Nlrp3 (NLR family, pyrin domain containing 3) - Rat Genome Database
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Gene: Nlrp3 (NLR family, pyrin domain containing 3) Mus musculus
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Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
RGD ID: 1318015
MGI Page MGI
Description: Exhibits sequence-specific DNA binding activity and transcription factor binding activity. Involved in several processes, including cytokine production; positive regulation of macromolecule metabolic process; and response to bacterium. Localizes to NLRP3 inflammasome complex and nucleus. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3); PARTICIPATES IN interleukin-1 signaling pathway; influenza A pathway; NOD-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-galactopyranose; 3-mercaptopropanoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AGTAVPRL; AII/AVP; Ci; Cias1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein homolog; cry; cryopyrin; FCAS; FCU; mast cell maturation inducible protein 1; mast cell maturation-associated-inducible protein 1; MGC129375; Mmig; Mmig1; MWS; N; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NALP3; Pyp; Pypaf1; PYRIN-containing APAF1-like protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,432,395 - 59,457,781 (+)NCBIGRCm39mm39
GRCm381159,541,569 - 59,566,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,541,568 - 59,566,956 (+)EnsemblGRCm38mm10GRCm38
MGSCv371159,356,188 - 59,380,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv361160,078,786 - 60,103,056 (+)NCBImm8
MGSCv361159,358,881 - 59,383,151 (+)NCBImm8
Cytogenetic Map11B1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,5-hexanedione  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
3-mercaptopropanoic acid  (EXP)
3-methyladenine  (ISO)
4-hydroxynon-2-enal  (EXP)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
4-phenylbutyric acid  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (EXP)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
allicin  (EXP)
allopurinol  (ISO)
aluminium hydroxide  (EXP)
aluminium sulfate (anhydrous)  (EXP)
amitriptyline  (EXP)
amphetamine  (ISO)
amphibole asbestos  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asbestos  (ISO)
astragaloside IV  (ISO)
ATP  (EXP,ISO)
atropine  (ISO)
azathioprine  (EXP)
bafilomycin A1  (ISO)
baicalin  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Bergenin  (ISO)
bisphenol A  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
celastrol  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
crocidolite asbestos  (EXP,ISO)
cycloheximide  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (EXP)
dexmedetomidine  (EXP)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicloxacillin  (EXP)
diethyldithiocarbamic acid  (EXP)
dihydroartemisinin  (ISO)
dimethyldithiocarbamate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
ergosterol  (ISO)
Erionite  (ISO)
ethanol  (ISO)
flutamide  (EXP,ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (ISO)
furosemide  (ISO)
Fusaric acid  (ISO)
glucose  (EXP,ISO)
glyburide  (EXP,ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
hexadecanoic acid  (EXP,ISO)
HU-308  (EXP)
hydrogen peroxide  (EXP)
iohexol  (ISO)
ketoconazole  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
magnesium dihydroxide  (EXP)
maneb  (EXP)
mebendazole  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP)
mercury(0)  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nigericin  (ISO)
NMN zwitterion  (EXP,ISO)
obeticholic acid  (ISO)
omeprazole  (ISO)
ozone  (ISO)
Palbinone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
pentanal  (ISO)
permethrin  (EXP)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
procyanidin B2  (ISO)
propanal  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
rotenone  (EXP,ISO)
rutin  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salidroside  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (EXP)
tetramethylpyrazine  (EXP)
thapsigargin  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (EXP)
triclosan  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tungsten carbide  (ISO)
vinclozolin  (ISO)
XL147  (EXP)
zearalenone  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
cellular response to lipopolysaccharide  (IDA,ISO)
cellular response to peptidoglycan  (IMP)
defense response to Gram-positive bacterium  (IMP)
