Eps8 (epidermal growth factor receptor pathway substrate 8) - Rat Genome Database

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Gene: Eps8 (epidermal growth factor receptor pathway substrate 8) Mus musculus
Analyze
Symbol: Eps8
Name: epidermal growth factor receptor pathway substrate 8
RGD ID: 1321588
MGI Page MGI
Description: Enables actin binding activity and small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; actin filament organization; and barbed-end actin filament capping. Acts upstream of or within several processes, including adult locomotory behavior; behavioral response to ethanol; and cellular response to leukemia inhibitory factor. Located in several cellular components, including brush border; ruffle membrane; and stereocilium tip. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and metanephros. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW261790; epidermal growth factor receptor kinase substrate 8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396137,454,242 - 137,626,262 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6137,454,243 - 137,631,874 (-)EnsemblGRCm39 Ensembl
GRCm386137,477,245 - 137,649,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6137,477,245 - 137,654,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv376137,425,766 - 137,597,641 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366137,441,441 - 137,613,316 (-)NCBIMGSCv36mm8
MGSCv366137,872,768 - 137,987,281 (-)NCBIMGSCv36mm8
Celera6140,541,302 - 140,657,063 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
Aroclor 1254  (EXP)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
capecitabine  (ISO)
CGP 52608  (ISO)
chromium(6+)  (EXP)
clothianidin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
disodium selenite  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
folic acid  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7517397   PMID:7537362   PMID:7566980   PMID:8084614   PMID:8404850   PMID:9010225   PMID:9303002   PMID:10349636   PMID:10499589   PMID:10512203   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11524436   PMID:12466851   PMID:12477932   PMID:12515821   PMID:12620401   PMID:12904583   PMID:14565974   PMID:14610273   PMID:14699156   PMID:15289329  
PMID:15489334   PMID:15558031   PMID:15782199   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16225669   PMID:16602821   PMID:16773716   PMID:17018287   PMID:17115031   PMID:17967808  
PMID:18799693   PMID:19208628   PMID:19528316   PMID:19564905   PMID:19933840   PMID:20209148   PMID:20418908   PMID:20439489   PMID:20532239   PMID:21236676   PMID:21267068   PMID:21357683  
PMID:21526224   PMID:21835647   PMID:21873635   PMID:22114352   PMID:22794259   PMID:23314863   PMID:23392693   PMID:23685357   PMID:23918390   PMID:24154525   PMID:24475274   PMID:24533597  
PMID:24741995   PMID:26252776   PMID:26668327   PMID:26969129   PMID:27132230   PMID:27450093   PMID:28340616   PMID:28663585   PMID:30233314   PMID:30314980   PMID:30827920   PMID:31040226  
PMID:31448880   PMID:32325033   PMID:32595041   PMID:34321999   PMID:35044843   PMID:36260679   PMID:36395759   PMID:36604605   PMID:38355793  


Genomics

Comparative Map Data
Eps8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396137,454,242 - 137,626,262 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6137,454,243 - 137,631,874 (-)EnsemblGRCm39 Ensembl
GRCm386137,477,245 - 137,649,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6137,477,245 - 137,654,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv376137,425,766 - 137,597,641 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366137,441,441 - 137,613,316 (-)NCBIMGSCv36mm8
MGSCv366137,872,768 - 137,987,281 (-)NCBIMGSCv36mm8
Celera6140,541,302 - 140,657,063 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.78NCBI
EPS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381215,620,134 - 15,789,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1215,620,134 - 15,882,329 (-)EnsemblGRCh38hg38GRCh38
GRCh371215,773,068 - 15,942,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361215,664,342 - 15,833,601 (-)NCBINCBI36Build 36hg18NCBI36
Build 341215,664,342 - 15,833,601NCBI
Celera1220,917,962 - 21,087,395 (-)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1215,542,405 - 15,711,684 (-)NCBIHuRef
CHM1_11215,739,030 - 15,908,465 (-)NCBICHM1_1
T2T-CHM13v2.01215,497,359 - 15,666,619 (-)NCBIT2T-CHM13v2.0
Eps8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,119,497 - 172,291,670 (-)NCBIGRCr8
mRatBN7.24170,388,378 - 170,486,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4170,388,378 - 170,486,873 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,680,716 - 176,779,656 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04172,465,042 - 172,563,994 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,085,423 - 171,184,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04171,475,155 - 171,645,620 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4171,475,567 - 171,591,882 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,732,277 - 235,903,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44174,601,291 - 174,672,247 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,848,196 - 174,917,371 (-)NCBI
Celera4158,967,950 - 159,084,908 (-)NCBICelera
Cytogenetic Map4q44NCBI
Eps8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541312,266,371 - 12,386,088 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541312,267,701 - 12,386,088 (-)NCBIChiLan1.0ChiLan1.0
EPS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21021,063,405 - 21,262,151 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11221,060,141 - 21,255,181 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01215,617,536 - 15,788,537 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11216,013,270 - 16,184,203 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,013,276 - 16,076,117 (-)Ensemblpanpan1.1panPan2
EPS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12730,893,884 - 31,070,401 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2730,893,713 - 31,069,770 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2715,378,134 - 15,554,665 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02731,213,204 - 31,391,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2731,213,046 - 31,391,090 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12731,212,841 - 31,279,922 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,058,974 - 31,235,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02715,100,205 - 15,276,688 (-)NCBIUU_Cfam_GSD_1.0
Eps8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,057,948 - 92,223,689 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365871,785,303 - 1,951,332 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365871,785,721 - 1,951,474 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl556,817,606 - 57,005,113 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1556,817,445 - 57,005,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2560,303,025 - 60,409,561 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,522,761 - 15,691,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,522,616 - 15,691,133 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606919,609,645 - 19,778,199 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eps8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475222,295,413 - 22,426,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475222,250,988 - 22,424,957 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eps8
7509 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2028
Count of miRNA genes:723
Interacting mature miRNAs:910
Transcripts:ENSMUST00000058210, ENSMUST00000100841, ENSMUST00000111878, ENSMUST00000127179, ENSMUST00000130274, ENSMUST00000132920, ENSMUST00000134630, ENSMUST00000139753, ENSMUST00000146442, ENSMUST00000147526, ENSMUST00000152046, ENSMUST00000153933, ENSMUST00000156916
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128180868149588044Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301084Bpq5_mblood pressure QTL 5 (mouse)Not determined6129330484149588044Mouse
14746990Manh61_mmandible shape 61 (mouse)6130156355149588044Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
10766452Sle23_msystematic lupus erythematosus susceptibility 23 (mouse)6128601582149588044Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
14746999Mancz6_mmandible centroid size 6 (mouse)6130156355149588044Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1301686Trmq1_mT cell ratio modifier QTL 1 (mouse)Not determined6129330484149588044Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
1301620Insq8_minsulin QTL 8 (mouse)Not determined6129534979149588044Mouse
12879916Shm5_msperm head morphology 5 (mouse)6132266532145601739Mouse
10053680Lith25_mlithogenic gene 25 (mouse)Not determined6128601582149588044Mouse
4141974Skmw14_mskeletal muscle weight 14 (mouse)Not determined6129330484149588044Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301820Mop1_mmorphine preference 1 (mouse)Not determined6132578005146330736Mouse
1301027Hdlq12_mHDL QTL 12 (mouse)Not determined6128601582149588044Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
1558959Eamcd2_mexperimental autoimmune myocarditis 2 (mouse)Not determined6129953954149588044Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse

Markers in Region
AW261790  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386137,477,998 - 137,478,103UniSTSGRCm38
MGSCv376137,426,519 - 137,426,624UniSTSGRCm37
Celera6140,542,056 - 140,542,161UniSTS
Cytogenetic Map6G1UniSTS
cM Map666.0UniSTS
Whitehead/MRC_RH61349.22UniSTS
L21671  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386137,478,753 - 137,478,880UniSTSGRCm38
MGSCv376137,427,274 - 137,427,401UniSTSGRCm37
Celera6140,542,811 - 140,542,938UniSTS
Cytogenetic Map6G1UniSTS
cM Map666.0UniSTS
Whitehead/MRC_RH61349.22UniSTS
UniSTS:235568  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386137,586,371 - 137,586,635UniSTSGRCm38
MGSCv376137,534,892 - 137,535,156UniSTSGRCm37
Celera6140,651,902 - 140,652,166UniSTS
Cytogenetic Map6G1UniSTS
cM Map666.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB854890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY209758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L21671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000058210   ⟹   ENSMUSP00000052776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,454,243 - 137,626,283 (-)Ensembl
GRCm38.p6 Ensembl6137,477,245 - 137,649,285 (-)Ensembl
Ensembl Acc Id: ENSMUST00000100841   ⟹   ENSMUSP00000098402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,454,666 - 137,548,015 (-)Ensembl
GRCm38.p6 Ensembl6137,477,668 - 137,571,017 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111878   ⟹   ENSMUSP00000107509
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,455,175 - 137,626,283 (-)Ensembl
GRCm38.p6 Ensembl6137,478,177 - 137,649,285 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127179
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,491,338 - 137,496,758 (-)Ensembl
GRCm38.p6 Ensembl6137,514,340 - 137,519,760 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132920   ⟹   ENSMUSP00000122517
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,494,069 - 137,631,874 (-)Ensembl
GRCm38.p6 Ensembl6137,517,071 - 137,654,876 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134630   ⟹   ENSMUSP00000120648
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,516,335 - 137,626,240 (-)Ensembl
GRCm38.p6 Ensembl6137,539,337 - 137,649,242 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139753   ⟹   ENSMUSP00000145059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,514,636 - 137,625,281 (-)Ensembl
GRCm38.p6 Ensembl6137,537,638 - 137,648,283 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146442   ⟹   ENSMUSP00000119997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,499,860 - 137,566,024 (-)Ensembl
GRCm38.p6 Ensembl6137,522,862 - 137,589,026 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147526   ⟹   ENSMUSP00000120044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,476,637 - 137,625,281 (-)Ensembl
GRCm38.p6 Ensembl6137,499,639 - 137,648,283 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152046
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,494,093 - 137,496,701 (-)Ensembl
GRCm38.p6 Ensembl6137,517,095 - 137,519,703 (-)Ensembl
Ensembl Acc Id: ENSMUST00000153933
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,504,393 - 137,626,227 (-)Ensembl
GRCm38.p6 Ensembl6137,527,395 - 137,649,229 (-)Ensembl
Ensembl Acc Id: ENSMUST00000203515
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,511,751 - 137,515,087 (-)Ensembl
GRCm38.p6 Ensembl6137,534,753 - 137,538,089 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205037
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6137,544,138 - 137,547,757 (-)Ensembl
GRCm38.p6 Ensembl6137,567,140 - 137,570,759 (-)Ensembl
RefSeq Acc Id: NM_001271587   ⟹   NP_001258516
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,242 - 137,548,043 (-)NCBI
GRCm386137,477,245 - 137,571,009 (-)NCBI
Celera6140,541,302 - 140,636,376 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271588   ⟹   NP_001258517
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,242 - 137,626,262 (-)NCBI
GRCm386137,477,245 - 137,649,285 (-)NCBI
Celera6140,541,302 - 140,636,376 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271589   ⟹   NP_001258518
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,242 - 137,496,891 (-)NCBI
GRCm386137,477,245 - 137,519,895 (-)NCBI
Celera6140,541,302 - 140,636,376 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271595   ⟹   NP_001258524
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,242 - 137,548,043 (-)NCBI
GRCm386137,477,245 - 137,571,009 (-)NCBI
Celera6140,541,302 - 140,636,376 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001409747   ⟹   NP_001396676
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,242 - 137,625,282 (-)NCBI
RefSeq Acc Id: NM_001409750   ⟹   NP_001396679
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,242 - 137,626,262 (-)NCBI
RefSeq Acc Id: NM_001409751   ⟹   NP_001396680
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,242 - 137,626,262 (-)NCBI
RefSeq Acc Id: NM_001409752   ⟹   NP_001396681
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,242 - 137,496,740 (-)NCBI
RefSeq Acc Id: NM_001409757   ⟹   NP_001396686
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,467,120 - 137,496,891 (-)NCBI
RefSeq Acc Id: NM_007945   ⟹   NP_031971
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,242 - 137,626,262 (-)NCBI
GRCm386137,477,245 - 137,649,285 (-)NCBI
MGSCv376137,425,766 - 137,597,641 (-)RGD
Celera6140,541,302 - 140,636,376 (-)NCBI
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011241204   ⟹   XP_011239506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,670 - 137,566,019 (-)NCBI
GRCm386137,477,672 - 137,589,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255145   ⟹   XP_030111005
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396137,454,670 - 137,626,257 (-)NCBI
GRCm386137,477,672 - 137,649,259 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258516 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258517 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258518 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258524 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396676 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396679 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396680 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396681 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396686 (Get FASTA)   NCBI Sequence Viewer  
  NP_031971 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239506 (Get FASTA)   NCBI Sequence Viewer  
  XP_030111005 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16358 (Get FASTA)   NCBI Sequence Viewer  
  AAH16890 (Get FASTA)   NCBI Sequence Viewer  
  BAE28197 (Get FASTA)   NCBI Sequence Viewer  
  BAE28546 (Get FASTA)   NCBI Sequence Viewer  
  BAE29023 (Get FASTA)   NCBI Sequence Viewer  
  BAE32995 (Get FASTA)   NCBI Sequence Viewer  
  BAE38337 (Get FASTA)   NCBI Sequence Viewer  
  BAE38601 (Get FASTA)   NCBI Sequence Viewer  
  EDL10584 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000052776
  ENSMUSP00000052776.7
  ENSMUSP00000098402
  ENSMUSP00000098402.3
  ENSMUSP00000107509
  ENSMUSP00000107509.2
  ENSMUSP00000119997.2
  ENSMUSP00000120044.2
  ENSMUSP00000120648.2
  ENSMUSP00000122517.2
  ENSMUSP00000145059.2
GenBank Protein Q08509 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031971   ⟸   NM_007945
- Peptide Label: isoform 1
- UniProtKB: Q3TM41 (UniProtKB/Swiss-Prot),   Q08509 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258516   ⟸   NM_001271587
- Peptide Label: isoform 2
- UniProtKB: Q3U2Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258524   ⟸   NM_001271595
- Peptide Label: isoform 1
- UniProtKB: Q3TM41 (UniProtKB/Swiss-Prot),   Q08509 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258517   ⟸   NM_001271588
- Peptide Label: isoform 1
- UniProtKB: Q3TM41 (UniProtKB/Swiss-Prot),   Q08509 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258518   ⟸   NM_001271589
- Peptide Label: isoform 3
- UniProtKB: Q3TMV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011239506   ⟸   XM_011241204
- Peptide Label: isoform X1
- UniProtKB: Q3TM41 (UniProtKB/Swiss-Prot),   Q08509 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030111005   ⟸   XM_030255145
- Peptide Label: isoform X1
- UniProtKB: Q08509 (UniProtKB/Swiss-Prot),   Q3TM41 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000107509   ⟸   ENSMUST00000111878
Ensembl Acc Id: ENSMUSP00000145059   ⟸   ENSMUST00000139753
Ensembl Acc Id: ENSMUSP00000120044   ⟸   ENSMUST00000147526
Ensembl Acc Id: ENSMUSP00000122517   ⟸   ENSMUST00000132920
Ensembl Acc Id: ENSMUSP00000119997   ⟸   ENSMUST00000146442
Ensembl Acc Id: ENSMUSP00000120648   ⟸   ENSMUST00000134630
Ensembl Acc Id: ENSMUSP00000098402   ⟸   ENSMUST00000100841
Ensembl Acc Id: ENSMUSP00000052776   ⟸   ENSMUST00000058210
RefSeq Acc Id: NP_001396680   ⟸   NM_001409751
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001396679   ⟸   NM_001409750
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001396676   ⟸   NM_001409747
- Peptide Label: isoform 1
- UniProtKB: Q08509 (UniProtKB/Swiss-Prot),   Q3TM41 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001396681   ⟸   NM_001409752
- Peptide Label: isoform 3
- UniProtKB: Q3TMV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396686   ⟸   NM_001409757
- Peptide Label: isoform 5
Protein Domains
PID   PTB   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08509-F1-model_v2 AlphaFold Q08509 1-821 view protein structure

Promoters
RGD ID:6839268
Promoter ID:MM_KWN:48055
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung,   MEF_B6
Transcripts:OTTMUST00000054656,   OTTMUST00000054667,   OTTMUST00000054668,   UC009EMZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366137,468,421 - 137,469,147 (-)MPROMDB
RGD ID:6839271
Promoter ID:MM_KWN:48056
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:UC009ENA.1,   UC009ENB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366137,519,096 - 137,519,596 (-)MPROMDB
RGD ID:6891376
Promoter ID:EPDNEW_M9139
Type:multiple initiation site
Name:Eps8_2
Description:Mus musculus epidermal growth factor receptor pathway substrate8 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9140  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386137,570,753 - 137,570,813EPDNEW
RGD ID:6839269
Promoter ID:MM_KWN:48058
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000054669,   UC009ENE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366137,597,281 - 137,597,781 (-)MPROMDB
RGD ID:6891378
Promoter ID:EPDNEW_M9140
Type:initiation region
Name:Eps8_1
Description:Mus musculus epidermal growth factor receptor pathway substrate8 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9139  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386137,649,264 - 137,649,324EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104684 AgrOrtholog
Ensembl Genes ENSMUSG00000015766 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000058210 ENTREZGENE
  ENSMUST00000058210.13 UniProtKB/Swiss-Prot
  ENSMUST00000100841 ENTREZGENE
  ENSMUST00000100841.9 UniProtKB/Swiss-Prot
  ENSMUST00000111878 ENTREZGENE
  ENSMUST00000111878.8 UniProtKB/Swiss-Prot
  ENSMUST00000132920.8 UniProtKB/TrEMBL
  ENSMUST00000134630.6 UniProtKB/TrEMBL
  ENSMUST00000139753.8 UniProtKB/TrEMBL
  ENSMUST00000146442.4 UniProtKB/TrEMBL
  ENSMUST00000147526.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EPS8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPS8_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Eps8_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13860 UniProtKB/Swiss-Prot
MGD MGI:104684 ENTREZGENE
NCBI Gene 13860 ENTREZGENE
PANTHER PTHR12287 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12287:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eps8 PhenoGen
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SVD8_MOUSE UniProtKB/TrEMBL
  D3YXC3_MOUSE UniProtKB/TrEMBL
  D3Z5I5_MOUSE UniProtKB/TrEMBL
  D3Z7F4_MOUSE UniProtKB/TrEMBL
  EPS8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TM41 ENTREZGENE
  Q3TMV3 ENTREZGENE, UniProtKB/TrEMBL
  Q3U2Z5 ENTREZGENE, UniProtKB/TrEMBL
  Q3UFL4_MOUSE UniProtKB/TrEMBL
  Q3UGL1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TM41 UniProtKB/Swiss-Prot