RGD Reference Report - Neuropeptide K stimulates corticosterone release in the rat. - Rat Genome Database

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Neuropeptide K stimulates corticosterone release in the rat.

Authors: Kalra, PS  Kalra, SP 
Citation: Kalra PS and Kalra SP, Brain Res. 1993 May 7;610(2):330-3.
RGD ID: 5147624
Pubmed: PMID:8391371   (View Abstract at PubMed)

We have investigated the effects of the tachykinin, neurokinin A (NKA) and N-terminally extended forms NPK and NP gamma on plasma levels of corticosterone. Both peripheral and central injections of these three NK-2 receptor agonists stimulated adrenal corticosterone release in gonad-intact and castrated male rats. A comparison of their effects revealed that NPK was relatively more potent than NKA and NP gamma. These results suggest that tachykinins may act at both central and peripheral sites to stimulate corticosterone release and that NKA and NP gamma may represent degradation forms of the larger, biologically effective tachykinin, NPK.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of corticosterone secretion  IDA 5147624 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tac1  (tachykinin, precursor 1)


Additional Information