defense response to virus  (IMP)
immune system process  (IEA)
inflammatory response  (IDA,ISO)
innate immune response  (IEA)
leukocyte migration involved in inflammatory response  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of NIK/NF-kappaB signaling  (IBA,ISO)
NLRP3 inflammasome complex assembly  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA,ISO)
positive regulation of interleukin-1 beta production  (IDA,IGI,IMP,ISO)
positive regulation of interleukin-13 production  (IMP)
positive regulation of interleukin-4 production  (IDA)
positive regulation of interleukin-5 production  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of T-helper 17 cell differentiation  (IMP)
positive regulation of T-helper 2 cell cytokine production  (IMP)
positive regulation of T-helper 2 cell differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of type 2 immune response  (IMP)
regulation of inflammatory response  (IMP)
response to ethanol  (ISO)
response to organic cyclic compound  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal CD4-positive, alpha beta T cell number  (IAGP)
abnormal chondrocyte physiology  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell antigen presentation  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal gut flora balance  (IAGP)
abnormal interleukin-1 beta secretion  (IEA)
abnormal intestine morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lipid metabolism  (IAGP)
abnormal liver morphology  (IAGP)
abnormal long bone epiphysis morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal macrophage cytokine production  (IEA)
abnormal macrophage physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal response to infection  (IAGP)
abnormal skeleton development  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
absent B cells  (IAGP)
absent T cells  (IAGP)
adipose tissue inflammation  (IAGP)
anemia  (IAGP)
chronic inflammation  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone trabecula number  (IAGP)
decreased cell proliferation  (IAGP)
decreased chondrocyte number  (IAGP)
decreased circulating interleukin-1 beta level  (IAGP)
decreased circulating interleukin-12b level  (IAGP)
decreased circulating interleukin-18 level  (IAGP)
decreased circulating interleukin-5 level  (IAGP)
decreased compact bone area  (IAGP)
decreased compact bone thickness  (IAGP)
decreased energy expenditure  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased femur size  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased lactate dehydrogenase level  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to induced colitis  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased trabecular bone mass  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
dermatitis  (IAGP)
disorganized long bone epiphyseal plate  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
hairless  (IAGP)
hepatic steatosis  (IAGP)
increased activated T cell number  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased body fat mass  (IAGP)
increased bone resorption  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-13 level  (IAGP)
increased circulating interleukin-18 level  (IAGP)
increased circulating interleukin-3 level  (IAGP)
increased circulating interleukin-4 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating interleukin-9 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased granulocyte number  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-18 secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased lymphocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to type IV hypersensitivity reaction  (IAGP)
increased T-helper 1 cell number  (IAGP)
joint inflammation  (IAGP)
meningitis  (IAGP)
no abnormal phenotype detected  (IAGP)
osteomyelitis  (IAGP)
oxidative stress  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
reddish skin  (IAGP)
reduced fertility  (IAGP)
scaly skin  (IAGP)
skin inflammation  (IAGP)
slow postnatal weight gain  (IAGP)
thrombocytosis  (IAGP)
References

Additional References at PubMed
PMID:8889548   PMID:12466851   PMID:12477932   PMID:12633874   PMID:14688236   PMID:15302403   PMID:16407888   PMID:16407889   PMID:16407890   PMID:16546100   PMID:16602821   PMID:16717117  
PMID:16785251   PMID:16984919   PMID:17008311   PMID:17403772   PMID:17433728   PMID:17442855   PMID:17491021   PMID:17599094   PMID:17878377   PMID:17907925   PMID:17935074   PMID:18070936  
