Tfr2 (transferrin receptor 2) - Rat Genome Database

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Gene: Tfr2 (transferrin receptor 2) Mus musculus
Analyze
Symbol: Tfr2
Name: transferrin receptor 2
RGD ID: 1320888
MGI Page MGI
Description: Predicted to enable co-receptor binding activity and transferrin receptor activity. Acts upstream of or within multicellular organismal-level iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in liver lobe; mesonephros; and urinary system. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Orthologous to human TFR2 (transferrin receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Tfr; transferrin receptor protein 2; Trf; Trfr2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,568,127 - 137,586,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,568,102 - 137,585,743 (+)EnsemblGRCm39 Ensembl
GRCm385137,569,822 - 137,588,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,569,840 - 137,587,481 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,011,079 - 138,028,709 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,800,593 - 137,817,260 (+)NCBIMGSCv36mm8
Celera5134,553,519 - 134,571,033 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
CGS 15943  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
epoxiconazole  (EXP)
ferric ammonium citrate  (ISO)
flutamide  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
glafenine  (ISO)
glycidol  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP)
iron(0)  (EXP,ISO)
kenpaullone  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nitrofen  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sotorasib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
tolcapone  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)

References

References - curated
# Reference Title Reference Citation
1. A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2. Bartnikas TB, etal., Comp Med. 2013 Apr;63(2):143-55.
2. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Camaschella C, etal., Nat Genet. 2000 May;25(1):14-5.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Elevated levels of transferrin receptor 2 mRNA, not transferrin receptor 1 mRNA, are associated with increased survival in acute myeloid leukaemia. Nakamaki T, etal., Br J Haematol. 2004 Apr;125(1):42-9.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models. Weizer-Stern O, etal., Am J Hematol. 2006 Jul;81(7):479-83.
Additional References at PubMed
PMID:6641714   PMID:7567998   PMID:10349636   PMID:10681454   PMID:11042159   PMID:11076861   PMID:11239002   PMID:11535534   PMID:12134060   PMID:12477932   PMID:15124225   PMID:15192150  
PMID:15319276   PMID:15345587   PMID:15489334   PMID:15684062   PMID:15951546   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16893896   PMID:16935854   PMID:17241880   PMID:18094142  
PMID:18561026   PMID:19254567   PMID:19824072   PMID:19924283   PMID:20133002   PMID:20177050   PMID:20179178   PMID:20231891   PMID:20634490   PMID:20826723   PMID:21245482   PMID:21267068  
PMID:21408141   PMID:21873635   PMID:22244935   PMID:22383097   PMID:22460705   PMID:22858058   PMID:22960056   PMID:23333676   PMID:24155934   PMID:24658816   PMID:24703692   PMID:24880340  
PMID:25403101   PMID:25499454   PMID:26527688   PMID:26608187   PMID:26707700   PMID:26880306   PMID:27169626   PMID:27477597   PMID:28540293   PMID:30209118   PMID:32054685   PMID:32083318  
PMID:32325033   PMID:33180328   PMID:36071579   PMID:36746004   PMID:37349056   PMID:38214117   PMID:38355793  


Genomics

Comparative Map Data
Tfr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,568,127 - 137,586,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,568,102 - 137,585,743 (+)EnsemblGRCm39 Ensembl
GRCm385137,569,822 - 137,588,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,569,840 - 137,587,481 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,011,079 - 138,028,709 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,800,593 - 137,817,260 (+)NCBIMGSCv36mm8
Celera5134,553,519 - 134,571,033 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.57NCBI
TFR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,620,420 - 100,641,552 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,620,416 - 100,642,779 (-)EnsemblGRCh38hg38GRCh38
GRCh377100,218,043 - 100,239,175 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,055,975 - 100,077,109 (-)NCBINCBI36Build 36hg18NCBI36
Build 34799,862,690 - 99,883,810NCBI
Celera794,947,821 - 94,968,950 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,849,520 - 94,870,648 (-)NCBIHuRef
