RGD Reference Report - Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats. - Rat Genome Database

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Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats.

Authors: Evangelista, S  Tramontana, M  Maggi, CA 
Citation: Evangelista S, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):663-70. Epub 2008 Aug 19.
RGD ID: 2304260
Pubmed: PMID:18715640   (View Abstract at PubMed)
DOI: DOI:10.1016/j.npep.2008.07.001   (Journal Full-text)

The distribution and modification of the tachykinins Substance P (SP) and neurokinin A (NKA), their precursor beta-preprotachykinins (beta-PPT) and the receptors involved in their activity, NK-1 and NK-2, were studied in trinitrobenzensulphonic acid (TNB) colitis. Rats were intrarectally treated with a 120 mg/ml of TNB solution and sacrificed at various times after colitis induction. During the acute phases of colitis, a marked decrease in tissue SP and NKA levels were observed along with an increased transcription of beta-PPT mRNA in the neurons of the myenteric plexus and an increased myeloperoxidase activity, which is an index of the tissue's inflammatory status. De novo expression of both NK(1) and NK(2) receptor mRNA was observed during the acute phase of TNB-colitis in mesenchymal cells around dilated submucosal vessels but their expression in smooth muscle cells of the muscularis mucosae and propria was moderately down-regulated. The peptide levels, myeloperoxidase activity and gene expression of tachykinin receptors were then restored during the late phases (2-4 weeks after the apten administration) while beta-PPT mRNA remained highly expressed in the myenteric plexus ganglia showing that SP and NKA are involved in repair processes. These results point to the enhanced release of tachykinins during the initial phase of colitis and a restoration of this neuropeptide pool in the healing of the tissue.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TAC1Humancolitis  ISOTac1 (Rattus norvegicus) RGD 
TACR1Humancolitis  ISOTacr1 (Rattus norvegicus) RGD 
TACR2Humancolitis  ISOTacr2 (Rattus norvegicus) RGD 
Tac1Ratcolitis  IEP  RGD 
Tac1Mousecolitis  ISOTac1 (Rattus norvegicus) RGD 
Tacr1Ratcolitis  IEP  RGD 
Tacr1Mousecolitis  ISOTacr1 (Rattus norvegicus) RGD 
Tacr2Ratcolitis  IEP  RGD 
Tacr2Mousecolitis  ISOTacr2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tac1  (tachykinin, precursor 1)
Tacr1  (tachykinin receptor 1)
Tacr2  (tachykinin receptor 2)

Genes (Mus musculus)
Tac1  (tachykinin 1)
Tacr1  (tachykinin receptor 1)
Tacr2  (tachykinin receptor 2)

Genes (Homo sapiens)
TAC1  (tachykinin precursor 1)
TACR1  (tachykinin receptor 1)
TACR2  (tachykinin receptor 2)


Additional Information