Nlrp3 (NLR family, pyrin domain containing 3) - Rat Genome Database

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Gene: Nlrp3 (NLR family, pyrin domain containing 3) Mus musculus
Analyze
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
RGD ID: 1318015
MGI Page MGI
Description: Enables several functions, including ATP hydrolysis activity; phosphatidylinositol-4-phosphate binding activity; and signaling adaptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and response to bacterium. Acts upstream of or within acute inflammatory response; defense response to virus; and regulation of inflammatory response. Located in interphase microtubule organizing center; mitochondrion; and nucleus. Part of NLRP3 inflammasome complex. Is active in membrane. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AGTAVPRL; AII/AVP; Ci; Cias1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein homolog; cry; cryopyrin; FCAS; FCU; mast cell maturation inducible protein 1; mast cell maturation-associated-inducible protein 1; MGC129375; Mmig; Mmig1; MWS; N; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NALP3; Pyp; Pypaf1; PYRIN-containing APAF1-like protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,432,395 - 59,457,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,432,394 - 59,457,782 (+)EnsemblGRCm39 Ensembl
GRCm381159,541,569 - 59,566,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,541,568 - 59,566,956 (+)EnsemblGRCm38mm10GRCm38
MGSCv371159,356,188 - 59,380,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,078,786 - 60,103,056 (+)NCBIMGSCv36mm8
MGSCv361159,358,881 - 59,383,151 (+)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1137.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(-)-acanthoic acid  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (EXP,ISO)
(R)-carnitine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
3-mercaptopropanoic acid  (EXP)
3-methyladenine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxybenzoic acid  (EXP)
4-hydroxynon-2-enal  (EXP)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
4-phenylbutyric acid  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (EXP)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
allicin  (EXP)
allopurinol  (EXP,ISO)
allyl methyl disulfide  (EXP)
aluminium hydroxide  (EXP)
aluminium sulfate (anhydrous)  (EXP)
amitriptyline  (EXP)
amphetamine  (ISO)
amphibole asbestos  (ISO)
andrographolide  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asbestos  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
atropine  (ISO)
aucubin  (EXP,ISO)
aurantio-obtusin  (EXP)
azathioprine  (EXP)
bafilomycin A1  (ISO)
baicalein  (EXP)
baicalin  (EXP)
BAPTA  (EXP)
Bavachinin  (EXP)
bellidifolin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bosutinib  (EXP)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium telluride  (EXP)
cannabidiol  (EXP,ISO)
CARBENOXOLONE  (EXP)
carvacrol  (ISO)
CCCP  (EXP,ISO)
celastrol  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chitosan  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
chlorquinaldol  (EXP)
cholesterol  (EXP,ISO)
choline  (EXP)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP,ISO)
corilagin  (EXP)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cytochalasin D  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
dapagliflozin  (ISO)
deoxynivalenol  (EXP)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicloxacillin  (EXP)
diethyldithiocarbamic acid  (EXP)
dihydroartemisinin  (ISO)
dimethyl fumarate  (ISO)
dimethyldithiocarbamate  (EXP)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (EXP)
donepezil hydrochloride  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (EXP)
empagliflozin  (ISO)
endosulfan  (ISO)
ergosterol  (ISO)
eriodictyol  (EXP)
Erionite  (ISO)
eritoran  (EXP)
ethanol  (EXP,ISO)
Evodiamine  (ISO)
fenofibrate  (EXP)
fenpropathrin  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (ISO)
formaldehyde  (ISO)
formononetin  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (EXP,ISO)
furosemide  (ISO)
Fusaric acid  (ISO)
galangin  (ISO)
Genipin  (EXP)
genkwanin  (ISO)
gentamycin  (ISO)
ginsenoside Rb1  (EXP,ISO)
glucose  (EXP,ISO)
glyburide  (EXP,ISO)
glycerol  (ISO)
glycidol  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
graphene oxide  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP)
hexadecanoic acid  (EXP,ISO)
HU-308  (EXP)
hyaluronic acid  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxysafflor yellow A  (EXP)
hypoxanthine  (EXP)
ibuprofen  (EXP)
icariin  (ISO)
indometacin  (EXP,ISO)
iohexol  (EXP,ISO)
iron dextran  (ISO)
isoflurane  (EXP)
JTE-013  (ISO)
Jujuboside A  (EXP)
ketoconazole  (EXP,ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
letrozole  (ISO)
levocabastine  (EXP)
Liensinine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium carbonate  (EXP)
lithocholic acid  (EXP)
loganin  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (EXP)
lysophosphatidylcholine  (ISO)
magnesium dihydroxide  (EXP)
malvidin  (EXP,ISO)
maneb  (EXP)
mangiferin  (ISO)
mebendazole  (ISO)
melatonin  (EXP,ISO)
memantine  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
mesalamine  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
microcystin-LR  (EXP)
minocycline  (EXP)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
morphine  (EXP)
Morroniside  (EXP)
myrtenol  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N-dimethylformamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
Neoisoliquiritin  (EXP,ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotine  (ISO)
nigericin  (EXP,ISO)
NMN zwitterion  (EXP,ISO)
Nonylphenol  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
omeprazole  (ISO)
Ondansetron  (ISO)
ozone  (EXP,ISO)
paeoniflorin  (EXP,ISO)
Palbinone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
patulin  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorodecanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
ponatinib  (EXP)
