Twf2 (twinfilin actin binding protein 2)

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Gene: Twf2 (twinfilin actin binding protein 2) Mus musculus

Analyze

Symbol:

Twf2

Name:

twinfilin actin binding protein 2

RGD ID:

1312985

MGI Page

MGI

Description:

Exhibits actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in barbed-end actin filament capping and sequestering of actin monomers. Localizes to several cellular components, including lamellipodium; myofibril; and stereocilium. Is expressed in several structures, including ear; early embryo; genitourinary system; nervous system; and respiratory system. Orthologous to human TWF2 (twinfilin actin binding protein 2); INTERACTS WITH (S)-nicotine; 1,1-dichloroethene; 1,2-dimethylhydrazine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

A6-rel; A6-related; AU014993; mA6RP; protein tyrosine kinase 9 related protein; protein tyrosine kinase 9-like (A6-related protein); Ptk; PTK9 protein typrotein tyrosine kinase 9-like (A6-related protein); Ptk9l; Ptk9r; Twinf; twinfilin, actin-binding protein, homolog 2; twinfilin-1-like protein; twinfilin-2

RGD Orthologs

Human

Rat

Chinchilla

Dog

Pig

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TWF2 (twinfilin actin binding protein 2)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Twf2 (twinfilin actin-binding protein 2)	HGNC	NCBI, OMA, HomoloGene, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Twf2 (twinfilin actin binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TWF2 (twinfilin actin binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TWF2 (twinfilin actin binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TWF2 (twinfilin actin binding protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Rattus norvegicus (Norway rat):	Twf2 (twinfilin actin-binding protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	twf2b (twinfilin actin-binding protein 2b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|TreeFam\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	TWF1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Drosophila melanogaster (fruit fly):	twf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Caenorhabditis elegans (roundworm):	twf-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	106,080,307 - 106,092,586 (+)	NCBI	GRCm39		mm39
GRCm38	9	106,203,108 - 106,215,387 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	106,203,108 - 106,215,389 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	106,105,439 - 106,117,718 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	106,061,209 - 106,073,488 (+)	NCBI			mm8
Celera	9	105,828,685 - 105,841,171 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (EXP)

1,1-dichloroethene (EXP)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (EXP)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (EXP)

acetamide (ISO)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

choline (EXP)

cisplatin (ISO)

clofibrate (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP,ISO)

doxorubicin (ISO)

endosulfan (ISO)

enzyme inhibitor (ISO)

folic acid (EXP)

L-methionine (EXP)

menadione (EXP)

mercury atom (ISO)

mercury(0) (ISO)

nicotine (EXP)

paracetamol (EXP,ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (EXP)

raloxifene (ISO)

resveratrol (ISO)

rotenone (ISO)

sodium fluoride (EXP)

tamibarotene (ISO)

tamoxifen (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament depolymerization (IBA)

barbed-end actin filament capping (IBA,IDA)

cell projection organization (IEA)

cellular response to growth factor stimulus (ISO)

cellular response to retinoic acid (ISO)

intracellular signal transduction (ISO)

multicellular organism development (IEA)

negative regulation of actin filament polymerization (IDA)

positive regulation of axon extension (ISO)

positive regulation of lamellipodium assembly (ISO)

positive regulation of neuron projection development (IBA,ISO)

regulation of actin cytoskeleton organization (ISO)

regulation of lamellipodium assembly (IBA)

regulation of microvillus length (IC)

sequestering of actin monomers (IBA,IDA)

Cellular Component

actin filament (IBA)

cell projection (IEA)

cytoplasm (IBA,ISO)

cytoskeleton (IEA)

filopodium (IDA)

growth cone (ISO)

lamellipodium (IDA)

myofibril (IBA,IDA)

perinuclear region of cytoplasm (IDA)

stereocilium (IDA)

Molecular Function

actin binding (IEA)

actin filament binding (IBA)

actin monomer binding (IBA,IDA)

ATP binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (IDA)

protein binding (ISO)

protein kinase C binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

no abnormal phenotype detected (IAGP)

References

References - curated


1.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3.	MGD data from the GO Consortium
4.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5.	RGD automated import pipeline
6.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:10406962	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11870207	PMID:12477932	PMID:12520002	PMID:12807912	PMID:12904583	PMID:14610273	PMID:14681479
PMID:15489334	PMID:15782199	PMID:16141072	PMID:16141073	PMID:16537572	PMID:16602821	PMID:18799693	PMID:18837697	PMID:19774077	PMID:19955359	PMID:21267068	PMID:21677750
PMID:21731673	PMID:21873635	PMID:21876732	PMID:24457600	PMID:25807483	PMID:28743718	PMID:30333137	PMID:30827920	PMID:32325033

