Egr2 (early growth response 2) - Rat Genome Database

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Gene: Egr2 (early growth response 2) Mus musculus
Symbol: Egr2
Name: early growth response 2
RGD ID: 733541
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SUMO ligase activity. Involved in several processes, including nervous system development; positive regulation of myelination; and protein sumoylation. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including nervous system development; regulation of ossification; and rhythmic behavior. Located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; head mesenchyme derived from neural crest; nervous system; neural ectoderm; and vibrissa. Used to study Charcot-Marie-Tooth disease type 4E. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; early growth response protein 2; Egr-; Egr-2; Krox; Krox-; Krox-20; Krox20; NGF1-; NGF1-B; Zfp-2; Zfp-25; Zfp-6; zinc finger protein Krox-20
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391067,370,334 - 67,383,354 (+)NCBIGRCm39mm39
GRCm39 Ensembl1067,371,305 - 67,378,018 (+)Ensembl
GRCm381067,534,469 - 67,542,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1067,535,475 - 67,542,188 (+)EnsemblGRCm38mm10GRCm38
MGSCv371067,000,617 - 67,004,936 (+)NCBIGRCm37mm9NCBIm37
MGSCv361066,933,235 - 66,937,545 (+)NCBImm8
Celera1068,629,352 - 68,633,671 (+)NCBICelera
Cytogenetic Map10B5.1NCBI
cM Map1034.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-demecolcine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-butoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-azacytidine  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aripiprazole  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
azathioprine  (ISO)
baicalein  (EXP)
bathocuproine disulfonic acid  (ISO)
bazedoxifene  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
beryllium sulfate  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bortezomib  (EXP,ISO)
bucladesine  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
Calcimycin  (EXP)
carbon nanotube  (EXP)
cefaloridine  (ISO)
cerium trichloride  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
ferric oxide  (EXP)
fluoranthene  (EXP)
flusilazole  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
haloperidol  (EXP,ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
manganese(II) chloride  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (EXP)
morphine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP)
nicotine  (EXP)
nicotinic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
palytoxin  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP)
pirenzepine  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rifampicin  (ISO)
risperidone  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
scopolamine  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
succimer  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
triazoles  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abducens nerve morphology  (IAGP)
abnormal aortic valve cusp morphology  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal auditory brainstem response  (IAGP)
abnormal auditory brainstem response waveform shape  (IAGP)
abnormal autonomic nervous system physiology  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal brain commissure morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cochlear ganglion morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal distortion product otoacoustic emission  (IAGP)
abnormal dorsal spinal root morphology  (IAGP)
abnormal facial nerve morphology  (IAGP)
abnormal gait  (IAGP)
abnormal geniculate ganglion morphology  (IAGP)
abnormal glossopharyngeal ganglion morphology  (IAGP)
abnormal glossopharyngeal nerve morphology  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal hindbrain development  (IAGP)
abnormal horizontal vestibuloocular reflex  (IAGP)
abnormal innervation  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal nerve conduction  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal optokinetic reflex  (IAGP)
abnormal pons morphology  (IAGP)
abnormal reflex  (IAGP)
abnormal respiratory function  (IAGP)
abnormal retrotrapezoid nucleus morphology  (IAGP)
