Twf2 (twinfilin actin binding protein 2) - Rat Genome Database
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Gene: Twf2 (twinfilin actin binding protein 2) Mus musculus
Analyze
Symbol: Twf2
Name: twinfilin actin binding protein 2
RGD ID: 1312985
MGI Page MGI
Description: Exhibits actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in barbed-end actin filament capping and sequestering of actin monomers. Localizes to several cellular components, including lamellipodium; myofibril; and stereocilium. Is expressed in several structures, including ear; early embryo; genitourinary system; nervous system; and respiratory system. Orthologous to human TWF2 (twinfilin actin binding protein 2); INTERACTS WITH (S)-nicotine; 1,1-dichloroethene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A6-rel; A6-related; AU014993; mA6RP; protein tyrosine kinase 9 related protein; protein tyrosine kinase 9-like (A6-related protein); Ptk; PTK9 protein typrotein tyrosine kinase 9-like (A6-related protein); Ptk9l; Ptk9r; Twinf; twinfilin, actin-binding protein, homolog 2; twinfilin-1-like protein; twinfilin-2
RGD Orthologs
Human
Rat
Chinchilla
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,080,307 - 106,092,586 (+)NCBIGRCm39mm39
GRCm389106,203,108 - 106,215,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,203,108 - 106,215,389 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,105,439 - 106,117,718 (+)NCBIGRCm37mm9NCBIm37
MGSCv369106,061,209 - 106,073,488 (+)NCBImm8
Celera9105,828,685 - 105,841,171 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:10406962   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11870207   PMID:12477932   PMID:12520002   PMID:12807912   PMID:12904583   PMID:14610273   PMID:14681479  
PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16537572   PMID:16602821   PMID:18799693   PMID:18837697   PMID:19774077   PMID:19955359   PMID:21267068   PMID:21677750  
PMID:21731673   PMID:21873635   PMID:21876732   PMID:24457600   PMID:25807483   PMID:28743718   PMID:30333137   PMID:30827920   PMID:32325033  


Genomics

Comparative Map Data
Twf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,080,307 - 106,092,586 (+)NCBIGRCm39mm39
GRCm389106,203,108 - 106,215,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,203,108 - 106,215,389 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,105,439 - 106,117,718 (+)NCBIGRCm37mm9NCBIm37
MGSCv369106,061,209 - 106,073,488 (+)NCBImm8
Celera9105,828,685 - 105,841,171 (+)NCBICelera
Cytogenetic Map9F1NCBI
TWF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl352,228,612 - 52,239,158 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl352,228,612 - 52,246,788 (-)EnsemblGRCh38hg38GRCh38
GRCh38352,228,612 - 52,239,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,262,626 - 52,273,183 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,237,666 - 52,248,223 (-)NCBINCBI36hg18NCBI36
Build 34352,237,666 - 52,248,223NCBI
Celera352,241,938 - 52,252,496 (-)NCBI
Cytogenetic Map3p21.2NCBI
HuRef352,324,788 - 52,335,347 (-)NCBIHuRef
CHM1_1352,215,154 - 52,225,723 (-)NCBICHM1_1
Twf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08114,897,011 - 114,909,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,897,011 - 114,909,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,259,815 - 114,272,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8106,167,478 - 106,179,370 (+)NCBICelera
Cytogenetic Map8q32NCBI
Twf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555323,834,579 - 3,844,760 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555323,835,620 - 3,844,760 (-)NCBIChiLan1.0ChiLan1.0
TWF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2037,529,401 - 37,539,957 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12037,529,322 - 37,539,955 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
TWF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,361,292 - 34,371,842 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,361,294 - 34,370,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,634,368 - 37,644,046 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
AW554607  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389106,215,086 - 106,215,198UniSTSGRCm38
MGSCv379106,117,417 - 106,117,529UniSTSGRCm37
Celera9105,840,870 - 105,840,982UniSTS
Cytogenetic Map9F1UniSTS
Whitehead/MRC_RH91095.57UniSTS
AU014993  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389106,215,118 - 106,215,366UniSTSGRCm38
MGSCv379106,117,449 - 106,117,697UniSTSGRCm37
Celera9105,840,902 - 105,841,150UniSTS
Cytogenetic Map9F1UniSTS
Whitehead/MRC_RH91100.43UniSTS
Twf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F1UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:199
Interacting mature miRNAs:227
Transcripts:ENSMUST00000024047
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024047   ⟹   ENSMUSP00000024047
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,203,108 - 106,215,389 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187647   ⟹   ENSMUSP00000140617
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,203,145 - 106,212,819 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187944   ⟹   ENSMUSP00000139905
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,203,137 - 106,212,351 (+)Ensembl
RefSeq Acc Id: ENSMUST00000188650   ⟹   ENSMUSP00000140339
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,206,798 - 106,215,387 (+)Ensembl
RefSeq Acc Id: ENSMUST00000189708
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,206,776 - 106,215,385 (+)Ensembl
RefSeq Acc Id: ENSMUST00000216348   ⟹   ENSMUSP00000150626
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,203,114 - 106,214,398 (+)Ensembl
RefSeq Acc Id: ENSMUST00000216541
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,212,262 - 106,214,876 (+)Ensembl
RefSeq Acc Id: ENSMUST00000216850   ⟹   ENSMUSP00000150259
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,211,719 - 106,214,423 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217523
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9106,212,189 - 106,214,979 (+)Ensembl
RefSeq Acc Id: NM_011876   ⟹   NP_036006
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399106,080,307 - 106,092,586 (+)NCBI
GRCm389106,203,108 - 106,215,387 (+)ENTREZGENE
MGSCv379106,105,439 - 106,117,718 (+)RGD
Celera9105,828,685 - 105,841,171 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036006   ⟸   NM_011876
- UniProtKB: Q9Z0P5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000150259   ⟸   ENSMUST00000216850
RefSeq Acc Id: ENSMUSP00000140339   ⟸   ENSMUST00000188650
RefSeq Acc Id: ENSMUSP00000139905   ⟸   ENSMUST00000187944
RefSeq Acc Id: ENSMUSP00000140617   ⟸   ENSMUST00000187647
RefSeq Acc Id: ENSMUSP00000150626   ⟸   ENSMUST00000216348
RefSeq Acc Id: ENSMUSP00000024047   ⟸   ENSMUST00000024047
Protein Domains
ADF-H