Potassium 2,6-dihydroxytriazinecarboxylate  (EXP)
PRIM-O-GLUCOSYLCIMIFUGIN  (EXP)
procyanidin B2  (ISO)
propanal  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
Rhein  (EXP)
rifampicin  (EXP)
rimonabant  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
rutin  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salidroside  (EXP,ISO)
Salinomycin  (EXP)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
scutellarin  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sinapic acid  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP)
tabersonine  (EXP)
tamoxifen  (ISO)
taurine  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloromethane  (EXP)
tetramethylpyrazine  (EXP)
thapsigargin  (ISO)
thiamine(1+) chloride  (ISO)
thioacetamide  (EXP,ISO)
thiram  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (EXP)
toyocamycin  (EXP)
trichloroethene  (EXP)
triclosan  (EXP,ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
ubiquinone-0  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)
water  (EXP)
XL147  (EXP)
zearalenone  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (IDA)
cellular response to lipopolysaccharide  (IDA,IEA,ISO)
cellular response to peptidoglycan  (IMP)
cellular response to virus  (ISO)
defense response to Gram-positive bacterium  (IMP)
defense response to virus  (IMP)
detection of biotic stimulus  (IDA,IEA,ISO)
immune system process  (IEA)
inflammatory response  (IDA,IEA,ISO,ISS)
innate immune response  (IEA)
interleukin-1-mediated signaling pathway  (ISO)
interleukin-18-mediated signaling pathway  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of non-canonical NF-kappaB signal transduction  (IBA,ISO,ISS)
NLRP3 inflammasome complex assembly  (IDA,IEA,IMP,ISO)
osmosensory signaling pathway  (NAS)
pattern recognition receptor signaling pathway  (NAS)
positive regulation of cytokine production involved in immune response  (IMP)
positive regulation of inflammatory response  (IDA,IEA,ISO,NAS)
positive regulation of interleukin-1 beta production  (IDA,IEA,IGI,IMP,ISO,ISS)
positive regulation of interleukin-13 production  (IMP)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-4 production  (IDA)
positive regulation of interleukin-5 production  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of T-helper 17 cell differentiation  (IMP)
positive regulation of T-helper 2 cell cytokine production  (IMP)
positive regulation of T-helper 2 cell differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of type 2 immune response  (IMP)
protein homooligomerization  (IDA,IEA,ISO)
protein maturation  (ISO)
protein secretion  (ISO)
pyroptotic inflammatory response  (ISO,NAS)
regulation of DNA-templated transcription  (IEA)
regulation of inflammatory response  (IBA,IMP)
response to ethanol  (IEA,ISO)
response to virus  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal CD4-positive, alpha-beta T cell number  (IAGP)
abnormal chondrocyte physiology  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell antigen presentation  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal gut flora balance  (IAGP)
abnormal interleukin-1 beta secretion  (IEA)
abnormal intestine morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lipid metabolism  (IAGP)
abnormal liver morphology  (IAGP)
abnormal long bone epiphysis morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal macrophage cytokine production  (IEA)
abnormal macrophage physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal response to infection  (IAGP)
abnormal skeleton development  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
absent B cells  (IAGP)
absent T cells  (IAGP)
anemia  (IAGP)
chronic inflammation  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone trabecula number  (IAGP)
decreased cell proliferation  (IAGP)
decreased chondrocyte number  (IAGP)
decreased circulating interleukin-1 beta level  (IAGP)
decreased circulating interleukin-12b level  (IAGP)
decreased circulating interleukin-18 level  (IAGP)
decreased circulating interleukin-5 level  (IAGP)
decreased compact bone area  (IAGP)
decreased compact bone thickness  (IAGP)
decreased energy expenditure  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased femur size  (IAGP)
decreased inflammatory response  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased lactate dehydrogenase level  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to induced colitis  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased trabecular bone mass  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
dermatitis  (IAGP)
disorganized long bone epiphyseal plate  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
hairless  (IAGP)
hepatic steatosis  (IAGP)
increased activated T cell number  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased body fat mass  (IAGP)
increased bone resorption  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-13 level  (IAGP)
increased circulating interleukin-18 level  (IAGP)
increased circulating interleukin-3 level  (IAGP)
increased circulating interleukin-4 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating interleukin-9 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased granulocyte number  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-18 secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased lymphocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to type IV hypersensitivity reaction  (IAGP)
increased T-helper 1 cell number  (IAGP)
joint inflammation  (IAGP)
meningitis  (IAGP)
no abnormal phenotype detected  (IAGP)
osteomyelitis  (IAGP)
oxidative stress  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
reddish skin  (IAGP)
reduced fertility  (IAGP)
scaly skin  (IAGP)
skin inflammation  (IAGP)
slow postnatal weight gain  (IAGP)
thrombocytosis  (IAGP)
white adipose tissue inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation. Chang YS, etal., Int J Mol Sci. 2020 Apr 30;21(9). pii: ijms21093179. doi: 10.3390/ijms21093179.
2. Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury. Choudhury A, etal., Alcohol Clin Exp Res. 2020 Jun;44(6):1300-1311. doi: 10.1111/acer.14338. Epub 2020 May 18.
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PMID:30485804   PMID:30485805   PMID:30487600   PMID:30510167   PMID:30518920   PMID:30522866   PMID:30523277   PMID:30523572   PMID:30531979   PMID:30587058   PMID:30590393   PMID:30593918  
PMID:30596885   PMID:30606476   PMID:30612879   PMID:30622184   PMID:30622955   PMID:30625325   PMID:30633869   PMID:30635040   PMID:30653583   PMID:30662948   PMID:30673616   PMID:30689886  
PMID:30696442   PMID:30700851   PMID:30704457   PMID:30742078   PMID:30745418   PMID:30747211   PMID:30747229   PMID:30748031   PMID:30787184   PMID:30794604   PMID:30853521   PMID:30858427  
PMID:30869997   PMID:30909283   PMID:30919410   PMID:30937919   PMID:30952009   PMID:30955811   PMID:30962463   PMID:30966861   PMID:30971286   PMID:30971430   PMID:30982580   PMID:30982734  
PMID:30997938   PMID:31013297   PMID:31029578   PMID:31036561   PMID:31055218   PMID:31063608   PMID:31071239   PMID:31084401   PMID:31085177   PMID:31087643   PMID:31089880   PMID:31109954  
PMID:31110285   PMID:31118442   PMID:31141808   PMID:31169521   PMID:31170267   PMID:31174271   PMID:31185753   PMID:31211803   PMID:31229841   PMID:31270454   PMID:31276670   PMID:31278375  
PMID:31316105   PMID:31320730   PMID:31332247   PMID:31333677   PMID:31336248   PMID:31367214   PMID:31379813   PMID:31379826   PMID:31385664   PMID:31387986   PMID:31407595   PMID:31411068  
PMID:31411729   PMID:31412958   PMID:31420376   PMID:31439870   PMID:31445901   PMID:31453709   PMID:31474993   PMID:31485604   PMID:31485755   PMID:31507096   PMID:31511697   PMID:31558756  
PMID:31563023   PMID:31586037   PMID:31596526   PMID:31597697   PMID:31622786   PMID:31625260   PMID:31632284   PMID:31647995   PMID:31673056   PMID:31676250   PMID:31694740   PMID:31700106  
PMID:31703838   PMID:31719149   PMID:31723262   PMID:31735593   PMID:31740004   PMID:31741224   PMID:31748742   PMID:31754185   PMID:31768838   PMID:31787240   PMID:31787755   PMID:31796125  
PMID:31817997   PMID:31836541   PMID:31840571   PMID:31843468   PMID:31846625   PMID:31857693   PMID:31860763   PMID:31865729   PMID:31866999   PMID:31869420   PMID:31882076   PMID:31895698  
PMID:31912235   PMID:31914698   PMID:31918161   PMID:31935195   PMID:31939051   PMID:31949113   PMID:31953217   PMID:31982429   PMID:31989218   PMID:31992567   PMID:31996485   PMID:31999304  
PMID:31999974   PMID:32003282   PMID:32032542   PMID:32032696   PMID:32041990   PMID:32070376   PMID:32087352   PMID:32088213   PMID:32107769   PMID:32108663   PMID:32115713   PMID:32150150  
PMID:32171704   PMID:32181339   PMID:32187211   PMID:32188057   PMID:32193329   PMID:32199914   PMID:32205422   PMID:32205880   PMID:32210476   PMID:32226647   PMID:32234476   PMID:32239396  
PMID:32239449   PMID:32244067   PMID:32244997   PMID:32246016   PMID:32268091   PMID:32273022   PMID:32273259   PMID:32283822   PMID:32290861   PMID:32291445   PMID:32298652   PMID:32308747  
PMID:32311777   PMID:32321638   PMID:32325423   PMID:32335773   PMID:32342103   PMID:32350463   PMID:32350570   PMID:32353421   PMID:32367047   PMID:32385413   PMID:32400277   PMID:32402278  
PMID:32402947   PMID:32415059   PMID:32417375   PMID:32421904   PMID:32432571   PMID:32445196   PMID:32452554   PMID:32454054   PMID:32475381   PMID:32477361   PMID:32488871   PMID:32499379  
PMID:32510137   PMID:32529941   PMID:32564937   PMID:32571988   PMID:32573820   PMID:32595041   PMID:32607760   PMID:32607763   PMID:32608058   PMID:32622527   PMID:32630144   PMID:32635937  
PMID:32641981   PMID:32646056   PMID:32648626   PMID:32656558   PMID:32660670   PMID:32661868   PMID:32666684   PMID:32667092   PMID:32680528   PMID:32700178   PMID:32703402   PMID:32703418  