PMID:18288107   PMID:18322214   PMID:18403674   PMID:18490757   PMID:18496530   PMID:18511561   PMID:18566365   PMID:18577586   PMID:18604209   PMID:18624356   PMID:18656551   PMID:18768827  
PMID:18769497   PMID:19139171   PMID:19139407   PMID:19158675   PMID:19164858   PMID:19218193   PMID:19222370   PMID:19237518   PMID:19339971   PMID:19342685   PMID:19362020   PMID:19362023  
PMID:19364881   PMID:19414800   PMID:19454352   PMID:19494813   PMID:19501000   PMID:19501001   PMID:19509280   PMID:19542372   PMID:19570822   PMID:19576795   PMID:19587006   PMID:19596994  
PMID:19605353   PMID:19652017   PMID:19652710   PMID:19675207   PMID:19684085   PMID:19696895   PMID:19717510   PMID:19717512   PMID:19734227   PMID:19767732   PMID:19783673   PMID:19805629  
PMID:19812205   PMID:19826485   PMID:19915568   PMID:19918053   PMID:19950187   PMID:20007575   PMID:20008285   PMID:20023662   PMID:20114021   PMID:20114027   PMID:20177071   PMID:20201022  
PMID:20303296   PMID:20333626   PMID:20348425   PMID:20368281   PMID:20383149   PMID:20385749   PMID:20393140   PMID:20407867   PMID:20428172   PMID:20442201   PMID:20457908   PMID:20490635  
PMID:20495560   PMID:20506351   PMID:20566831   PMID:20574004   PMID:20579764   PMID:20603313   PMID:20610650   PMID:20610651   PMID:20668698   PMID:20688930   PMID:20713892   PMID:20722078  
PMID:20802146   PMID:20808838   PMID:20818395   PMID:20835230   PMID:20849355   PMID:20855874   PMID:20861349   PMID:20872834   PMID:20884650   PMID:20947763   PMID:20971108   PMID:20974980  
PMID:21037094   PMID:21041719   PMID:21048113   PMID:21059855   PMID:21059925   PMID:21106820   PMID:21109192   PMID:21118981   PMID:21124315   PMID:21128730   PMID:21151103   PMID:21159638  
PMID:21228274   PMID:21257968   PMID:21267068   PMID:21270336   PMID:21278344   PMID:21282379   PMID:21289120   PMID:21349431   PMID:21396389   PMID:21439959   PMID:21443539   PMID:21464320  
PMID:21471445   PMID:21474346   PMID:21478880   PMID:21484785   PMID:21497116   PMID:21533069   PMID:21540455   PMID:21565393   PMID:21566220   PMID:21600797   PMID:21602824   PMID:21622869  
PMID:21646297   PMID:21677136   PMID:21690334   PMID:21718313   PMID:21731762   PMID:21765404   PMID:21777570   PMID:21844393   PMID:21856950   PMID:21862613   PMID:21873635   PMID:21876127  
PMID:21892172   PMID:21930705   PMID:21940629   PMID:21957143   PMID:22002608   PMID:22003197   PMID:22006336   PMID:22046355   PMID:22058415   PMID:22101787   PMID:22105559   PMID:22106299  
PMID:22119862   PMID:22147977   PMID:22174673   PMID:22213227   PMID:22227418   PMID:22241982   PMID:22250086   PMID:22276187   PMID:22297845   PMID:22308473   PMID:22323538   PMID:22323544  
PMID:22325453   PMID:22331066   PMID:22342844   PMID:22361326   PMID:22365665   PMID:22387558   PMID:22393394   PMID:22426419   PMID:22440612   PMID:22461501   PMID:22461621   PMID:22474394  
PMID:22484808   PMID:22531249   PMID:22531291   PMID:22538615   PMID:22541070   PMID:22558291   PMID:22569257   PMID:22606244   PMID:22634614   PMID:22647887   PMID:22699511   PMID:22733741  
PMID:22753929   PMID:22768222   PMID:22777876   PMID:22801494   PMID:22817986   PMID:22819042   PMID:22832107   PMID:22840842   PMID:22848083   PMID:22848390   PMID:22854286   PMID:22888139  
PMID:22898816   PMID:22904305   PMID:22905357   PMID:22911706   PMID:22921586   PMID:22926439   PMID:22933232   PMID:22933241   PMID:22948162   PMID:22981536   PMID:22986739   PMID:23010873  
PMID:23075849   PMID:23075874   PMID:23090995   PMID:23100513   PMID:23115038   PMID:23143333   PMID:23144495   PMID:23148704   PMID:23209411   PMID:23216160   PMID:23221343   PMID:23225887  
PMID:23246432   PMID:23254930   PMID:23260196   PMID:23264657   PMID:23267025   PMID:23271661   PMID:23280493   PMID:23297192   PMID:23297415   PMID:23307811   PMID:23318584   PMID:23334413  
PMID:23348507   PMID:23371061   PMID:23376234   PMID:23401008   PMID:23430110   PMID:23436933   PMID:23454767   PMID:23460746   PMID:23468973   PMID:23487464   PMID:23487794   PMID:23502856  
PMID:23509366   PMID:23511475   PMID:23580606   PMID:23585683   PMID:23619996   PMID:23625200   PMID:23630357   PMID:23636457   PMID:23644505   PMID:23645208   PMID:23658628   PMID:23680490  
PMID:23686720   PMID:23703389   PMID:23704226   PMID:23708522   PMID:23708968   PMID:23737748   PMID:23739234   PMID:23770281   PMID:23809161   PMID:23809162   PMID:23812099   PMID:23813842  