abnormal rhombomere morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal Schwann cell precursor morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal somatic nervous system morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal trigeminal nerve morphology  (IAGP)
abnormal vagus ganglion morphology  (IAGP)
abnormal vagus nerve morphology  (IAGP)
abnormal ventral spinal root morphology  (IAGP)
absent rhombomere 3  (IAGP)
absent rhombomere 5  (IAGP)
alkalemia  (IAGP)
aorta stenosis  (IAGP)
aortic valve regurgitation  (IAGP)
cachexia  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased diameter of femur  (IAGP)
decreased diameter of long bones  (IAGP)
decreased diameter of radius  (IAGP)
decreased diameter of tibia  (IAGP)
decreased lean body mass  (IAGP)
decreased length of long bones  (IAGP)
decreased motor neuron number  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased neuron number  (IAGP)
decreased pulmonary ventilation  (IAGP)
decreased rhombomere 3 size  (IAGP)
decreased rhombomere 5 size  (IAGP)
decreased rhombomere 6 size  (IAGP)
decreased Schwann cell number  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed eyelid opening  (IAGP)
demyelination  (IAGP)
enlarged aortic valve  (IAGP)
fusion of glossopharyngeal and vagus nerve  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hindlimb paralysis  (IAGP)
hypermyelination  (IAGP)
hypoactivity  (IAGP)
impaired coordination  (IAGP)
impaired limb coordination  (IAGP)
increased myelin sheath thickness  (IAGP)
increased nerve conduction velocity  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased Schwann cell proliferation  (IAGP)
kinked tail  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
paralysis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
respiratory distress  (IAGP)
short femur  (IAGP)
short radius  (IAGP)
short tibia  (IAGP)
thick aortic valve cusps  (IAGP)
thick pulmonary valve cusps  (IAGP)
tomacula  (IAGP)
tremors  (IAGP)
weakness  (IAGP)
weight loss  (IAGP)

Additional References at PubMed
PMID:1295734   PMID:1363087   PMID:1598206   PMID:1673098   PMID:1674431   PMID:1682814   PMID:1688180   PMID:1768617   PMID:1797234   PMID:1969796   PMID:2452975   PMID:2496302  
PMID:2571936   PMID:2915691   PMID:3129290   PMID:3140236   PMID:7477375   PMID:7588062   PMID:7590242   PMID:7615634   PMID:7700351   PMID:7729586   PMID:7903221   PMID:7903600  
PMID:7903601   PMID:7903632   PMID:7918100   PMID:7925021   PMID:7925028   PMID:7935840   PMID:7947319   PMID:7956823   PMID:8019912   PMID:8043949   PMID:8075499   PMID:8093858  
PMID:8100767   PMID:8102800   PMID:8224839   PMID:8344366   PMID:8486351   PMID:8565822   PMID:8565836   PMID:8575627   PMID:8625806   PMID:8805699   PMID:8806819   PMID:8861099  
PMID:8893031   PMID:8895582   PMID:8898234   PMID:8967950   PMID:8975712   PMID:8995769   PMID:9053316   PMID:9056778   PMID:9060414   PMID:9102308   PMID:9108364   PMID:9126293  
PMID:9152013   PMID:9159136   PMID:9247335   PMID:9256343   PMID:9271116   PMID:9338783   PMID:9418958   PMID:9425139   PMID:9463349   PMID:9463359   PMID:9464245   PMID:9486536  
PMID:9598342   PMID:9603423   PMID:9620767   PMID:9636176   PMID:9671576   PMID:9671659   PMID:9716656   PMID:9767163   PMID:9784592   PMID:9790191   PMID:9799734   PMID:9806922  
PMID:9858769   PMID:9895322   PMID:10068633   PMID:10191046   PMID:10192390   PMID:10230789   PMID:10349636   PMID:10373014   PMID:10431240   PMID:10441743   PMID:10452857   PMID:10529420  
PMID:10529422   PMID:10589677   PMID:10638493   PMID:10642791   PMID:10654602   PMID:10654606   PMID:10662633   PMID:10686605   PMID:10688202   PMID:10704452   PMID:10725249   PMID:10862151  
PMID:10887078   PMID:10960786   PMID:11025215   PMID:11042159   PMID:11044623   PMID:11076752   PMID:11076861   PMID:11118892   PMID:11157778   PMID:11163240   PMID:11180801   PMID:11217851  
PMID:11290295   PMID:11291866   PMID:11335127   PMID:11353388   PMID:11356033   PMID:11412024   PMID:11431695   PMID:11493525   PMID:11500373   PMID:11509733   PMID:11509834   PMID:11532923  
PMID:11748134   PMID:11748135   PMID:11782409   PMID:11823429   PMID:11857793   PMID:11880356   PMID:11884616   PMID:11886449   PMID:11891986   PMID:11988578   PMID:12015293   PMID:12086465  