CHM1_17100,148,586 - 100,169,685 (-)NCBICHM1_1
T2T-CHM13v2.07101,860,501 - 101,881,634 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,577,671 - 99,598,799 (-)NCBI
Tfr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,744,450 - 24,761,413 (-)NCBIGRCr8
mRatBN7.21219,107,673 - 19,124,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,107,673 - 19,124,591 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,263,117 - 20,280,127 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,875,998 - 20,893,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01219,940,332 - 19,957,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,177,382 - 22,194,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,177,382 - 22,194,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,194,288 - 24,211,237 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,638,502 - 19,655,420 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,628,960 - 19,644,982 (+)NCBI
Celera1220,912,852 - 20,929,749 (-)NCBICelera
Cytogenetic Map12q12NCBI
Tfr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573272,289 - 291,668 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955573272,315 - 289,227 (+)NCBIChiLan1.0ChiLan1.0
TFR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,531,714 - 118,554,217 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,796,330 - 166,818,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,647,431 - 92,669,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,048,497 - 106,060,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,048,935 - 106,069,238 (-)Ensemblpanpan1.1panPan2
TFR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,059,501 - 9,076,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,060,629 - 9,076,158 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,763,917 - 10,781,061 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,993,681 - 9,010,842 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,993,652 - 9,010,354 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,846,198 - 8,863,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,823,694 - 8,841,037 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,006,114 - 9,023,274 (+)NCBIUU_Cfam_GSD_1.0
Tfr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,353,500 - 133,368,393 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543668,157 - 682,174 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543667,570 - 681,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,539,320 - 8,578,763 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,539,316 - 8,553,993 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,934,261 - 7,948,960 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,570,604 - 12,592,269 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,571,841 - 12,592,266 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,712,690 - 3,733,677 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,452,504 - 16,466,781 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,451,520 - 16,469,393 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tfr2
587 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:110
Interacting mature miRNAs:112
Transcripts:ENSMUST00000031729
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001289507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC148018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF207741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF207742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF222895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF312033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV027736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB736789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY199481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000031729   ⟹   ENSMUSP00000031729
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,568,113 - 137,585,743 (+)Ensembl
GRCm38.p6 Ensembl5137,569,851 - 137,587,481 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196375   ⟹   ENSMUSP00000142731
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,577,155 - 137,579,094 (+)Ensembl
GRCm38.p6 Ensembl5137,578,893 - 137,580,832 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196450
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,581,547 - 137,582,371 (+)Ensembl
GRCm38.p6 Ensembl5137,583,285 - 137,584,109 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196471   ⟹   ENSMUSP00000142814
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,568,982 - 137,585,727 (+)Ensembl