PMID:23817414   PMID:23818043   PMID:23838163   PMID:23843215   PMID:23887873   PMID:23904166   PMID:23935505   PMID:23942110   PMID:23942123   PMID:23948399   PMID:23955712   PMID:23964013  
PMID:23980097   PMID:23994575   PMID:23995233   PMID:23997220   PMID:24007300   PMID:24008734   PMID:24012762   PMID:24041971   PMID:24043892   PMID:24082072   PMID:24084736   PMID:24089192  
PMID:24093676   PMID:24098823   PMID:24116148   PMID:24127597   PMID:24157462   PMID:24158569   PMID:24164497   PMID:24194505   PMID:24265316   PMID:24280937   PMID:24307525   PMID:24336249  
PMID:24337744   PMID:24340123   PMID:24352154   PMID:24361386   PMID:24379360   PMID:24388751   PMID:24395792   PMID:24395802   PMID:24418550   PMID:24453255   PMID:24453428   PMID:24453977  
PMID:24454932   PMID:24458363   PMID:24464629   PMID:24470197   PMID:24475307   PMID:24478101   PMID:24484406   PMID:24508233   PMID:24516390   PMID:24549849   PMID:24595807   PMID:24631027  
PMID:24638169   PMID:24663677   PMID:24687021   PMID:24687687   PMID:24690602   PMID:24692555   PMID:24696236   PMID:24743949   PMID:24769733   PMID:24778451   PMID:24789624   PMID:24795455  
PMID:24798340   PMID:24799678   PMID:24803432   PMID:24805106   PMID:24807222   PMID:24823805   PMID:24827856   PMID:24828532   PMID:24841199   PMID:24849809   PMID:24861026   PMID:24875775  
PMID:24876671   PMID:24879791   PMID:24917577   PMID:24919149   PMID:24943899   PMID:24958845   PMID:24988285   PMID:24990442   PMID:25011057   PMID:25015733   PMID:25024200   PMID:25043000  
PMID:25059664   PMID:25065288   PMID:25065886   PMID:25075770   PMID:25115174   PMID:25121752   PMID:25126727   PMID:25130466   PMID:25135254   PMID:25138219   PMID:25141024   PMID:25152324  
PMID:25166912   PMID:25171193   PMID:25172489   PMID:25193701   PMID:25216263   PMID:25224305   PMID:25225402   PMID:25225670   PMID:25240383   PMID:25260607   PMID:25267545   PMID:25271165  
PMID:25294243   PMID:25295542   PMID:25326752   PMID:25327779   PMID:25343834   PMID:25356867   PMID:25372293   PMID:25404286   PMID:25405767   PMID:25405768   PMID:25406505   PMID:25422268  
PMID:25422455   PMID:25445147   PMID:25447538   PMID:25450976   PMID:25473914   PMID:25477279   PMID:25481711   PMID:25524927   PMID:25535911   PMID:25547136   PMID:25548278   PMID:25574840  
PMID:25580516   PMID:25581126   PMID:25582856   PMID:25594175   PMID:25603858   PMID:25605870   PMID:25613820   PMID:25628461   PMID:25637014   PMID:25655831   PMID:25671600   PMID:25681332  
PMID:25684123   PMID:25686105   PMID:25686106   PMID:25686493   PMID:25689249   PMID:25690658   PMID:25693118   PMID:25694478   PMID:25704009   PMID:25710917   PMID:25714839   PMID:25715986  
PMID:25740324   PMID:25750210   PMID:25762200   PMID:25770182   PMID:25774715   PMID:25775556   PMID:25793272   PMID:25793779   PMID:25815426   PMID:25825440   PMID:25828455   PMID:25834832  
PMID:25847984   PMID:25847985   PMID:25855661   PMID:25862090   PMID:25862092   PMID:25867480   PMID:25934928   PMID:25959047   PMID:25972159   PMID:25993444   PMID:26008898   PMID:26027935  
PMID:26045078   PMID:26045547   PMID:26056255   PMID:26071556   PMID:26074074   PMID:26079065   PMID:26081624   PMID:26091541   PMID:26098997   PMID:26100631   PMID:26104484   PMID:26119225  
PMID:26119741   PMID:26147228   PMID:26166692   PMID:26173909   PMID:26198480   PMID:26200799   PMID:26214524   PMID:26218747   PMID:26253422   PMID:26254306   PMID:26269257   PMID:26275995  
PMID:26293846   PMID:26305961   PMID:26320999   PMID:26332085   PMID:26332156   PMID:26341399   PMID:26349656   PMID:26360504   PMID:26361146   PMID:26362308   PMID:26367131   PMID:26371131  
PMID:26375259   PMID:26384545   PMID:26407722   PMID:26412089   PMID:26427397   PMID:26431797   PMID:26471297   PMID:26488087   PMID:26489382   PMID:26516184   PMID:26529046   PMID:26536497  
PMID:26544941   PMID:26553871   PMID:26555265   PMID:26555554   PMID:26572062   PMID:26577567   PMID:26582949   PMID:26611836   PMID:26627461   PMID:26628639   PMID:26635145   PMID:26638072  
PMID:26639408   PMID:26642356   PMID:26655906   PMID:26676570   PMID:26681113   PMID:26683666   PMID:26687278   PMID:26689285   PMID:26706279   PMID:26722520   PMID:26744177   PMID:26777707  
PMID:26786981   PMID:26788246   PMID:26814970   PMID:26876170   PMID:26877061   PMID:26883974   PMID:26887832   PMID:26891693   PMID:26893104   PMID:26907476   PMID:26919428   PMID:26921636  