PMID:12376559   PMID:12401452   PMID:12466851   PMID:12471260   PMID:12477932   PMID:12490556   PMID:12514106   PMID:12522767   PMID:12538520   PMID:12575949   PMID:12588852   PMID:12645927  
PMID:12701106   PMID:12706208   PMID:12798298   PMID:12799077   PMID:12799134   PMID:12810586   PMID:12842913   PMID:12900932   PMID:12917333   PMID:12923530   PMID:12954718   PMID:14522948  
PMID:14532282   PMID:14560009   PMID:14592971   PMID:14651926   PMID:14668413   PMID:14699164   PMID:14745958   PMID:14757751   PMID:15070898   PMID:15084457   PMID:15155580   PMID:15173177  
PMID:15282162   PMID:15322547   PMID:15367676   PMID:15376323   PMID:15489334   PMID:15533824   PMID:15585857   PMID:15618518   PMID:15634700   PMID:15678491   PMID:15695336   PMID:15713637  
PMID:15741321   PMID:15741322   PMID:15747579   PMID:15751078   PMID:15790971   PMID:15799026   PMID:15829518   PMID:15829521   PMID:15834410   PMID:15836632   PMID:15857913   PMID:15857914  
PMID:15872002   PMID:15872003   PMID:15886484   PMID:15908955   PMID:15951419   PMID:16046619   PMID:16054051   PMID:16136673   PMID:16141072   PMID:16141073   PMID:16221730   PMID:16341215  
PMID:16373334   PMID:16423343   PMID:16452098   PMID:16477142   PMID:16495311   PMID:16508307   PMID:16564040   PMID:16571633   PMID:16582099   PMID:16598713   PMID:16630833   PMID:16651541  
PMID:16675951   PMID:16790476   PMID:16875803   PMID:16902088   PMID:16943282   PMID:16988048   PMID:17067568   PMID:17299135   PMID:17312150   PMID:17325040   PMID:17507393   PMID:17507402  
PMID:17537790   PMID:17576798   PMID:17609112   PMID:17897445   PMID:17900554   PMID:17916431   PMID:17938205   PMID:17971221   PMID:17973254   PMID:18198176   PMID:18203138   PMID:18241853  
PMID:18268105   PMID:18280047   PMID:18287559   PMID:18332127   PMID:18344997   PMID:18396140   PMID:18456662   PMID:18495817   PMID:18524893   PMID:18547144   PMID:18701545   PMID:18703040  
PMID:18779345   PMID:18787068   PMID:18794329   PMID:18929642   PMID:18930042   PMID:18958188   PMID:19000991   PMID:19017967   PMID:19053061   PMID:19056886   PMID:19169262   PMID:19179536  
PMID:19208226   PMID:19218566   PMID:19229250   PMID:19235731   PMID:19243017   PMID:19244508   PMID:19401217   PMID:19479951   PMID:19487693   PMID:19524524   PMID:19525946   PMID:19578380  
PMID:19651900   PMID:19666526   PMID:19706684   PMID:19741118   PMID:19805360   PMID:19818654   PMID:19837037   PMID:19877014   PMID:19914164   PMID:19922439   PMID:19940179   PMID:20039366  
PMID:20059953   PMID:20144603   PMID:20184720   PMID:20220021   PMID:20231872   PMID:20427655   PMID:20457761   PMID:20630950   PMID:20631168   PMID:20716776   PMID:20805985   PMID:20873986  
PMID:20886122   PMID:20941375   PMID:21068328   PMID:21173153   PMID:21187408   PMID:21193208   PMID:21220101   PMID:21262468   PMID:21267068   PMID:21267074   PMID:21320481   PMID:21322058  
PMID:21357543   PMID:21362415   PMID:21364975   PMID:21411665   PMID:21497760   PMID:21514423   PMID:21533046   PMID:21533228   PMID:21572967   PMID:21613327   PMID:21670295   PMID:21784065  
PMID:21836637   PMID:21873635   PMID:21880919   PMID:21897363   PMID:21900566   PMID:21930923   PMID:22049075   PMID:22075149   PMID:22147266   PMID:22151329   PMID:22306690   PMID:22337526  
PMID:22363567   PMID:22379615   PMID:22451728   PMID:22492709   PMID:22678062   PMID:22767514   PMID:22842221   PMID:23012656   PMID:23021953   PMID:23129747   PMID:23150495   PMID:23152916  
PMID:23203924   PMID:23213481   PMID:23261662   PMID:23307742   PMID:23349024   PMID:23355739   PMID:23536637   PMID:23548837   PMID:23575864   PMID:23637629   PMID:23664551   PMID:23708139  
PMID:23716134   PMID:23720781   PMID:23751188   PMID:23792428   PMID:23824574   PMID:23852112   PMID:23950737   PMID:23988635   PMID:24048834   PMID:24061538   PMID:24080509   PMID:24151333  
PMID:24368733   PMID:24453317   PMID:24487590   PMID:24493648   PMID:24574009   PMID:24623780   PMID:24952961   PMID:25079316   PMID:25343783   PMID:25344368   PMID:25368162   PMID:25401279  
PMID:25446898   PMID:25497093   PMID:25553923   PMID:25680202   PMID:25695838   PMID:25843547   PMID:25864617   PMID:25866925   PMID:25885041   PMID:25942625   PMID:25948683   PMID:25977363  
