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Neuropeptide K stimulates corticosterone release in the rat.

Authors: Kalra, PS  Kalra, SP 
Citation: Kalra PS and Kalra SP, Brain Res. 1993 May 7;610(2):330-3.
Pubmed: (View Article at PubMed) PMID:8391371

We have investigated the effects of the tachykinin, neurokinin A (NKA) and N-terminally extended forms NPK and NP gamma on plasma levels of corticosterone. Both peripheral and central injections of these three NK-2 receptor agonists stimulated adrenal corticosterone release in gonad-intact and castrated male rats. A comparison of their effects revealed that NPK was relatively more potent than NKA and NP gamma. These results suggest that tachykinins may act at both central and peripheral sites to stimulate corticosterone release and that NKA and NP gamma may represent degradation forms of the larger, biologically effective tachykinin, NPK.


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RGD Object Information
RGD ID: 5147624
Created: 2011-08-16
Species: All species
Last Modified: 2011-08-16
Status: ACTIVE


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