PMID:32707273   PMID:32716024   PMID:32722183   PMID:32726464   PMID:32726802   PMID:32727891   PMID:32748971   PMID:32750036   PMID:32758418   PMID:32758727   PMID:32760056   PMID:32762493  
PMID:32763970   PMID:32782151   PMID:32788872   PMID:32791101   PMID:32819611   PMID:32894580   PMID:32908485   PMID:32918847   PMID:32929041   PMID:32929357   PMID:32943500   PMID:32947010  
PMID:32954500   PMID:32968928   PMID:32971400   PMID:32976511   PMID:32977490   PMID:32989095   PMID:33002446   PMID:33006110   PMID:33010000   PMID:33017381   PMID:33027646   PMID:33041005  
PMID:33051464   PMID:33087357   PMID:33093455   PMID:33097533   PMID:33097834   PMID:33104527   PMID:33124745   PMID:33128438   PMID:33135636   PMID:33158955   PMID:33161108   PMID:33161415  
PMID:33166810   PMID:33202149   PMID:33202644   PMID:33202867   PMID:33207188   PMID:33216713   PMID:33232925   PMID:33236134   PMID:33243234   PMID:33247121   PMID:33254688   PMID:33268842  
PMID:33268895   PMID:33273482   PMID:33295913   PMID:33296289   PMID:33305736   PMID:33307174   PMID:33308101   PMID:33308446   PMID:33309808   PMID:33327751   PMID:33345685   PMID:33358726  
PMID:33382502   PMID:33387462   PMID:33388881   PMID:33390812   PMID:33391484   PMID:33397971   PMID:33398185   PMID:33402173   PMID:33409553   PMID:33416127   PMID:33416142   PMID:33432150  
PMID:33440153   PMID:33440601   PMID:33446652   PMID:33457411   PMID:33460751   PMID:33462188   PMID:33477467   PMID:33490276   PMID:33505459   PMID:33515677   PMID:33520088   PMID:33523143  
PMID:33523841   PMID:33526807   PMID:33549095   PMID:33549727   PMID:33567275   PMID:33576456   PMID:33596932   PMID:33597269   PMID:33621212   PMID:33623143   PMID:33628368   PMID:33628380  
PMID:33644037   PMID:33649199   PMID:33656514   PMID:33667712   PMID:33675822   PMID:33676236   PMID:33717109   PMID:33717117   PMID:33717152   PMID:33727530   PMID:33731931   PMID:33741346  
PMID:33758356   PMID:33770895   PMID:33783473   PMID:33783986   PMID:33792531   PMID:33798196   PMID:33802349   PMID:33812228   PMID:33815373   PMID:33830232   PMID:33853366   PMID:33860063  
PMID:33860064   PMID:33866944   PMID:33871879   PMID:33875790   PMID:33876420   PMID:33877580   PMID:33923693   PMID:33931568   PMID:33932961   PMID:33939881   PMID:33939927   PMID:33963043  
PMID:33963060   PMID:33963333   PMID:33976225   PMID:33976226   PMID:33992596   PMID:34000757   PMID:34003774   PMID:34003868   PMID:34006824   PMID:34013370   PMID:34017331   PMID:34029695  
PMID:34052361   PMID:34052623   PMID:34055976   PMID:34082381   PMID:34092247   PMID:34093535   PMID:34102208   PMID:34112286   PMID:34122445   PMID:34144035   PMID:34162771   PMID:34166779  
PMID:34188052   PMID:34193605   PMID:34211462   PMID:34224819   PMID:34229722   PMID:34231604   PMID:34237408   PMID:34278447   PMID:34278465   PMID:34279193   PMID:34284798   PMID:34315884  
PMID:34333111   PMID:34341353   PMID:34348577   PMID:34359830   PMID:34373456   PMID:34383985   PMID:34399601   PMID:34413860   PMID:34419568   PMID:34433035   PMID:34433049   PMID:34440688  
PMID:34453120   PMID:34471287   PMID:34472725   PMID:34473956   PMID:34477811   PMID:34486483   PMID:34512673   PMID:34513725   PMID:34517723   PMID:34518217   PMID:34523690   PMID:34524457  
PMID:34526512   PMID:34530693   PMID:34534636   PMID:34551300   PMID:34554188   PMID:34561424   PMID:34565303   PMID:34571975   PMID:34576036   PMID:34589402   PMID:34612661   PMID:34615873  
PMID:34626587   PMID:34628369   PMID:34630429   PMID:34651582   PMID:34659244   PMID:34659265   PMID:34666797   PMID:34671981   PMID:34676876   PMID:34678046   PMID:34685598   PMID:34686350  
PMID:34687223   PMID:34698806   PMID:34704457   PMID:34706239   PMID:34715018   PMID:34726071   PMID:34740613   PMID:34745110   PMID:34755743   PMID:34766179   PMID:34769018   PMID:34773253  
PMID:34773639   PMID:34797502   PMID:34801085   PMID:34801938   PMID:34830316   PMID:34830364   PMID:34860583   PMID:34861190   PMID:34864055   PMID:34869071   PMID:34869331   PMID:34890841  