PMID:25979336   PMID:26085643   PMID:26212322   PMID:26212662   PMID:26272614   PMID:26275053   PMID:26402606   PMID:26410627   PMID:26456821   PMID:26466203   PMID:26494785   PMID:26519537  
PMID:26542008   PMID:26711547   PMID:26740329   PMID:26806701   PMID:26809587   PMID:26858598   PMID:26941017   PMID:27026076   PMID:27210552   PMID:27251629   PMID:27288457   PMID:27294512  
PMID:27395006   PMID:27517863   PMID:27725662   PMID:27729526   PMID:27777310   PMID:27840001   PMID:27851959   PMID:27911796   PMID:27956219   PMID:28115575   PMID:28169300   PMID:28350297  
PMID:28396882   PMID:28445456   PMID:28455436   PMID:28487311   PMID:28611210   PMID:28663199   PMID:28723564   PMID:28749941   PMID:28798046   PMID:28880149   PMID:28964716   PMID:28981898  
PMID:29158447   PMID:29314730   PMID:29343636   PMID:29343638   PMID:29361054   PMID:29444422   PMID:29491350   PMID:29728568   PMID:29748249   PMID:29781132   PMID:30012846   PMID:30134070  
PMID:30254164   PMID:30348676   PMID:30443252   PMID:30548566   PMID:30661739   PMID:30679703   PMID:30917309   PMID:31356769   PMID:31395862   PMID:31398266   PMID:31801063   PMID:31852952  
PMID:31924792   PMID:32579924   PMID:32672815   PMID:33060136   PMID:33322598   PMID:33691115   PMID:33986293  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391067,370,334 - 67,383,354 (+)NCBIGRCm39mm39
GRCm39 Ensembl1067,371,305 - 67,378,018 (+)Ensembl
GRCm381067,534,469 - 67,542,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1067,535,475 - 67,542,188 (+)EnsemblGRCm38mm10GRCm38
MGSCv371067,000,617 - 67,004,936 (+)NCBIGRCm37mm9NCBIm37
MGSCv361066,933,235 - 66,937,545 (+)NCBImm8
Celera1068,629,352 - 68,633,671 (+)NCBICelera
Cytogenetic Map10B5.1NCBI
cM Map1034.96NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1062,811,996 - 62,919,900 (-)EnsemblGRCh38hg38GRCh38
GRCh381062,811,996 - 62,819,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371064,571,756 - 64,578,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361064,241,763 - 64,246,133 (-)NCBINCBI36hg18NCBI36
Build 341064,241,762 - 64,246,133NCBI
Celera1057,839,025 - 57,846,195 (-)NCBI
Cytogenetic Map10q21.3NCBI
HuRef1058,563,537 - 58,570,711 (-)NCBIHuRef
CHM1_11064,853,748 - 64,860,918 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22021,051,270 - 21,056,322 (-)NCBI
Rnor_6.0 Ensembl2022,454,463 - 22,459,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02022,452,170 - 22,461,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02024,551,935 - 24,556,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,883,885 - 21,888,177 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12021,897,685 - 21,901,977 (-)NCBI
Celera2022,412,625 - 22,416,917 (-)NCBICelera
Cytogenetic Map20p11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542516,055,748 - 16,060,048 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542516,055,748 - 16,068,429 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11061,648,364 - 61,652,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1061,648,364 - 61,652,846 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01059,320,073 - 59,326,869 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1414,705,384 - 14,810,130 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl414,706,600 - 14,709,497 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha414,923,311 - 15,027,362 (-)NCBI
ROS_Cfam_1.0414,969,904 - 15,074,026 (-)NCBI
UMICH_Zoey_3.1414,952,564 - 15,056,593 (-)NCBI
UNSW_CanFamBas_1.0415,077,597 - 15,181,626 (-)NCBI
UU_Cfam_GSD_1.0415,433,193 - 15,537,238 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721366,381,281 - 66,388,026 (+)NCBI
SpeTri2.0NW_0049367531,958,250 - 1,962,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1466,284,577 - 66,291,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11466,280,665 - 66,291,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21471,516,963 - 71,523,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q23-q25NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1968,472,640 - 68,479,612 (+)NCBI
ChlSab1.1 Ensembl968,475,102 - 68,479,595 (+)Ensembl
