Tac1 (tachykinin 1) - Rat Genome Database

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Gene: Tac1 (tachykinin 1) Mus musculus
Analyze
Symbol: Tac1
Name: tachykinin 1
RGD ID: 11379
MGI Page MGI
Description: Predicted to enable neurokinin receptor binding activity and receptor ligand activity. Acts upstream of or within several processes, including cellular response to nerve growth factor stimulus; response to pain; and sensory perception of pain. Located in axon; extracellular region; and neuronal cell body. Is expressed in several structures, including alimentary system; integumental system; limb; nervous system; and sensory organ. Orthologous to human TAC1 (tachykinin precursor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930528L02Rik; MGC151458; N; neurokinin 1; neurokinin A; NK; NK-; NK-1; NK1; Nkna; P; PP; PPT; PPT-A; PPTA; preprotachykinin A; protachykinin-1; SP; substance P
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3967,555,061 - 7,562,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl67,554,879 - 7,565,834 (+)EnsemblGRCm39 Ensembl
GRCm3867,555,061 - 7,562,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl67,554,879 - 7,565,834 (+)EnsemblGRCm38mm10GRCm38
MGSCv3767,505,071 - 7,512,973 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3667,505,071 - 7,512,973 (+)NCBIMGSCv36mm8
Celera67,693,231 - 7,701,130 (+)NCBICelera
Cytogenetic Map6A1NCBI
cM Map63.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-amphetamine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-nitropropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alfuzosin  (ISO)
allyl isothiocyanate  (ISO)
ammonium chloride  (ISO)
amoxapine  (ISO)
amphetamine  (ISO)
Anetholtrithion  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apomorphine  (ISO)
aprepitant  (EXP)
arsenite(3-)  (ISO)
ATP  (ISO)
baclofen  (ISO)
batimastat  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
Botulinum toxin type A  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP,ISO)
carbamazepine  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
clomipramine  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
corn oil  (ISO)
CP-96345(1+)  (EXP,ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
desipramine  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diazepam  (ISO)
diazinon  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
dioxygen  (ISO)
diprotium oxide  (ISO)
disodium cromoglycate  (ISO)
dizocilpine maleate  (ISO)
dobutamine  (ISO)
dodecane  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fluphenazine  (ISO)
folic acid  (EXP)
formaldehyde  (EXP,ISO)
furan  (ISO)
gabapentin  (ISO)
genistein  (ISO)
ginsenoside Re  (EXP)
glyphosate  (EXP)
Goe 6976  (ISO)
GW 4064  (EXP)
haloperidol  (ISO)
herbimycin  (ISO)
histamine  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP)
icatibant  (ISO)
iloprost  (ISO)
imipramine  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
kainic acid  (ISO)
Kallidin  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
maneb  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mianserin  (ISO)
misoprostol  (ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (EXP)
morphine  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N-Vanillyloleamide  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (ISO)
nedocromil  (ISO)
nimesulide  (ISO)
nitroglycerin  (ISO)
nizatidine  (ISO)
nonane  (ISO)
Norbinaltorphimine  (EXP)
NS-398  (ISO)
O-methyleugenol  (ISO)
Olopatadine hydrochloride  (EXP)
omega-conotoxin GVIA  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (EXP)
PCB138  (EXP)
pemirolast  (ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phosphoramidon  (ISO)
piperine  (ISO)
pirinixic acid  (EXP)
potassium atom  (ISO)
potassium chloride  (EXP,ISO)
potassium dichromate  (EXP)
pregabalin  (ISO)
progesterone  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
quercetin  (EXP)
quinpirole  (ISO)
ranitidine  (ISO)
reserpine  (ISO)
resiniferatoxin  (EXP)
rofecoxib  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
SKF 38393  (ISO)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
sorbinil  (ISO)
streptozocin  (ISO)
sucrose  (ISO)
T-2 toxin  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
toluene 2,6-diisocyanate  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
U69593  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
water  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial humoral response  (ISO)
antifungal humoral response  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
associative learning  (ISO)
cellular response to nerve growth factor stimulus  (IDA)
chemical synaptic transmission  (IEA)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
inflammatory response  (IBA,IDA)
innate immune response  (ISO)
killing of cells of another organism  (ISO)
long-term memory  (ISO)
negative regulation of heart rate  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
neuropeptide signaling pathway  (IEA)
positive regulation of action potential  (ISO)
positive regulation of acute inflammatory response  (ISO)
positive regulation of corticosterone secretion  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,IEA,ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of flagellated sperm motility  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of ossification  (ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of synaptic transmission, GABAergic  (ISO)
regulation of blood pressure  (ISO)
regulation of sensory perception of pain  (ISO)
response to hormone  (ISO)
response to lipopolysaccharide  (ISO)
response to pain  (IMP)
response to yeast  (ISO)
sensory perception of pain  (IMP)
tachykinin receptor signaling pathway  (IBA,IEA,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin. Caudle RM, etal., BMC Neurosci. 2007 May 10;8:30.
2. Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension. Chen MJ and Lai YL, Toxicol Appl Pharmacol. 2003 Mar 15;187(3):178-85.
3. Substance P and its receptor neurokinin 1 expression in asthmatic airways. Chu HW, etal., J Allergy Clin Immunol. 2000 Oct;106(4):713-22.
4. Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats. Evangelista S, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):663-70. Epub 2008 Aug 19.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Substance P is involved in the cutaneous blood flow increase response to sympathetic nerve stimulation in persistently inflamed rats. Koeda T, etal., J Physiol Sci. 2007 Dec;57(6):361-6. Epub 2007 Dec 4.
7. Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A. Krause JE, etal., Proc Natl Acad Sci U S A 1987 Feb;84(3):881-5.
8. The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Lau HY and Bhatia M, J Pathol. 2006 Feb;208(3):364-71.
9. Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure. Li PC, etal., Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L912-20. Epub 2008 Mar 7.
10. Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness. McKay LC and Feldman JL, Am J Respir Crit Care Med. 2008 Jul 1;178(1):89-95. Epub 2008 Apr 17.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats. Nagashima A, etal., Brain Res. 1989 May 22;487(2):392-6.
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Piedimonte G, etal., Am J Physiol. 1999 Oct;277(4 Pt 1):L831-40.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. Sio SW, etal., Am J Respir Crit Care Med. 2010 Jan 1;181(1):36-46. Epub 2009 Oct 1.
19. TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats. Wang Y, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1517-23. Epub 2008 Mar 12.
Additional References at PubMed
PMID:1283163   PMID:1317267   PMID:1644219   PMID:1684952   PMID:1708336   PMID:7486007   PMID:7521790   PMID:7541320   PMID:7545574   PMID:7588260   PMID:8394987   PMID:8661009  
PMID:8809809   PMID:8861630   PMID:8876243   PMID:8889548   PMID:9126737   PMID:9217002   PMID:9482938   PMID:9537322   PMID:9537323   PMID:9724810   PMID:9853118   PMID:9924185  
PMID:10069332   PMID:10349636   PMID:10490918   PMID:10518582   PMID:10564361   PMID:10651856   PMID:10803593   PMID:10821273   PMID:10880535   PMID:10998124   PMID:11042159   PMID:11076861  
PMID:11124115   PMID:11180952   PMID:11433347   PMID:11498051   PMID:11581415   PMID:11588191   PMID:11684339   PMID:11748295   PMID:11805341   PMID:12012374   PMID:12091546   PMID:12117965  
PMID:12270041   PMID:12427862   PMID:12467588   PMID:12477932   PMID:12618303   PMID:12671046   PMID:12684214   PMID:12716420   PMID:12743318   PMID:12773411   PMID:12867261   PMID:12888222  
PMID:12906843   PMID:14500676   PMID:14502084   PMID:14527739   PMID:14598259   PMID:14681479   PMID:14711972   PMID:14975719   PMID:15100316   PMID:15153465   PMID:15158076   PMID:15158164  
PMID:15159534   PMID:15167973   PMID:15217369   PMID:15226823   PMID:15664666   PMID:15700029   PMID:15778345   PMID:15832292   PMID:15845098   PMID:15862536   PMID:15964817   PMID:15972963  
PMID:15987503   PMID:16049186   PMID:16122428   PMID:16141072   PMID:16141073   PMID:16388914   PMID:16446141   PMID:16446142   PMID:16517752   PMID:16580148   PMID:16602821   PMID:16798781  
PMID:16873895   PMID:16951258   PMID:16952405   PMID:16987237   PMID:17145500   PMID:17251415   PMID:17257750   PMID:17273166   PMID:17307297   PMID:17525292   PMID:17554007   PMID:17620183  
PMID:17632507   PMID:17692507   PMID:17693550   PMID:17697146   PMID:17785854   PMID:17895403   PMID:17911468   PMID:17953485   PMID:17998302   PMID:18163347   PMID:18250082   PMID:18313668  
