TAC1 (tachykinin precursor 1) - Rat Genome Database

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Gene: TAC1 (tachykinin precursor 1) Sus scrofa
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Symbol: TAC1
Name: tachykinin precursor 1
RGD ID: 14171449
Description: ENCODES a protein that exhibits neuromedin K receptor binding (ortholog); receptor ligand activity (ortholog); substance K receptor binding (ortholog); INVOLVED IN antibacterial humoral response (ortholog); antifungal humoral response (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic disease (ortholog); amnestic disorder (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH acrylamide; bisphenol A; capsaicin
Type: protein-coding
RefSeq Status: MODEL
Also known as: protachykinin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl977,197,535 - 77,206,526 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1977,197,403 - 77,206,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2984,764,564 - 84,773,747 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial humoral response  (ISO)
antifungal humoral response  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
associative learning  (ISO)
cellular response to nerve growth factor stimulus  (IEA,ISO)
chemical synaptic transmission  (IEA)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
inflammatory response  (IBA,ISO)
innate immune response  (ISO)
killing of cells of other organism  (ISO)
long-term memory  (ISO)
negative regulation of heart rate  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
neuropeptide signaling pathway  (IEA)
positive regulation of action potential  (ISO)
positive regulation of acute inflammatory response  (ISO)
positive regulation of corticosterone secretion  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of flagellated sperm motility  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of ossification  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of saliva secretion  (ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of synaptic transmission, GABAergic  (ISO)
regulation of blood pressure  (ISO)
regulation of sensory perception of pain  (ISO)
response to hormone  (ISO)
response to lipopolysaccharide  (ISO)
response to morphine  (ISO)
response to pain  (IEA,ISO)
response to yeast  (ISO)
sensory perception of pain  (IEA,ISO)
tachykinin receptor signaling pathway  (IBA,IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:24155273   PMID:24713103  