Genomics

Comparative Map Data

Twf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	106,080,307 - 106,092,586 (+)	NCBI	GRCm39		mm39
GRCm38	9	106,203,108 - 106,215,387 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	106,203,108 - 106,215,389 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	106,105,439 - 106,117,718 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	106,061,209 - 106,073,488 (+)	NCBI			mm8
Celera	9	105,828,685 - 105,841,171 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI

TWF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	3	52,228,612 - 52,239,158 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	3	52,228,612 - 52,246,788 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	3	52,228,612 - 52,239,158 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	3	52,262,626 - 52,273,183 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	52,237,666 - 52,248,223 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	3	52,237,666 - 52,248,223	NCBI
Celera	3	52,241,938 - 52,252,496 (-)	NCBI
Cytogenetic Map	3	p21.2	NCBI
HuRef	3	52,324,788 - 52,335,347 (-)	NCBI		HuRef
CHM1_1	3	52,215,154 - 52,225,723 (-)	NCBI		CHM1_1

Twf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	8	114,897,011 - 114,909,531 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	114,897,011 - 114,909,531 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	114,259,815 - 114,272,429 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	8	106,167,478 - 106,179,370 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Twf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	3,834,579 - 3,844,760 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	3,835,620 - 3,844,760 (-)	NCBI	ChiLan1.0	ChiLan1.0

TWF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	37,529,401 - 37,539,957 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	37,529,322 - 37,539,955 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

TWF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	34,361,292 - 34,371,842 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	34,361,294 - 34,370,997 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	37,634,368 - 37,644,046 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Position Markers

AW554607

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	9	106,215,086 - 106,215,198	UniSTS	GRCm38
MGSCv37	9	106,117,417 - 106,117,529	UniSTS	GRCm37
Celera	9	105,840,870 - 105,840,982	UniSTS
Cytogenetic Map	9	F1	UniSTS
Whitehead/MRC_RH	9	1095.57	UniSTS

AU014993

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	9	106,215,118 - 106,215,366	UniSTS	GRCm38
MGSCv37	9	106,117,449 - 106,117,697	UniSTS	GRCm37
Celera	9	105,840,902 - 105,841,150	UniSTS
Cytogenetic Map	9	F1	UniSTS
Whitehead/MRC_RH	9	1100.43	UniSTS