Vero_WHO_p1.0NW_02366604829,356,837 - 29,363,580 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_004624791953,009 - 959,656 (+)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371067,003,950 - 67,004,051UniSTSGRCm37
MGSCv371067,004,777 - 67,004,913UniSTSGRCm37
MGSCv371067,004,053 - 67,004,123UniSTSGRCm37
Celera1068,632,788 - 68,632,858UniSTS
Celera1068,632,685 - 68,632,786UniSTS
Celera1068,633,512 - 68,633,648UniSTS
Cytogenetic Map10B5UniSTS
cM Map1035.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381067,541,675 - 67,541,874UniSTSGRCm38
MGSCv371067,004,423 - 67,004,622UniSTSGRCm37
Celera1068,633,158 - 68,633,357UniSTS
Cytogenetic Map10B5UniSTS
cM Map1035.0UniSTS
Whitehead_YAC10 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381067,540,154 - 67,540,445UniSTSGRCm38
MGSCv371067,002,902 - 67,003,193UniSTSGRCm37
Celera1068,631,637 - 68,631,928UniSTS
Cytogenetic Map10B5UniSTS
cM Map1035.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381067,541,305 - 67,541,375UniSTSGRCm38
MGSCv371067,004,053 - 67,004,123UniSTSGRCm37
Celera1068,632,788 - 68,632,858UniSTS
Cytogenetic Map10B5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381067,542,029 - 67,542,165UniSTSGRCm38
MGSCv371067,004,777 - 67,004,913UniSTSGRCm37
Celera1068,633,512 - 68,633,648UniSTS
Cytogenetic Map10B5UniSTS
cM Map1035.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381067,541,202 - 67,541,303UniSTSGRCm38
MGSCv371067,003,950 - 67,004,051UniSTSGRCm37
Celera1068,632,685 - 68,632,786UniSTS
Cytogenetic Map10B5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381067,541,350 - 67,541,477UniSTSGRCm38
MGSCv371067,004,098 - 67,004,225UniSTSGRCm37
Celera1068,632,833 - 68,632,960UniSTS
Cytogenetic Map10B5UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102171529368255809Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103390000071000000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4140150475401504Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104570000069300000Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104640000069400000Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104809840370276821Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105868113592681262Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1064100000116100000Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106565510499655287Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106565510499655287Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106565510499655287Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106701240892422811Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067500000111900000Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:2100
Count of miRNA genes:645
Interacting mature miRNAs:815
Transcripts:ENSMUST00000048289, ENSMUST00000105438, ENSMUST00000127820, ENSMUST00000130933, ENSMUST00000145754, ENSMUST00000145936, ENSMUST00000146986
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_001347458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001373983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001373985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001373986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001373987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP753840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY209001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY742929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000048289   ⟹   ENSMUSP00000041053
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1067,537,869 - 67,542,188 (+)Ensembl
RefSeq Acc Id: ENSMUST00000105438   ⟹   ENSMUSP00000101078
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1067,537,870 - 67,542,188 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127820   ⟹   ENSMUSP00000116799
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1067,538,683 - 67,542,188 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130933   ⟹   ENSMUSP00000116502
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1067,537,870 - 67,538,380 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145754   ⟹   ENSMUSP00000116621
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1067,535,475 - 67,540,246 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145936   ⟹   ENSMUSP00000115709
