Maoa (monoamine oxidase A) - Rat Genome Database

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Gene: Maoa (monoamine oxidase A) Mus musculus
Analyze
Symbol: Maoa
Name: monoamine oxidase A
RGD ID: 62191
MGI Page MGI
Description: Enables primary amine oxidase activity. Acts upstream of or within dopamine catabolic process and positive regulation of signal transduction. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Used to study Brunner Syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (monoamine oxidase A); PARTICIPATES IN alkaptonuria pathway; citalopram pharmacodynamics pathway; citalopram pharmacokinetics pathway; INTERACTS WITH (5-hydroxyindol-3-yl)acetaldehyde; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110061B18Rik; AA407771; amine oxidase [flavin-containing] A; MA; MAO-A; MGC27811; monoamine oxidase type A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X16,485,937 - 16,554,051 (+)NCBIGRCm39mm39
GRCm39 EnsemblX16,485,937 - 16,554,057 (+)Ensembl
GRCm38X16,619,698 - 16,687,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX16,619,698 - 16,687,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X16,196,824 - 16,264,938 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X15,776,657 - 15,844,677 (+)NCBImm8
CeleraX14,235,521 - 14,303,664 (+)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX11.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-selegiline  (ISO)
(5-hydroxyindol-3-yl)acetaldehyde  (EXP)
(5-hydroxyindol-3-yl)acetic acid  (ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-methoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
almotriptan  (ISO)
alpha-methyltryptamine  (ISO)
alpha-Zearalanol  (ISO)
amitraz  (ISO)
amitriptyline  (ISO)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antimonite  (ISO)
arecoline  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
astemizole  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzyl benzoate  (ISO)
benzyl cinnamate  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
caffeine  (EXP)
calcitriol  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chrysene  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clorgyline  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorvos  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dizocilpine maleate  (ISO)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (ISO)
finasteride  (ISO)
flavanone  (ISO)
flavone  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
fructose  (ISO)
fucoxanthin  (ISO)
genistein  (EXP,ISO)
harmaline  (ISO)
harman  (ISO)
harmine  (ISO)
Heliotrine  (ISO)
hydralazine  (ISO)
indol-3-ylacetaldehyde  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (ISO)
kojic acid  (ISO)
kynuramine  (ISO)
L-methionine  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lead(II) chloride  (EXP)
luteolin  (EXP,ISO)
Metanephrine  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
mifepristone  (ISO)
mithramycin  (ISO)
moclobemide  (EXP,ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nitroprusside  (EXP)
ochratoxin A  (ISO)
olanzapine  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
parathion-methyl  (ISO)
Pargyline  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phosphamidon  (ISO)
piperine  (EXP,ISO)
pirinixic acid  (EXP,ISO)
procarbazine  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP)
risperidone  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serotonin  (EXP,ISO)
sertraline  (ISO)
simazine  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sulindac  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP)
toloxatone  (ISO)
toluene  (ISO)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tryptamine  (ISO)
tyramine  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1741163   PMID:1916808   PMID:1916827   PMID:2573045   PMID:7792602   PMID:7969716   PMID:8041507   PMID:8431636   PMID:8468042   PMID:8789945   PMID:8835523   PMID:8889548  
PMID:9159177   PMID:9520487   PMID:9712661   PMID:9730605   PMID:10081922   PMID:10202537   PMID:10349636   PMID:10436056   PMID:10498279   PMID:10591056   PMID:10758149   PMID:10844034  
PMID:10920247   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11113033   PMID:11113335   PMID:11118898   PMID:11157075   PMID:11166062   PMID:11438596   PMID:11766896   PMID:11793338  
PMID:11834493   PMID:11906526   PMID:12028362   PMID:12077195   PMID:12351728   PMID:12427678   PMID:12435414   PMID:12447479   PMID:12477932   PMID:12694941   PMID:12900932   PMID:14681479  
PMID:15009159   PMID:15135164   PMID:15251892   PMID:15272015   PMID:15489334   PMID:15659608   PMID:16112493   PMID:16121945   PMID:16141072   PMID:16141073   PMID:16419078   PMID:16602821  
PMID:16638624   PMID:16829576   PMID:16893910   PMID:17090537   PMID:17158340   PMID:17287506   PMID:17441000   PMID:17561096   PMID:18373617   PMID:18418249   PMID:18439826   PMID:18480277  
PMID:18614015   PMID:18634763   PMID:18771734   PMID:18783379   PMID:19070605   PMID:19111597   PMID:19162038   PMID:19445388   PMID:19446603   PMID:19521500   PMID:19705758   PMID:19906978  
PMID:19910579   PMID:20490692   PMID:20702706   PMID:20808911   PMID:21156093   PMID:21267068   PMID:21373759   PMID:21512572   PMID:21607742   PMID:21677750   PMID:21697081   PMID:21832987  
PMID:21873635   PMID:21901841   PMID:22169038   PMID:22718343   PMID:22723698   PMID:22850464   PMID:22967998   PMID:22971542   PMID:23581564   PMID:23670301   PMID:23858446   PMID:23871843  
PMID:23926250   PMID:24262147   PMID:24497636   PMID:24564461   PMID:24681257   PMID:24952961   PMID:25398695   PMID:25502632   PMID:25857821   PMID:26546820   PMID:26841904   PMID:26959532  
PMID:27238716   PMID:27322419   PMID:28012831   PMID:28365314   PMID:29111324   PMID:29459772   PMID:29637670   PMID:29844571   PMID:30003648   PMID:30550785   PMID:30716416   PMID:31348967  
PMID:32094113   PMID:32325033   PMID:32892421   PMID:33451754   PMID:34174788  