PMID:26933834   PMID:26937141   PMID:26972847   PMID:26978520   PMID:26989816   PMID:26996064   PMID:26998763   PMID:27006116   PMID:27006445   PMID:27008885   PMID:27010539   PMID:27010854  
PMID:27011353   PMID:27014913   PMID:27036651   PMID:27043286   PMID:27053298   PMID:27062120   PMID:27071119   PMID:27084336   PMID:27103670   PMID:27105502   PMID:27111234   PMID:27139490  
PMID:27158778   PMID:27170638   PMID:27188492   PMID:27208584   PMID:27214553   PMID:27217302   PMID:27225830   PMID:27256568   PMID:27262946   PMID:27270401   PMID:27287410   PMID:27308893  
PMID:27315109   PMID:27321991   PMID:27322427   PMID:27337507   PMID:27339979   PMID:27344638   PMID:27345021   PMID:27362650   PMID:27374331   PMID:27374884   PMID:27382187   PMID:27384322  
PMID:27433030   PMID:27462105   PMID:27465336   PMID:27476670   PMID:27509058   PMID:27509078   PMID:27509875   PMID:27543123   PMID:27566828   PMID:27583382   PMID:27589872   PMID:27601185  
PMID:27607578   PMID:27610005   PMID:27617861   PMID:27630169   PMID:27632566   PMID:27665233   PMID:27670879   PMID:27682204   PMID:27692610   PMID:27692612   PMID:27693356   PMID:27708283  
PMID:27730320   PMID:27732661   PMID:27733681   PMID:27769021   PMID:27779186   PMID:27779191   PMID:27779193   PMID:27780404   PMID:27783111   PMID:27785882   PMID:27793052   PMID:27803035  
PMID:27813491   PMID:27816762   PMID:27820602   PMID:27845246   PMID:27846608   PMID:27869651   PMID:27880990   PMID:27882934   PMID:27911804   PMID:27912077   PMID:27913620   PMID:27917412  
PMID:27924062   PMID:27926940   PMID:27929086   PMID:27929533   PMID:27930969   PMID:27933491   PMID:27939674   PMID:27974218   PMID:27984712   PMID:27987394   PMID:28002730   PMID:28004759  
PMID:28031338   PMID:28032341   PMID:28034752   PMID:28039299   PMID:28040362   PMID:28052869   PMID:28056339   PMID:28056996   PMID:28065854   PMID:28073832   PMID:28084303   PMID:28087471  
PMID:28087651   PMID:28087670   PMID:28092375   PMID:28093255   PMID:28096356   PMID:28096401   PMID:28096454   PMID:28099758   PMID:28117341   PMID:28130494   PMID:28140444   PMID:28151471  
PMID:28151474   PMID:28152446   PMID:28153878   PMID:28193546   PMID:28193826   PMID:28202418   PMID:28219839   PMID:28249038   PMID:28249154   PMID:28252317   PMID:28270571   PMID:28275154  
PMID:28288918   PMID:28341446   PMID:28348462   PMID:28370493   PMID:28380377   PMID:28394319   PMID:28404518   PMID:28404595   PMID:28424239   PMID:28434881   PMID:28442553   PMID:28447181  
PMID:28465465   PMID:28479336   PMID:28479366   PMID:28487310   PMID:28493895   PMID:28499273   PMID:28536183   PMID:28537251   PMID:28544564   PMID:28558839   PMID:28576828   PMID:28576980  
PMID:28584055   PMID:28596375   PMID:28606793   PMID:28612844   PMID:28623127   PMID:28628921   PMID:28636595   PMID:28652704   PMID:28656530   PMID:28656979   PMID:28659345   PMID:28662502  
PMID:28671985   PMID:28684277   PMID:28687790   PMID:28708885   PMID:28716882   PMID:28729291   PMID:28730512   PMID:28733486   PMID:28739881   PMID:28740109   PMID:28747793   PMID:28762847  
PMID:28779175   PMID:28782714   PMID:28784846   PMID:28785377   PMID:28786745   PMID:28790324   PMID:28799242   PMID:28808303   PMID:28814068   PMID:28847925   PMID:28882883   PMID:28887870  
PMID:28902427   PMID:28903492   PMID:28905319   PMID:28923684   PMID:28930866   PMID:28939830   PMID:28941191   PMID:28942141   PMID:28943315   PMID:28953873   PMID:28965161   PMID:28968459  
PMID:28970254   PMID:28971472   PMID:29016824   PMID:29021150   PMID:29030458   PMID:29033131   PMID:29045901   PMID:29051224   PMID:29059152   PMID:29061706   PMID:29089078   PMID:29097427  
PMID:29099934   PMID:29130929   PMID:29144508   PMID:29146733   PMID:29180292   PMID:29196621   PMID:29203400   PMID:29212744   PMID:29230270   PMID:29241624   PMID:29262411   PMID:29264825  
PMID:29269298   PMID:29269609   PMID:29270247   PMID:29274035   PMID:29277561   PMID:29278702   PMID:29279328   PMID:29281832   PMID:29281833   PMID:29281837   PMID:29295651   PMID:29301957  
PMID:29317641   PMID:29321274   PMID:29322034   PMID:29328911   PMID:29339053   PMID:29353059   PMID:29355515   PMID:29358279   PMID:29366678   PMID:29393339   PMID:29421335   PMID:29435463  