PMID:18325388   PMID:18400903   PMID:18430798   PMID:18441096   PMID:18498732   PMID:18498735   PMID:18505813   PMID:18523290   PMID:18523300   PMID:18576810   PMID:18599605   PMID:18675571  
PMID:18721803   PMID:18845912   PMID:18987169   PMID:19017671   PMID:19029199   PMID:19030180   PMID:19114063   PMID:19520130   PMID:19660865   PMID:19898633   PMID:19906978   PMID:19944731  
PMID:20034568   PMID:20080794   PMID:20096094   PMID:20206166   PMID:20303589   PMID:20346763   PMID:20392955   PMID:20438764   PMID:20454520   PMID:20539012   PMID:20579732   PMID:20676845  
PMID:20844136   PMID:20921407   PMID:20926798   PMID:20951772   PMID:21044181   PMID:21106239   PMID:21172866   PMID:21205893   PMID:21289528   PMID:21294877   PMID:21308776   PMID:21415372  
PMID:21452241   PMID:21467195   PMID:21601581   PMID:21752988   PMID:21763243   PMID:21873635   PMID:21878523   PMID:21908647   PMID:21917790   PMID:21931742   PMID:21945803   PMID:21969295  
PMID:21989918   PMID:22009727   PMID:22028026   PMID:22042746   PMID:22080974   PMID:22084095   PMID:22182301   PMID:22326227   PMID:22346746   PMID:22392530   PMID:22427743   PMID:22471406  
PMID:22634872   PMID:22674265   PMID:22687356   PMID:22717580   PMID:22745377   PMID:22787056   PMID:22828515   PMID:22913923   PMID:22982142   PMID:22991445   PMID:23024265   PMID:23041339  
PMID:23065762   PMID:23191958   PMID:23232501   PMID:23257919   PMID:23499760   PMID:23516556   PMID:23532063   PMID:23626716   PMID:23637859   PMID:23671638   PMID:24027274   PMID:24082127  
PMID:24154525   PMID:24173031   PMID:24275230   PMID:24351932   PMID:24463367   PMID:24760869   PMID:24886508   PMID:24952961   PMID:25049388   PMID:25063231   PMID:25071457   PMID:25209287  
PMID:25301750   PMID:25422875   PMID:25489075   PMID:25543145   PMID:25589759   PMID:25734767   PMID:25751638   PMID:25830093   PMID:25856429   PMID:25871534   PMID:26072188   PMID:26223840  
PMID:26349209   PMID:26373800   PMID:26389685   PMID:26511239   PMID:26727548   PMID:26743624   PMID:26949938   PMID:27068287   PMID:27405468   PMID:27452460   PMID:27750083   PMID:27902570  
PMID:28073937   PMID:28114571   PMID:28167615   PMID:28289129   PMID:28387937   PMID:28433741   PMID:28444173   PMID:28460633   PMID:28514446   PMID:28673722   PMID:28683326   PMID:29043563  
PMID:29328505   PMID:29394901   PMID:29482159   PMID:29625453   PMID:29659809   PMID:29775595   PMID:29907830   PMID:29967281   PMID:30007418   PMID:30038273   PMID:30318414   PMID:30398624  
PMID:30413696   PMID:30449655   PMID:30532001   PMID:30553791   PMID:30554781   PMID:30593496   PMID:30734936   PMID:30803756   PMID:30872278   PMID:30917305   PMID:31012376   PMID:31146259  
PMID:31358823   PMID:31399471   PMID:31491374   PMID:31591569   PMID:31666704   PMID:31831729   PMID:31926346   PMID:32017713   PMID:32060036   PMID:32160549   PMID:32170006   PMID:32239544  
PMID:32240599   PMID:32386544   PMID:32512561   PMID:32561725   PMID:32571909   PMID:32634530   PMID:32965648   PMID:33098765   PMID:33116307   PMID:33147466   PMID:33186530   PMID:33188746  
PMID:33238113   PMID:33288908   PMID:33333245   PMID:33591273   PMID:33649316   PMID:33691135   PMID:33712552   PMID:33729475   PMID:33731445   PMID:33744254   PMID:33744374   PMID:33765440  
PMID:33789083   PMID:33839770   PMID:33913808   PMID:33986154   PMID:33999474   PMID:34004146   PMID:34014554   PMID:34043943   PMID:34095148   PMID:34376651   PMID:34387544   PMID:34607806  
PMID:34698773   PMID:34958108   PMID:34998469   PMID:35045339   PMID:35045975   PMID:35065713   PMID:35082448   PMID:35303432   PMID:35334220   PMID:35507386   PMID:35615067   PMID:35675799  
PMID:35727300   PMID:35793630   PMID:35793636   PMID:35830813   PMID:35913117   PMID:35974052   PMID:36070775   PMID:36081908   PMID:36113428   PMID:36170850   PMID:36240781   PMID:36317965  