Genomics

Comparative Map Data
Maoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X16,485,937 - 16,554,051 (+)NCBIGRCm39mm39
GRCm39 EnsemblX16,485,937 - 16,554,057 (+)Ensembl
GRCm38X16,619,698 - 16,687,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX16,619,698 - 16,687,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X16,196,824 - 16,264,938 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X15,776,657 - 15,844,677 (+)NCBImm8
CeleraX14,235,521 - 14,303,664 (+)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX11.78NCBI
MAOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX43,654,907 - 43,746,824 (+)EnsemblGRCh38hg38GRCh38
GRCh38X43,655,006 - 43,746,817 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X43,514,254 - 43,606,064 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X43,400,353 - 43,491,012 (+)NCBINCBI36hg18NCBI36
Build 34X43,271,662 - 43,362,321NCBI
CeleraX47,658,765 - 47,745,839 (+)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX41,244,782 - 41,335,636 (+)NCBIHuRef
CHM1_1X43,547,315 - 43,639,233 (+)NCBICHM1_1
Maoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X6,032,172 - 6,098,308 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX6,030,795 - 6,099,593 (-)Ensembl
Rnor_6.0X6,554,698 - 6,620,722 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,554,698 - 6,620,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X7,373,101 - 7,439,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,678,960 - 17,745,908 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X17,731,861 - 17,799,225 (-)NCBI
CeleraX6,522,076 - 6,588,367 (-)NCBICelera
Cytogenetic MapXq11NCBI
Maoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555164,493,946 - 4,576,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555164,494,133 - 4,576,317 (-)NCBIChiLan1.0ChiLan1.0
MAOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X43,931,198 - 44,022,199 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX43,931,044 - 44,022,199 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X36,106,680 - 36,197,907 (+)NCBIMhudiblu_PPA_v0panPan3
MAOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X37,678,933 - 37,744,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX37,677,493 - 37,744,757 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX24,906,697 - 24,972,819 (+)NCBI
ROS_Cfam_1.0X37,766,823 - 37,832,990 (+)NCBI
UMICH_Zoey_3.1X37,808,131 - 37,874,259 (+)NCBI
UNSW_CanFamBas_1.0X37,790,918 - 37,857,220 (+)NCBI
UU_Cfam_GSD_1.0X37,886,004 - 37,952,154 (+)NCBI
Maoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X29,974,871 - 30,047,257 (+)NCBI
SpeTri2.0NW_0049365029,816,443 - 9,888,002 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X38,930,452 - 39,006,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X43,132,736 - 43,208,694 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAOA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X40,834,158 - 40,920,404 (+)NCBI
ChlSab1.1 EnsemblX40,834,159 - 40,920,444 (+)Ensembl
Vero_WHO_p1.0NW_0236660766,054,881 - 6,139,601 (+)NCBI
Maoa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476211,743,833 - 11,820,529 (-)NCBI

Position Markers
Maoa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA2UniSTS
cM MapX5.2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126335934Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7360056151324042Mouse
1301551Spha1_msperm head anomaly 1 (mouse)Not determinedX1039998640832775Mouse
13208553Wght11_mweight 11 (mouse)X1200000060000000Mouse
13208557Lgth13_mbody length 13 (mouse)X1200000060000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:627
Count of miRNA genes:399
Interacting mature miRNAs:471
Transcripts:ENSMUST00000026013
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026013   ⟹   ENSMUSP00000026013
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX16,485,937 - 16,554,057 (+)Ensembl
GRCm38.p6 EnsemblX16,619,698 - 16,687,818 (+)Ensembl
RefSeq Acc Id: NM_173740   ⟹   NP_776101
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X16,485,937 - 16,554,051 (+)NCBI
GRCm38X16,619,698 - 16,687,812 (+)ENTREZGENE
MGSCv37X16,196,824 - 16,264,938 (+)RGD
CeleraX14,235,521 - 14,303,664 (+)RGD
cM MapX ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_776101   ⟸   NM_173740
- UniProtKB: Q64133 (UniProtKB/Swiss-Prot),   Q3TPD9 (UniProtKB/TrEMBL),   Q3UJ53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026013   ⟸   ENSMUST00000026013
Protein Domains
Amino_oxidase

Promoters
RGD ID:6845935
Promoter ID:MM_KWN:59675
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000041061
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X16,195,856 - 16,197,052 (+)MPROMDB
RGD ID:13680142
Promoter ID:EPDNEW_M24220
Type:multiple initiation site
Name:Maoa_1
Description:Mus musculus monoamine oxidase A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X16,619,836 - 16,619,896EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96915 AgrOrtholog
Ensembl Genes ENSMUSG00000025037 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000026013 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026013 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Amino_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_amine_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17161 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96915 ENTREZGENE
NCBI Gene 17161 ENTREZGENE
Pfam Amino_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAOA RGD
PhenoGen Maoa PhenoGen
PRINTS AMINEOXDASEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AOFA_MOUSE UniProtKB/Swiss-Prot
  Q3TPD9 ENTREZGENE, UniProtKB/TrEMBL
  Q3U2X5_MOUSE UniProtKB/TrEMBL
  Q3UJ53 ENTREZGENE, UniProtKB/TrEMBL
  Q64133 ENTREZGENE
UniProt Secondary B1AX52 UniProtKB/Swiss-Prot
  Q8K0Z8 UniProtKB/Swiss-Prot