PMID:34907600   PMID:34912336   PMID:34918381   PMID:34929351   PMID:34930303   PMID:34930895   PMID:34931753   PMID:34943932   PMID:34943988   PMID:34952919   PMID:34955683   PMID:34974110  
PMID:34979342   PMID:34987507   PMID:34996874   PMID:34998855   PMID:35002527   PMID:35008765   PMID:35013905   PMID:35025664   PMID:35081502   PMID:35085893   PMID:35098371   PMID:35110683  
PMID:35139355   PMID:35145063   PMID:35148667   PMID:35154163   PMID:35174546   PMID:35199642   PMID:35219871   PMID:35224772   PMID:35228630   PMID:35247698   PMID:35256512   PMID:35279596  
PMID:35281020   PMID:35299058   PMID:35332327   PMID:35355995   PMID:35371052   PMID:35404106   PMID:35432726   PMID:35451177   PMID:35464766   PMID:35489388   PMID:35504893   PMID:35512472  
PMID:35551047   PMID:35618036   PMID:35622000   PMID:35649302   PMID:35654037   PMID:35687753   PMID:35714308   PMID:35714422   PMID:35733245   PMID:35743288   PMID:35779608   PMID:35780081  
PMID:35787975   PMID:35798413   PMID:35820936   PMID:35833522   PMID:35838447   PMID:35866513   PMID:35868482   PMID:35870427   PMID:35883151   PMID:35893807   PMID:35901931   PMID:35906252  
PMID:35958024   PMID:35968506   PMID:35985421   PMID:35993019   PMID:35993366   PMID:36017373   PMID:36032139   PMID:36045672   PMID:36059543   PMID:36063115   PMID:36066157   PMID:36129987  
PMID:36135959   PMID:36155655   PMID:36163404   PMID:36177744   PMID:36178239   PMID:36181338   PMID:36183679   PMID:36194522   PMID:36194627   PMID:36199191   PMID:36208489   PMID:36238284  
PMID:36288697   PMID:36308466   PMID:36403854   PMID:36405726   PMID:36427810   PMID:36440584   PMID:36446229   PMID:36450446   PMID:36461592   PMID:36481355   PMID:36494392   PMID:36502520  
PMID:36505450   PMID:36515571   PMID:36529965   PMID:36537208   PMID:36539796   PMID:36563905   PMID:36566348   PMID:36586012   PMID:36586411   PMID:36593964   PMID:36600050   PMID:36600053  
PMID:36602874   PMID:36608372   PMID:36631013   PMID:36641116   PMID:36670473   PMID:36694200   PMID:36708143   PMID:36719079   PMID:36746963   PMID:36749596   PMID:36758176   PMID:36758943  
PMID:36765034   PMID:36778007   PMID:36778113   PMID:36800288   PMID:36828815   PMID:36866548   PMID:36876522   PMID:36932155   PMID:36939354   PMID:36965549   PMID:36989949   PMID:36999514  
PMID:37018971   PMID:37023458   PMID:37029500   PMID:37072933   PMID:37077909   PMID:37118341   PMID:37148425   PMID:37155697   PMID:37158595   PMID:37172930   PMID:37196062   PMID:37204068  
PMID:37209992   PMID:37256266   PMID:37256935   PMID:37257668   PMID:37268099   PMID:37269079   PMID:37271284   PMID:37292200   PMID:37335321   PMID:37336688   PMID:37337032   PMID:37357357  
PMID:37359091   PMID:37364329   PMID:37385228   PMID:37389784   PMID:37487005   PMID:37511208   PMID:37528567   PMID:37534578   PMID:37573690   PMID:37575012   PMID:37603754   PMID:37622117  
PMID:37651190   PMID:37652008   PMID:37676465   PMID:37698938   PMID:37710276   PMID:37710420   PMID:37730693   PMID:37744356   PMID:37781816   PMID:37790275   PMID:37815748   PMID:37824732  
PMID:37879955   PMID:37890377   PMID:37913775   PMID:37948033   PMID:37951199   PMID:37988162   PMID:37989934   PMID:38000038   PMID:38003466   PMID:38037161   PMID:38047519   PMID:38053332  
PMID:38068904   PMID:38069134   PMID:38091080   PMID:38092000   PMID:38092312   PMID:38110429   PMID:38118343   PMID:38124741   PMID:38134241   PMID:38135154   PMID:38146057   PMID:38154620  
PMID:38172511   PMID:38180747   PMID:38218935   PMID:38238499   PMID:38252657   PMID:38291200   PMID:38297162   PMID:38308301   PMID:38315735   PMID:38326859   PMID:38330794   PMID:38341852  
PMID:38352874   PMID:38357791   PMID:38373380   PMID:38409108   PMID:38419581   PMID:38421705   PMID:38427558   PMID:38441141   PMID:38447057   PMID:38458103   PMID:38493579   PMID:38497110  
PMID:38497930   PMID:38498004   PMID:38520688   PMID:38552738   PMID:38580672   PMID:38583156   PMID:38657496   PMID:38662771   PMID:38663314   PMID:38700011   PMID:38725851   PMID:38725863  