PMID:29439156   PMID:29447697   PMID:29459437   PMID:29475132   PMID:29475133   PMID:29477360   PMID:29490278   PMID:29500178   PMID:29515025   PMID:29518228   PMID:29520027   PMID:29531021  
PMID:29545090   PMID:29547450   PMID:29549176   PMID:29551594   PMID:29576451   PMID:29588315   PMID:29601102   PMID:29610142   PMID:29654318   PMID:29674674   PMID:29681442   PMID:29694887  
PMID:29723525   PMID:29735414   PMID:29737568   PMID:29752038   PMID:29767259   PMID:29774028   PMID:29775613   PMID:29786072   PMID:29789522   PMID:29853850   PMID:29863495   PMID:29884801  
PMID:29886157   PMID:29907661   PMID:29937272   PMID:29937375   PMID:29953588   PMID:29954866   PMID:29958799   PMID:29966531   PMID:29981343   PMID:30016155   PMID:30021146   PMID:30030504  
PMID:30046112   PMID:30051350   PMID:30051912   PMID:30054450   PMID:30060081   PMID:30069026   PMID:30080445   PMID:30098377   PMID:30105037   PMID:30107806   PMID:30126430   PMID:30133699  
PMID:30146006   PMID:30152849   PMID:30157429   PMID:30159587   PMID:30180270   PMID:30185517   PMID:30201970   PMID:30208322   PMID:30209191   PMID:30216227   PMID:30232264   PMID:30258045  
PMID:30260469   PMID:30276509   PMID:30280383   PMID:30315247   PMID:30315268   PMID:30354239   PMID:30371306   PMID:30373775   PMID:30382081   PMID:30387131   PMID:30387132   PMID:30388107  
PMID:30389578   PMID:30392787   PMID:30392956   PMID:30394308   PMID:30396035   PMID:30413620   PMID:30417081   PMID:30425063   PMID:30451870   PMID:30455347   PMID:30466433   PMID:30483252  
PMID:30485804   PMID:30485805   PMID:30487600   PMID:30510167   PMID:30518920   PMID:30522866   PMID:30523277   PMID:30523572   PMID:30531979   PMID:30587058   PMID:30590393   PMID:30593918  
PMID:30596885   PMID:30606476   PMID:30612879   PMID:30622184   PMID:30622955   PMID:30625325   PMID:30633869   PMID:30635040   PMID:30653583   PMID:30662948   PMID:30673616   PMID:30696442  
PMID:30700851   PMID:30704457   PMID:30745418   PMID:30747211   PMID:30747229   PMID:30748031   PMID:30794604   PMID:30853521   PMID:30858427   PMID:30869997   PMID:30909283   PMID:30919410  
PMID:30952009   PMID:30955811   PMID:30971286   PMID:30971430   PMID:30982580   PMID:30982734   PMID:30997938   PMID:31013297   PMID:31036561   PMID:31055218   PMID:31063608   PMID:31071239  
PMID:31084401   PMID:31085177   PMID:31087643   PMID:31089880   PMID:31109954   PMID:31110285   PMID:31118442   PMID:31170267   PMID:31174271   PMID:31185753   PMID:31211803   PMID:31229841  
PMID:31270454   PMID:31278375   PMID:31316105   PMID:31332247   PMID:31333677   PMID:31336248   PMID:31367214   PMID:31379826   PMID:31385664   PMID:31387986   PMID:31407595   PMID:31411068  
PMID:31411729   PMID:31412958   PMID:31420376   PMID:31445901   PMID:31453709   PMID:31474993   PMID:31485604   PMID:31485755   PMID:31507096   PMID:31511697   PMID:31558756   PMID:31563023  
PMID:31586037   PMID:31596526   PMID:31597697   PMID:31625260   PMID:31632284   PMID:31647995   PMID:31694740   PMID:31700106   PMID:31703838   PMID:31719149   PMID:31735593   PMID:31740004  
PMID:31748742   PMID:31787240   PMID:31787755   PMID:31796125   PMID:31817997   PMID:31843468   PMID:31846625   PMID:31857693   PMID:31860763   PMID:31865729   PMID:31866999   PMID:31869420  
PMID:31895698   PMID:31912235   PMID:31914698   PMID:31935195   PMID:31953217   PMID:31989218   PMID:31996485   PMID:31999304   PMID:31999974   PMID:32041990   PMID:32070376   PMID:32087352  
PMID:32088213   PMID:32107769   PMID:32108663   PMID:32187211   PMID:32193329   PMID:32199914   PMID:32205422   PMID:32210476   PMID:32226647   PMID:32234476   PMID:32244067   PMID:32244997  
PMID:32246016   PMID:32273022   PMID:32290861   PMID:32298652   PMID:32321638   PMID:32350570   PMID:32353421   PMID:32367047   PMID:32385413   PMID:32417375   PMID:32454054   PMID:32499379  
PMID:32707273   PMID:32758727   PMID:32760056   PMID:32763970   PMID:32791101   PMID:32943500   PMID:32971400   PMID:32976511   PMID:33002446   PMID:33135636   PMID:33247121   PMID:33254688  


Genomics

Comparative Map Data
Nlrp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,432,395 - 59,457,781 (+)NCBIGRCm39mm39
GRCm381159,541,569 - 59,566,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,541,568 - 59,566,956 (+)EnsemblGRCm38mm10GRCm38
MGSCv371159,356,188 - 59,380,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv361160,078,786 - 60,103,056 (+)NCBImm8
MGSCv361159,358,881 - 59,383,151 (+)NCBImm8
Cytogenetic Map11B1.3NCBI