Twf2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	9	F1	UniSTS
cM Map	9		UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
13207569	Tcq13_m	total cholesterol QTL 13 (mouse)					9	59990000	109260000	Mouse
4141833	W10q13_m	weight 10 weeks QTL 13 (mouse)			Not determined			63332429	120362868	Mouse
4141545	Tailaq2_m	tail length adjusted QTL 2 (mouse)			Not determined			63332429	120362868	Mouse
1357635	Splq4_m	spleen weight QTL 4 (mouse)			Not determined		9	63332429	120362868	Mouse
1301573	Etohcta8_m	ethanol conditioned taste aversion 8 (mouse)			Not determined		9	72977005	106977152	Mouse
10054068	El8_m	epilepsy 8 (mouse)			Not determined		9	72977005	106977152	Mouse
1301725	Lifespan1_m	life span 1 (mouse)			Not determined		9	74368177	108368325	Mouse
1302065	El1_m	epilepsy 1 (mouse)			Not determined		9	75775364	114474379	Mouse
10054492	El7_m	epilepsy 7 (mouse)			Not determined		9	75775364	114474379	Mouse
1301407	Rapop2_m	radiation-induced apoptosis 2 (mouse)			Not determined		9	76535936	110536130	Mouse
1301192	Skts6_m	skin tumor susceptibility 6 (mouse)			Not determined		9	78640645	112640755	Mouse
10401247	Bglu14_m	blood glucose level 14 (mouse)			Not determined		9	79397810	113397888	Mouse
1301732	Char1_m	P. chabaudi malaria resistance QTL 1 (mouse)			Not determined		9	81798268	115798392	Mouse
1300884	Sluc11_m	susceptibility to lung cancer 11 (mouse)			Not determined		9	82910333	116910428	Mouse
1357461	Idd2_m	insulin dependent diabetes susceptibility 2 (mouse)			Not determined		9	82910333	116910428	Mouse
10766454	Char10_m	P. chabaudi malaria resistance QTL 10 (mouse)					9	82910333	116910428	Mouse
1301487	Nociq1_m	nociceptive sensitivity inflammatory QTL 1 (mouse)			Not determined		9	84528818	118528921	Mouse
10412180	Msam3_m	muscle, skeletal, activity measure 3 (mouse)			Not determined		9	85897510	108641186	Mouse
1300549	Bbaa17_m	B. burgdorferi-associated arthritis 17 (mouse)			Not determined		9	86230401	120230530	Mouse
1302103	Dob2_m	dietary obesity 2 (mouse)			Not determined		9	86239845	120289624	Mouse
11251716	Siim2_m	stress induced immobility 2 (mouse)					9	86748483	120748483	Mouse
12880422	V25Dq6_m	vitamin D inactive form serum level QTL 6 (mouse)					9	87800000	121800000	Mouse
10412242	Alpq8_m	alcohol preference QTL 8 (mouse)			Not determined		9	89284925	123284925	Mouse
1301649	Psl1_m	promotion susceptibility QTL 1 (mouse)			Not determined		9	89412277	123412396	Mouse
18182932	Metl3_m	metabolite locus 3, N-acetylglutamate (mouse)					9	89563342	123563342	Mouse
1357657	Pymr_m	Plasmodium yoelli malaria resistance (mouse)			Not determined		9	89977005	118938021	Mouse
12910770	Splic1_m	spleen iron content 1 (mouse)					9	91413879	124595110	Mouse
12910772	Lvic6_m	liver iron content 6 (mouse)					9	91413879	124595110	Mouse
12910773	Splic3_m	spleen iron content 3 (mouse)					9	91413879	124595110	Mouse
1558767	Skmw11_m	skeletal muscle weight 11 (mouse)			Not determined		9	91641084	124595110	Mouse
13463474	Hbbcq5_m	hemoglobin concentration QTL 5 (mouse)					9	91641084	124595110	Mouse
13463475	Hctq7_m	hematocrit QTL 7 (mouse)					9	91641084	124595110	Mouse
13463477	Rbc9_m	red blood cell count 9 (mouse)					9	91641084	124595110	Mouse
13463478	Mchq18_m	mean corpuscular hemoglobin QTL 18 (mouse)					9	91641084	124595110	Mouse
13463480	Mchcq2_m	mean corpuscular hemoglobin concentration QTL 2 (mouse)					9	91641084	124595110	Mouse
12904937	Edlmmq9_m	extensor digitorum longus muscle mass QTL 9 (mouse)					9	91683173	124595110	Mouse
12904947	Tammq7_m	tibialis anterior muscle mass QTL 7 (mouse)					9	91683173	124595110	Mouse
12904961	Gmmq7_m	gastrocnemius muscle mass QTL 7 (mouse)					9	91683173	124595110	Mouse
1302001	Bdln5_m	body length 5 (mouse)			Not determined		9	93762590	124595110	Mouse
1301484	Bwq6_m	body weight (mouse)			Not determined		9	93762590	124595110	Mouse
14746992	Manh67_m	mandible shape 67 (mouse)					9	94036768	124595110	Mouse
11081166	Psl5_m	promotion susceptibility QTL 5 (mouse)					9	94981301	112872929	Mouse
11537364	Cnes5_m	C. neoformans susceptibility locus 5 (mouse)					9	96917590	124595110	Mouse
1301297	Lcho1_m	liver cholesterol 1 (mouse)			Not determined		9	101060861	124595110	Mouse
1357627	Tgq2_m	triglyceride QTL 2 (mouse)			Not determined		9	102000187	124595110	Mouse
1357648	Obq18_m	obesity QTL 18 (mouse)			Not determined		9	102000187	124595110	Mouse
1301789	Pbwg4_m	postnatal body weight growth 4 (mouse)			Not determined		9	103289445	124595110	Mouse
10412290	Pvacm1l_m	plasma vascular cell adhesion molecule 1 levels (mouse)			Not determined		9	103289445	124595110	Mouse
12879896	Berr3_m	berghei resistance locus 3 (mouse)					9	103289445	124595110	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	249
Count of miRNA genes:	199
Interacting mature miRNAs:	227
Transcripts:	ENSMUST00000024047
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_011876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC164430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK002699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK003997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK084026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK087422	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK155204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK157886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK166900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK170441	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK186461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK198749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY267189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC003338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Y17808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000024047 ⟹ ENSMUSP00000024047

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	106,203,108 - 106,215,389 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000187647 ⟹ ENSMUSP00000140617

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	106,203,145 - 106,212,819 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000187944 ⟹ ENSMUSP00000139905

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	106,203,137 - 106,212,351 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000188650 ⟹ ENSMUSP00000140339

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	106,206,798 - 106,215,387 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000189708

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	106,206,776 - 106,215,385 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000216348 ⟹ ENSMUSP00000150626

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	106,203,114 - 106,214,398 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000216541

