Gene: Camk2b (calcium/calmodulin-dependent protein kinase II, beta) Mus musculus
Analyze
Symbol:
Camk2b
Name:
calcium/calmodulin-dependent protein kinase II, beta
Description:
Exhibits calmodulin-dependent protein kinase activity. Involved in several processes, including activation of meiosis involved in egg activation; modulation of chemical synaptic transmission; and protein phosphorylation. Localizes to cytosol; postsynaptic density; and spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 54. Orthologous to human CAMK2B (calcium/calmodulin dependent protein kinase II beta); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; p38 MAPK signaling pathway; type II interferon signaling pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
calcium/calmodulin-dependent protein kinase II, delta; calcium/calmodulin-dependent protein kinase type II subunit beta; caM kinase II subunit beta; CaMK II; caMK-II subunit beta; Camk2d; CaMKII; MGC90738
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CAMK2B (calcium/calmodulin dependent protein kinase II beta) HGNC
Ensembl, HGNC, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Camk2b (calcium/calmodulin-dependent protein kinase II beta) HGNC
NCBI, HomoloGene, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Camk2b (calcium/calmodulin dependent protein kinase II beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CAMK2B (calcium/calmodulin dependent protein kinase II beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Camk2b (calcium/calmodulin dependent protein kinase II beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CAMK2B (calcium/calmodulin dependent protein kinase II beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CAMK2B (calcium/calmodulin dependent protein kinase II beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Camk2b (calcium/calmodulin dependent protein kinase II beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CAMK2G (calcium/calmodulin dependent protein kinase II gamma) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
CAMK2D (calcium/calmodulin dependent protein kinase II delta) HGNC
OrthoDB
Homo sapiens (human):
CAMK2A (calcium/calmodulin dependent protein kinase II alpha) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Camk2b (calcium/calmodulin-dependent protein kinase II beta)
Alliance
DIOPT (PANTHER|Ensembl Compara|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Homo sapiens (human):
CAMK2B (calcium/calmodulin dependent protein kinase II beta)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|PhylomeDB|OrthoFinder|TreeFam|Roundup)
Danio rerio (zebrafish):
camk2b1 (calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1)
Alliance
DIOPT (TreeFam|Roundup|OrthoFinder|PANTHER)
Drosophila melanogaster (fruit fly):
CaMKII
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam|Roundup)
Caenorhabditis elegans (roundworm):
unc-43
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam|Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38.p6 Ensembl 11 5,969,644 - 6,066,362 (-) Ensembl GRCm38 mm10 GRCm38 GRCm38 11 5,969,629 - 6,066,357 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 11 5,869,645 - 5,965,751 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 11 5,869,675 - 5,965,751 (-) NCBI mm8 Celera 11 6,461,702 - 6,553,628 (-) NCBI Celera Cytogenetic Map 11 A1 NCBI cM Map 11 3.89 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Apnea ISO RGD:735326 8554872 ClinVar Annotator: match by term: Apnea ClinVar PMID:11994750 more ... autosomal dominant mental retardation 54 ISO RGD:735326 8554872 ClinVar Annotator: match by term: MENTAL RETARDATION, AUTOSOMAL DOMINANT 54 ClinVar PMID:29100089 autosomal dominant mental retardation 54 ISO RGD:735326 8554872 ClinVar Annotator: match by term: MENTAL RETARDATION, AUTOSOMAL DOMINANT 54 ClinVar PMID:29560374 autosomal dominant mental retardation 54 ISO RGD:735326 8554872 ClinVar Annotator: match by term: MENTAL RETARDATION, AUTOSOMAL DOMINANT 54 ClinVar PMID:11994750 more ... autosomal dominant mental retardation 54 ISO RGD:735326 8554872 ClinVar Annotator: match by term: MENTAL RETARDATION, AUTOSOMAL DOMINANT 54 ClinVar PMID:11994750 more ... Developmental Disabilities ISO RGD:735326 8554872 ClinVar Annotator: match by term: Global developmental delay ClinVar PMID:11994750 more ... dystonia ISO RGD:735326 8554872 ClinVar Annotator: match by term: Dystonia ClinVar PMID:11994750 