PMID:38728187   PMID:38756775   PMID:38772301   PMID:38789414   PMID:38789583   PMID:38831600   PMID:38838044   PMID:38848887   PMID:38869447   PMID:38870946   PMID:38886341   PMID:38914598  
PMID:38920626   PMID:38933263   PMID:39004863   PMID:39024103   PMID:39032077   PMID:39080660   PMID:39102928   PMID:39112714   PMID:39122224   PMID:39213434   PMID:39218978   PMID:39226826  
PMID:39242551   PMID:39252576   PMID:39289506   PMID:39340778   PMID:39390397   PMID:39404121   PMID:39407211   PMID:39519191   PMID:39571574   PMID:39571575   PMID:39642242   PMID:39742811  
PMID:39837661   PMID:39982821   PMID:40100932  


Genomics

Comparative Map Data
Nlrp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,432,395 - 59,457,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,432,394 - 59,457,782 (+)EnsemblGRCm39 Ensembl
GRCm381159,541,569 - 59,566,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,541,568 - 59,566,956 (+)EnsemblGRCm38mm10GRCm38
MGSCv371159,356,188 - 59,380,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,078,786 - 60,103,056 (+)NCBIMGSCv36mm8
MGSCv361159,358,881 - 59,383,151 (+)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1137.73NCBI
NLRP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381247,416,077 - 247,448,817 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1247,332,331 - 247,449,108 (+)EnsemblGRCh38hg38GRCh38
GRCh371247,579,475 - 247,612,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,646,098 - 245,679,033 (+)NCBINCBI36Build 36hg18NCBI36
Build 341243,907,391 - 243,938,445NCBI
Celera1220,878,780 - 220,911,159 (+)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1217,973,841 - 218,006,798 (+)NCBIHuRef
CHM1_11248,851,104 - 248,884,745 (+)NCBICHM1_1
T2T-CHM13v2.01246,852,567 - 246,885,459 (+)NCBIT2T-CHM13v2.0
Nlrp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,826,299 - 44,853,373 (+)NCBIGRCr8
GRCr8 Ensembl1044,828,014 - 44,853,394 (+)EnsemblGRCr8 Ensembl
mRatBN7.21044,326,770 - 44,353,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,328,566 - 44,352,811 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,023,259 - 49,047,629 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,513,616 - 48,537,987 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,017,231 - 44,041,597 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,884,324 - 45,918,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,893,018 - 45,918,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,648,191 - 45,674,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,850,224 - 45,874,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1043,590,413 - 43,614,602 (+)NCBICelera
RGSC_v3.11045,864,282 - 45,887,837 (+)NCBI
Cytogenetic Map10q22NCBI
Nlrp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581597,667 - 617,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955581597,952 - 616,903 (+)NCBIChiLan1.0ChiLan1.0
NLRP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211,607,444 - 1,639,994 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111,880,494 - 1,912,984 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01223,052,307 - 223,084,736 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11228,505,147 - 228,537,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1228,505,147 - 228,537,216 (+)Ensemblpanpan1.1panPan2
NLRP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.18251,776 - 313,290 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl8253,407 - 313,059 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha8277,639 - 339,097 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.08299,639 - 361,123 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl8301,633 - 360,913 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.18242,540 - 300,444 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.08204,531 - 262,443 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.08337,026 - 389,302 (+)NCBIUU_Cfam_GSD_1.0