PMID:36323317   PMID:36409884   PMID:36596814   PMID:36774552   PMID:36796363   PMID:36810133   PMID:36810601   PMID:36898496   PMID:37054767   PMID:37122730   PMID:37390821   PMID:37437602  
PMID:37462672   PMID:37572660   PMID:37625400   PMID:37699522   PMID:37925641   PMID:37983249   PMID:38355793   PMID:38599213   PMID:38640347   PMID:38649427   PMID:39349721  


Genomics

Comparative Map Data
Tac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3967,555,061 - 7,562,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl67,554,879 - 7,565,834 (+)EnsemblGRCm39 Ensembl
GRCm3867,555,061 - 7,562,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl67,554,879 - 7,565,834 (+)EnsemblGRCm38mm10GRCm38
MGSCv3767,505,071 - 7,512,973 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3667,505,071 - 7,512,973 (+)NCBIMGSCv36mm8
Celera67,693,231 - 7,701,130 (+)NCBICelera
Cytogenetic Map6A1NCBI
cM Map63.31NCBI
TAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38797,732,086 - 97,740,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl797,732,084 - 97,740,472 (+)EnsemblGRCh38hg38GRCh38
GRCh37797,361,398 - 97,369,784 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36797,199,311 - 97,207,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 34797,006,025 - 97,014,433NCBI
Celera792,055,970 - 92,064,483 (+)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef791,962,648 - 91,971,157 (+)NCBIHuRef
CHM1_1797,291,306 - 97,299,818 (+)NCBICHM1_1
T2T-CHM13v2.0798,961,638 - 98,970,024 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2796,683,759 - 96,692,272 (+)NCBI
Tac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8436,645,344 - 36,653,548 (+)NCBIGRCr8
mRatBN7.2435,679,183 - 35,687,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl435,679,704 - 35,687,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx440,638,023 - 40,645,989 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0436,564,213 - 36,572,177 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0434,981,526 - 34,989,526 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0433,638,853 - 33,646,819 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl433,638,709 - 33,646,819 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0433,499,891 - 33,507,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4432,649,666 - 32,657,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1432,768,205 - 32,776,170 (+)NCBI
Celera431,183,136 - 31,191,779 (+)NCBICelera
Cytogenetic Map4q21NCBI
Tac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543213,991,414 - 13,999,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543213,991,647 - 13,999,665 (+)NCBIChiLan1.0ChiLan1.0
TAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26115,561,721 - 115,570,273 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17163,826,347 - 163,834,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0789,675,834 - 89,684,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17103,257,450 - 103,266,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7103,257,501 - 103,266,389 (+)Ensemblpanpan1.1panPan2
TAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11422,631,106 - 22,640,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1422,632,642 - 22,640,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1422,207,754 - 22,215,926 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01422,451,048 - 22,459,223 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11422,597,269 - 22,605,445 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01422,330,414 - 22,338,555 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01422,594,017 - 22,602,196 (+)NCBIUU_Cfam_GSD_1.0