more ... genetic disease ISO RGD:735326 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:11994750 more ... genetic disease ISO RGD:735326 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:11994750 more ... Hyperventilation ISO RGD:735326 8554872 ClinVar Annotator: match by term: Hyperventilation ClinVar PMID:11994750 more ... intellectual disability ISO RGD:735326 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar PMID:29100089 intellectual disability ISO RGD:735326 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar PMID:11994750 more ... intellectual disability ISO RGD:735326 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar PMID:11994750 more ... microcephaly ISO RGD:735326 8554872 ClinVar Annotator: match by term: Microcephaly ClinVar PMID:11994750 more ... pleomorphic xanthoastrocytoma ISO RGD:735326 8554872 ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma ClinVar PMID:28299358
Imported Annotations - CTD
cannabis abuse ISO RGD:735326 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17205118 Cocaine-Related Disorders ISO RGD:735326 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17205118 phencyclidine abuse ISO RGD:735326 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17205118 schizophrenia ISO RGD:735326 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11042361 , PMID:20336626 substance-induced psychosis ISO RGD:735326 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17603807 Imported Annotations - OMIM
autosomal dominant mental retardation 54 ISO RGD:735326 7240710 OMIM
(S)-amphetamine increases expression ISO RGD:2262 6480464 Dextroamphetamine results in increased expression of CAMK2B mRNA CTD PMID:17603807 1,2-dichloroethane increases expression EXP 6480464 ethylene dichloride results in increased expression of CAMK2B mRNA CTD PMID:28960355 1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of CAMK2B mRNA CTD PMID:22206623 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of CAMK2B mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:735326 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of CAMK2B mRNA CTD PMID:30165855 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether affects expression EXP 6480464 2 more ... CTD PMID:30294300 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CAMK2B mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:2262 6480464 Tetrachlorodibenzodioxin results in increased expression of CAMK2B mRNA CTD PMID:32109520 2,4,6-trinitrobenzenesulfonic acid decreases expression ISO RGD:2262 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of CAMK2B mRNA CTD PMID:23537331 3-methylcholanthrene multiple interactions EXP 6480464 [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CAMK2B mRNA CTD PMID:23519560 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of CAMK2B mRNA CTD PMID:18648102 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol multiple interactions ISO RGD:2262 6480464 ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] CTD PMID:24718106 acetamide increases expression ISO RGD:2262 6480464 acetamide results in increased expression of CAMK2B mRNA CTD PMID:31881176 acrylamide decreases expression ISO RGD:2262 6480464 Acrylamide results in decreased expression of CAMK2B mRNA CTD PMID:28959563 aflatoxin B1 decreases expression ISO RGD:735326 6480464 Aflatoxin B1 results in decreased expression of CAMK2B mRNA CTD PMID:22100608 aflatoxin B1 decreases methylation ISO RGD:735326 6480464 Aflatoxin B1 results in decreased methylation of CAMK2B intron CTD PMID:30157460 aflatoxin B2 affects methylation ISO RGD:735326 6480464 aflatoxin B2 affects the methylation of CAMK2B intron CTD PMID:30157460 all-trans-retinoic acid multiple interactions ISO RGD:2262 6480464 CAMK2B protein promotes the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein], CAMK2B protein promotes the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein] CTD PMID:19635392 all-trans-retinoic acid decreases expression ISO RGD:735326 6480464 Tretinoin results in decreased expression of CAMK2B mRNA CTD PMID:23724009 ammonium chloride affects expression ISO RGD:2262 6480464 Ammonium Chloride affects the expression of CAMK2B mRNA CTD PMID:16483693 androgen antagonist multiple interactions ISO RGD:2262 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CAMK2B mRNA CTD PMID:25607892 arsane affects methylation ISO RGD:735326 6480464 Arsenic affects the methylation