Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Eps8 (epidermal growth factor receptor pathway substrate 8) Mus musculus
Symbol: Eps8
Name: epidermal growth factor receptor pathway substrate 8
Description: Exhibits Rac GTPase binding activity and actin binding activity. Predicted to contribute to Rac guanyl-nucleotide exchange factor activity. Involved in several processes, including Rac protein signal transduction; actin cytoskeleton organization; and barbed-end actin filament capping. Localizes to several cellular components, including the NMDA selective glutamate receptor complex; ruffle membrane; and stereocilium tip. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and metanephros. Orthologous to human EPS8 (epidermal growth factor receptor pathway substrate 8); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW261790; epidermal growth factor receptor kinase substrate 8
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm386137,477,245 - 137,649,397 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376137,425,766 - 137,597,641 (-)NCBIGRCm37mm9NCBIm37
MGSCv366137,441,441 - 137,613,316 (-)NCBImm8
MGSCv366137,872,768 - 137,987,281 (-)NCBImm8
Celera6140,541,302 - 140,636,376 (-)NCBICelera
Cytogenetic Map6 G1NCBI
cM Map666.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Eps8
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321588
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.