Tac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511835,921,952 - 35,930,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365852,932,727 - 2,941,384 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365852,932,783 - 2,941,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl977,197,536 - 77,206,523 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1977,197,403 - 77,206,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2984,764,564 - 84,773,747 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12151,339,085 - 51,347,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2151,339,095 - 51,347,550 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604253,024,229 - 53,032,700 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248134,542,011 - 4,550,486 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248134,542,226 - 4,550,378 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tac1
282 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:421
Count of miRNA genes:198
Interacting mature miRNAs:242
Transcripts:ENSMUST00000090679, ENSMUST00000184481, ENSMUST00000184986, ENSMUST00000185130, ENSMUST00000185187
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751333Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
14746985Manh59_mmandible shape 59 (mouse)6120847193Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
12904934Edlmmq4_mextensor digitorum longus muscle mass QTL 4 (mouse)6125514064Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
1301178Lith10_mlithogenic gene 10 (mouse)Not determined6121465015Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
12904942Tammq3_mtibialis anterior muscle mass QTL 3 (mouse)6125514064Mouse
1357503Nhdlq5_mnon-HDL QTL 5 (mouse)Not determined6121465015Mouse
10043884Bhr8_mbronchial hyperresponsiveness 8 (mouse)Not determined6121465015Mouse
10044000Mobq9_mmultigenetic obesity QTL 9 (mouse)Not determined6121465015Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
12904955Gmmq3_mgastrocnemius muscle mass QTL 3 (mouse)6125514064Mouse

Markers in Region
D17584  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3867,562,662 - 7,562,764UniSTSGRCm38
MGSCv3767,512,662 - 7,512,764UniSTSGRCm37
Celera67,700,819 - 7,700,921UniSTS
Cytogenetic Map6A1UniSTS
cM Map65.0UniSTS
Whitehead/MRC_RH674.85UniSTS
Tac1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6A1UniSTS
cM Map65.0UniSTS
cM Map65.0UniSTS
Tac1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6A1UniSTS
cM Map65.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001311060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI835507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI837972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ057335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ059943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX238160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D17584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M68908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M68909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000090679   ⟹   ENSMUSP00000088175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl67,555,074 - 7,562,976 (+)Ensembl
GRCm38.p6 Ensembl67,555,074 - 7,562,976 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184481
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl67,562,368 - 7,565,834 (+)Ensembl
GRCm38.p6 Ensembl67,562,368 - 7,565,834 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184986   ⟹   ENSMUSP00000138818
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl67,555,096 - 7,562,700 (+)Ensembl
GRCm38.p6 Ensembl67,555,096 - 7,562,700 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185130   ⟹   ENSMUSP00000139032
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl67,556,091 - 7,559,114 (+)Ensembl
