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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10643
Species: Mus musculus
RGD Object: Gene
Symbol: Gh
Name: growth hormone
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ghdecreases expressionISOGh1 (Rattus norvegicus)6480464CTDdeoxynivalenol results in decreased expression of GH1 mRNAPMID:26141394 PMID:32738333 PMID:34673182
Ghdecreases secretionISOGh1 (Rattus norvegicus)6480464CTDdeoxynivalenol results in decreased secretion of GH1 proteinPMID:34673182
Ghmultiple interactionsISOGh1 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; deoxynivalenol results in decreased expression of and results in decreased secretion of GH1 protein; farnesylthiosalicylic acid inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; farnesylthiosalicylic acid inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]; pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]PMID:26141394 PMID:34673182
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