of CAMK2B gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:735326 6480464 Arsenic affects the methylation of CAMK2B gene CTD PMID:25304211 azamethiphos multiple interactions ISO RGD:2262 6480464 azamethiphos promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 benzo[a]pyrene increases mutagenesis ISO RGD:735326 6480464 Benzo(a)pyrene results in increased mutagenesis of CAMK2B gene CTD PMID:25435355 benzo[a]pyrene affects methylation ISO RGD:735326 6480464 Benzo(a)pyrene affects the methylation of CAMK2B intron CTD PMID:30157460 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to CAMK2B promoter] CTD PMID:19654925 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CAMK2B mRNA CTD PMID:19770486 benzo[e]pyrene increases methylation ISO RGD:735326 6480464 benzo(e)pyrene results in increased methylation of CAMK2B intron CTD PMID:30157460 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of CAMK2B mRNA CTD PMID:15674844 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:2262 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA CTD PMID:25607892 bisphenol A multiple interactions ISO RGD:2262 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CAMK2B mRNA, [bisphenol A co-treated with tributyltin] results in increased expression of CAMK2B mRNA CTD PMID:25607892 , PMID:31129395 bisphenol A increases methylation ISO RGD:2262 6480464 bisphenol A results in increased methylation of CAMK2B gene CTD PMID:28505145 bisphenol A decreases expression ISO RGD:2262 6480464 bisphenol A results in decreased expression of CAMK2B mRNA CTD PMID:25181051 butan-1-ol multiple interactions ISO RGD:735326 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CAMK2B mRNA CTD PMID:29432896 Butylparaben multiple interactions ISO RGD:2262 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CAMK2B mRNA CTD PMID:25607892 carbon dioxide multiple interactions ISO RGD:2262 6480464 [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein more ... CTD PMID:24718106 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of CAMK2B mRNA, Nanotubes, Carbon results in increased expression of CAMK2B mRNA CTD PMID:25620056 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of CAMK2B mRNA CTD PMID:20350560 chlorpyrifos multiple interactions ISO RGD:2262 6480464 Chlorpyrifos promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 choline affects expression ISO RGD:2262 6480464 Choline affects the expression of CAMK2B mRNA, Choline affects the expression of CAMK2B protein CTD PMID:17264169 ciguatoxin CTX1B affects expression EXP 6480464 Ciguatoxins affects the expression of CAMK2B mRNA CTD PMID:18353800 cisplatin multiple interactions ISO RGD:2262 6480464 trichostatin A inhibits the reaction [Cisplatin results in decreased expression of CAMK2B mRNA] CTD PMID:23558232 cisplatin decreases expression ISO RGD:2262 6480464 Cisplatin results in decreased expression of CAMK2B mRNA CTD PMID:23558232 clozapine decreases expression ISO RGD:2262 6480464 Clozapine results in decreased expression of CAMK2B mRNA CTD PMID:15860345 cocaine decreases expression ISO RGD:735326 6480464 Cocaine results in decreased expression of CAMK2B mRNA CTD PMID:17205118 cocaine affects expression ISO RGD:2262 6480464 Cocaine affects the expression of CAMK2B mRNA CTD PMID:20187946 cyfluthrin increases expression ISO RGD:735326 6480464 cyfluthrin results in increased expression of CAMK2B mRNA CTD PMID:32028016 cyhalothrin multiple interactions ISO RGD:2262 6480464 cyhalothrin promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 cypermethrin increases expression ISO RGD:735326 6480464 cypermethrin results in increased expression of CAMK2B mRNA CTD PMID:32028016 DDE multiple interactions ISO RGD:2262 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA CTD PMID:25607892 dibutyl phthalate decreases expression ISO RGD:2262 6480464 Dibutyl Phthalate results in decreased expression of CAMK2B mRNA CTD PMID:21266533 dibutyl phthalate multiple interactions ISO RGD:2262 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA CTD PMID:25607892 diclofenac increases expression ISO RGD:2262 6480464 Diclofenac results in increased expression of CAMK2B mRNA CTD PMID:30723492 dieldrin affects expression ISO RGD:2262 6480464 Dieldrin affects the expression of CAMK2B mRNA CTD PMID:22546817 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of CAMK2B protein modified form CTD PMID:20433902 dioxygen multiple