GRCm38.p6 Ensembl67,556,091 - 7,559,114 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185187   ⟹   ENSMUSP00000139347
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl67,554,879 - 7,562,977 (+)Ensembl
GRCm38.p6 Ensembl67,554,879 - 7,562,977 (+)Ensembl
RefSeq Acc Id: NM_001311060   ⟹   NP_001297989
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3967,555,061 - 7,562,978 (+)NCBI
GRCm3867,555,061 - 7,562,978 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009311   ⟹   NP_033337
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3967,555,061 - 7,562,978 (+)NCBI
GRCm3867,555,061 - 7,562,978 (+)NCBI
MGSCv3767,505,071 - 7,512,973 (+)RGD
Celera67,693,231 - 7,701,130 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505027   ⟹   XP_006505090
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3967,555,168 - 7,562,978 (+)NCBI
GRCm3867,555,168 - 7,562,978 (+)NCBI
Sequence:
RefSeq Acc Id: NP_033337   ⟸   NM_009311
- Peptide Label: isoform 1 precursor
- UniProtKB: Q00073 (UniProtKB/Swiss-Prot),   P41539 (UniProtKB/Swiss-Prot),   Q149W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505090   ⟸   XM_006505027
- Peptide Label: isoform X1
- UniProtKB: Q00073 (UniProtKB/Swiss-Prot),   P41539 (UniProtKB/Swiss-Prot),   Q149W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001297989   ⟸   NM_001311060
- Peptide Label: isoform 2 precursor
- UniProtKB: B7ZMQ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000138818   ⟸   ENSMUST00000184986
Ensembl Acc Id: ENSMUSP00000088175   ⟸   ENSMUST00000090679
Ensembl Acc Id: ENSMUSP00000139032   ⟸   ENSMUST00000185130
Ensembl Acc Id: ENSMUSP00000139347   ⟸   ENSMUST00000185187
Protein Domains
Tachykinin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41539-F1-model_v2 AlphaFold P41539 1-130 view protein structure

Promoters
RGD ID:6840045
Promoter ID:MM_KWN:45125
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000115546,   NM_009311
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3667,504,856 - 7,505,356 (+)MPROMDB
RGD ID:6888978
Promoter ID:EPDNEW_M7940
Type:multiple initiation site
Name:Tac1_1
Description:Mus musculus tachykinin 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3867,555,061 - 7,555,121EPDNEW
RGD ID:6888980
Promoter ID:EPDNEW_M7941
Type:multiple initiation site
Name:AK019709_1
Description:n/a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3867,562,368 - 7,562,428EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98474 AgrOrtholog
Ensembl Genes ENSMUSG00000061762 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000090679.9 UniProtKB/TrEMBL
  ENSMUST00000184986 ENTREZGENE
  ENSMUST00000184986.2 UniProtKB/Swiss-Prot
  ENSMUST00000185130.2 UniProtKB/TrEMBL
  ENSMUST00000185187 ENTREZGENE
  ENSMUST00000185187.8 UniProtKB/Swiss-Prot
InterPro Tachy_Neuro_lke_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tachykinin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tachykinin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21333 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98474 ENTREZGENE
NCBI Gene 21333 ENTREZGENE
PANTHER PROTACHYKININ-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TACHYKININ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tachykinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tac1 PhenoGen
PRINTS PROTACHYKNIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TACHYKININ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MQA8_MOUSE UniProtKB/TrEMBL
  B7ZMQ2 ENTREZGENE, UniProtKB/TrEMBL
  P41539 ENTREZGENE
  Q00073 ENTREZGENE
  Q149W7 ENTREZGENE, UniProtKB/TrEMBL
  TKN1_MOUSE UniProtKB/Swiss-Prot
  V9GX83_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q00073 UniProtKB/Swiss-Prot