Genomics

Comparative Map Data
TAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl977,197,535 - 77,206,526 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1977,197,403 - 77,206,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2984,764,564 - 84,773,747 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl797,732,084 - 97,740,472 (+)EnsemblGRCh38hg38GRCh38
GRCh38797,732,086 - 97,740,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37797,361,398 - 97,369,784 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36797,199,311 - 97,207,720 (+)NCBINCBI36hg18NCBI36
Build 34797,006,025 - 97,014,433NCBI
Celera792,055,970 - 92,064,483 (+)NCBI
Cytogenetic Map7q21.3NCBI
HuRef791,962,648 - 91,971,157 (+)NCBIHuRef
CHM1_1797,291,306 - 97,299,818 (+)NCBICHM1_1
CRA_TCAGchr7v2796,683,759 - 96,692,272 (+)NCBI
Tac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3967,555,061 - 7,562,978 (+)NCBIGRCm39mm39
GRCm39 Ensembl67,554,879 - 7,565,834 (+)Ensembl
GRCm3867,555,061 - 7,562,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl67,554,879 - 7,565,834 (+)EnsemblGRCm38mm10GRCm38
MGSCv3767,505,071 - 7,512,973 (+)NCBIGRCm37mm9NCBIm37
MGSCv3667,505,071 - 7,512,973 (+)NCBImm8
Celera67,693,231 - 7,701,130 (+)NCBICelera
Cytogenetic Map6A1NCBI
cM Map63.31NCBI
Tac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2435,679,183 - 35,687,180 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl433,638,709 - 33,646,819 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0433,638,853 - 33,646,819 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0433,499,891 - 33,507,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4432,649,666 - 32,657,632 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1432,768,205 - 32,776,170 (+)NCBI
Celera431,183,136 - 31,191,779 (+)NCBICelera
Cytogenetic Map4q21NCBI
Tac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543213,991,414 - 13,999,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543213,991,647 - 13,999,665 (+)NCBIChiLan1.0ChiLan1.0
TAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17103,257,450 - 103,266,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7103,257,501 - 103,266,389 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0789,675,834 - 89,684,391 (+)NCBIMhudiblu_PPA_v0panPan3
TAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11422,631,106 - 22,640,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1422,632,642 - 22,640,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1422,207,754 - 22,215,926 (+)NCBI
ROS_Cfam_1.01422,451,048 - 22,459,223 (+)NCBI
UMICH_Zoey_3.11422,597,269 - 22,605,445 (+)NCBI
UNSW_CanFamBas_1.01422,330,414 - 22,338,555 (+)NCBI
UU_Cfam_GSD_1.01422,594,017 - 22,602,196 (+)NCBI
Tac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511835,921,952 - 35,930,508 (+)NCBI
SpeTri2.0NW_0049365852,932,783 - 2,941,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12151,339,085 - 51,347,561 (-)NCBI
ChlSab1.1 Ensembl2151,339,095 - 51,347,550 (-)Ensembl
Vero_WHO_p1.0NW_02366604253,024,229 - 53,032,700 (+)NCBI
Tac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248134,542,226 - 4,550,378 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system reproductive system
High
Medium 4
Low 5 3 2 16 1
Below cutoff 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000027581   ⟹   ENSSSCP00000020239
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl977,197,639 - 77,206,519 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000037660   ⟹   ENSSSCP00000031562
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl977,197,535 - 77,206,526 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048830   ⟹   ENSSSCP00000038049
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl977,197,586 - 77,206,523 (+)Ensembl
RefSeq Acc Id: XM_003130163   ⟹   XP_003130211
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1977,197,420 - 77,206,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003130164   ⟹   XP_003130212
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1977,197,409 - 77,206,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003357447   ⟹   XP_003357495
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1977,197,420 - 77,206,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005667633   ⟹   XP_005667690
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1977,197,403 - 77,206,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013979715   ⟹   XP_013835169
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1977,197,704 - 77,206,529 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005667690   ⟸   XM_005667633
- Peptide Label: isoform X3
- UniProtKB: A0A286ZJ61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003130212   ⟸   XM_003130164
- Peptide Label: isoform X1
- UniProtKB: A0A287A283 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003130211   ⟸   XM_003130163
- Peptide Label: isoform X2
- UniProtKB: I3L881 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003357495   ⟸   XM_003357447
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013835169   ⟸   XM_013979715
- Peptide Label: isoform X1
- UniProtKB: A0A287A283 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000038049   ⟸   ENSSSCT00000048830
RefSeq Acc Id: ENSSSCP00000020239   ⟸   ENSSSCT00000027581
RefSeq Acc Id: ENSSSCP00000031562   ⟸   ENSSSCT00000037660
Protein Domains
TK


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000023592 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070011292 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000020239 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000031562 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000038049 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070018216 UniProtKB/TrEMBL
  ENSSSCP00070018223 UniProtKB/TrEMBL
  ENSSSCP00070018228 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000027581 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000037660 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000048830 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070021996 UniProtKB/TrEMBL
  ENSSSCT00070022003 UniProtKB/TrEMBL
  ENSSSCT00070022008 UniProtKB/TrEMBL
InterPro Tachy_Neuro_lke_CS UniProtKB/TrEMBL
  Tachykinin_dom UniProtKB/TrEMBL
  Tachykinin_fam UniProtKB/TrEMBL
KEGG Report ssc:100525179 UniProtKB/TrEMBL
NCBI Gene TAC1 ENTREZGENE
Pfam Tachykinin UniProtKB/TrEMBL
PRINTS PROTACHYKNIN UniProtKB/TrEMBL
PROSITE TACHYKININ UniProtKB/TrEMBL
SMART SM00203 UniProtKB/TrEMBL
UniProt A0A286ZJ61 ENTREZGENE, UniProtKB/TrEMBL
  A0A287A283 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TPS0_PIG UniProtKB/TrEMBL
  A0A4X1TSN8_PIG UniProtKB/TrEMBL
  A0A4X1TSP2_PIG UniProtKB/TrEMBL
  I3L881 ENTREZGENE, UniProtKB/TrEMBL
  Q2A136_PIG UniProtKB/TrEMBL
VGNC ID VGNC:93697 ENTREZGENE