Nlrp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721388,366,531 - 88,390,960 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936864709,709 - 731,718 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936864709,693 - 732,119 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl256,892,243 - 56,977,228 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1256,892,241 - 56,977,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2257,789,084 - 57,873,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NLRP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12584,431,436 - 84,463,387 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2584,434,527 - 84,463,249 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605586,817,681 - 86,848,042 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlrp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937564,191 - 584,470 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nlrp3
658 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:733
Count of miRNA genes:359
Interacting mature miRNAs:399
Transcripts:ENSMUST00000079476, ENSMUST00000101148, ENSMUST00000149126
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115925661769482699Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
13513917Heal54_mwound healing/ regeneration 54 (mouse)115787291759879610Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001359638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_153314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF486632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW121591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY337285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY355340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY495376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY495377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY186774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY722759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF032621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000079476   ⟹   ENSMUSP00000078440
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,432,394 - 59,457,781 (+)Ensembl
GRCm38.p6 Ensembl1159,541,568 - 59,566,955 (+)Ensembl
Ensembl Acc Id: ENSMUST00000101148   ⟹   ENSMUSP00000098707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,433,512 - 59,457,782 (+)Ensembl
GRCm38.p6 Ensembl1159,542,686 - 59,566,956 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149126   ⟹   ENSMUSP00000114231
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,433,582 - 59,438,944 (+)Ensembl
GRCm38.p6 Ensembl1159,542,756 - 59,548,118 (+)Ensembl
RefSeq Acc Id: NM_001359638   ⟹   NP_001346567
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,432,395 - 59,457,781 (+)NCBI
GRCm381159,541,569 - 59,566,955 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145827   ⟹   NP_665826
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,512 - 59,457,781 (+)NCBI
GRCm381159,542,686 - 59,566,955 (+)NCBI
MGSCv371159,356,188 - 59,380,458 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_153314
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,512 - 59,457,781 (+)NCBI
GRCm381159,542,686 - 59,566,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532858   ⟹   XP_006532921
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,510 - 59,457,781 (+)NCBI
GRCm381159,542,685 - 59,566,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156548   ⟹   XP_036012441
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,432,915 - 59,457,781 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156549   ⟹   XP_036012442
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,549 - 59,457,781 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004936916
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,433,549 - 59,455,954 (+)NCBI
Sequence:
RefSeq Acc Id: NP_665826   ⟸   NM_145827