GRCm38.p6 Ensembl5137,570,720 - 137,587,465 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197705
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,572,777 - 137,576,037 (+)Ensembl
GRCm38.p6 Ensembl5137,574,515 - 137,577,775 (+)Ensembl
Ensembl Acc Id: ENSMUST00000198783   ⟹   ENSMUSP00000142502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,569,067 - 137,585,738 (+)Ensembl
GRCm38.p6 Ensembl5137,570,805 - 137,587,476 (+)Ensembl
Ensembl Acc Id: ENSMUST00000198866   ⟹   ENSMUSP00000142720
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,568,102 - 137,585,741 (+)Ensembl
GRCm38.p6 Ensembl5137,569,840 - 137,587,479 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199054   ⟹   ENSMUSP00000142478
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,568,131 - 137,585,741 (+)Ensembl
GRCm38.p6 Ensembl5137,569,869 - 137,587,479 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199069
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,581,547 - 137,585,251 (+)Ensembl
GRCm38.p6 Ensembl5137,583,285 - 137,586,989 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199957
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,569,713 - 137,572,684 (+)Ensembl
GRCm38.p6 Ensembl5137,571,451 - 137,574,422 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200190
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5137,568,126 - 137,569,624 (+)Ensembl
GRCm38.p6 Ensembl5137,569,864 - 137,571,362 (+)Ensembl
RefSeq Acc Id: NM_001289507   ⟹   NP_001276436
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395137,569,237 - 137,586,344 (+)NCBI
GRCm385137,570,975 - 137,588,081 (+)NCBI
Celera5134,553,508 - 134,571,633 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289509   ⟹   NP_001276438
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395137,568,127 - 137,586,344 (+)NCBI
GRCm385137,569,840 - 137,588,081 (+)NCBI
Celera5134,553,508 - 134,571,633 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289511   ⟹   NP_001276440
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395137,569,006 - 137,586,344 (+)NCBI
GRCm385137,570,720 - 137,588,081 (+)NCBI
Celera5134,553,508 - 134,571,633 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001359206   ⟹   NP_001346135
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395137,568,127 - 137,586,344 (+)NCBI
GRCm385137,569,840 - 137,588,081 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001425505   ⟹   NP_001412434
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395137,568,127 - 137,586,344 (+)NCBI
RefSeq Acc Id: NM_001425506   ⟹   NP_001412435
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395137,568,127 - 137,586,344 (+)NCBI
RefSeq Acc Id: NM_001425507   ⟹   NP_001412436
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395137,568,127 - 137,586,344 (+)NCBI
RefSeq Acc Id: NM_015799   ⟹   NP_056614
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395137,568,127 - 137,586,344 (+)NCBI
GRCm385137,569,840 - 137,588,081 (+)NCBI
MGSCv375138,011,079 - 138,028,709 (+)RGD
Celera5134,553,508 - 134,571,633 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001276436 (Get FASTA)   NCBI Sequence Viewer  
  NP_001276438 (Get FASTA)   NCBI Sequence Viewer  
  NP_001276440 (Get FASTA)   NCBI Sequence Viewer  
  NP_001346135 (Get FASTA)   NCBI Sequence Viewer  
  NP_001412434 (Get FASTA)   NCBI Sequence Viewer  
  NP_001412435 (Get FASTA)   NCBI Sequence Viewer  
  NP_001412436 (Get FASTA)   NCBI Sequence Viewer  
  NP_056614 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF37272 (Get FASTA)   NCBI Sequence Viewer  
  AAH13654 (Get FASTA)   NCBI Sequence Viewer  
  AAK28830 (Get FASTA)   NCBI Sequence Viewer  
  AAL05976 (Get FASTA)   NCBI Sequence Viewer  
  AAL05977 (Get FASTA)   NCBI Sequence Viewer  
  BAB23614 (Get FASTA)   NCBI Sequence Viewer  
  BAB23705 (Get FASTA)   NCBI Sequence Viewer  
  EDL19255 (Get FASTA)   NCBI Sequence Viewer  
  EDL19256 (Get FASTA)   NCBI Sequence Viewer  
  EDL19257 (Get FASTA)   NCBI Sequence Viewer  
  EDL19258 (Get FASTA)   NCBI Sequence Viewer  
  EDL19259 (Get FASTA)   NCBI Sequence Viewer  
  EDL19260 (Get FASTA)   NCBI Sequence Viewer  
  EDL19261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000031729
  ENSMUSP00000031729.9
  ENSMUSP00000142478
  ENSMUSP00000142478.2
  ENSMUSP00000142502
  ENSMUSP00000142502.2
  ENSMUSP00000142720
  ENSMUSP00000142720.2
  ENSMUSP00000142731.2
  ENSMUSP00000142814
  ENSMUSP00000142814.2
GenBank Protein Q9JKX3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_056614   ⟸   NM_015799
- UniProtKB: Q99MQ9 (UniProtKB/Swiss-Prot),   Q920I6 (UniProtKB/Swiss-Prot),   Q9CPT2 (UniProtKB/Swiss-Prot),   Q9JKX3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276438   ⟸   NM_001289509
- UniProtKB: Q99MQ9 (UniProtKB/Swiss-Prot),   Q920I6 (UniProtKB/Swiss-Prot),   Q9CPT2 (UniProtKB/Swiss-Prot),   Q9JKX3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276440   ⟸   NM_001289511
- UniProtKB: Q99MQ9 (UniProtKB/Swiss-Prot),   Q920I6 (UniProtKB/Swiss-Prot),   Q9CPT2 (UniProtKB/Swiss-Prot),   Q9JKX3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276436   ⟸   NM_001289507
- UniProtKB: Q9JKX3 (UniProtKB/Swiss-Prot),   Q99MQ9 (UniProtKB/Swiss-Prot),   Q920I6 (UniProtKB/Swiss-Prot),   Q9CPT2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001346135   ⟸   NM_001359206
- UniProtKB: Q9JKX3 (UniProtKB/Swiss-Prot),   Q99MQ9 (UniProtKB/Swiss-Prot),   Q920I6 (UniProtKB/Swiss-Prot),   Q9CPT2 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000142502   ⟸   ENSMUST00000198783
Ensembl Acc Id: ENSMUSP00000142720   ⟸   ENSMUST00000198866
Ensembl Acc Id: ENSMUSP00000031729   ⟸   ENSMUST00000031729
Ensembl Acc Id: ENSMUSP00000142478   ⟸   ENSMUST00000199054
Ensembl Acc Id: ENSMUSP00000142731   ⟸   ENSMUST00000196375
Ensembl Acc Id: ENSMUSP00000142814   ⟸   ENSMUST00000196471
RefSeq Acc Id: NP_001412434   ⟸   NM_001425505
- UniProtKB: Q9JKX3 (UniProtKB/Swiss-Prot),   Q9CPT2 (UniProtKB/Swiss-Prot),   Q99MQ9 (UniProtKB/Swiss-Prot),   Q920I6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001412436   ⟸   NM_001425507
- UniProtKB: Q9JKX3 (UniProtKB/Swiss-Prot),   Q9CPT2 (UniProtKB/Swiss-Prot),   Q99MQ9 (UniProtKB/Swiss-Prot),   Q920I6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001412435   ⟸   NM_001425506
- UniProtKB: Q9JKX3 (UniProtKB/Swiss-Prot),   Q9CPT2 (UniProtKB/Swiss-Prot),   Q99MQ9 (UniProtKB/Swiss-Prot),   Q920I6 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKX3-F1-model_v2 AlphaFold Q9JKX3 1-798 view protein structure

Promoters
RGD ID:6888440
Promoter ID:EPDNEW_M7671
Type:initiation region
Name:Tfr2_1
Description:Mus musculus transferrin receptor 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385137,569,865 - 137,569,925EPDNEW
RGD ID:6838569
Promoter ID:MM_KWN:44479
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000111009,   NM_015799,   UC009ACV.1,   UC009ACX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365138,010,881 - 138,011,381 (+)MPROMDB
RGD ID:6838571
Promoter ID:MM_KWN:44480
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:UC009ACY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365138,012,281 - 138,012,781 (+)MPROMDB
RGD ID:6847972
Promoter ID:MM_ACW:39879
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung
Transcripts:TRFR2.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365138,015,524 - 138,016,024 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354956 AgrOrtholog
Ensembl Genes ENSMUSG00000029716 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031729 ENTREZGENE
  ENSMUST00000031729.13 UniProtKB/Swiss-Prot
  ENSMUST00000196375.2 UniProtKB/TrEMBL
  ENSMUST00000196471 ENTREZGENE
  ENSMUST00000196471.5 UniProtKB/Swiss-Prot
  ENSMUST00000198783 ENTREZGENE
  ENSMUST00000198783.5 UniProtKB/Swiss-Prot
  ENSMUST00000198866 ENTREZGENE
  ENSMUST00000198866.5 UniProtKB/Swiss-Prot
  ENSMUST00000199054 ENTREZGENE
  ENSMUST00000199054.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.930.40 UniProtKB/Swiss-Prot
  3.50.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn peptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PA_dom_sf UniProtKB/Swiss-Prot
  PA_domain UniProtKB/Swiss-Prot
  Peptidase_M28 UniProtKB/Swiss-Prot
  Peptidase_M28B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFR-like_dimer_dom_sf UniProtKB/Swiss-Prot
  TfR1/2_PA UniProtKB/Swiss-Prot
KEGG Report mmu:50765 UniProtKB/Swiss-Prot
MGD MGI:1354956 ENTREZGENE
NCBI Gene 50765 ENTREZGENE
PANTHER PTHR10404 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFERRIN RECEPTOR PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M28 UniProtKB/Swiss-Prot
  PF02225 UniProtKB/Swiss-Prot
PhenoGen Tfr2 PhenoGen
Superfamily-SCOP PA domain UniProtKB/Swiss-Prot
  SSF47672 UniProtKB/Swiss-Prot
  Zn-dependent exopeptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JED7_MOUSE UniProtKB/TrEMBL
  Q920I6 ENTREZGENE
  Q99MQ9 ENTREZGENE
  Q9CPT2 ENTREZGENE
  Q9JKX3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q920I6 UniProtKB/Swiss-Prot
  Q99MQ9 UniProtKB/Swiss-Prot
  Q9CPT2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-03-20 Tfr2  transferrin receptor 2  Trfr2  transferrin receptor 2  Symbol and/or name change 5135510 APPROVED