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1067,535,583 - 67,540,381 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146986   ⟹   ENSMUSP00000118941
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1067,537,930 - 67,539,941 (+)Ensembl
RefSeq Acc Id: NM_001347458   ⟹   NP_001334387
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391067,373,760 - 67,378,018 (+)NCBI
GRCm381067,537,930 - 67,542,188 (+)NCBI
RefSeq Acc Id: NM_001373983   ⟹   NP_001360912
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391067,371,329 - 67,378,018 (+)NCBI
GRCm381067,535,499 - 67,542,188 (+)NCBI
RefSeq Acc Id: NM_001373985   ⟹   NP_001360914
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391067,373,041 - 67,378,018 (+)NCBI
GRCm381067,537,211 - 67,542,188 (+)NCBI
RefSeq Acc Id: NM_001373986   ⟹   NP_001360915
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391067,373,396 - 67,378,018 (+)NCBI
GRCm381067,537,566 - 67,542,188 (+)NCBI
RefSeq Acc Id: NM_001373987   ⟹   NP_001360916
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391067,373,700 - 67,378,018 (+)NCBI
GRCm381067,537,870 - 67,542,188 (+)NCBI
RefSeq Acc Id: NM_010118   ⟹   NP_034248
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391067,373,699 - 67,378,018 (+)NCBI
GRCm381067,537,869 - 67,542,188 (+)NCBI
MGSCv371067,000,617 - 67,004,936 (+)RGD
Celera1068,629,352 - 68,633,671 (+)RGD
RefSeq Acc Id: XM_030244870   ⟹   XP_030100730
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm391067,370,334 - 67,383,354 (+)NCBI
GRCm381067,534,492 - 67,542,188 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_034248   ⟸   NM_010118
- Peptide Label: isoform 1
- UniProtKB: P08152 (UniProtKB/Swiss-Prot),   Q3U207 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030100730   ⟸   XM_030244870
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001334387   ⟸   NM_001347458
- Peptide Label: isoform 2
- UniProtKB: P08152 (UniProtKB/Swiss-Prot),   Q3U207 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001360912   ⟸   NM_001373983
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001360914   ⟸   NM_001373985
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001360915   ⟸   NM_001373986
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001360916   ⟸   NM_001373987
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000101078   ⟸   ENSMUST00000105438
RefSeq Acc Id: ENSMUSP00000116502   ⟸   ENSMUST00000130933
RefSeq Acc Id: ENSMUSP00000116799   ⟸   ENSMUST00000127820
RefSeq Acc Id: ENSMUSP00000118941   ⟸   ENSMUST00000146986
RefSeq Acc Id: ENSMUSP00000041053   ⟸   ENSMUST00000048289
RefSeq Acc Id: ENSMUSP00000116621   ⟸   ENSMUST00000145754
RefSeq Acc Id: ENSMUSP00000115709   ⟸   ENSMUST00000145936
Protein Domains
C2H2-type   DUF3446

RGD ID:6819227
Promoter ID:MM_KWN:4417
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:NM_010118,   OTTMUST00000084547,   OTTMUST00000084548,   OTTMUST00000084549,   OTTMUST00000084552
Mouse AssemblyChrPosition (strand)Source
MGSCv361066,999,636 - 67,001,512 (+)MPROMDB
RGD ID:8672200
Promoter ID:EPDNEW_M14130
Type:initiation region
Description:Mus musculus early growth response 2 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381067,537,870 - 67,537,930EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95296 AgrOrtholog
Ensembl Genes ENSMUSG00000037868 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000041053 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000101078 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000115709 UniProtKB/TrEMBL
  ENSMUSP00000116502 UniProtKB/TrEMBL
  ENSMUSP00000116621 UniProtKB/TrEMBL
  ENSMUSP00000116799 UniProtKB/TrEMBL
  ENSMUSP00000118941 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048289 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000105438 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000127820 UniProtKB/TrEMBL
  ENSMUST00000130933 UniProtKB/TrEMBL
  ENSMUST00000145754 UniProtKB/TrEMBL
  ENSMUST00000145936 UniProtKB/TrEMBL
  ENSMUST00000146986 UniProtKB/TrEMBL
InterPro EGR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13654 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3446 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Egr2 PhenoGen
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL