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Gene: Eps8 (epidermal growth factor receptor pathway substrate 8) Mus musculus
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Symbol: Eps8
Name: epidermal growth factor receptor pathway substrate 8
Description: Exhibits Rac GTPase binding activity and actin binding activity. Predicted to contribute to Rac guanyl-nucleotide exchange factor activity. Involved in several processes, including Rac protein signal transduction; actin cytoskeleton organization; and barbed-end actin filament capping. Localizes to several cellular components, including the NMDA selective glutamate receptor complex; ruffle membrane; and stereocilium tip. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and metanephros. Orthologous to human EPS8 (epidermal growth factor receptor pathway substrate 8); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW261790; epidermal growth factor receptor kinase substrate 8
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm386137,477,245 - 137,649,397 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376137,425,766 - 137,597,641 (-)NCBIGRCm37mm9NCBIm37
MGSCv366137,441,441 - 137,613,316 (-)NCBImm8
MGSCv366137,872,768 - 137,987,281 (-)NCBImm8
Celera6140,541,302 - 140,636,376 (-)NCBICelera
Cytogenetic Map6 G1NCBI
cM Map666.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Eps8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321588
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.