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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10643
Species: Mus musculus
RGD Object: Gene
Symbol: Gh
Name: growth hormone
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ghincreases secretionISOGH1 (Homo sapiens)6480464CTDProgesterone results in increased secretion of GH1 proteinPMID:15772906
Ghmultiple interactionsISOGh1 (Rattus norvegicus)6480464CTDGH1 protein inhibits the reaction [BMP4 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; GH1 protein inhibits the reaction [BMP6 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; GH1 protein inhibits the reaction [BMP7 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; GH1 protein promotes the reaction [[FSHB protein results in increased expression of CYP11A1 mRNA] which results in increased abundance of Progesterone]; GH1 protein promotes the reaction [[FSHB protein results in increased expression of HSD3B2 mRNA] which results in increased abundance of Progesterone]; GH1 protein promotes the reaction [[FSHB protein results in increased expression of STAR mRNA] which results in increased abundance of Progesterone]; GH1 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]; NOG protein promotes the reaction [GH1 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]]PMID:22067323
Ghmultiple interactionsISOGH1 (Homo sapiens)6480464CTD[Progesterone co-treated with Estradiol] results in increased secretion of GH1 proteinPMID:15772906
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