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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lisuride
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Accession:CHEBI:51164 term browser browse the term
Definition:A monocarboxylic acid amide that has formula C20H26N4O.
Synonyms:exact_synonym: 1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea
 related_synonym: Formula=C20H26N4O;   InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1;   InChIKey=BKRGVLQUQGGVSM-KBXCAEBGSA-N;   N'-((8alpha)-9,10-Didehydro-6-methylergolin-8-yl)-N,N-diethylurea;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(C1=C[C@@H](CN2C)NC(=O)N(CC)CC)c34;   lisurida;   lisuridum
 xref: Beilstein:4716660;   CAS:18016-80-3;   DrugBank:DB00589;   Drug_Central:1588
 xref_mesh: MESH:D008090



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lisuride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Lisuride binds to and results in decreased activity of ADRA1A protein; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Lisuride binds to and results in decreased activity of HTR7 protein CTD PMID:18996971 PMID:19509219 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Ifng interferon gamma increases expression ISO Lisuride results in increased expression of IFNG CTD PMID:7948314 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Prl prolactin multiple interactions
decreases secretion
ISO
EXP
Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Lisuride results in decreased expression of and results in decreased secretion of PRL protein
Lisuride analog results in decreased secretion of PRL protein; Lisuride results in decreased secretion of PRL protein
CTD PMID:386688 PMID:6492995 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Lisuride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

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  CHEBI ontology 19812
    role 19763
      application 19477
        pharmaceutical 19327
          drug 19327
            antidyskinesia agent 1147
              lisuride 5
                lisuride maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        carboacyl group 17487
                                          univalent carboacyl group 17487
                                            carbamoyl group 17303
                                              carboxamide 17303
                                                monocarboxylic acid amide 15020
                                                  lisuride 5
                                                    lisuride maleate 0
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