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	106,212,262 - 106,214,876 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000216850 ⟹ ENSMUSP00000150259

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	106,211,719 - 106,214,423 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000217523

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	106,212,189 - 106,214,979 (+)	Ensembl

RefSeq Acc Id:

NM_011876 ⟹ NP_036006

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	9	106,080,307 - 106,092,586 (+)	NCBI
GRCm38	9	106,203,108 - 106,215,387 (+)	ENTREZGENE
MGSCv37	9	106,105,439 - 106,117,718 (+)	RGD
Celera	9	105,828,685 - 105,841,171 (+)	RGD
cM Map	9		ENTREZGENE

Sequence:

show sequence

GGGGGCGGGTCCTGCGGCACCGCCCGGGAAGCTGCGCGAGGCTCGGTGCCGTCGCCACATCCTC
CGGAGCTCTGGGTCCAGGCGAGCCGAGTCGAGCCGGGCCAGGACCAAGAGGAGAACTCCGACGG
CACGGGCGAGCCGAAAGCTGAGCCATGGCGCACCAGACCGGCATCCACGCCACTGAAGAGCTAA
AGGAATTCTTTGCCAAGGCCCGGGCTGGCTCCATCCGACTTATCAAAGTCATCATTGAGGACGA
ACAGCTCGTGCTGGGTGCCTCACAGGAGCCAGTGGGACGCTGGGACCAGGACTACGACCGGGCT
GTGCTGCCACTGCTAGACGCCCAAGAGCCCTGCTACCTCCTCTTCCGACTTGATTCGCAGAATG
CTCAGGGTTTCGAGTGGCTTTTCCTGGCCTGGTCACCTGACAATTCGCCGGTGCGGCTGAAGAT
GCTATATGCAGCCACACGCGCCACCGTGAAGAAGGAGTTTGGAGGCGGCCACATCAAGGATGAG
CTCTTCGGGACAGTAAAGGATGACCTCTCCTTGGCTGGGTACCAGAAGCACCTGTCATCGTGTG
CCGCACCTGCCCCACTGACTTCTGCCGAGAGAGAACTCCAGCAGATCCGAATCAATGAGGTGAA
GACTGAGATCAGCGTGGAAAGTAAACACCAGACGCTGCAGGGCCTGGCCTTCCCTCTGCAGCCT
GAGGCCCAGAGGGCACTTCAGCAACTCAAACAGAAGACGGTCAACTATATCCAGCTGAAGCTGG
ACCTGGAACGGGAGACCATCGAGCTGGTACACACAGAACCCACAAATGTGGCCCAGCTGCCCTC
ACGGATTCCTCGAGATGCTGCCCGCTACCACTTCTTCCTATACAAGCATACTCATGAGGGTGAT
GCCCTTGAATCTGTGGTGTTCATCTACTCCATGCCCGGGTACAAGTGCAGCATCAAGGAGCGGA
TGCTCTACTCCAGCTGCAAGAGCCGCCTCCTTGACTCCGTAGAGCAAGACTTCCAGCTGGAGAT
AGCTAAGAAGATTGAGATCGGCGATGGAGCAGAGCTGACAGCTGAGTTCCTCTATGACGAGGTA
CATCCCAAGCAACACGCGTTCAAGCAGGCGTTCGCCAAGCCCAAAGGCCCCGGGGGCAAGCGGG
GCCACAAGCGCCTCATCCGGGGCCCCGGGGAGAACGGGGAAGACAGCTAGGTGTCTGGACTGGG
AACAGGGCCGGGCACGTGGACTACAGGGTTGCCACTCTGCCACCCCTGGACTTCCTTCCTCCCC
AGCCTGGGCTCTAAGGAATTGCTTTCCTGTGGGACAAGGAGGGCAGGTGGCTGACCATATCTGA
GGGCCTGCCTCTGGACCAGCACTGTGTGACCTTGCCCTGTCACTGTCCCTGCCTCTCATCTGTG
TGTACAGGGTGGCTGGCGAAACCCCACCTTGGCACAAACCTAGCCTCCAGAAAATTTCGTGCTG
TGGTTGCAGCCCAGCCCAAAAGCCTTTGGCTACAGTGGGTGGGGACGGTTGGCAGGGGCCAGAT
GTCACAGGAAGGGATGGTTGAATGCTGTATTTTGTAAAGAATAAAATATTTTTAAATC