NLRP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1247,416,156 - 247,449,108 (+)EnsemblGRCh38hg38GRCh38
GRCh381247,416,163 - 247,448,823 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371247,579,247 - 247,612,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,646,098 - 245,679,033 (+)NCBINCBI36hg18NCBI36
Build 341243,907,391 - 243,938,445NCBI
Celera1220,878,780 - 220,911,159 (+)NCBI
Cytogenetic Map1q44NCBI
HuRef1217,973,841 - 218,006,798 (+)NCBIHuRef
CHM1_11248,851,104 - 248,884,745 (+)NCBICHM1_1
Nlrp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01045,884,324 - 45,918,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,893,018 - 45,918,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,648,191 - 45,674,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,850,224 - 45,874,533 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11045,864,282 - 45,887,837 (+)NCBI
Celera1043,590,413 - 43,614,602 (+)NCBICelera
Cytogenetic Map10q22NCBI
Nlrp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581597,667 - 617,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955581597,952 - 616,903 (+)NCBIChiLan1.0ChiLan1.0
NLRP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11228,505,147 - 228,537,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1228,505,147 - 228,537,216 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01223,052,307 - 223,084,736 (+)NCBIMhudiblu_PPA_v0panPan3
NLRP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl8253,407 - 313,059 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.18251,776 - 313,290 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nlrp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936864709,693 - 732,119 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl256,892,242 - 56,977,234 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1256,892,241 - 56,977,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2257,789,084 - 57,873,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NLRP3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12584,431,436 - 84,463,387 (+)NCBI
ChlSab1.1 Ensembl2584,434,527 - 84,463,249 (+)Ensembl
Nlrp3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937564,191 - 584,470 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111180000066100000Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11890000061500000Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5417484463428696Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113111738265117382Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115419011565213015Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112827504662275149Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112867832062678320Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11330000060800000Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115417484467187585Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112881775462817873Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112588179959881914Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113220975066209867Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113787775360511890Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:733
Count of miRNA genes:359
Interacting mature miRNAs:399
Transcripts:ENSMUST00000079476, ENSMUST00000101148, ENSMUST00000149126
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001359638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_153314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF486632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW121591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY337285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY355340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY495376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY495377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY186774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY722759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF032621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000079476   ⟹   ENSMUSP00000078440
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1159,541,568 - 59,566,955 (+)Ensembl
RefSeq Acc Id: ENSMUST00000101148   ⟹   ENSMUSP00000098707
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1159,542,686 - 59,566,956 (+)Ensembl
RefSeq Acc Id: ENSMUST00000149126   ⟹   ENSMUSP00000114231
