,105,719 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,103,332 - 63,105,067 (-)Ensemblpanpan1.1panPan2
LOC101969021
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,668,568 - 14,670,240 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365414,524,397 - 4,528,234 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0

Variants

.
Variants in Gh
84 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:206
Interacting mature miRNAs:211
Transcripts:ENSMUST00000103071
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103273992115021444Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102344123112384123Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
BGH  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,300,550 - 106,300,812UniSTSGRCm38
MGSCv3711106,161,864 - 106,162,126UniSTSGRCm37
Celera11118,031,037 - 118,031,299UniSTS
Cytogenetic Map11DUniSTS
cM Map1165.0UniSTS
Gh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,300,366 - 106,301,775UniSTSGRCm38
MGSCv3711106,161,680 - 106,163,089UniSTSGRCm37
Celera11118,030,853 - 118,032,262UniSTS
Cytogenetic Map11DUniSTS
cM Map1165.0UniSTS
cM Map1165.0UniSTS
cM Map1165.0UniSTS
GHI  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,300,830 - 106,301,522UniSTSGRCm38
MGSCv3711106,162,144 - 106,162,836UniSTSGRCm37
Celera11118,031,317 - 118,032,009UniSTS
Cytogenetic Map11DUniSTS
cM Map1165.0UniSTS
Gh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,300,423 - 106,300,503UniSTSGRCm38
MGSCv3711106,161,737 - 106,161,817UniSTSGRCm37
Celera11118,030,910 - 118,030,990UniSTS
Cytogenetic Map11DUniSTS
cM Map1165.0UniSTS
Gh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,300,355 - 106,300,484UniSTSGRCm38
MGSCv3711106,161,669 - 106,161,798UniSTSGRCm37
Celera11118,030,842 - 118,030,971UniSTS
Cytogenetic Map11DUniSTS
cM Map1165.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK019952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL604045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB024006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LM644167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z46663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000103071   ⟹   ENSMUSP00000099360
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11106,191,097 - 106,192,691 (-)Ensembl
GRCm38.p6 Ensembl11106,300,271 - 106,301,865 (-)Ensembl
RefSeq Acc Id: NM_008117   ⟹   NP_032143
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911106,191,087 - 106,192,722 (-)NCBI
GRCm3811106,300,261 - 106,301,896 (-)NCBI
MGSCv3711106,161,582 - 106,163,124 (-)RGD
Celera11118,030,748 - 118,032,383 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532223   ⟹   XP_006532286
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911106,191,094 - 106,194,529 (-)NCBI
GRCm3811106,300,268 - 106,303,703 (-)NCBI
Sequence:
RefSeq Acc Id: NP_032143   ⟸   NM_008117
- Peptide Label: precursor
- UniProtKB: Q544X1 (UniProtKB/Swiss-Prot),   P06880 (UniProtKB/Swiss-Prot),   A0A0M6L0K7 (UniProtKB/TrEMBL),   Q9R2C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532286   ⟸   XM_006532223
- Peptide Label: isoform X1
- UniProtKB: Q9R2C3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099360   ⟸   ENSMUST00000103071

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06880-F1-model_v2 AlphaFold P06880 1-216 view protein structure

Promoters
RGD ID:8677080
Promoter ID:EPDNEW_M16571
Type:multiple initiation site
Name:Gh_1
Description:Mus musculus growth hormone , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811106,301,810 - 106,301,870EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95707 AgrOrtholog
Ensembl Genes ENSMUSG00000020713 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000103071 ENTREZGENE
  ENSMUST00000103071.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin/Prolactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14599 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95707 ENTREZGENE
NCBI Gene 14599 ENTREZGENE
PANTHER PTHR11417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11417:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gh PhenoGen
PRINTS SOMATOTROPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOMATOTROPIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOTROPIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0M6L0K7 ENTREZGENE, UniProtKB/TrEMBL
  P06880 ENTREZGENE
  Q544X1 ENTREZGENE
  Q8BK24_MOUSE UniProtKB/TrEMBL
  Q9R2C3 ENTREZGENE, UniProtKB/TrEMBL
  SOMA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q544X1 UniProtKB/Swiss-Prot