hide sequence

Protein Sequences


Protein RefSeqs	NP_036006	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH03338	(Get FASTA)	NCBI Sequence Viewer
	AAP31405	(Get FASTA)	NCBI Sequence Viewer
	BAB22293	(Get FASTA)	NCBI Sequence Viewer
	BAC39101	(Get FASTA)	NCBI Sequence Viewer
	BAC39867	(Get FASTA)	NCBI Sequence Viewer
	BAE33117	(Get FASTA)	NCBI Sequence Viewer
	BAE34246	(Get FASTA)	NCBI Sequence Viewer
	BAE39103	(Get FASTA)	NCBI Sequence Viewer
	BAE41799	(Get FASTA)	NCBI Sequence Viewer
	CAB38083	(Get FASTA)	NCBI Sequence Viewer
	EDL21123	(Get FASTA)	NCBI Sequence Viewer
	EDL21124	(Get FASTA)	NCBI Sequence Viewer
	Q9Z0P5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_036006 ⟸ NM_011876

- UniProtKB:

Q9Z0P5 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQ
EPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDD
LSLAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQ
LKQKTVNYIQLKLDLERETIELVHTEPTNVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFI
YSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFK
QAFAKPKGPGGKRGHKRLIRGPGENGEDS

hide sequence

RefSeq Acc Id:

ENSMUSP00000150259 ⟸ ENSMUST00000216850

RefSeq Acc Id:

ENSMUSP00000140339 ⟸ ENSMUST00000188650

RefSeq Acc Id:

ENSMUSP00000139905 ⟸ ENSMUST00000187944

RefSeq Acc Id:

ENSMUSP00000140617 ⟸ ENSMUST00000187647

RefSeq Acc Id:

ENSMUSP00000150626 ⟸ ENSMUST00000216348

RefSeq Acc Id:

ENSMUSP00000024047 ⟸ ENSMUST00000024047

Protein Domains

ADF-H

Promoters

RGD ID:

6845290

Promoter ID:

MM_KWN:58652

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

NM_011876

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	106,105,301 - 106,105,802 (+)	MPROMDB

RGD ID:

6845291

Promoter ID:

MM_KWN:58653

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_4Hour, Lung

Transcripts:

UC009RJG.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	106,108,436 - 106,109,577 (+)	MPROMDB

RGD ID:

6848501

Promoter ID:

MM_ACW:51891

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_4Hour, Brain, ES_Cell, Lung, MEF_B6, Spleen

Transcripts:

TWF2.CSEP07

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	106,114,121 - 106,114,647 (+)	MPROMDB

RGD ID:

8670710

Promoter ID:

EPDNEW_M13385

Type:

initiation region

Name:

Twf2_1

Description:

Mus musculus twinfilin actin binding protein 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M13386

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	9	106,203,164 - 106,203,224	EPDNEW

RGD ID:

8670712

Promoter ID:

EPDNEW_M13386

Type:

multiple initiation site

Name:

Twf2_2

Description:

Mus musculus twinfilin actin binding protein 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M13385

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	9	106,206,798 - 106,206,858	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1346078	AgrOrtholog
Ensembl Genes	ENSMUSG00000023277	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000024047	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000139905	UniProtKB/TrEMBL
	ENSMUSP00000140339	UniProtKB/Swiss-Prot
	ENSMUSP00000140617	UniProtKB/TrEMBL
	ENSMUSP00000150259	UniProtKB/TrEMBL
	ENSMUSP00000150626	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000024047	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000187647	UniProtKB/TrEMBL
	ENSMUST00000187944	UniProtKB/TrEMBL
	ENSMUST00000188650	UniProtKB/Swiss-Prot
	ENSMUST00000216348	UniProtKB/TrEMBL
	ENSMUST00000216850	UniProtKB/TrEMBL
Gene3D-CATH	3.40.20.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ADF-H	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADF-H/Gelsolin-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Twinfilin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:23999	UniProtKB/Swiss-Prot
MGD	MGI:1346078	ENTREZGENE
NCBI Gene	23999	ENTREZGENE
PANTHER	PTHR13759	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Cofilin_ADF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Twf2	PhenoGen
PROSITE	ADF_H	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	ADF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Mm.274346	ENTREZGENE
UniProt	A0A087WPT3_MOUSE	UniProtKB/TrEMBL
	A0A087WRG4_MOUSE	UniProtKB/TrEMBL
	A0A1L1STC8_MOUSE	UniProtKB/TrEMBL
	A0A1L1SU53_MOUSE	UniProtKB/TrEMBL
	Q9Z0P5	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q3TD06	UniProtKB/Swiss-Prot
	Q3TZG2	UniProtKB/Swiss-Prot
	Q8BN77	UniProtKB/Swiss-Prot
	Q9DCK8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-14	Twf2	twinfilin actin binding protein 2		twinfilin, actin-binding protein, homolog 2 (Drosophila)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)