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1159,542,756 - 59,548,118 (+)Ensembl
RefSeq Acc Id: NM_001359638   ⟹   NP_001346567
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,432,395 - 59,457,781 (+)NCBI
GRCm381159,541,569 - 59,566,955 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145827   ⟹   NP_665826
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,512 - 59,457,781 (+)NCBI
GRCm381159,542,686 - 59,566,955 (+)NCBI
MGSCv371159,356,188 - 59,380,458 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_153314
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,512 - 59,457,781 (+)NCBI
GRCm381159,542,686 - 59,566,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532858   ⟹   XP_006532921
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,510 - 59,457,781 (+)NCBI
GRCm381159,542,685 - 59,566,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156548   ⟹   XP_036012441
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,432,915 - 59,457,781 (+)NCBI
RefSeq Acc Id: XM_036156549   ⟹   XP_036012442
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,549 - 59,457,781 (+)NCBI
RefSeq Acc Id: XR_004936916
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,549 - 59,455,954 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_665826   ⟸   NM_145827
- UniProtKB: Q8R4B8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532921   ⟸   XM_006532858
- Peptide Label: isoform X1
- UniProtKB: Q8R4B8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001346567   ⟸   NM_001359638
RefSeq Acc Id: ENSMUSP00000078440   ⟸   ENSMUST00000079476
RefSeq Acc Id: ENSMUSP00000114231   ⟸   ENSMUST00000149126
RefSeq Acc Id: ENSMUSP00000098707   ⟸   ENSMUST00000101148
RefSeq Acc Id: XP_036012441   ⟸   XM_036156548
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036012442   ⟸   XM_036156549
- Peptide Label: isoform X2
Protein Domains
NACHT   Pyrin

Promoters
RGD ID:6821436
Promoter ID:MM_KWN:7647
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC007JEH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361159,354,244 - 59,354,744 (+)MPROMDB
RGD ID:6821438
Promoter ID:MM_KWN:7648
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000101147,   ENSMUST00000108758,   NM_145827,   OTTMUST00000012841
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361159,355,449 - 59,355,949 (+)MPROMDB
RGD ID:8674822
Promoter ID:EPDNEW_M15442
Type:multiple initiation site
Name:Nlrp3_1
Description:Mus musculus NLR family, pyrin domain containing 3 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15443  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,541,585 - 59,541,645EPDNEW
RGD ID:8674824
Promoter ID:EPDNEW_M15443
Type:initiation region
Name:Nlrp3_2
Description:Mus musculus NLR family, pyrin domain containing 3 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15442  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,542,720 - 59,542,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2653833 AgrOrtholog
Ensembl Genes ENSMUSG00000032691 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000078440 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000098707 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114231 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079476 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000101148 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000149126 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro DAPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  NACHT-assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/Swiss-Prot
  NLRC_HD2 UniProtKB/Swiss-Prot
  NOD2_WH UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:216799 UniProtKB/Swiss-Prot
MGD MGI:2653833 ENTREZGENE
NCBI Gene 216799 ENTREZGENE
Pfam FISNA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_6 UniProtKB/Swiss-Prot
  NACHT UniProtKB/Swiss-Prot
  NLRC4_HD2 UniProtKB/Swiss-Prot
  NOD2_WH UniProtKB/Swiss-Prot
  PYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nlrp3 PhenoGen
PROSITE DAPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot
  NACHT UniProtKB/Swiss-Prot
SMART FISNA UniProtKB/Swiss-Prot
  PYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot
UniProt NLRP3_MOUSE UniProtKB/Swiss-Prot
  Q5SXI6_MOUSE UniProtKB/TrEMBL
  Q8R4B8 ENTREZGENE
UniProt Secondary Q1JQ87 UniProtKB/Swiss-Prot
  Q1JQ88 UniProtKB/Swiss-Prot
  Q6JEL0 UniProtKB/Swiss-Prot
  T1W2H6 UniProtKB/Swiss-Prot