interactions ISO RGD:2262 6480464 [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein more ... CTD PMID:24718106 dioxygen decreases expression ISO RGD:735326 6480464 Oxygen deficiency results in decreased expression of CAMK2B mRNA CTD PMID:26516004 doxorubicin decreases expression ISO RGD:735326 6480464 Doxorubicin results in decreased expression of CAMK2B mRNA CTD PMID:29803840 elemental selenium increases expression ISO RGD:735326 6480464 Selenium results in increased expression of CAMK2B mRNA CTD PMID:19244175 endosulfan decreases expression ISO RGD:735326 6480464 Endosulfan results in decreased expression of CAMK2B mRNA CTD PMID:26615145 enzacamene multiple interactions ISO RGD:2262 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CAMK2B mRNA CTD PMID:25607892 epoxiconazole multiple interactions ISO RGD:2262 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA CTD PMID:25607892 ethanol decreases expression ISO RGD:2262 6480464 Ethanol results in decreased expression of CAMK2B mRNA CTD PMID:20655511 ethanol multiple interactions EXP 6480464 Ethanol affects the expression of and affects the splicing of CAMK2B mRNA CTD PMID:30319688 ethanol multiple interactions ISO RGD:735326 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CAMK2B mRNA CTD PMID:29432896 ferroheme b decreases expression EXP 6480464 Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 folic acid decreases expression EXP 6480464 Folic Acid results in decreased expression of CAMK2B mRNA CTD PMID:25629700 furan increases expression ISO RGD:2262 6480464 furan results in increased expression of CAMK2B mRNA CTD PMID:22079235 haloperidol decreases expression ISO RGD:2262 6480464 Haloperidol results in decreased expression of CAMK2B mRNA CTD PMID:15860345 heme b decreases expression EXP 6480464 Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of CAMK2B mRNA CTD PMID:20003209 lead(0) affects expression ISO RGD:735326 6480464 Lead affects the expression of CAMK2B mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:735326 6480464 Lead affects the expression of CAMK2B mRNA CTD PMID:28903495 linuron multiple interactions ISO RGD:2262 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA CTD PMID:25607892 lovastatin multiple interactions ISO RGD:2262 6480464 Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] CTD PMID:24718106 malathion multiple interactions ISO RGD:2262 6480464 Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 methapyrilene increases methylation ISO RGD:735326 6480464 Methapyrilene results in increased methylation of CAMK2B intron CTD PMID:30157460 monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of CAMK2B mRNA CTD PMID:22078008 nickel dichloride affects expression ISO RGD:2262 6480464 nickel chloride affects the expression of CAMK2B mRNA CTD PMID:22546817 ochratoxin A increases expression ISO RGD:2262 6480464 ochratoxin A results in increased expression of CAMK2B mRNA CTD PMID:23358140 ouabain increases expression ISO RGD:735326 6480464 Ouabain results in increased expression of CAMK2B protein CTD PMID:31436044 paclitaxel affects response to substance ISO RGD:735326 6480464 CAMK2B protein affects the susceptibility to Paclitaxel CTD PMID:16217747 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of CAMK2B mRNA CTD PMID:17562736 paracetamol multiple interactions ISO RGD:2262 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CAMK2B mRNA CTD PMID:25607892 phencyclidine decreases expression ISO RGD:735326 6480464 Phencyclidine results in decreased expression of CAMK2B mRNA CTD PMID:17205118 phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CAMK2B mRNA CTD PMID:23519560 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of CAMK2B mRNA CTD PMID:18445702 prochloraz multiple interactions ISO RGD:2262 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA CTD PMID:25607892 procymidone multiple interactions ISO RGD:2262 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA CTD PMID:25607892 progesterone decreases expression ISO RGD:735326 6480464 Progesterone results in decreased expression of CAMK2B mRNA CTD PMID:21540246 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of CAMK2B mRNA CTD PMID:21278054 quercitrin decreases expression ISO RGD:735326 6480464 quercitrin results in decreased expression of CAMK2B mRNA CTD PMID:25193878 rotenone affects expression EXP 6480464 Rotenone affects the expression of CAMK2B mRNA CTD PMID:23186747 selenium atom increases expression ISO RGD:735326 6480464 Selenium results in increased expression of CAMK2B mRNA CTD PMID:19244175 Soman decreases expression ISO RGD:2262 6480464 Soman results in decreased expression of CAMK2B mRNA CTD PMID:19281266 sunitinib decreases expression ISO RGD:735326 6480464 Sunitinib results in decreased expression of CAMK2B mRNA CTD PMID:31533062 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of CAMK2B mRNA CTD PMID:20937368 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of CAMK2B mRNA CTD PMID:23557971 triazines multiple interactions EXP 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased expression of CAMK2B mRNA] CTD PMID:27469509 tributylstannane increases activity EXP 6480464 tributyltin results in increased activity of CAMK2B protein CTD PMID:20810541 tributylstannane multiple interactions ISO RGD:2262 6480464 [bisphenol A co-treated with tributyltin] results in increased expression of CAMK2B mRNA CTD PMID:31129395 tributylstannane decreases expression ISO RGD:2262 6480464 tributyltin results in decreased expression of CAMK2B mRNA CTD PMID:31129395 trichostatin A multiple interactions ISO RGD:2262 6480464 trichostatin A inhibits the reaction [Cisplatin results in decreased expression of CAMK2B mRNA] CTD PMID:23558232 tris(2-chloroethyl) phosphate increases expression ISO RGD:2262 6480464 tris(chloroethyl)phosphate results in increased expression of CAMK2B mRNA, tris(chloroethyl)phosphate results in increased expression of CAMK2B protein CTD PMID:24717766 tungsten decreases expression EXP 6480464 Tungsten results in decreased expression of CAMK2B mRNA CTD PMID:30912803 urethane decreases expression ISO RGD:735326 6480464 Urethane results in decreased expression of CAMK2B mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:735326 6480464 Valproic Acid results in increased methylation of CAMK2B gene CTD PMID:29154799 venlafaxine hydrochloride affects expression ISO RGD:2262 6480464 Venlafaxine Hydrochloride affects the expression of CAMK2B mRNA CTD PMID:25423262 vinclozolin multiple interactions ISO RGD:2262 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA CTD PMID:25607892 vinclozolin affects expression ISO RGD:2262 6480464 vinclozolin affects the expression of CAMK2B mRNA CTD PMID:19015723 vitamin E increases expression ISO RGD:735326 6480464 Vitamin E results in increased expression of CAMK2B mRNA CTD PMID:19244175
Biological Process activation of meiosis involved in egg activation IMP 2290270 (MGI:MGI:1327475, PMID:9882483) MGI MGI:MGI:1327475 , PMID:9882483 calcium ion transport IMP 2290270 (MGI:MGI:2667242, PMID:12660151) MGI MGI:MGI:2667242 , PMID:12660151 cell differentiation IEA UniProtKB-KW:KW-0221 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cell projection morphogenesis ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cellular response to homocysteine ISO RGD:2262 9068941 RGD PMID:25126162 , REF_RGD_ID:13681928 G1/S transition of mitotic cell cycle IMP 2290270 (MGI:MGI:2667242, PMID:12660151) MGI MGI:MGI:2667242 , PMID:12660151 hippocampal neuron apoptotic process ISO RGD:2262 9068941 RGD PMID:25126162 , REF_RGD_ID:13681928 inhibitory G protein-coupled receptor phosphorylation IDA 2290270 (MGI:MGI:4352609, PMID:19332541) MGI MGI:MGI:4352609 , PMID:19332541 long-term synaptic potentiation ISO UniProtKB:P08413 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 nervous system development IEA UniProtKB-KW:KW-0524 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 neuromuscular process controlling balance IMP MGI:MGI:4359775 2290270 (MGI:MGI:4359140, PMID:19503086) MGI MGI:MGI:4359140 , PMID:19503086 peptidyl-serine phosphorylation IDA 2290270 (MGI:MGI:4352609, PMID:19332541) MGI MGI:MGI:4352609 , PMID:19332541 phosphorylation IEA UniProtKB-KW:KW-0418 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 positive regulation of apoptotic signaling pathway IDA 2290270 (MGI:MGI:3710042, PMID:17367784) MGI MGI:MGI:3710042 , PMID:17367784 positive regulation of dendritic spine morphogenesis ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of neuron projection development ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of phospholipase A2 activity ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of synapse maturation ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein autophosphorylation IMP 2290270 (MGI:MGI:2667242, PMID:12660151) MGI MGI:MGI:2667242 , PMID:12660151 protein autophosphorylation ISO UniProtKB:Q13554 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein phosphorylation IBA FB:FBgn0264607 more ... 2290270 (MGI:MGI:6201960, PMID:21873635) GOC MGI:MGI:6201960 , PMID:21873635 regulation of long-term neuronal synaptic plasticity IMP MGI:MGI:4359775 2290270 (MGI:MGI:4359140, PMID:19503086) MGI MGI:MGI:4359140 , PMID:19503086 regulation of neuron migration ISO UniProtKB:Q13554 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of neuron migration IMP 2290270 (MGI:MGI:6160628, PMID:29100089) UniProtKB MGI:MGI:6160628 , PMID:29100089 regulation of protein localization to plasma membrane ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 regulation of synaptic transmission, cholinergic IMP 2290270 (MGI:MGI:4352609, PMID:19332541) MGI MGI:MGI:4352609 , PMID:19332541 response to cadmium ion IDA 2290270 (MGI:MGI:3710042, PMID:17367784) MGI MGI:MGI:3710042 , PMID:17367784 response to psychosocial stress ISO RGD:2262 9068941 RGD PMID:23313435 , REF_RGD_ID:13681929 Cellular Component calcium- and calmodulin-dependent protein kinase complex ISO UniProtKB:Q13554 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cell junction IEA UniProtKB-KW:KW-0965 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cytoplasm IBA PANTHER:PTN002389359 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cytoskeleton IEA UniProtKB-KW:KW-0206 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cytosol IDA 2290270 (MGI:MGI:1327475, PMID:9882483) MGI MGI:MGI:1327475 , PMID:9882483 dendrite ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 glutamatergic synapse ISO RGD:2262 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 neuron projection IBA PANTHER:PTN002389359 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 perikaryon ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 postsynaptic density ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 postsynaptic density IDA 2290270 (MGI:MGI:5436301, PMID:17114649) MGI MGI:MGI:5436301 , PMID:17114649 sarcoplasmic reticulum IEA UniProtKB-KW:KW-0703 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 spindle midzone IDA 2290270 (MGI:MGI:1327475, PMID:9882483) MGI MGI:MGI:1327475 , PMID:9882483 synapse IEA UniProtKB-KW:KW-0770 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Molecular Function ATP binding IEA UniProtKB-KW:KW-0067 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 ATP binding IEA InterPro:IPR000719 , InterPro:IPR017441 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 calmodulin binding IBA PANTHER:PTN002389359 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 calmodulin-dependent protein kinase activity IDA 2290270 (MGI:MGI:1327475, PMID:9882483) MGI MGI:MGI:1327475 , PMID:9882483 calmodulin-dependent protein kinase activity IBA PANTHER:PTN002389359 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 calmodulin-dependent protein kinase activity ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 identical protein binding ISO UniProtKB:Q13554 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 kinase activity IEA UniProtKB-KW:KW-0418 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nucleotide binding IEA UniProtKB-KW:KW-0547 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 phospholipase binding ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein binding IPI UniProtKB:P11716 2290270 (MGI:MGI:5508705, PMID:22913516) IntAct MGI:MGI:5508705 , PMID:22913516 protein binding IPI UniProtKB:Q9WV31 2290270 (MGI:MGI:5431161, PMID:22579289) IntAct MGI:MGI:5431161 , PMID:22579289 protein homodimerization activity ISO UniProtKB:Q13554 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein kinase activity IEA InterPro:IPR000719 , InterPro:IPR008271 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 protein kinase binding ISO RGD:2262 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein serine/threonine kinase activity IMP 2290270 (MGI:MGI:2667242, PMID:12660151) MGI MGI:MGI:2667242 , PMID:12660151 protein serine/threonine kinase activity IDA 2290270 (MGI:MGI:4352609, PMID:19332541) MGI MGI:MGI:4352609 , PMID:19332541 structural constituent of postsynaptic actin cytoskeleton ISO RGD:2262 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 transferase activity IEA UniProtKB-KW:KW-0808 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194
Gene-Chemical Interaction Annotations