- UniProtKB: Q6JEL0 (UniProtKB/Swiss-Prot),   Q1JQ88 (UniProtKB/Swiss-Prot),   Q1JQ87 (UniProtKB/Swiss-Prot),   T1W2H6 (UniProtKB/Swiss-Prot),   Q8R4B8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532921   ⟸   XM_006532858
- Peptide Label: isoform X1
- UniProtKB: Q6JEL0 (UniProtKB/Swiss-Prot),   Q1JQ88 (UniProtKB/Swiss-Prot),   Q1JQ87 (UniProtKB/Swiss-Prot),   T1W2H6 (UniProtKB/Swiss-Prot),   Q8R4B8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001346567   ⟸   NM_001359638
- UniProtKB: Q8R4B8 (UniProtKB/Swiss-Prot),   Q6JEL0 (UniProtKB/Swiss-Prot),   Q1JQ88 (UniProtKB/Swiss-Prot),   Q1JQ87 (UniProtKB/Swiss-Prot),   T1W2H6 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000078440   ⟸   ENSMUST00000079476
Ensembl Acc Id: ENSMUSP00000114231   ⟸   ENSMUST00000149126
Ensembl Acc Id: ENSMUSP00000098707   ⟸   ENSMUST00000101148
RefSeq Acc Id: XP_036012441   ⟸   XM_036156548
- Peptide Label: isoform X1
- UniProtKB: Q8R4B8 (UniProtKB/Swiss-Prot),   Q6JEL0 (UniProtKB/Swiss-Prot),   Q1JQ88 (UniProtKB/Swiss-Prot),   Q1JQ87 (UniProtKB/Swiss-Prot),   T1W2H6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_036012442   ⟸   XM_036156549
- Peptide Label: isoform X2
Protein Domains
FISNA   NACHT   Pyrin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R4B8-F1-model_v2 AlphaFold Q8R4B8 1-1033 view protein structure

Promoters
RGD ID:6821436
Promoter ID:MM_KWN:7647
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC007JEH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361159,354,244 - 59,354,744 (+)MPROMDB
RGD ID:6821438
Promoter ID:MM_KWN:7648
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000101147,   ENSMUST00000108758,   NM_145827,   OTTMUST00000012841
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361159,355,449 - 59,355,949 (+)MPROMDB
RGD ID:8674822
Promoter ID:EPDNEW_M15442
Type:multiple initiation site
Name:Nlrp3_1
Description:Mus musculus NLR family, pyrin domain containing 3 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15443  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,541,585 - 59,541,645EPDNEW
RGD ID:8674824
Promoter ID:EPDNEW_M15443
Type:initiation region
Name:Nlrp3_2
Description:Mus musculus NLR family, pyrin domain containing 3 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15442  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,542,720 - 59,542,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2653833 AgrOrtholog
Ensembl Genes ENSMUSG00000032691 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000079476 ENTREZGENE
  ENSMUST00000079476.10 UniProtKB/Swiss-Prot
  ENSMUST00000101148 ENTREZGENE
  ENSMUST00000101148.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
InterPro DAPIN UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  NACHT-assoc UniProtKB/Swiss-Prot
  NACHT_NTPase UniProtKB/Swiss-Prot
  NLRC_HD2 UniProtKB/Swiss-Prot
  NLRP_innate_immun_reg UniProtKB/Swiss-Prot
  NOD2_WH UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:216799 UniProtKB/Swiss-Prot
MGD MGI:2653833 ENTREZGENE
NCBI Gene 216799 ENTREZGENE
PANTHER NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/Swiss-Prot
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3 UniProtKB/Swiss-Prot
Pfam FISNA UniProtKB/Swiss-Prot
  LRR_6 UniProtKB/Swiss-Prot
  NACHT UniProtKB/Swiss-Prot
  NLRC4_HD2 UniProtKB/Swiss-Prot
  NOD2_WH UniProtKB/Swiss-Prot
  PYRIN UniProtKB/Swiss-Prot
PhenoGen Nlrp3 PhenoGen
PROSITE DAPIN UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
  NACHT UniProtKB/Swiss-Prot
SMART FISNA UniProtKB/Swiss-Prot
  LRR_RI UniProtKB/Swiss-Prot
  PYRIN UniProtKB/Swiss-Prot
Superfamily-SCOP RNI-like UniProtKB/Swiss-Prot
  SSF47986 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt NLRP3_MOUSE UniProtKB/Swiss-Prot
  Q1JQ87 ENTREZGENE
  Q1JQ88 ENTREZGENE
  Q5SXI6_MOUSE UniProtKB/TrEMBL
  Q6JEL0 ENTREZGENE
  Q8R4B8 ENTREZGENE
  T1W2H6 ENTREZGENE
UniProt Secondary Q1JQ87 UniProtKB/Swiss-Prot
  Q1JQ88 UniProtKB/Swiss-Prot
  Q6JEL0 UniProtKB/Swiss-Prot
  T1W2H6 UniProtKB/Swiss-Prot