Promoters
RGD ID:6845290
Promoter ID:MM_KWN:58652
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_011876
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369106,105,301 - 106,105,802 (+)MPROMDB
RGD ID:6845291
Promoter ID:MM_KWN:58653
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Lung
Transcripts:UC009RJG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369106,108,436 - 106,109,577 (+)MPROMDB
RGD ID:6848501
Promoter ID:MM_ACW:51891
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Lung,   MEF_B6,   Spleen
Transcripts:TWF2.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369106,114,121 - 106,114,647 (+)MPROMDB
RGD ID:8670710
Promoter ID:EPDNEW_M13385
Type:initiation region
Name:Twf2_1
Description:Mus musculus twinfilin actin binding protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13386  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389106,203,164 - 106,203,224EPDNEW
RGD ID:8670712
Promoter ID:EPDNEW_M13386
Type:multiple initiation site
Name:Twf2_2
Description:Mus musculus twinfilin actin binding protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13385  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389106,206,798 - 106,206,858EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346078 AgrOrtholog
Ensembl Genes ENSMUSG00000023277 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000024047 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139905 UniProtKB/TrEMBL
  ENSMUSP00000140339 UniProtKB/Swiss-Prot
  ENSMUSP00000140617 UniProtKB/TrEMBL
  ENSMUSP00000150259 UniProtKB/TrEMBL
  ENSMUSP00000150626 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024047 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000187647 UniProtKB/TrEMBL
  ENSMUST00000187944 UniProtKB/TrEMBL
  ENSMUST00000188650 UniProtKB/Swiss-Prot
  ENSMUST00000216348 UniProtKB/TrEMBL
  ENSMUST00000216850 UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADF-H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Twinfilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:23999 UniProtKB/Swiss-Prot
MGD MGI:1346078 ENTREZGENE
NCBI Gene 23999 ENTREZGENE
PANTHER PTHR13759 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cofilin_ADF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Twf2 PhenoGen
PROSITE ADF_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ADF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.274346 ENTREZGENE
UniProt A0A087WPT3_MOUSE UniProtKB/TrEMBL
  A0A087WRG4_MOUSE UniProtKB/TrEMBL
  A0A1L1STC8_MOUSE UniProtKB/TrEMBL
  A0A1L1SU53_MOUSE UniProtKB/TrEMBL
  Q9Z0P5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TD06 UniProtKB/Swiss-Prot
  Q3TZG2 UniProtKB/Swiss-Prot
  Q8BN77 UniProtKB/Swiss-Prot
  Q9DCK8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 Twf2  twinfilin actin binding protein 2    twinfilin, actin-binding protein, homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED